Research Topics
| Gerald GartlehnerSummaryAffiliation: University of North Carolina Country: USA Publications
| Collaborators
|
Detail Information
Publications
A simple and valid tool distinguished efficacy from effectiveness studiesGerald Gartlehner
University of North Carolina at Chapel Hill, Cecil G Sheps Center for Health Services Research, NC 27599, USA
J Clin Epidemiol 59:1040-8. 2006..To propose and test a simple instrument based on seven criteria of study design to distinguish effectiveness (pragmatic) from efficacy (explanatory) trials...- Assessing the need to update prevention guidelines: a comparison of two methodsGerald Gartlehner
Cecil G Sheps Center for Health Services Research, University of North Carolina, 725 Airport Road, Chapel Hill, NC 27599 7590, USA
Int J Qual Health Care 16:399-406. 2004..Recently, Shekelle and colleagues proposed a model of limited literature searches with modest expert involvement as a way to reduce the cost and time requirements for assessing whether a guideline needs updating... - Discontinuation rates for selective serotonin reuptake inhibitors and other second-generation antidepressants in outpatients with major depressive disorder: a systematic review and meta-analysisGerald Gartlehner
Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 27599, USA
Int Clin Psychopharmacol 20:59-69. 2005.... - Biologics for the treatment of juvenile idiopathic arthritis: a systematic review and critical analysis of the evidenceGerald Gartlehner
Ludwig Boltzmann Institute for Health Technology Assessments, Garnisongasse 7 20, 1090, Vienna, Austria
Clin Rheumatol 27:67-76. 2008..Clinicians have to be aware of the lack of evidence supporting a long-term net benefit when considering biologics for patients with JIA... - Efficacy and safety of inhaled corticosteroids in patients with COPD: a systematic review and meta-analysis of health outcomesGerald Gartlehner
Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Ann Fam Med 4:253-62. 2006..We wanted to review systematically the efficacy, effectiveness, and safety of inhaled corticosteroids with respect to health outcomes in patients with chronic obstructive pulmonary disease (COPD)... - The comparative efficacy and safety of biologics for the treatment of rheumatoid arthritis: a systematic review and metaanalysisGerald Gartlehner
Cecil G Sheps Center for Health Services, and School of Public Health, Health Policy and Administration, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Rheumatol 33:2398-408. 2006..In addition, dosing regimens and routes of administration differ substantially among biologics. In a systematic review, we assessed the comparative efficacy and safety of biologic agents for RA... - Efficacy and safety of second-generation antidepressants in the treatment of major depressive disorderRichard A Hansen
Division of Pharmaceutical Policy and Evaluative Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Ann Intern Med 143:415-26. 2005.... - Efficacy and tolerability of second-generation antidepressants in social anxiety disorderRichard A Hansen
Division of Pharmaceutical Outcomes and Policy, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
Int Clin Psychopharmacol 23:170-9. 2008..Overall, a fair amount of evidence supports the efficacy of escitalopram, fluvoxamine, paroxetine, sertraline, and venlafaxine in social anxiety disorder. The drugs do not differ in efficacy, although their adverse event profiles do... - Systematic review: comparative effectiveness and harms of disease-modifying medications for rheumatoid arthritisKatrina E Donahue
University of North Carolina and Cecil G Sheps Center for Health Services Research, Chapel Hill, North Carolina 27599, USA
Ann Intern Med 148:124-34. 2008..The comparative effectiveness of rheumatoid arthritis therapies is uncertain... - Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysisRichard A Hansen
School of Pharmacy, Division of Pharmaceutical Outcomes and Policy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Clin Interv Aging 3:211-25. 2008..63 and 1.42, respectively). Indirect comparisons also favored donepezil over galantamine with regard to behavior. Across trials, the incidence of adverse events was generally lowest for donepezil and highest for rivastigmine... - Strategies in assessing the need for updating evidence-based guidelines for six clinical topics: an exploration of two search methodologiesChristiane E Voisin
Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, NC 27599 7590, USA
Health Info Libr J 25:198-207. 2008..Shekelle et al. (Journal of the American Medical Association 2001, 286, 1461-7) proposed using limited literature searches with expert involvement to reduce resources used in assessing whether a guideline needs updating... - Controlling for drug dose in systematic review and meta-analysis: a case study of the effect of antidepressant doseRichard A Hansen
School of Pharmacy, Division of Pharmaceutical Outcomes and Policy, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Med Decis Making 29:91-103. 2009..Second-generation antidepressants are used as an example to illustrate this method and to determine whether dose influences conclusions on comparative effectiveness... - Cesarean delivery on maternal request: maternal and neonatal outcomesAnthony G Visco
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Obstet Gynecol 108:1517-29. 2006..To review systematically the evidence about maternal and infant outcomes of cesarean delivery on maternal request and planned vaginal delivery... - Meta-analysis of major depressive disorder relapse and recurrence with second-generation antidepressantsRichard Hansen
Division of Pharmaceutical Outcomes and Policy, School of Pharmacy, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Psychiatr Serv 59:1121-30. 2008..This meta-analysis reviewed data on the efficacy and effectiveness of second-generation antidepressants for preventing major depression relapse and recurrence during continuation and maintenance phases of treatment, respectively... - Serious adverse events with infliximab: analysis of spontaneously reported adverse eventsRichard A Hansen
Center for Pharmaceutical Outcomes and Policy, Division of Pharmaceutical Outcomes and Policy, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Clin Gastroenterol Hepatol 5:729-35. 2007..The aims of this study were to explore adverse event signals with infliximab by using a long period of post-marketing experience, stratifying by indication... - Functional outcomes of drug treatment in Alzheimer's disease: A systematic review and meta-analysisRichard A Hansen
School of Pharmacy, Division of Pharmaceutical Outcomes and Policy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Drugs Aging 24:155-67. 2007..Patient functioning is an important outcome in Alzheimer's disease, but treatment-related improvements in patient function are difficult to quantify because a number of different scales are used in its measurement... - Outcomes of routine episiotomy: a systematic reviewKatherine Hartmann
Center for Women s Health Research, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, NC 27599 7521, USA
JAMA 293:2141-8. 2005..Episiotomy at the time of vaginal birth is common. Practice patterns vary widely, as do professional opinions about maternal risks and benefits associated with routine use... - Evidence-based medicine breaking the borders--a working model for the European Union to facilitate evidence-based health careGerald Gartlehner
Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, North Carolina 27599 7590, USA
Wien Med Wochenschr 154:127-32. 2004..The establishment of databases in native languages could also break down one of the main barriers existing between care providers and evidence-based medicine while adhering to the overall concepts of eHealth 2005... - Treating the physical symptoms of depression with second-generation antidepressants: a systematic review and metaanalysisErin E Krebs
Center on Implementing Evidence Based Practice, Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
Psychosomatics 49:191-8. 2008..Approximately two-thirds of patients with depression experience physical pain symptoms. Coexisting pain complicates the treatment of depression and is associated with worse depression outcomes... - [Randomised controlled trials]Philipp Mad
Ludwig Boltzmann Institut für Health Technology Assessment, Wien, Austria
Wien Med Wochenschr 158:234-9. 2008..As part of a methods series of the Wiener Medizinische Wochenschrift this paper will discuss principles of study design, critical appraisal and limitations of RCTs... - Perinatal depression: a systematic review of prevalence and incidenceNorma I Gavin
RTI International, 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC 27709 2194, USA
Obstet Gynecol 106:1071-83. 2005..We systematically review evidence on the prevalence and incidence of perinatal depression and compare these rates with those of depression in women at non-childbearing times...