W Garvey

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. doi request reprint Prevention of type 2 diabetes in subjects with prediabetes and metabolic syndrome treated with phentermine and topiramate extended release
    W Timothy Garvey
    Corresponding author W Timothy Garvey
    Diabetes Care 37:912-21. 2014
  2. pmc The impact of weight loss among seniors on Medicare spending
    Kenneth E Thorpe
    Long Associates, Keswick, VA 22947, USA
    Health Econ Rev 3:7. 2013
  3. pmc Phentermine and topiramate extended-release: a new treatment for obesity and its role in a complications-centric approach to obesity medical management
    William Timothy Garvey
    University of Alabama at Birmingham, Department of Nutritional Sciences, Webb 232, 1720 Second Ave South, Birmingham, AL 35294 3360, USA
    Expert Opin Drug Saf 12:741-56. 2013
  4. pmc Type 2 diabetes with partial lipodystrophy of the limbs: a new lipodystrophy phenotype
    Leah R Strickland
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Diabetes Care 36:2247-53. 2013
  5. pmc Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess
    Jiarong Liu
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    Am J Physiol Endocrinol Metab 303:E908-16. 2012
  6. pmc Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study
    W Timothy Garvey
    Department of Nutrition Sciences, UAB Diabetes Research and Training Center, University of Alabama at Birmingham, 35294 3360, USA
    Am J Clin Nutr 95:297-308. 2012
  7. pmc A clustering analysis of lipoprotein diameters in the metabolic syndrome
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, USA
    Lipids Health Dis 10:237. 2011
  8. pmc Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS
    Alexis C Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, Alabama, USA
    Lipids Health Dis 10:143. 2011
  9. pmc Adiponectin reduces lipid accumulation in macrophage foam cells
    Ling Tian
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, United States
    Atherosclerosis 202:152-61. 2009
  10. ncbi request reprint NR4A orphan nuclear receptors modulate insulin action and the glucose transport system: potential role in insulin resistance
    Yuchang Fu
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294 3360, USA
    J Biol Chem 282:31525-33. 2007

Research Grants

  1. NR4A Orphan Receptors And Insulin Resistance
    W Timothy Garvey; Fiscal Year: 2010
  2. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Timothy Garvey; Fiscal Year: 2010
  3. NR4A Orphan Receptors And Insulin Resistance
    W Garvey; Fiscal Year: 2009
  4. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2009
  5. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2007
  6. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2006
  7. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2004
  8. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2003
  9. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2002
  10. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2001

