Andrei Gartel

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells
    Uppoor G Bhat
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 4:e5592. 2009
  2. pmc FoxM1 is a general target for proteasome inhibitors
    Uppoor G Bhat
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    PLoS ONE 4:e6593. 2009
  3. pmc Thiazole antibiotic thiostrepton synergize with bortezomib to induce apoptosis in cancer cells
    Bulbul Pandit
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e17110. 2011
  4. pmc The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA
    Ming Wang
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA
    Oncotarget 2:1218-26. 2011
  5. pmc Suppression of FOXM1 sensitizes human cancer cells to cell death induced by DNA-damage
    Marianna Halasi
    Department of Medicine, University of Illinois, Chicago, Illinois, United States of America
    PLoS ONE 7:e31761. 2012
  6. pmc The oncogenic transcription factor FOXM1 and anticancer therapy
    Andrei L Gartel
    Department of Medicine, University of Illinois at Chicago, Chicago, IL USA
    Cell Cycle 11:3341-2. 2012
  7. pmc FOX(M1) news--it is cancer
    Marianna Halasi
    University of Illinois at Chicago, Department of Medicine, Chicago, IL 60612, USA
    Mol Cancer Ther 12:245-54. 2013
  8. ncbi Mechanisms of apoptosis induced by anticancer compounds in melanoma cells
    Andrei L Gartel
    University of Illinois at Chicago, Department of Medicine, 840, S Wood St, Room 1041, Chicago, IL 60612, USA
    Curr Top Med Chem 12:50-2. 2012
  9. doi miRNAs: Little known mediators of oncogenesis
    Andrei L Gartel
    Department of Medicine, University of Illinois at Chicago, 840, South Wood Street, Room 1041, Chicago, IL 60612, United States
    Semin Cancer Biol 18:103-10. 2008
  10. doi Transcriptional inhibitors, p53 and apoptoss
    Andrei L Gartel
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Biochim Biophys Acta 1786:83-6. 2008

