Research Topics
Genomes and Genes | W GarveySummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
Research Grants
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Publications
Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excessJiarong Liu
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
Am J Physiol Endocrinol Metab 303:E908-16. 2012..The above data for the first time implicate TRIB3 as a potent physiological regulator of insulin sensitivity and mitochondrial glucose oxidation under conditions of nutrient deprivation and excess...- Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension studyW Timothy Garvey
Department of Nutrition Sciences, UAB Diabetes Research and Training Center, University of Alabama at Birmingham, 35294 3360, USA
Am J Clin Nutr 95:297-308. 2012.... - A clustering analysis of lipoprotein diameters in the metabolic syndromeAlexis C Frazier-Wood
Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, USA
Lipids Health Dis 10:237. 2011.... - Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetSAlexis C Wood
Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, Alabama, USA
Lipids Health Dis 10:143. 2011.... - Adiponectin reduces lipid accumulation in macrophage foam cellsLing Tian
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, United States
Atherosclerosis 202:152-61. 2009..Our studies provide new insights into potential mechanisms of adiponectin-mediated alterations in lipid metabolism and macrophage foam cell formation which may impact the development of atherosclerosis... 
Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophagesYuchang Fu
Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
Atherosclerosis 188:102-11. 2006....- Adiponectin multimeric complexes and the metabolic syndrome trait clusterCristina Lara-Castro
Department of Nutrition Sciences, 1675 Webb Nutrition Sciences Bldg, Room 244, University of Alabama, Birmingham, AL 35294, USA
Diabetes 55:249-59. 2006..Finally, HMW adiponectin is an important factor in explaining the metabolic syndrome... - Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysisHelliner S Vestri
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
Neuropsychopharmacology 32:765-72. 2007..These effects of SGAs on adipocytes could explain, in part, the association of SGAs with weight gain and diabetes... - Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic womenJulian Munoz
Department of Nutrition Sciences, 1675 Webb Nutrition Sciences Building, Room 241, University of Alabama, Birmingham, AL 35294, USA
Diabetes 55:3630-4. 2006..Our data suggest that the TCF7L2 gene is an important factor regulating insulin secretion, which could explain its association with type 2 diabetes... - The effect of insulin on expression of genes and biochemical pathways in human skeletal muscleXuxia Wu
Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
Endocrine 31:5-17. 2007..The role of NGFI-B (NR4A1) as a new potential mediator of insulin action highlights the need for greater understanding of nuclear transcription factors in insulin action... - NR4A orphan nuclear receptors modulate insulin action and the glucose transport system: potential role in insulin resistanceYuchang Fu
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294 3360, USA
J Biol Chem 282:31525-33. 2007..Thus, NR4A3 and NR4A1 are attractive novel therapeutic targets for potential amelioration of insulin resistance, and treatment and prevention of type 2 diabetes and the metabolic syndrome... - Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjectsCristina Lara-Castro
Department of Nutrition Sciences, University of Alabama, Birmingham, AL 35294, USA
Metabolism 57:1-8. 2008..These observations are consistent with the idea that insulin resistance is more directly related to IMCL rather than to body fat per se... - Adiponectin multimers and metabolic syndrome traits: relative adiponectin resistance in African AmericansCristina Lara-Castro
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 16:2616-23. 2008..Thus, HMW adiponectin may exert less bioactivity in explaining the metabolic syndrome trait cluster in populations of predominant African genetic background... - Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulationYuchang Fu
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
J Lipid Res 46:1369-79. 2005.... - Role of UCP2 and UCP3 in nutrition and obesityTim R Nagy
Department of Nutrition Sciences and the Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294-3360, USA
Nutrition 20:139-44. 2004 - Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formationYuchang Fu
Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
Blood Cells Mol Dis 32:182-90. 2004..The role for high levels of the fructose transporter GLUT 5 in macrophages and foam cells is unknown since interstitial and circulating fructose concentrations are low in these cells... - Intracellular lipid accumulation in liver and muscle and the insulin resistance syndromeCristina Lara-Castro
Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
Endocrinol Metab Clin North Am 37:841-56. 2008.... - Genes and biochemical pathways in human skeletal muscle affecting resting energy expenditure and fuel partitioningXuxia Wu
Dept of Nutrition Sciences, The Univ of Alabama at Birmingham, 1675 University Blvd, Birmingham, AL 35294 3360, USA
J Appl Physiol 110:746-55. 2011..Individual variations in whole body REE and RQ are regulated by differential expressions of specific genes and pathways intrinsic to skeletal muscle... - Effective use of thiazolidinediones for the treatment of glucocorticoid-induced diabetesSteven M Willi
Department of Pediatrics and General Clinical Research Center, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
Diabetes Res Clin Pract 58:87-96. 2002..Thiazolidinediones may improve diabetes-related parameters by antagonizing pathways of glucocorticoid-induced insulin resistance and by reversing adverse effects of glucocorticoids on beta cell function... - The role of uncoupling protein 3 in human physiologyW Timothy Garvey
Division of Endocrinology, Diabetes, and Medical Genetics and Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Clin Invest 111:438-41. 2003 - Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular diseaseCristina Lara-Castro
Department of Nutrition Sciences, University of Alabama at Birmingham, 35294, USA
Curr Opin Lipidol 18:263-70. 2007..This review summarizes recent studies highlighting cellular effects of adiponectin and its role in human lipid metabolism and atherosclerosis... - Uncoupling protein 3 and human metabolismW Timothy Garvey
J Clin Endocrinol Metab 91:1226-8. 2006 - Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonanceW Timothy Garvey
Division of Endocrinology and Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
Diabetes 52:453-62. 2003..It will be important to study whether NMR lipoprotein subclass parameters can be used to manage risk more effectively and prevent cardiovascular disease in patients with the IRS... - The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophagesYuchang Fu
Department of Medicine, Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, STB 514, 114 Doughty Street, Charleston, SC 29403, USA
Atherosclerosis 165:259-69. 2002..e. thiazolidinediones) to treat Type 2 Diabetes could exacerbate atherosclerosis, and highlight the need for clinical trials that address this issue... - Critical evaluation of adult treatment panel III criteria in identifying insulin resistance with dyslipidemiaYoulian Liao
Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, USA
Diabetes Care 27:978-83. 2004..More sensitive criteria should be developed for clinical assessment of metabolic and cardiovascular disease risk relevant to the metabolic syndrome... - Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptinSteven M Willi
Department of Pediatrics, Medical University of South Carolina, Charleston 29425, USA
Diabetes 51:2895-902. 2002..By preventing or reversing insulin resistance, troglitazone may prove to be a valuable therapeutic agent in the difficult clinical task of controlling diabetes in patients receiving glucocorticoids... - Apolipoprotein C-III protein concentrations and gene polymorphisms in type 1 diabetes: associations with lipoprotein subclassesRichard L Klein
Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
Metabolism 53:1296-304. 2004.... - Diet, insulin resistance, and obesity: zoning in on data for Atkins dieters living in South BeachCristina Lara-Castro
Department of Nutrition Sciences, Webb 232, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, Alabama 35294-3360, USA
J Clin Endocrinol Metab 89:4197-205. 2004..Long-term studies to determine the efficacy and safety of both popular and experimental diets are warranted... - Serum lipoproteins in the diabetes control and complications trial/epidemiology of diabetes intervention and complications cohort: associations with gender and glycemiaAlicia J Jenkins
Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina 29403, USA
Diabetes Care 26:810-8. 2003..CONCLUSIONS: Male gender and poor glycemia are associated with a potentially more atherogenic NMR lipoprotein profile. Neither gender nor glycemia influence LDL oxidation in vitro... 
Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohortAlicia J Jenkins
Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, SC, USA
J Diabetes Complications 22:153-63. 2008..To determine the relationships between C-reactive protein (CRP) levels and features of Type 1 diabetes...- Plasma prekallikrein: a risk marker for hypertension and nephropathy in type 1 diabetesAyad A Jaffa
Department of Medicine, Endocrinology Diabetes Medical Genetics, Medical University of South Carolina, 114 Doughty Street, PO Box 250776, Charleston, SC 29425, USA
Diabetes 52:1215-21. 2003.... - Lipoproteins in the DCCT/EDIC cohort: associations with diabetic nephropathyAlicia J Jenkins
Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina, USA
Kidney Int 64:817-28. 2003..Longitudinal studies are needed to determine if dyslipoproteinemia can predict patients at risk of nephropathy, or if lipoprotein-related interventions retard nephropathy... - Three novel mtDNA restriction site polymorphisms allow exploration of population affinities of African AmericansDavid C McLean
Department of Medicine, Division of Endocrinology, Diabetes, and Medical Genetics, Sea Island Families Project and Project Sugar, The Medical University of South Carolina, Ralph H. Johnson Veteran Affairs Medical Center, Charleston, South Carolina, USA
Hum Biol 75:147-61. 2003..These RSPs may become valuable new tools in the study of ancestral affinities and admixture dynamics of African Americans... - Individual differences in the response to ingested nutrientsDavid B Allison
Department of Biostatistics Section on Statistical Genetics Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, Alabama, USA
Nutrition 20:1. 2004 - Molecular characterization of human melanocortin-3 receptor ligand-receptor interactionMin Chen
Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Biochemistry 45:1128-37. 2006..Importantly, L165 in TM3 is critical for agonist or antagonist selectivity. These results provide important information about the molecular determinants of hMC3R responsible for ligand binding and receptor signaling... - Diabetic retinopathy and serum lipoprotein subclasses in the DCCT/EDIC cohortTimothy J Lyons
Section of Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Invest Ophthalmol Vis Sci 45:910-8. 2004..To determine associations between retinopathy status and detailed serum lipoprotein subclass profiles in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) cohort... - Apolipoprotein C-III protein concentrations and gene polymorphisms in Type 1 diabetes: associations with microvascular disease complications in the DCCT/EDIC cohortRichard L Klein
Department of Medicine, Division of Endocrinology, Metabolism, and Medical Genetics, Medical University of South Carolina, Charleston, SC 29425, USA
J Diabetes Complications 19:18-25. 2005..We investigated the associations of apolipoprotein C-III (apoCIII) protein and apoCIII gene variation with microvascular disease complications in Type 1 diabetes... - Estimation of resting energy expenditure considering effects of race and diabetes statusKelley Martin
General Clinical Research Center, Medical University of South Carolina, Charleston, SC, USA
Diabetes Care 27:1405-11. 2004..Race and DSI have not been considered in equations commonly used to predict REE. Their inclusion could improve individualization of dietary prescriptions for type 2 diabetic subjects and heterogeneous populations...
Research Grants
- NR4A Orphan Receptors And Insulin ResistanceW Timothy Garvey; Fiscal Year: 2010....
- MECHANISMS OF HUMAN INSULIN RESISTANCEW Timothy Garvey; Fiscal Year: 2010..These studies will for the first time delineate functional and molecular defects in muscle mitochondria related to defects in substrate oxidation and IMCL in human insulin resistance. ..
- NR4A Orphan Receptors And Insulin ResistanceW Garvey; Fiscal Year: 2009....
- MECHANISMS OF HUMAN INSULIN RESISTANCEW Garvey; Fiscal Year: 2009..These studies will for the first time delineate functional and molecular defects in muscle mitochondria related to defects in substrate oxidation and IMCL in human insulin resistance. ..
- MECHANISMS OF HUMAN INSULIN RESISTANCEW Garvey; Fiscal Year: 2007..These studies will for the first time delineate functional and molecular defects in muscle mitochondria related to defects in substrate oxidation and IMCL in human insulin resistance. ..
- MECHANISMS OF HUMAN INSULIN RESISTANCEW Garvey; Fiscal Year: 2004..These experiments will for the first time examine relationships between muscle fat metabolism, IML, TNFalpha and insulin sensitivity in humans. ..
- HEREDITY AND MECHANISMS OF HUMAN INSULIN RESISTANCEW Garvey; Fiscal Year: 1999....
- MECHANISMS OF HUMAN INSULIN RESISTANCEW Timothy Garvey; Fiscal Year: 2010..These studies will for the first time delineate functional and molecular defects in muscle mitochondria related to defects in substrate oxidation and IMCL in human insulin resistance. ..