STANLEY GARTLER

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Normal histone modifications on the inactive X chromosome in ICF and Rett syndrome cells: implications for methyl-CpG binding proteins
    Stanley M Gartler
    Department of Medicine, University of Washington, Seattle, WA, USA
    BMC Biol 2:21. 2004
  2. ncbi request reprint ICF syndrome cells as a model system for studying X chromosome inactivation
    S M Gartler
    Department of Medicine, University of Washington, Seattle WA 98195 7720, USA
    Cytogenet Genome Res 99:25-9. 2002
  3. ncbi request reprint Biology of the X chromosome
    S M Gartler
    Departments of Medicine and Genetics, University of Washington, Seattle, Washington 98195 7360, USA
    Curr Opin Pediatr 13:340-5. 2001
  4. pmc Abnormal X: autosome ratio, but normal X chromosome inactivation in human triploid cultures
    Stanley M Gartler
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    BMC Genet 7:41. 2006
  5. ncbi request reprint The timing of XIST replication: dominance of the domain
    S M Gartler
    Department of Medicine, University of Washington, Seattle 98195, USA
    Hum Mol Genet 8:1085-9. 1999
  6. ncbi request reprint Satellite 2 methylation patterns in normal and ICF syndrome cells and association of hypomethylation with advanced replication
    K M Hassan
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Hum Genet 109:452-62. 2001
  7. pmc The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
    R S Hansen
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:14412-7. 1999
  8. ncbi request reprint Escape from gene silencing in ICF syndrome: evidence for advanced replication time as a major determinant
    R S Hansen
    Department of Medicine, Box 357360, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 9:2575-87. 2000
  9. pmc Very late DNA replication in the human cell cycle
    R J Widrow
    Molecular and Cellular Biology Program of the University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Proc Natl Acad Sci U S A 95:11246-50. 1998
  10. ncbi request reprint An analysis of meiotic pairing in trisomy 21 oocytes using fluorescent in situ hybridization
    E Y Cheng
    Department of Obstetrics and Gynecology, University of Washington, Seattle, USA
    Cytogenet Cell Genet 80:48-53. 1998

Research Grants

  1. DOSAGE COMPENSATION IN MAMMALS: X-INACTIVATION
    STANLEY GARTLER; Fiscal Year: 1999
  2. DOSAGE COMPENSATION IN MAMMALS: X-INACTIVATION
    STANLEY GARTLER; Fiscal Year: 2004

