William S Garver

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi Niemann-Pick C1 protein regulates cholesterol transport to the trans-Golgi network and plasma membrane caveolae
    William S Garver
    Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    J Lipid Res 43:579-89. 2002
  2. pmc The Niemann-Pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts
    William S Garver
    Department of Pediatrics, University of Arizona, Tucson, AZ 85724 5037, USA
    J Lipid Res 49:1090-102. 2008
  3. ncbi The National Niemann-Pick C1 disease database: report of clinical features and health problems
    William S Garver
    Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona, Tucson, Arizona 85724 5073, and Children s Hospital of Pittsburgh, PA, USA
    Am J Med Genet A 143:1204-11. 2007
  4. ncbi Characterization of liver disease and lipid metabolism in the Niemann-Pick C1 mouse
    William S Garver
    Department of Pediatrics, The University of Arizona, Tucson, AZ 85724, USA
    J Cell Biochem 101:498-516. 2007
  5. ncbi Niemann-Pick C1 expression is not regulated by the amount of cholesterol flowing through cells in the mouse
    William S Garver
    Department of Pediatrics, Arizona Health Sciences Center, University of Arizona, Tucson, AZ 85724, USA
    J Lipid Res 46:1745-54. 2005
  6. ncbi The Niemann-Pick C1 protein in feline fibroblasts
    William S Garver
    Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona, Tucson 85724, USA
    Mol Genet Metab 76:31-6. 2002
  7. ncbi The Niemann-Pick C proteins and trafficking of cholesterol through the late endosomal/lysosomal system
    William S Garver
    Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona, Tucson 85724, USA
    Curr Mol Med 2:485-505. 2002
  8. pmc The National Niemann-Pick Type C1 Disease Database: correlation of lipid profiles, mutations, and biochemical phenotypes
    William S Garver
    Department of Pediatrics, University of Arizona, Tucson, AZ 85724 5037, USA
    J Lipid Res 51:406-15. 2010
  9. doi Physiological and coordinate downregulation of the NPC1 and NPC2 genes are associated with the sequestration of LDL-derived cholesterol within endocytic compartments
    David Jelinek
    Department of Pediatrics, The University of Arizona, 1501 N Campbell Avenue, Tucson, Arizona 85724 5037, USA
    J Cell Biochem 108:1102-16. 2009
  10. pmc Decreased Npc1 gene dosage in mice is associated with weight gain
    David Jelinek
    Department of Pediatrics, The University of Arizona, Tucson, Arizona, USA
    Obesity (Silver Spring) 18:1457-9. 2010

Research Grants

  1. Insulin Resistance and ABCA1 Transporter Function
    WILLIAM GARVER; Fiscal Year: 2006

Collaborators

Detail Information

Publications12

  1. ncbi Niemann-Pick C1 protein regulates cholesterol transport to the trans-Golgi network and plasma membrane caveolae
    William S Garver
    Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    J Lipid Res 43:579-89. 2002
    ..These studies demonstrate that NPC1 regulates cholesterol transport to caveolin-1 and caveolin-2 containing compartments such as the TGN and plasma membrane caveolae...
  2. pmc The Niemann-Pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts
    William S Garver
    Department of Pediatrics, University of Arizona, Tucson, AZ 85724 5037, USA
    J Lipid Res 49:1090-102. 2008
    ....
  3. ncbi The National Niemann-Pick C1 disease database: report of clinical features and health problems
    William S Garver
    Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona, Tucson, Arizona 85724 5073, and Children s Hospital of Pittsburgh, PA, USA
    Am J Med Genet A 143:1204-11. 2007
    ..Together, these findings confirm and extend previous reports investigating the clinical features associated with NPC1 disease...
  4. ncbi Characterization of liver disease and lipid metabolism in the Niemann-Pick C1 mouse
    William S Garver
    Department of Pediatrics, The University of Arizona, Tucson, AZ 85724, USA
    J Cell Biochem 101:498-516. 2007
    ....
  5. ncbi Niemann-Pick C1 expression is not regulated by the amount of cholesterol flowing through cells in the mouse
    William S Garver
    Department of Pediatrics, Arizona Health Sciences Center, University of Arizona, Tucson, AZ 85724, USA
    J Lipid Res 46:1745-54. 2005
    ..We conclude that the relative expression of NPC1 is not regulated by the flow of cholesterol through cells in the mouse and is therefore constitutive...
  6. ncbi The Niemann-Pick C1 protein in feline fibroblasts
    William S Garver
    Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona, Tucson 85724, USA
    Mol Genet Metab 76:31-6. 2002
    ..In summary, the results presented in this report demonstrate that the NPC1 protein in feline fibroblasts has a similar distribution as that previously described for human and murine fibroblasts...
  7. ncbi The Niemann-Pick C proteins and trafficking of cholesterol through the late endosomal/lysosomal system
    William S Garver
    Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona, Tucson 85724, USA
    Curr Mol Med 2:485-505. 2002
    ....
  8. pmc The National Niemann-Pick Type C1 Disease Database: correlation of lipid profiles, mutations, and biochemical phenotypes
    William S Garver
    Department of Pediatrics, University of Arizona, Tucson, AZ 85724 5037, USA
    J Lipid Res 51:406-15. 2010
    ..Together, these findings provide novel information regarding the plasma lipoprotein changes and mutations in NPC1 disease, and suggest plasma HDL-C represents a potential biomarker of NPC1 disease severity...
  9. doi Physiological and coordinate downregulation of the NPC1 and NPC2 genes are associated with the sequestration of LDL-derived cholesterol within endocytic compartments
    David Jelinek
    Department of Pediatrics, The University of Arizona, 1501 N Campbell Avenue, Tucson, Arizona 85724 5037, USA
    J Cell Biochem 108:1102-16. 2009
    ....
  10. pmc Decreased Npc1 gene dosage in mice is associated with weight gain
    David Jelinek
    Department of Pediatrics, The University of Arizona, Tucson, Arizona, USA
    Obesity (Silver Spring) 18:1457-9. 2010
    ..Therefore, decreased Npc1 gene dosage resulting in decreased Npc1 protein function, promoted weight gain in mice fed a high-fat diet consistent with a gene-diet interaction...
  11. ncbi Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function
    Wenxin Yu
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    J Biol Chem 280:11731-9. 2005
    ..These results suggest that mitochondrial dysfunctions and subsequent ATP deficiency, which are induced by altered cholesterol metabolism in mitochondria, may be responsible for neuronal impairment in NPC1 disease...
  12. ncbi Impaired ABCA1-dependent lipid efflux and hypoalphalipoproteinemia in human Niemann-Pick type C disease
    Hong Y Choi
    Department of Medicine and the Canadian Institutes of Health Research Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biol Chem 278:32569-77. 2003
    ....

Research Grants1

  1. Insulin Resistance and ABCA1 Transporter Function
    WILLIAM GARVER; Fiscal Year: 2006
    ....