A Garg

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Comparison of efficacy and safety of leptin replacement therapy in moderately and severely hypoleptinemic patients with familial partial lipodystrophy of the Dunnigan variety
    Vinaya Simha
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, K5 214, Dallas, Texas 75390 8537, USA
    J Clin Endocrinol Metab 97:785-92. 2012
  2. ncbi Type 1 hyperlipoproteinemia and recurrent acute pancreatitis due to lipoprotein lipase antibody in a young girl with Sjogren's syndrome
    Ambika P Ashraf
    Division of Pediatric Endocrinology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Endocrinol Metab 96:3302-7. 2011
  3. ncbi Lipodystrophies: disorders of adipose tissue biology
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Biochim Biophys Acta 1791:507-13. 2009
  4. ncbi Update on dyslipidemia
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9052, USA
    J Clin Endocrinol Metab 92:1581-9. 2007
  5. ncbi Adipose tissue dysfunction in obesity and lipodystrophy
    Abhimanyu Garg
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Clin Cornerstone 8:S7-S13. 2006
  6. ncbi A novel homozygous Ala529Val LMNA mutation in Turkish patients with mandibuloacral dysplasia
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9052, USA
    J Clin Endocrinol Metab 90:5259-64. 2005
  7. ncbi Atypical progeroid syndrome due to heterozygous missense LMNA mutations
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8537, USA
    J Clin Endocrinol Metab 94:4971-83. 2009
  8. ncbi The ongoing saga of obestatin: is it a hormone?
    Abhimanyu Garg
    Department of Internal Midicine and Center for Human Nutrition, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9052, USA
    J Clin Endocrinol Metab 92:3396-8. 2007
  9. ncbi An autosomal recessive syndrome of joint contractures, muscular atrophy, microcytic anemia, and panniculitis-associated lipodystrophy
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 95:E58-63. 2010
  10. ncbi Phenotypic heterogeneity in patients with familial partial lipodystrophy (dunnigan variety) related to the site of missense mutations in lamin a/c gene
    A Garg
    Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 86:59-65. 2001

Research Grants

  1. Novel Therapies for Metabolic Complications in Patients with Lipodystrophies
    Abhimanyu Garg; Fiscal Year: 2007
  2. Therapeutic Approaches to HAART-Induced Lipodystrophy
    Abhimanyu Garg; Fiscal Year: 2006
  3. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2007
  4. Phase II study of cholic acid for hepatic steatosis in *
    Abhimanyu Garg; Fiscal Year: 2007
  5. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2009
  6. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2010
  7. Novel Therapies for Metabolic Complications in Patients with Lipodystrophies
    Abhimanyu Garg; Fiscal Year: 2010
  8. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2006
  9. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2002
  10. MECHANISMS OF LIPODYSTROPHY IN HIV INFECTED PATIENTS
    Abhimanyu Garg; Fiscal Year: 2002

Detail Information

Publications82

  1. ncbi Comparison of efficacy and safety of leptin replacement therapy in moderately and severely hypoleptinemic patients with familial partial lipodystrophy of the Dunnigan variety
    Vinaya Simha
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, K5 214, Dallas, Texas 75390 8537, USA
    J Clin Endocrinol Metab 97:785-92. 2012
    ..Leptin replacement therapy improves metabolic complications in patients with lipodystrophy and severe hypoleptinemia (SH), but whether the response is related to the degree of hypoleptinemia remains unclear...
  2. ncbi Type 1 hyperlipoproteinemia and recurrent acute pancreatitis due to lipoprotein lipase antibody in a young girl with Sjogren's syndrome
    Ambika P Ashraf
    Division of Pediatric Endocrinology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Endocrinol Metab 96:3302-7. 2011
    ..Type 1 hyperlipoproteinemia (T1HLP) in childhood is most often due to genetic deficiency of lipoprotein lipase (LPL) or other related proteins...
  3. ncbi Lipodystrophies: disorders of adipose tissue biology
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Biochim Biophys Acta 1791:507-13. 2009
    ..PPARgamma and AKT2 play important role in adipogenesis and lipid synthesis. In this review, we discuss and speculate about the contribution of various lipodystrophy genes and their products in the lipid droplet formation...