Collaborators

Detail Information

Publications41

  1. pmc Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells
    Uppoor G Bhat
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 4:e5592. 2009
    ....
  2. pmc FoxM1 is a general target for proteasome inhibitors
    Uppoor G Bhat
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    PLoS ONE 4:e6593. 2009
    ..These data suggest that negative regulation of FoxM1 by proteasome inhibitors is a general feature of these drugs and it may contribute to their anticancer properties...
  3. pmc Thiazole antibiotic thiostrepton synergize with bortezomib to induce apoptosis in cancer cells
    Bulbul Pandit
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e17110. 2011
    ....
  4. pmc The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA
    Ming Wang
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA
    Oncotarget 2:1218-26. 2011
    ..Our data suggests that anti-FoxM1 siRNA can be functional when administered into tumors in an in vivo system, and that anti-FoxM1 siRNA holds potential as part of a therapy for cancer treatment...
  5. pmc Suppression of FOXM1 sensitizes human cancer cells to cell death induced by DNA-damage
    Marianna Halasi
    Department of Medicine, University of Illinois, Chicago, Illinois, United States of America
    PLoS ONE 7:e31761. 2012
    ..Since FOXM1 is widely expressed in human cancers, our data further support the fact that it is a valid target for combinatorial anticancer therapy...
  6. pmc The oncogenic transcription factor FOXM1 and anticancer therapy
    Andrei L Gartel
    Department of Medicine, University of Illinois at Chicago, Chicago, IL USA
    Cell Cycle 11:3341-2. 2012
    ..Comment on: Halasi M,et al. PLoS ONE 2012; 7:e31761...
  7. pmc FOX(M1) news--it is cancer
    Marianna Halasi
    University of Illinois at Chicago, Department of Medicine, Chicago, IL 60612, USA
    Mol Cancer Ther 12:245-54. 2013
    ..In this review, the contribution of FOXM1 to each of the hallmarks of cancer will be summarized and discussed...
  8. ncbi Mechanisms of apoptosis induced by anticancer compounds in melanoma cells
    Andrei L Gartel
    University of Illinois at Chicago, Department of Medicine, 840, S Wood St, Room 1041, Chicago, IL 60612, USA
    Curr Top Med Chem 12:50-2. 2012
    ..These data may provide important information needed for designing more efficient combinations of anticancer drugs against melanoma...
  9. doi miRNAs: Little known mediators of oncogenesis
    Andrei L Gartel
    Department of Medicine, University of Illinois at Chicago, 840, South Wood Street, Room 1041, Chicago, IL 60612, United States
    Semin Cancer Biol 18:103-10. 2008
    ..We discuss the nature of published results, as well as the merits and pitfalls of various approaches aimed at identification of cancer-related miRNAs and their mRNA targets...
  10. doi Transcriptional inhibitors, p53 and apoptoss
    Andrei L Gartel
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Biochim Biophys Acta 1786:83-6. 2008
    ..However, the majority of other published data suggest that these drugs induce p53-independent apoptosis. In this article I discuss the mechanisms of TI-dependent cell death and the potential role of p53 in this process...
  11. doi p21(WAF1/CIP1) and cancer: a shifting paradigm?
    Andrei L Gartel
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Biofactors 35:161-4. 2009
    ..c) 2009 International Union of Biochemistry and Molecular Biology, Inc...
  12. pmc A new target for proteasome inhibitors: FoxM1
    Andrei L Gartel
    University of Illinois at Chicago, Department of Medicine, 840 S Wood St, Room 1041, Chicago, IL 60612, USA
    Expert Opin Investig Drugs 19:235-42. 2010
    ..In addition, FoxM1 may also drive tumor invasion, angiogenesis and metastasis. For these reasons, FoxM1 is an attractive target for anticancer drugs...
  13. ncbi P21(WAF1/CIP1) may be a tumor suppressor after all
    Andrei L Gartel
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612 USA
    Cancer Biol Ther 6:1171-2. 2007
    ..These data suggest that the ability of p21 to induce cell-cycle arrest may lead to tumor suppression in some types of cancer...
  14. ncbi Transcriptional regulation of the p21((WAF1/CIP1)) gene
    A L Gartel
    Department of Molecular Genetics, University of Illinois at Chicago, 900 South Ashland Avenue, Room 2072, Chicago, Illinois, 60607, USA
    Exp Cell Res 246:280-9. 1999
  15. ncbi Lost in transcription: p21 repression, mechanisms, and consequences
    Andrei L Gartel
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cancer Res 65:3980-5. 2005
    ..Further identification of factors that repress p21 is likely to contribute to the better understanding of its role in cancer...
  16. ncbi A new method for determining the status of p53 in tumor cell lines of different origin
    Andrei L Gartel
    Department of Molecular Genetics, University of Illinois at Chicago, 900 S Ashland Ave Chicago, IL 60607, USA
    Oncol Res 13:405-8. 2003
    ..have wild-type p53, and the colon cancer cell line Caco-2 as well as breast cancer cell lines MDA-MB-435 and MDA-MB-231 have mutant p53. This method may be applied to novel cell lines of any origin with unknown status of p53...
  17. ncbi A new mode of transcriptional repression by c-myc: methylation
    A L Gartel
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Oncogene 25:1989-90. 2006
  18. ncbi RNA interference in cancer
    Andrei L Gartel
    Department of Medicine, University of Illinois at Chicago, 60612, USA
    Biomol Eng 23:17-34. 2006
    ..In this article we review the evidence of microRNA involvement in cancer, the use of short interfering RNAs in forward and reverse genetics of this disease, and as well as both the benefits and limitations of experimental RNAi...
  19. ncbi Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes
    Andrei L Gartel
    Department of Molecular Genetics, M C 669, 900 S Ashland Avenue, University of Illinois at Chicago, Chicago, IL 60607, USA
    Exp Cell Res 283:17-21. 2003
    ..The ability of c-Myc to repress transcription of growth arrest genes may contribute to its potential to promote proliferation and oncogenesis...
  20. ncbi The role of the cyclin-dependent kinase inhibitor p21 in apoptosis
    Andrei L Gartel
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607, USA
    Mol Cancer Ther 1:639-49. 2002
    ..In the current review, we discuss the role of p21 in regulating cell death and the potential relevance of its expression in cancer...
  21. pmc Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3
    A L Gartel
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, IL 60607, USA
