Lee Ann Garrett-Sinha

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. pmc Ets1 induces dysplastic changes when expressed in terminally-differentiating squamous epidermal cells
    Priyadharsini Nagarajan
    Department of Biochemistry, State University of New York at Buffalo, Center for Excellence in Bioinformatics and Life Sciences, Buffalo, New York, USA
    PLoS ONE 4:e4179. 2009
  2. pmc Review of Ets1 structure, function, and roles in immunity
    Lee Ann Garrett-Sinha
    Department of Biochemistry, State University of New York at Buffalo, Center of Excellence in Bioinformatics and Life Sciences, Room B3 306, 701 Ellicott Street, Buffalo, NY 14203, USA
    Cell Mol Life Sci 70:3375-90. 2013
  3. ncbi request reprint IL-17 and the Th17 lineage in systemic lupus erythematosus
    Lee Ann Garrett-Sinha
    Department of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    Curr Opin Rheumatol 20:519-25. 2008
  4. ncbi request reprint Spi-1 and Spi-B control the expression of the Grap2 gene in B cells
    Lee Ann Garrett-Sinha
    Department of Biochemistry, State University of New York at Buffalo, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Gene 353:134-46. 2005
  5. doi request reprint Transcription factor Ets1, but not the closely related factor Ets2, inhibits antibody-secreting cell differentiation
    Shinu John
    Department of Biochemistry, Developmental Genetics Focus Group, Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, New York, USA
    Mol Cell Biol 34:522-32. 2014
  6. ncbi request reprint Impaired generation of CD8+ thymocytes in Ets-1-deficient mice
    James L Clements
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Immunol 177:905-12. 2006
  7. ncbi request reprint Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1
    Shinu A John
    Department of Biochemistry, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:951-62. 2008
  8. pmc Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators
    Priyadharsini Nagarajan
    Department of Biochemistry, Developmental Genomics Focus Group, Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA
    J Cell Sci 123:3566-75. 2010
  9. ncbi request reprint Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease
    Duncheng Wang
    Department of Biochemistry, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA
    Int Immunol 17:1179-91. 2005
  10. pmc Isolation and characterization of an immortalized oral keratinocyte cell line of mouse origin
    Neha Parikh
    Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Arch Oral Biol 53:1091-100. 2008

