Gerald Gartlehner

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Biologics for the treatment of juvenile idiopathic arthritis: a systematic review and critical analysis of the evidence
    Gerald Gartlehner
    Ludwig Boltzmann Institute for Health Technology Assessments, Garnisongasse 7 20, 1090, Vienna, Austria
    Clin Rheumatol 27:67-76. 2008
  2. ncbi request reprint A simple and valid tool distinguished efficacy from effectiveness studies
    Gerald Gartlehner
    University of North Carolina at Chapel Hill, Cecil G Sheps Center for Health Services Research, NC 27599, USA
    J Clin Epidemiol 59:1040-8. 2006
  3. pmc Efficacy and safety of inhaled corticosteroids in patients with COPD: a systematic review and meta-analysis of health outcomes
    Gerald Gartlehner
    Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Ann Fam Med 4:253-62. 2006
  4. ncbi request reprint The comparative efficacy and safety of biologics for the treatment of rheumatoid arthritis: a systematic review and metaanalysis
    Gerald Gartlehner
    Cecil G Sheps Center for Health Services, and School of Public Health, Health Policy and Administration, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Rheumatol 33:2398-408. 2006
  5. ncbi request reprint Discontinuation rates for selective serotonin reuptake inhibitors and other second-generation antidepressants in outpatients with major depressive disorder: a systematic review and meta-analysis
    Gerald Gartlehner
    Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 27599, USA
    Int Clin Psychopharmacol 20:59-69. 2005
  6. ncbi request reprint Assessing the need to update prevention guidelines: a comparison of two methods
    Gerald Gartlehner
    Cecil G Sheps Center for Health Services Research, University of North Carolina, 725 Airport Road, Chapel Hill, NC 27599 7590, USA
    Int J Qual Health Care 16:399-406. 2004
  7. ncbi request reprint Efficacy and safety of second-generation antidepressants in the treatment of major depressive disorder
    Richard A Hansen
    Division of Pharmaceutical Policy and Evaluative Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Ann Intern Med 143:415-26. 2005
  8. pmc Efficacy and tolerability of second-generation antidepressants in social anxiety disorder
    Richard A Hansen
    Division of Pharmaceutical Outcomes and Policy, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    Int Clin Psychopharmacol 23:170-9. 2008
  9. ncbi request reprint Systematic review: comparative effectiveness and harms of disease-modifying medications for rheumatoid arthritis
    Katrina E Donahue
    University of North Carolina and Cecil G Sheps Center for Health Services Research, Chapel Hill, North Carolina 27599, USA
    Ann Intern Med 148:124-34. 2008
  10. ncbi request reprint Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and meta-analysis
    Bradley N Gaynes
    Department of Psychiatry, CB 7160, 304 MacNider Hall, Room J, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160
    J Clin Psychiatry 75:477-89. 2014

Detail Information

Publications24

  1. ncbi request reprint Biologics for the treatment of juvenile idiopathic arthritis: a systematic review and critical analysis of the evidence
    Gerald Gartlehner
    Ludwig Boltzmann Institute for Health Technology Assessments, Garnisongasse 7 20, 1090, Vienna, Austria
    Clin Rheumatol 27:67-76. 2008
    ..Clinicians have to be aware of the lack of evidence supporting a long-term net benefit when considering biologics for patients with JIA...
  2. ncbi request reprint A simple and valid tool distinguished efficacy from effectiveness studies
    Gerald Gartlehner
    University of North Carolina at Chapel Hill, Cecil G Sheps Center for Health Services Research, NC 27599, USA
    J Clin Epidemiol 59:1040-8. 2006
    ..To propose and test a simple instrument based on seven criteria of study design to distinguish effectiveness (pragmatic) from efficacy (explanatory) trials...
  3. pmc Efficacy and safety of inhaled corticosteroids in patients with COPD: a systematic review and meta-analysis of health outcomes
    Gerald Gartlehner
    Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Ann Fam Med 4:253-62. 2006
    ..We wanted to review systematically the efficacy, effectiveness, and safety of inhaled corticosteroids with respect to health outcomes in patients with chronic obstructive pulmonary disease (COPD)...