  4. ncbi Update on dyslipidemia
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9052, USA
    J Clin Endocrinol Metab 92:1581-9. 2007
    ..Fibrates may reduce the risk of acute pancreatitis in severely hypertriglyceridemic patients and may be beneficial for CHD prevention. However, the safety and efficacy of combined therapy of fibrates and statins needs to be established...
  5. ncbi Adipose tissue dysfunction in obesity and lipodystrophy
    Abhimanyu Garg
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Clin Cornerstone 8:S7-S13. 2006
    ..Alterations in free fatty acid and adipocytokine release from adipose tissue may underlie metabolic complications...
  6. ncbi A novel homozygous Ala529Val LMNA mutation in Turkish patients with mandibuloacral dysplasia
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9052, USA
    J Clin Endocrinol Metab 90:5259-64. 2005
    ....
  7. ncbi Atypical progeroid syndrome due to heterozygous missense LMNA mutations
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8537, USA
    J Clin Endocrinol Metab 94:4971-83. 2009
    ..Heterozygous LMNA mutations have also been reported in a small number of patients with a less well-characterized atypical progeroid syndrome (APS)...
  8. ncbi The ongoing saga of obestatin: is it a hormone?
    Abhimanyu Garg
    Department of Internal Midicine and Center for Human Nutrition, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9052, USA
    J Clin Endocrinol Metab 92:3396-8. 2007
  9. ncbi An autosomal recessive syndrome of joint contractures, muscular atrophy, microcytic anemia, and panniculitis-associated lipodystrophy
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 95:E58-63. 2010
    ....
  10. ncbi Phenotypic heterogeneity in patients with familial partial lipodystrophy (dunnigan variety) related to the site of missense mutations in lamin a/c gene
    A Garg
    Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 86:59-65. 2001
    ..Therefore, a unique phenotype of atypical FPLD may result from disrupted interaction of lamin A with other proteins and chromatin compared with typical FPLD, in which interaction of both lamins A and C may be disrupted...
  11. ncbi Statins for all patients with type 2 diabetes: not so soon
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9052, USA
    Lancet 364:641-2. 2004
  12. ncbi Acquired and inherited lipodystrophies
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, and the Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9052, USA
    N Engl J Med 350:1220-34. 2004
  13. ncbi What is the role of alternative biomarkers for coronary heart disease?
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, UT Southwestern Medical Center, Dallas, TX, USA
    Clin Endocrinol (Oxf) 75:289-93. 2011
    ..Another way is to develop new models predicting long-term or life-time risk of CHD. Further research using novel biomarkers and long-term predictive models has the potential to improve CHD risk prediction...
  14. ncbi Clinical review#: Lipodystrophies: genetic and acquired body fat disorders
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8537, USA
    J Clin Endocrinol Metab 96:3313-25. 2011
    ..The current management includes cosmetic surgery and early identification and treatment of metabolic and other complications with diet, exercise, hypoglycemic drugs, and lipid-lowering agents...
  15. ncbi Regional adiposity and insulin resistance
    Abhimanyu Garg
    University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9052, USA
    J Clin Endocrinol Metab 89:4206-10. 2004
  16. ncbi Homozygous null mutations in ZMPSTE24 in restrictive dermopathy: evidence of genetic heterogeneity
    Z Ahmad
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Clin Genet 81:158-64. 2012
    ..This report provides evidence of genetic heterogeneity among RD and concludes that there may be an additional locus for RD which remains to be identified...
  17. ncbi Genetic and phenotypic heterogeneity in patients with mandibuloacral dysplasia-associated lipodystrophy
    Vinaya Simha
    Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 88:2821-4. 2003
    ..e. AGPAT2, Seipin, and PPARG also revealed no substantial alterations. We conclude that MAD is a genetically and phenotypically heterogeneous disorder. Besides LMNA gene, other as yet unmapped loci could be linked to MAD...
  18. ncbi Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia
    Anil K Agarwal
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Hum Mol Genet 12:1995-2001. 2003
    ..We conclude that mutations in ZMPSTE24 may cause MAD by affecting prelamin A processing...