Collaborators

Detail Information

Publications42

  1. doi request reprint Prevention of type 2 diabetes in subjects with prediabetes and metabolic syndrome treated with phentermine and topiramate extended release
    W Timothy Garvey
    Corresponding author W Timothy Garvey
    Diabetes Care 37:912-21. 2014
    ....
  2. pmc The impact of weight loss among seniors on Medicare spending
    Kenneth E Thorpe
    Long Associates, Keswick, VA 22947, USA
    Health Econ Rev 3:7. 2013
    ..Weight loss of this magnitude is consistent with next generation anti-obesity medications recently approved by the Food and Drug Administration...
  3. pmc Phentermine and topiramate extended-release: a new treatment for obesity and its role in a complications-centric approach to obesity medical management
    William Timothy Garvey
    University of Alabama at Birmingham, Department of Nutritional Sciences, Webb 232, 1720 Second Ave South, Birmingham, AL 35294 3360, USA
    Expert Opin Drug Saf 12:741-56. 2013
    ....
  4. pmc Type 2 diabetes with partial lipodystrophy of the limbs: a new lipodystrophy phenotype
    Leah R Strickland
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Diabetes Care 36:2247-53. 2013
    ..acquired). We examined whether a group of patients with partial lipodystrophy of the limbs (PLL), type 2 diabetes mellitus (T2DM), and an absence of a family history of lipodystrophy constitute a new clinical subtype...
  5. pmc Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess
    Jiarong Liu
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    Am J Physiol Endocrinol Metab 303:E908-16. 2012
    ..The above data for the first time implicate TRIB3 as a potent physiological regulator of insulin sensitivity and mitochondrial glucose oxidation under conditions of nutrient deprivation and excess...
  6. pmc Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study
    W Timothy Garvey
    Department of Nutrition Sciences, UAB Diabetes Research and Training Center, University of Alabama at Birmingham, 35294 3360, USA
    Am J Clin Nutr 95:297-308. 2012
    ....
  7. pmc A clustering analysis of lipoprotein diameters in the metabolic syndrome
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, USA
    Lipids Health Dis 10:237. 2011
    ....
  8. pmc Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS
    Alexis C Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, Alabama, USA
    Lipids Health Dis 10:143. 2011
    ....
  9. pmc Adiponectin reduces lipid accumulation in macrophage foam cells
    Ling Tian
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, United States
    Atherosclerosis 202:152-61. 2009
    ..Our studies provide new insights into potential mechanisms of adiponectin-mediated alterations in lipid metabolism and macrophage foam cell formation which may impact the development of atherosclerosis...
  10. ncbi request reprint NR4A orphan nuclear receptors modulate insulin action and the glucose transport system: potential role in insulin resistance
    Yuchang Fu
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294 3360, USA
    J Biol Chem 282:31525-33. 2007
    ..Thus, NR4A3 and NR4A1 are attractive novel therapeutic targets for potential amelioration of insulin resistance, and treatment and prevention of type 2 diabetes and the metabolic syndrome...
  11. ncbi request reprint Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation
    Yuchang Fu
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    J Lipid Res 46:1369-79. 2005
    ....
  12. ncbi request reprint Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophages
    Yuchang Fu
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
    Atherosclerosis 188:102-11. 2006
    ....
  13. ncbi request reprint Role of UCP2 and UCP3 in nutrition and obesity
    Tim R Nagy
    Department of Nutrition Sciences and the Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 3360, USA
    Nutrition 20:139-44. 2004
  14. ncbi request reprint Adiponectin multimeric complexes and the metabolic syndrome trait cluster
    Cristina Lara-Castro
    Department of Nutrition Sciences, 1675 Webb Nutrition Sciences Bldg, Room 244, University of Alabama, Birmingham, AL 35294, USA
    Diabetes 55:249-59. 2006
    ..Finally, HMW adiponectin is an important factor in explaining the metabolic syndrome...
  15. ncbi request reprint Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women
    Julian Munoz
    Department of Nutrition Sciences, 1675 Webb Nutrition Sciences Building, Room 241, University of Alabama, Birmingham, AL 35294, USA
    Diabetes 55:3630-4. 2006
    ..Our data suggest that the TCF7L2 gene is an important factor regulating insulin secretion, which could explain its association with type 2 diabetes...
  16. ncbi request reprint The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle
    Xuxia Wu
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
    Endocrine 31:5-17. 2007
    ..The role of NGFI-B (NR4A1) as a new potential mediator of insulin action highlights the need for greater understanding of nuclear transcription factors in insulin action...
  17. pmc Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects
    Cristina Lara-Castro
    Department of Nutrition Sciences, University of Alabama, Birmingham, AL 35294, USA
    Metabolism 57:1-8. 2008
    ..These observations are consistent with the idea that insulin resistance is more directly related to IMCL rather than to body fat per se...
  18. ncbi request reprint Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysis
    Helliner S Vestri
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    Neuropsychopharmacology 32:765-72. 2007
    ..These effects of SGAs on adipocytes could explain, in part, the association of SGAs with weight gain and diabetes...
  19. ncbi request reprint Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formation
    Yuchang Fu
    Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    Blood Cells Mol Dis 32:182-90. 2004
    ..The role for high levels of the fructose transporter GLUT 5 in macrophages and foam cells is unknown since interstitial and circulating fructose concentrations are low in these cells...
  20. pmc Adiponectin multimers and metabolic syndrome traits: relative adiponectin resistance in African Americans
    Cristina Lara-Castro
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obesity (Silver Spring) 16:2616-23. 2008
    ..Thus, HMW adiponectin may exert less bioactivity in explaining the metabolic syndrome trait cluster in populations of predominant African genetic background...
  21. pmc Intracellular lipid accumulation in liver and muscle and the insulin resistance syndrome
    Cristina Lara-Castro
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
    Endocrinol Metab Clin North Am 37:841-56. 2008
    ....
  22. pmc Genes and biochemical pathways in human skeletal muscle affecting resting energy expenditure and fuel partitioning
    Xuxia Wu
    Dept of Nutrition Sciences, The Univ of Alabama at Birmingham, 1675 University Blvd, Birmingham, AL 35294 3360, USA
    J Appl Physiol (1985) 110:746-55. 2011
    ..Individual variations in whole body REE and RQ are regulated by differential expressions of specific genes and pathways intrinsic to skeletal muscle...