  4. ncbi request reprint The comparative efficacy and safety of biologics for the treatment of rheumatoid arthritis: a systematic review and metaanalysis
    Gerald Gartlehner
    Cecil G Sheps Center for Health Services, and School of Public Health, Health Policy and Administration, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Rheumatol 33:2398-408. 2006
    ..In addition, dosing regimens and routes of administration differ substantially among biologics. In a systematic review, we assessed the comparative efficacy and safety of biologic agents for RA...
  5. ncbi request reprint Discontinuation rates for selective serotonin reuptake inhibitors and other second-generation antidepressants in outpatients with major depressive disorder: a systematic review and meta-analysis
    Gerald Gartlehner
    Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 27599, USA
    Int Clin Psychopharmacol 20:59-69. 2005
    ....
  6. ncbi request reprint Assessing the need to update prevention guidelines: a comparison of two methods
    Gerald Gartlehner
    Cecil G Sheps Center for Health Services Research, University of North Carolina, 725 Airport Road, Chapel Hill, NC 27599 7590, USA
    Int J Qual Health Care 16:399-406. 2004
    ..Recently, Shekelle and colleagues proposed a model of limited literature searches with modest expert involvement as a way to reduce the cost and time requirements for assessing whether a guideline needs updating...
  7. ncbi request reprint Efficacy and safety of second-generation antidepressants in the treatment of major depressive disorder
    Richard A Hansen
    Division of Pharmaceutical Policy and Evaluative Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Ann Intern Med 143:415-26. 2005
    ....
  8. pmc Efficacy and tolerability of second-generation antidepressants in social anxiety disorder
    Richard A Hansen
    Division of Pharmaceutical Outcomes and Policy, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    Int Clin Psychopharmacol 23:170-9. 2008
    ..Overall, a fair amount of evidence supports the efficacy of escitalopram, fluvoxamine, paroxetine, sertraline, and venlafaxine in social anxiety disorder. The drugs do not differ in efficacy, although their adverse event profiles do...
  9. ncbi request reprint Systematic review: comparative effectiveness and harms of disease-modifying medications for rheumatoid arthritis
    Katrina E Donahue
    University of North Carolina and Cecil G Sheps Center for Health Services Research, Chapel Hill, North Carolina 27599, USA
    Ann Intern Med 148:124-34. 2008
    ..The comparative effectiveness of rheumatoid arthritis therapies is uncertain...
  10. ncbi request reprint Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and meta-analysis
    Bradley N Gaynes
    Department of Psychiatry, CB 7160, 304 MacNider Hall, Room J, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160
    J Clin Psychiatry 75:477-89. 2014
    ..These patients are less likely to recover with medications alone and often consider nonpharmacologic treatments such as rTMS...
  11. pmc Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis
    Richard A Hansen
    School of Pharmacy, Division of Pharmaceutical Outcomes and Policy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Interv Aging 3:211-25. 2008
    ..63 and 1.42, respectively). Indirect comparisons also favored donepezil over galantamine with regard to behavior. Across trials, the incidence of adverse events was generally lowest for donepezil and highest for rivastigmine...
  12. pmc Controlling for drug dose in systematic review and meta-analysis: a case study of the effect of antidepressant dose
    Richard A Hansen
    School of Pharmacy, Division of Pharmaceutical Outcomes and Policy, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Med Decis Making 29:91-103. 2009
    ..Second-generation antidepressants are used as an example to illustrate this method and to determine whether dose influences conclusions on comparative effectiveness...
  13. doi request reprint Strategies in assessing the need for updating evidence-based guidelines for six clinical topics: an exploration of two search methodologies
    Christiane E Voisin
    Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, NC 27599 7590, USA
    Health Info Libr J 25:198-207. 2008
    ..Shekelle et al. (Journal of the American Medical Association 2001, 286, 1461-7) proposed using limited literature searches with expert involvement to reduce resources used in assessing whether a guideline needs updating...