  19. ncbi Severe mandibuloacral dysplasia-associated lipodystrophy and progeria in a young girl with a novel homozygous Arg527Cys LMNA mutation
    Anil K Agarwal
    Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8537, USA
    J Clin Endocrinol Metab 93:4617-23. 2008
    ..Mandibuloacral dysplasia (MAD) is a rare autosomal recessive progeroid syndrome due to mutations in genes encoding nuclear lamina proteins, lamins A/C (LMNA) or prelamin A processing enzyme, and zinc metalloproteinase (ZMPSTE24)...
  20. ncbi A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy
    Anil K Agarwal
    Department of Internal Medicine, Division of Nutrition and Metabolic Diseases and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 87:408-11. 2002
    ..None of the four unaffected family members harbored the mutation. We conclude that heterozygous, R425C, mutation in PPARG could be the molecular basis for one of the familial partial lipodystrophy phenotypes...
  21. ncbi A gene for congenital generalized lipodystrophy maps to human chromosome 9q34
    A Garg
    Department of Internal Medicine, and Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    J Clin Endocrinol Metab 84:3390-4. 1999
    ..Identification of the CGL gene(s) will contribute to our understanding of the adipocyte differentiation and elucidation of the mechanisms of insulin resistance in disorders of adipose tissue...
  22. ncbi Gender differences in the prevalence of metabolic complications in familial partial lipodystrophy (Dunnigan variety)
    A Garg
    Department of Internal Medicine and the Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas 75235 9052, USA
    J Clin Endocrinol Metab 85:1776-82. 2000
    ..These observations raise the possibility that women with generalized and regional obesity may also have more severe metabolic sequelae of insulin resistance...
  23. ncbi Overlapping syndrome with familial partial lipodystrophy, Dunnigan variety and cardiomyopathy due to amino-terminal heterozygous missense lamin A/C mutations
    L Subramanyam
    Department of Internal Medicine, Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8537, USA
    Clin Genet 78:66-73. 2010
    ..Furthermore, the underlying molecular mechanisms by which these amino-terminal mutations cause lipodystrophy as well as cardiomyopathy remain to be understood...
  24. ncbi Multisystem dystrophy syndrome due to novel missense mutations in the amino-terminal head and alpha-helical rod domains of the lamin A/C gene
    Abhimanyu Garg
    Center for Human Nutrition and Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9052, USA
    Am J Med 112:549-55. 2002
    ....
  25. ncbi AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34
    Anil K Agarwal
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, USA
    Nat Genet 31:21-3. 2002
    ..AGPAT2 mRNA is highly expressed in adipose tissue. We conclude that mutations in AGPAT2 may cause congenital generalized lipodystrophy by inhibiting triacylglycerol synthesis and storage in adipocytes...
  26. ncbi Severe islet amyloidosis in congenital generalized lipodystrophy
    A Garg
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas 75235 9052, USA
    Diabetes Care 19:28-31. 1996
    ..We studied pancreatic islet pathology in congenital generalized lipodystrophy, a genetic syndrome of extreme insulin resistance that may provide some clues...
  27. ncbi Phenotypic and genetic heterogeneity in congenital generalized lipodystrophy
    Anil K Agarwal
    Department of Internal Medicine, Division of Nutrition and Metabolic Diseases and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 88:4840-7. 2003
    ..We conclude that besides AGPAT2 and BSCL2, there may be additional loci for CGL. The genetic heterogeneity in CGL patients is accompanied by phenotypic heterogeneity...
  28. ncbi Body fat distribution and metabolic variables in patients with neonatal progeroid syndrome
    Vinaya Simha
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
    Am J Med Genet A 143:1421-30. 2007
    ..Metabolic abnormalities related to insulin resistance are also uncommon in this condition...
  29. ncbi Phenotypic heterogeneity in body fat distribution in patients with atypical Werner's syndrome due to heterozygous Arg133Leu lamin A/C mutation
    Katherine N Jacob
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9052, USA
    J Clin Endocrinol Metab 90:6699-706. 2005
    ..Furthermore, the severity of metabolic complications seems to correlate with the extent of lipodystrophy...