Collaborators

Detail Information

Publications16

  1. pmc Normal histone modifications on the inactive X chromosome in ICF and Rett syndrome cells: implications for methyl-CpG binding proteins
    Stanley M Gartler
    Department of Medicine, University of Washington, Seattle, WA, USA
    BMC Biol 2:21. 2004
    ..In addition, we determined whether a specific methyl-CpG binding protein, MeCP2, is necessary for the inactive X histone modification pattern by studying Rett syndrome cells which are deficient in MeCP2 function...
  2. ncbi request reprint ICF syndrome cells as a model system for studying X chromosome inactivation
    S M Gartler
    Department of Medicine, University of Washington, Seattle WA 98195 7720, USA
    Cytogenet Genome Res 99:25-9. 2002
    ..The abnormal hypomethylation in ICF cells provides an important model system for determining the relationships between replication time, CpG island methylation, chromatin structure, and gene silencing in X chromosome inactivation...
  3. ncbi request reprint Biology of the X chromosome
    S M Gartler
    Departments of Medicine and Genetics, University of Washington, Seattle, Washington 98195 7360, USA
    Curr Opin Pediatr 13:340-5. 2001
    ..Then we consider an unusual feature of X inactivation, the mosaic nature of the female and subsequent exposure to somatic cell selection...
  4. pmc Abnormal X: autosome ratio, but normal X chromosome inactivation in human triploid cultures
    Stanley M Gartler
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    BMC Genet 7:41. 2006
    ....
  5. ncbi request reprint The timing of XIST replication: dominance of the domain
    S M Gartler
    Department of Medicine, University of Washington, Seattle 98195, USA
    Hum Mol Genet 8:1085-9. 1999
    ....
  6. ncbi request reprint Satellite 2 methylation patterns in normal and ICF syndrome cells and association of hypomethylation with advanced replication
    K M Hassan
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Hum Genet 109:452-62. 2001
    ..Another such factor may be altered replication timing because we have discovered that the hypomethylation of satellite 2 in ICF cultures is associated with advanced replication...
  7. pmc The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
    R S Hansen
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:14412-7. 1999
    ..None of the mutations were found in over 200 normal chromosomes. We conclude that mutations in the DNMT3B are responsible for the ICF syndrome...
  8. ncbi request reprint Escape from gene silencing in ICF syndrome: evidence for advanced replication time as a major determinant
    R S Hansen
    Department of Medicine, Box 357360, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 9:2575-87. 2000
    ..The persistence of inactivation in these latter cases appears to depend critically on delayed replication of DNA because escape from silencing was only seen when replication was advanced to an active X-like pattern...
  9. pmc Very late DNA replication in the human cell cycle
    R J Widrow
    Molecular and Cellular Biology Program of the University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Proc Natl Acad Sci U S A 95:11246-50. 1998
    ..We conclude that the G2 period is much shorter than previously thought and may, in some cells, be nonexistent...
  10. ncbi request reprint An analysis of meiotic pairing in trisomy 21 oocytes using fluorescent in situ hybridization
    E Y Cheng
    Department of Obstetrics and Gynecology, University of Washington, Seattle, USA
    Cytogenet Cell Genet 80:48-53. 1998
    ..In addition, the asynaptic cells exhibited asynapsis of chromosomes other than 21, which we interpret as an interchromosomal effect of trisomy 21...
  11. pmc A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication
    R S Hansen
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 94:4587-92. 1997
    ..This example of variable spreading of late replication into multiple replicons in fragile X provides a model for the spread of inactivation associated with position-effect variegation or X chromosome inactivation...
  12. ncbi request reprint Analysis of a paracentric inversion in human oocytes: nonhomologous pairing in pachytene
    E Y Cheng
    Department of Obstetrics and Gynecology, University of Washington Medical Center, Seattle 98195 6460, USA
    Hum Genet 105:191-6. 1999
    ..23. Of 1079 pachytene cells, 58% exhibited complete heterosynapsis of the inverted region while only 10.3% of cells exhibited the expected loop formation. Meiotic progression was observed to be normal...
  13. pmc Analysis of CpG suppression in methylated and nonmethylated species
    D F Schorderet
    Department of Medicine, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 89:957-61. 1992
    ..We speculate that the excess of CpGs at position III-I in nonmethylated forms may be related to a requirement for minimal thermal stability of the DNA...
  14. ncbi request reprint Hemimethylation and non-CpG methylation levels in a promoter region of human LINE-1 (L1) repeated elements
    Alice F Burden
    Department of Biology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:14413-9. 2005
    ....
  15. ncbi request reprint The chromosome number in humans: a brief history
    Stanley M Gartler
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Nat Rev Genet 7:655-60. 2006
    ..In 1956 a discovery was reported that markedly altered human cytogenetics and genetics. The following is an analysis of that discovery...
  16. ncbi request reprint Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity
    Jimena V Goldstine
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    DNA Repair (Amst) 5:432-43. 2006
    ..Our findings indicate that although phosphorylation at serine-1981 is essential in the activation of the ATM kinase, serine-1981 phosphorylation is insufficient to render ATM an active kinase towards downstream substrates, including p53...

Research Grants12

  1. DOSAGE COMPENSATION IN MAMMALS: X-INACTIVATION
    STANLEY GARTLER; Fiscal Year: 1999
    ..The health relatedness of this project derives from the fact that the two genes at the basis of this study, FMR1 and XIST, are critical to normal mental and sexual development. ..
  2. DOSAGE COMPENSATION IN MAMMALS: X-INACTIVATION
    STANLEY GARTLER; Fiscal Year: 2004
    ..Such border shifting may have evolutionary implications for genome organization. We propose an extensive test of this model. ..