  23. ncbi request reprint Serum lipoproteins in the diabetes control and complications trial/epidemiology of diabetes intervention and complications cohort: associations with gender and glycemia
    Alicia J Jenkins
    Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Diabetes Care 26:810-8. 2003
    ..To relate the nuclear magnetic resonance (NMR)-determined lipoprotein profile, conventional lipid and apolipoprotein measures, and in vitro oxidizibility of LDL with gender and glycemia in type 1 diabetes...
  24. ncbi request reprint Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease
    Cristina Lara-Castro
    Department of Nutrition Sciences, University of Alabama at Birmingham, 35294, USA
    Curr Opin Lipidol 18:263-70. 2007
    ..This review summarizes recent studies highlighting cellular effects of adiponectin and its role in human lipid metabolism and atherosclerosis...
  25. ncbi request reprint Uncoupling protein 3 and human metabolism
    W Timothy Garvey
    J Clin Endocrinol Metab 91:1226-8. 2006
  26. ncbi request reprint The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages
    Yuchang Fu
    Department of Medicine, Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, STB 514, 114 Doughty Street, Charleston, SC 29403, USA
    Atherosclerosis 165:259-69. 2002
    ..e. thiazolidinediones) to treat Type 2 Diabetes could exacerbate atherosclerosis, and highlight the need for clinical trials that address this issue...
  27. ncbi request reprint Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance
    W Timothy Garvey
    Division of Endocrinology and Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 52:453-62. 2003
    ..It will be important to study whether NMR lipoprotein subclass parameters can be used to manage risk more effectively and prevent cardiovascular disease in patients with the IRS...
  28. pmc The role of uncoupling protein 3 in human physiology
    W Timothy Garvey
    Division of Endocrinology, Diabetes, and Medical Genetics and Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Clin Invest 111:438-41. 2003
  29. ncbi request reprint Effective use of thiazolidinediones for the treatment of glucocorticoid-induced diabetes
    Steven M Willi
    Department of Pediatrics and General Clinical Research Center, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    Diabetes Res Clin Pract 58:87-96. 2002
    ..Thiazolidinediones may improve diabetes-related parameters by antagonizing pathways of glucocorticoid-induced insulin resistance and by reversing adverse effects of glucocorticoids on beta cell function...
  30. ncbi request reprint Critical evaluation of adult treatment panel III criteria in identifying insulin resistance with dyslipidemia
    Youlian Liao
    Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, USA
    Diabetes Care 27:978-83. 2004
    ....
  31. ncbi request reprint Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin
    Steven M Willi
    Department of Pediatrics, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 51:2895-902. 2002
    ..By preventing or reversing insulin resistance, troglitazone may prove to be a valuable therapeutic agent in the difficult clinical task of controlling diabetes in patients receiving glucocorticoids...
  32. ncbi request reprint Apolipoprotein C-III protein concentrations and gene polymorphisms in type 1 diabetes: associations with lipoprotein subclasses
    Richard L Klein
    Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Metabolism 53:1296-304. 2004
    ....
  33. ncbi request reprint Diet, insulin resistance, and obesity: zoning in on data for Atkins dieters living in South Beach
    Cristina Lara-Castro
    Department of Nutrition Sciences, Webb 232, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, Alabama 35294 3360, USA
    J Clin Endocrinol Metab 89:4197-205. 2004
    ..Long-term studies to determine the efficacy and safety of both popular and experimental diets are warranted...
  34. ncbi request reprint Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction
    Min Chen
    Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Biochemistry 45:1128-37. 2006
    ....
  35. ncbi request reprint Apolipoprotein C-III protein concentrations and gene polymorphisms in Type 1 diabetes: associations with microvascular disease complications in the DCCT/EDIC cohort
    Richard L Klein
    Department of Medicine, Division of Endocrinology, Metabolism, and Medical Genetics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Diabetes Complications 19:18-25. 2005
    ..We investigated the associations of apolipoprotein C-III (apoCIII) protein and apoCIII gene variation with microvascular disease complications in Type 1 diabetes...
  36. ncbi request reprint Plasma prekallikrein: a risk marker for hypertension and nephropathy in type 1 diabetes
    Ayad A Jaffa
    Department of Medicine, Endocrinology Diabetes Medical Genetics, Medical University of South Carolina, 114 Doughty Street, PO Box 250776, Charleston, SC 29425, USA
    Diabetes 52:1215-21. 2003
    ....
  37. ncbi request reprint Lipoproteins in the DCCT/EDIC cohort: associations with diabetic nephropathy
    Alicia J Jenkins
    Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina, USA
    Kidney Int 64:817-28. 2003
    ..The relationship between detailed lipoprotein analyses and diabetic nephropathy is of interest...
  38. ncbi request reprint Three novel mtDNA restriction site polymorphisms allow exploration of population affinities of African Americans
    David C McLean
    Department of Medicine, Division of Endocrinology, Diabetes, and Medical Genetics, Sea Island Families Project and Project Sugar, The Medical University of South Carolina, Ralph H Johnson Veteran Affairs Medical Center, Charleston, South Carolina, USA
    Hum Biol 75:147-61. 2003
    ..These RSPs may become valuable new tools in the study of ancestral affinities and admixture dynamics of African Americans...
  39. ncbi request reprint Individual differences in the response to ingested nutrients
    David B Allison
    Department of Biostatistics Section on Statistical Genetics Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nutrition 20:1. 2004
  40. ncbi request reprint Diabetic retinopathy and serum lipoprotein subclasses in the DCCT/EDIC cohort
    Timothy J Lyons
    Section of Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Invest Ophthalmol Vis Sci 45:910-8. 2004
    ..To determine associations between retinopathy status and detailed serum lipoprotein subclass profiles in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) cohort...
  41. ncbi request reprint Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohort
    Alicia J Jenkins
    Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, SC, USA
    J Diabetes Complications 22:153-63. 2008
    ..To determine the relationships between C-reactive protein (CRP) levels and features of Type 1 diabetes...
  42. ncbi request reprint Estimation of resting energy expenditure considering effects of race and diabetes status
    Kelley Martin
    General Clinical Research Center, Medical University of South Carolina, Charleston, SC, USA
    Diabetes Care 27:1405-11. 2004
    ..To evaluate the impact of diabetes status and race, in addition to other covariables, on the estimation of resting energy expenditure (REE)...