  30. ncbi Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3
    Suja Sukumaran
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Mol Endocrinol 42:469-78. 2009
    ..These observations strongly suggest that the cDNA previously identified as GPAT3 has AGPAT activity and thus we prefer to identify this clone as AGPAT10 as well...
  31. ncbi Focal segmental glomerulosclerosis in patients with mandibuloacral dysplasia owing to ZMPSTE24 deficiency
    Anil K Agarwal
    From the Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390 9052, USA
    J Investig Med 54:208-13. 2006
    ....
  32. ncbi Phenotypic heterogeneity in body fat distribution in patients with congenital generalized lipodystrophy caused by mutations in the AGPAT2 or seipin genes
    Vinaya Simha
    Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 88:5433-7. 2003
    ..We conclude that CGL patients with Seipin mutations have a more severe lack of body fat, which affects both metabolically active and mechanical adipose tissue, compared with patients with mutations in the AGPAT2 gene...
  33. ncbi Genetic basis of congenital generalized lipodystrophy
    A K Agarwal
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Int J Obes Relat Metab Disord 28:336-9. 2004
    ..Thus, several distinct mechanisms can lead to extreme lack of adipose tissue in humans and cause CGL...
  34. ncbi Post-mortem findings in familial partial lipodystrophy, Dunnigan variety
    W A Haque
    Department of Internal Medicine, Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9052, USA
    Diabet Med 19:1022-5. 2002
    ..Our data show predisposition to atherosclerosis and polycystic ovaries and suggest that pancreatic amyloidosis may underlie development of hyperglycaemia in FPLD patients...
  35. ncbi Novel subtype of congenital generalized lipodystrophy associated with muscular weakness and cervical spine instability
    Vinaya Simha
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Am J Med Genet A 146:2318-26. 2008
    ..The genetic basis of this novel subtype remains to be determined...
  36. ncbi Laminopathies: multisystem dystrophy syndromes
    Katherine N Jacob
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, 75390 9052, USA
    Mol Genet Metab 87:289-302. 2006
    ..The mechanisms by which mutations in LMNA gene cause multisystem dystrophy are an active area of current investigation. Further studies are needed to understand the underlying mechanisms of marked pleiotropy in laminopathies...
  37. ncbi Genetic basis of lipodystrophies and management of metabolic complications
    Anil K Agarwal
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine and the Center for Human Nutrition, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9052, USA
    Annu Rev Med 57:297-311. 2006
    ..Additional loci remain to be discovered. We discuss features of autosomal recessive and dominant types of lipodystrophies and therapeutic interventions available for these patients...
  38. ncbi The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology
    Kimberly M Szymanski
    Department of Pharmacology, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:20890-5. 2007
    ..The genes identified in our screen should be of value in understanding the pathway of lipid droplet biogenesis and maintenance and the cause of some lipodystrophies...
  39. ncbi Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity
    Anil K Agarwal
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Arch Biochem Biophys 449:64-76. 2006
    ....
  40. ncbi Clinical features and metabolic derangements in acquired generalized lipodystrophy: case reports and review of the literature
    Anoop Misra
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Medicine (Baltimore) 82:129-46. 2003
    ..Leptin therapy, however, remains investigational. Fibrates alone or in combination with statins may be used to treat hypertriglyceridemia...
  41. ncbi A novel syndrome of mandibular hypoplasia, deafness, and progeroid features associated with lipodystrophy, undescended testes, and male hypogonadism
    Savitha Shastry
    Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8537, USA
    J Clin Endocrinol Metab 95:E192-7. 2010
    ..Mandibuloacral dysplasia (MAD) is an autosomal recessive progeroid disorder associated with type A (partial) or B (generalized) lipodystrophy and is due to mutations in lamin A/C (LMNA) or zinc metalloproteinase (ZMPSTE24) genes...
  42. ncbi Effect of high-carbohydrate or high-cis-monounsaturated fat diets on blood pressure: a meta-analysis of intervention trials
    Meena Shah
    Division of Nutrition and Metabolic Diseases and Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9052, USA
    Am J Clin Nutr 85:1251-6. 2007
    ..The DASH diet is low in saturated fat, but it is not clear whether saturated fat should be preferentially replaced with carbohydrate or unsaturated fat, especially cis-monounsaturated fat...