Research Grants

Collaborators

Detail Information

Publications17

  1. pmc Ets1 induces dysplastic changes when expressed in terminally-differentiating squamous epidermal cells
    Priyadharsini Nagarajan
    Department of Biochemistry, State University of New York at Buffalo, Center for Excellence in Bioinformatics and Life Sciences, Buffalo, New York, USA
    PLoS ONE 4:e4179. 2009
    ..Thus, Ets1 is believed to mainly play a role in later stages of the oncogenic process, but not early events...
  2. pmc Review of Ets1 structure, function, and roles in immunity
    Lee Ann Garrett-Sinha
    Department of Biochemistry, State University of New York at Buffalo, Center of Excellence in Bioinformatics and Life Sciences, Room B3 306, 701 Ellicott Street, Buffalo, NY 14203, USA
    Cell Mol Life Sci 70:3375-90. 2013
    ..We also review evidence that suggests that Ets1 may play a role in malignant transformation of hematopoietic malignancies including B cell malignancies...
  3. ncbi request reprint IL-17 and the Th17 lineage in systemic lupus erythematosus
    Lee Ann Garrett-Sinha
    Department of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    Curr Opin Rheumatol 20:519-25. 2008
    ..In particular, the T-cell components that contribute to systemic lupus erythematosus pathogenesis are incompletely defined...
  4. ncbi request reprint Spi-1 and Spi-B control the expression of the Grap2 gene in B cells
    Lee Ann Garrett-Sinha
    Department of Biochemistry, State University of New York at Buffalo, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Gene 353:134-46. 2005
    ....
  5. doi request reprint Transcription factor Ets1, but not the closely related factor Ets2, inhibits antibody-secreting cell differentiation
    Shinu John
    Department of Biochemistry, Developmental Genetics Focus Group, Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, New York, USA
    Mol Cell Biol 34:522-32. 2014
    ..Differences between the N termini of Ets1 and Ets2, rather than differences in the DNA binding domains, determine whether the proteins are capable of blocking ASC formation or not. ..
  6. ncbi request reprint Impaired generation of CD8+ thymocytes in Ets-1-deficient mice
    James L Clements
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Immunol 177:905-12. 2006
    ..These data identify Ets-1 as a key transcription factor regulating thymocyte positive selection and lineage commitment of MHC class I-restricted thymocytes...
  7. ncbi request reprint Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1
    Shinu A John
    Department of Biochemistry, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:951-62. 2008
    ..These results reveal a previously unknown mechanism for the control of Blimp-1 activity by Ets-1 and suggest that expression of Ets-1 must be down-regulated before plasmacytic differentiation can occur...
  8. pmc Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators
    Priyadharsini Nagarajan
    Department of Biochemistry, Developmental Genomics Focus Group, Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA
    J Cell Sci 123:3566-75. 2010
    ..Collectively, our data reveal that elevated expression of Ets1 has a much broader array of pro-tumorigenic effects on epithelial cells than previously appreciated...
  9. ncbi request reprint Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease
    Duncheng Wang
    Department of Biochemistry, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA
    Int Immunol 17:1179-91. 2005
    ..Hence, our studies establish Ets-1 as an important regulator of peripheral B cell differentiation and B cell responses to TLR9 activation...
  10. pmc Isolation and characterization of an immortalized oral keratinocyte cell line of mouse origin
    Neha Parikh
    Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Arch Oral Biol 53:1091-100. 2008
    ..To establish an oral epithelial cell line of mouse origin for molecular and biochemical assays...
  11. doi request reprint Transcription factor Ets-1 in cytokine and chemokine gene regulation
    Lisa Russell
    Department of Biochemistry, Developmental Genetics Focus Group, Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA
    Cytokine 51:217-26. 2010
    ..Furthermore, we review in detail the current understanding of Ets-1 regulation of cytokine and chemokine expression and how this may relate to the biological roles of Ets-1 in regulating immunity as well as in cancer progression...
  12. ncbi request reprint The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids
    Judith Agudo
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Immunol 15:54-62. 2014
    ..Our studies identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs. ..
  13. pmc A unique form of haptoglobin produced by murine hematopoietic cells supports B-cell survival, differentiation and immune response
    Kristin M Huntoon
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Immunol 55:345-54. 2013
    ....
  14. ncbi request reprint A Balance between B Cell Receptor and Inhibitory Receptor Signaling Controls Plasma Cell Differentiation by Maintaining Optimal Ets1 Levels
    Wei Luo
    Department of Biochemistry, Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, NY 14203
    J Immunol 193:909-20. 2014
    ....
  15. doi request reprint Blimp1: a conserved transcriptional repressor critical for differentiation of many tissues
    Shinu A John
    Department of Biochemistry, Center for Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA
    Exp Cell Res 315:1077-84. 2009
    ..In this review, we focus on the novel and emerging roles of Blimp1 in multiple tissues, on mechanisms of transcriptional repression by Blimp1 and on the activity of Blimp1 as a tumor suppressor...
  16. ncbi request reprint Enforced expression of Spi-B reverses T lineage commitment and blocks beta-selection
    Juliette M Lefebvre
    Immunobiology Working Group, Division of Basic Sciences, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 174:6184-94. 2005
    ....

Research Grants3

  1. Ets-1 Expression in Squamous Cells of the Oral Cavity
    LEE GARRETT SINHA; Fiscal Year: 2007
    ..Our studies are designed to identify the role of the oncogene Ets-1 in regulating OSCC initiation and progression, with the eventual hope of developing novel strategies to target Ets-1 activity and regulate tumor cell growth. ..
  2. Identification of Specific Roles for Ets-1 in B Cell Tolerance
    Lee Ann Garrett Sinha; Fiscal Year: 2010
    ....