Lee Ann Garrett Sinha

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. ncbi Spi-1 and Spi-B control the expression of the Grap2 gene in B cells
    Lee Ann Garrett-Sinha
    Department of Biochemistry, State University of New York at Buffalo, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Gene 353:134-46. 2005
  2. ncbi IL-17 and the Th17 lineage in systemic lupus erythematosus
    Lee Ann Garrett-Sinha
    Department of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    Curr Opin Rheumatol 20:519-25. 2008
  3. ncbi Impaired generation of CD8+ thymocytes in Ets-1-deficient mice
    James L Clements
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Immunol 177:905-12. 2006
  4. ncbi Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1
    Shinu A John
    Department of Biochemistry, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:951-62. 2008
  5. ncbi Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease
    Duncheng Wang
    Department of Biochemistry, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA
    Int Immunol 17:1179-91. 2005
  6. ncbi Isolation and characterization of an immortalized oral keratinocyte cell line of mouse origin
    Neha Parikh
    Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Arch Oral Biol 53:1091-100. 2008
  7. ncbi Transcription factor Ets-1 in cytokine and chemokine gene regulation
    Lisa Russell
    Department of Biochemistry, Developmental Genetics Focus Group, Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA
    Cytokine 51:217-26. 2010
  8. ncbi Enforced expression of Spi-B reverses T lineage commitment and blocks beta-selection
    Juliette M Lefebvre
    Immunobiology Working Group, Division of Basic Sciences, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 174:6184-94. 2005

Research Grants

  1. Ets-1 Expression in Squamous Cells of the Oral Cavity
    LEE GARRETT SINHA; Fiscal Year: 2007
  2. Identification of Specific Roles for Ets-1 in B Cell Tolerance
    Lee Ann Garrett Sinha; Fiscal Year: 2010

Collaborators

  • James L Clements
  • Sarah L Gaffen
  • Neha Parikh
  • MARCUS CLARK
  • Edward Clark
  • Lee Ann Garrett-Sinha
  • Shinu A John
  • Duncheng Wang
  • Lisa Russell
  • Juliette M Lefebvre
  • M Celeste Simon
  • Shinu John
  • Lisa M Russell
  • Ping Hou
  • Brian Grabiner
  • Kevin P Barton
  • Michael O Carleton
  • David L Wiest
  • Theodore J Yun
  • Laurence C Eisenlohr
  • Dean H Percy
  • Mariëlle C Haks
  • Elizabeth Araujo
  • Sridhar Rao
  • Michele Rhodes
  • Gomathinayagam Sinnathamby

Detail Information

Publications8

  1. ncbi Spi-1 and Spi-B control the expression of the Grap2 gene in B cells
    Lee Ann Garrett-Sinha
    Department of Biochemistry, State University of New York at Buffalo, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Gene 353:134-46. 2005
    ....
  2. ncbi IL-17 and the Th17 lineage in systemic lupus erythematosus
    Lee Ann Garrett-Sinha
    Department of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    Curr Opin Rheumatol 20:519-25. 2008
    ..In particular, the T-cell components that contribute to systemic lupus erythematosus pathogenesis are incompletely defined...
  3. ncbi Impaired generation of CD8+ thymocytes in Ets-1-deficient mice
    James L Clements
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Immunol 177:905-12. 2006
    ..These data identify Ets-1 as a key transcription factor regulating thymocyte positive selection and lineage commitment of MHC class I-restricted thymocytes...
  4. ncbi Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1
    Shinu A John
    Department of Biochemistry, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:951-62. 2008
    ..These results reveal a previously unknown mechanism for the control of Blimp-1 activity by Ets-1 and suggest that expression of Ets-1 must be down-regulated before plasmacytic differentiation can occur...
  5. ncbi Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease
    Duncheng Wang
    Department of Biochemistry, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA
    Int Immunol 17:1179-91. 2005
    ..Hence, our studies establish Ets-1 as an important regulator of peripheral B cell differentiation and B cell responses to TLR9 activation...
  6. ncbi Isolation and characterization of an immortalized oral keratinocyte cell line of mouse origin
    Neha Parikh
    Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Arch Oral Biol 53:1091-100. 2008
    ..To establish an oral epithelial cell line of mouse origin for molecular and biochemical assays...
  7. ncbi Transcription factor Ets-1 in cytokine and chemokine gene regulation
    Lisa Russell
    Department of Biochemistry, Developmental Genetics Focus Group, Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA
    Cytokine 51:217-26. 2010
    ..Furthermore, we review in detail the current understanding of Ets-1 regulation of cytokine and chemokine expression and how this may relate to the biological roles of Ets-1 in regulating immunity as well as in cancer progression...
  8. ncbi Enforced expression of Spi-B reverses T lineage commitment and blocks beta-selection
    Juliette M Lefebvre
    Immunobiology Working Group, Division of Basic Sciences, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 174:6184-94. 2005
    ....

Research Grants3

  1. Ets-1 Expression in Squamous Cells of the Oral Cavity
    LEE GARRETT SINHA; Fiscal Year: 2007
    ..Our studies are designed to identify the role of the oncogene Ets-1 in regulating OSCC initiation and progression, with the eventual hope of developing novel strategies to target Ets-1 activity and regulate tumor cell growth. ..
  2. Identification of Specific Roles for Ets-1 in B Cell Tolerance
    Lee Ann Garrett Sinha; Fiscal Year: 2010
    ....