  14. doi request reprint Interventions to prevent post-traumatic stress disorder: a systematic review
    Catherine A Forneris
    Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599 7160, USA
    Am J Prev Med 44:635-50. 2013
    ..This review assessed the efficacy, comparative effectiveness, and harms of psychological, pharmacologic, and emerging interventions to prevent PTSD...
  15. doi request reprint Mixed treatment comparison of the treatment discontinuations of biologic disease-modifying antirheumatic drugs in adults with rheumatoid arthritis
    Rishi J Desai
    Division of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA
    Ann Pharmacother 46:1491-505. 2012
    ..Very little information is available on comparative discontinuation rates of the biologics...
  16. ncbi request reprint Cesarean delivery on maternal request: maternal and neonatal outcomes
    Anthony G Visco
    Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Obstet Gynecol 108:1517-29. 2006
    ..To review systematically the evidence about maternal and infant outcomes of cesarean delivery on maternal request and planned vaginal delivery...
  17. pmc Meta-analysis of major depressive disorder relapse and recurrence with second-generation antidepressants
    Richard Hansen
    Division of Pharmaceutical Outcomes and Policy, School of Pharmacy, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Psychiatr Serv 59:1121-30. 2008
    ..This meta-analysis reviewed data on the efficacy and effectiveness of second-generation antidepressants for preventing major depression relapse and recurrence during continuation and maintenance phases of treatment, respectively...
  18. ncbi request reprint Functional outcomes of drug treatment in Alzheimer's disease: A systematic review and meta-analysis
    Richard A Hansen
    School of Pharmacy, Division of Pharmaceutical Outcomes and Policy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Drugs Aging 24:155-67. 2007
    ..Patient functioning is an important outcome in Alzheimer's disease, but treatment-related improvements in patient function are difficult to quantify because a number of different scales are used in its measurement...
  19. ncbi request reprint Outcomes of routine episiotomy: a systematic review
    Katherine Hartmann
    Center for Women s Health Research, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, NC 27599 7521, USA
    JAMA 293:2141-8. 2005
    ..Episiotomy at the time of vaginal birth is common. Practice patterns vary widely, as do professional opinions about maternal risks and benefits associated with routine use...
  20. ncbi request reprint Serious adverse events with infliximab: analysis of spontaneously reported adverse events
    Richard A Hansen
    Center for Pharmaceutical Outcomes and Policy, Division of Pharmaceutical Outcomes and Policy, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Clin Gastroenterol Hepatol 5:729-35. 2007
    ..The aims of this study were to explore adverse event signals with infliximab by using a long period of post-marketing experience, stratifying by indication...
  21. ncbi request reprint Evidence-based medicine breaking the borders--a working model for the European Union to facilitate evidence-based health care
    Gerald Gartlehner
    Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, North Carolina 27599 7590, USA
    Wien Med Wochenschr 154:127-32. 2004
    ..The establishment of databases in native languages could also break down one of the main barriers existing between care providers and evidence-based medicine while adhering to the overall concepts of eHealth 2005...
  22. doi request reprint [Randomised controlled trials]
    Philipp Mad
    Ludwig Boltzmann Institut für Health Technology Assessment, Wien, Austria
    Wien Med Wochenschr 158:234-9. 2008
    ..As part of a methods series of the Wiener Medizinische Wochenschrift this paper will discuss principles of study design, critical appraisal and limitations of RCTs...
  23. doi request reprint Treating the physical symptoms of depression with second-generation antidepressants: a systematic review and metaanalysis
    Erin E Krebs
    Center on Implementing Evidence Based Practice, Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Psychosomatics 49:191-8. 2008
    ..Approximately two-thirds of patients with depression experience physical pain symptoms. Coexisting pain complicates the treatment of depression and is associated with worse depression outcomes...
  24. ncbi request reprint Perinatal depression: a systematic review of prevalence and incidence
    Norma I Gavin
    RTI International, 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC 27709 2194, USA
    Obstet Gynecol 106:1071-83. 2005
    ..We systematically review evidence on the prevalence and incidence of perinatal depression and compare these rates with those of depression in women at non-childbearing times...