    Proc Natl Acad Sci U S A 98:4510-5. 2001
    ..Repression of the p21 promoter may contribute to the ability of c-Myc to promote cell proliferation...
  22. pmc Micelle-encapsulated thiostrepton as an effective nanomedicine for inhibiting tumor growth and for suppressing FOXM1 in human xenografts
    Ming Wang
    Department of Medicine, University of Illinois at Chicago, 840, S Wood St, Chicago, IL 60612, USA
    Mol Cancer Ther 10:2287-97. 2011
    ..Our data suggest that the thiazole antibiotic/proteasome inhibitor thiostrepton, when formulated into nanoparticles, may be highly suited as a nanomedicine for treating human cancer...
  23. pmc Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage
    Eugene S Kandel
    Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Mol Cell Biol 22:7831-41. 2002
    ..We suggest that this new activity of Akt in conjunction with its antiapoptotic activity may contribute to genetic instability and could explain its frequent activation in human cancers...
  24. ncbi A novel p21WAF1/CIP1 transcript is highly dependent on p53 for its basal expression in mouse tissues
    Andrei L Gartel
    Department of Medicine, 840 S Wood St, University of Illinois at Chicago, Chicago, IL 60612, USA
    Oncogene 23:8154-7. 2004
    ..Our data suggest that p53-dependent induction of p21 may be an additive effect conferred by individual increases in the alternate and classical p21 transcripts...
  25. ncbi Constitutive expression of E2F-1 leads to p21-dependent cell cycle arrest in S phase of the cell cycle
    Senthil K Radhakrishnan
    Department of Medicine, University of Illinois at Chicago, 60612, USA
    Oncogene 23:4173-6. 2004
    ....
  26. ncbi Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc
    Abhishek Datta
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA
    J Biol Chem 279:36698-707. 2004
    ..Our results strongly suggest that cMyc is a bona fide target of ARF and that ARF attenuates c-Myc independently of the ARF-p53 axis...
  27. ncbi The PPAR-gamma agonist pioglitazone post-transcriptionally induces p21 in PC3 prostate cancer but not in other cell lines
    Senthil K Radhakrishnan
    Department of Medicine, University of Illinois at Chicago, Chicago, Ilinois 60612, USA
    Cell Cycle 4:582-4. 2005
    ..These results imply that pioglitazone generally does not modulate p21 transcription in human cancer cell lines...
  28. ncbi A novel transcriptional inhibitor induces apoptosis in tumor cells and exhibits antiangiogenic activity
    Senthil K Radhakrishnan
    Department of Medicine, University of Illinois at Chicago, Illinois 60612, USA
    Cancer Res 66:3264-70. 2006
    ..Taken together, our data suggests that ARC may be an attractive candidate for anticancer drug development...
  29. ncbi Differential sensitivity of human colon cancer cell lines to the nucleoside analogs ARC and DRB
    Uppoor G Bhat
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Cancer 122:1426-9. 2008
    ..Overall, ARC could represent an attractive candidate for anti-cancer drug development that targets multiple survival pathways in colon cancer cells...
  30. doi New potential anti-cancer agents synergize with bortezomib and ABT-737 against prostate cancer
    Bulbul Pandit
    Department of Medicine, University of Illinois, Chicago, Illinois, USA
    Prostate 70:825-33. 2010
    ..Here, we report the characterization of these drugs individually or in combination with ABT-737 and bortezomib on a panel of prostate cancer cell lines...
  31. ncbi Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1
    Senthil K Radhakrishnan
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Cancer Res 66:9731-5. 2006
    ..Taken together, our data suggest that FoxM1 inhibitor Siomycin A could represent a useful starting point for the development of anticancer therapeutics...
  32. pmc ARC synergizes with ABT-737 to induce apoptosis in human cancer cells
    Uppoor G Bhat
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Mol Cancer Ther 9:1688-96. 2010
    ..These data suggest that the ABT-737/ARC combination, which simultaneously targets Bcl-2 and Mcl-1, may be efficient against human cancer...
  33. ncbi CDK9 phosphorylates p53 on serine residues 33, 315 and 392
    Senthil K Radhakrishnan
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cell Cycle 5:519-21. 2006
    ..Specifically, Ser33 on the N-terminus and, Ser315 and Ser392 on the C-terminus of p53 were found to be phosphorylated. The precise biological role of this phosphorylation remains to be elucidated...
  34. ncbi RNA interference as a new strategy against viral hepatitis
    Senthil K Radhakrishnan
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Virology 323:173-81. 2004
    ..Though this new approach looks promising, problems of nonspecific effects and delivery may need to be addressed before the full therapeutic potential of RNAi against viral infections in patients is realized...
  35. ncbi Novel anticancer compounds induce apoptosis in melanoma cells
    Uppoor G Bhat
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cell Cycle 7:1851-5. 2008
    ..In general, these drugs may represent important candidates for anti-cancer drug development against melanoma...
  36. ncbi FoxM1 inhibitors as potential anticancer drugs
    Andrei L Gartel
    Expert Opin Ther Targets 12:663-5. 2008
    ..In addition, FoxM1 is involved in tumor invasion, angiogenesis and metastasis. For these reasons, FoxM1 is an appealing target for anticancer therapeutics...
  37. ncbi Is p21 an oncogene?
    Andrei L Gartel
    Mol Cancer Ther 5:1385-6. 2006
  38. ncbi Inducer and inhibitor: "antagonistic duality" of p21 in differentiation
    Andrei L Gartel
    Leuk Res 30:1215-6. 2006
  39. ncbi FOXM1: the Achilles' heel of cancer?
    Senthil K Radhakrishnan
    Nat Rev Cancer 8:c1; author reply c2. 2008

Research Grants5

  1. Evaluation of novel FoxM1 inhibitors against liver cancer
    Andrei L Gartel; Fiscal Year: 2010
    ..Completion of our proposal will enable us to determine if thiazole antibiotics are suitable for further clinical development. ..
  2. P21 transcriptional inhibitors as proapoptotic compounds
    Andrei Gartel; Fiscal Year: 2003
    ..This study may improve treatment of cancer by leading to the identification of new compounds that will increase the efficiency of cell death promoting anticancer drugs for cancer treatment. ..
  3. Evaluation of novel FoxM1 inhibitors against liver cancer
    Andrei Gartel; Fiscal Year: 2009
    ..Completion of our proposal will enable us to determine if thiazole antibiotics are suitable for further clinical development. ..