Research Grants19

  1. NR4A Orphan Receptors And Insulin Resistance
    W Timothy Garvey; Fiscal Year: 2010
    ....
  2. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Timothy Garvey; Fiscal Year: 2010
    ..These studies will for the first time delineate functional and molecular defects in muscle mitochondria related to defects in substrate oxidation and IMCL in human insulin resistance. ..
  3. NR4A Orphan Receptors And Insulin Resistance
    W Garvey; Fiscal Year: 2009
    ....
  4. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2009
    ..These studies will for the first time delineate functional and molecular defects in muscle mitochondria related to defects in substrate oxidation and IMCL in human insulin resistance. ..
  5. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2007
    ..These studies will for the first time delineate functional and molecular defects in muscle mitochondria related to defects in substrate oxidation and IMCL in human insulin resistance. ..
  6. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2006
    ..These studies will for the first time delineate functional and molecular defects in muscle mitochondria related to defects in substrate oxidation and IMCL in human insulin resistance. ..
  7. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2004
    ..These experiments will for the first time examine relationships between muscle fat metabolism, IML, TNFalpha and insulin sensitivity in humans. ..
  8. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2003
    ..These experiments will for the first time examine relationships between muscle fat metabolism, IML, TNFalpha and insulin sensitivity in humans. ..
  9. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2002
    ..These experiments will for the first time examine relationships between muscle fat metabolism, IML, TNFalpha and insulin sensitivity in humans. ..
  10. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2001
    ..These experiments will for the first time examine relationships between muscle fat metabolism, IML, TNFalpha and insulin sensitivity in humans. ..
  11. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 2000
    ..These experiments will for the first time examine relationships between muscle fat metabolism, IML, TNFalpha and insulin sensitivity in humans. ..
  12. HEREDITY AND MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Garvey; Fiscal Year: 1999
    ....
  13. MECHANISMS OF HUMAN INSULIN RESISTANCE
    W Timothy Garvey; Fiscal Year: 2010
    ..These studies will for the first time delineate functional and molecular defects in muscle mitochondria related to defects in substrate oxidation and IMCL in human insulin resistance. ..