  43. ncbi Functional characterization of human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 9: cloning, tissue distribution, gene structure, and enzymatic activity
    Anil K Agarwal
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 USA
    J Endocrinol 193:445-57. 2007
    ..Based on the activity and expression pattern of AGPAT9 in the lung and spleen, this novel isoform could be implicated in the biosynthesis of phospholipids and TG in these tissues...
  44. ncbi Sex steroid hormones, upper body obesity, and insulin resistance
    Nicola Abate
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 87:4522-7. 2002
    ..Low plasma levels of bioavailable testosterone do not independently predict excessive insulin resistance, beta-cell dysfunction, or hepatic glucose output in normogonadal men...
  45. ncbi Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers
    Anil K Agarwal
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine and Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Lipid Res 51:2143-52. 2010
    ..Our enzymatic assays strongly suggest that the cDNA previously identified as LPCAT2/lyso platelet-activating factor-acetyltransferase cDNA has AGPAT activity and thus we prefer to identify this clone as AGPAT11 as well...
  46. ncbi Risk factors for diabetes in familial partial lipodystrophy, Dunnigan variety
    Wasim A Haque
    Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Diabetes Care 26:1350-5. 2003
    ..CONCLUSIONS: We conclude that increased adiposity as reflected by excess subcutaneous fat accumulation in the chin region and parity may predispose women with FPLD to develop diabetes...
  47. ncbi Body fat distribution and metabolic derangements in patients with familial partial lipodystrophy associated with mandibuloacral dysplasia
    Vinaya Simha
    Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 87:776-85. 2002
    ..We conclude that familial partial lipodystrophy associated with MAD presents with two types of body fat distribution patterns, both of which are associated with insulin resistance and its metabolic complications...
  48. ncbi Clinical features and metabolic and autoimmune derangements in acquired partial lipodystrophy: report of 35 cases and review of the literature
    Anoop Misra
    Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 75390-9052, USA
    Medicine (Baltimore) 83:18-34. 2004
    ..The use of thiazolidinediones to treat fat loss in patients with APL remains anecdotal. Prognosis is mainly determined by renal insufficiency due to MPGN...
  49. ncbi Physico-chemical properties of low density lipoproteins in normolipidemic Asian Indian men
    N Abate
    Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, USA
    Horm Metab Res 27:326-31. 1995
    ..Therefore, we exclude a genetic predisposition to atherogenic LDL phenotype as a factor contributing to the high incidence of coronary heart disease in migrant Asian Indians...
  50. ncbi High-monounsaturated-fat diets for patients with diabetes mellitus: a meta-analysis
    A Garg
    Center for Human Nutrition and the Department of Internal Medicine and Clinical Nutrition, University of Texas Southwestern Medical Center, and Department of Veterans Affairs Medical Center, Dallas 75235 9052, USA
    Am J Clin Nutr 67:577S-582S. 1998
    ..Therefore, a diet rich in cis-monounsaturated fat can be advantageous for both patients with type 1 or type 2 diabetes who are trying to maintain or lose weight...
  51. ncbi Regional body fat distribution in HIV-infected patients with lipodystrophy
    Warren L Dinges
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9052, USA
    J Investig Med 53:15-25. 2005
    ..CONCLUSIONS: We conclude that MRI provides the best tools for definition of LDHIV syndrome and reveals variable phenotypes among LDHIV patients...
  52. ncbi Clinical review 153: Lipodystrophy in human immunodeficiency virus-infected patients
    Dali Chen
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Clin Endocrinol Metab 87:4845-56. 2002
    ..Future research is needed to discover the biochemical and molecular markers of lipodystrophy in HIV patients and develop PIs or other antiretroviral agents that are free of metabolic toxicity...
  53. ncbi A homozygous mutation in the lamin A/C gene associated with a novel syndrome of arthropathy, tendinous calcinosis, and progeroid features
    Hilde Van Esch
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9052, USA
    J Clin Endocrinol Metab 91:517-21. 2006
    ..Thus, arthropathy with tendinous calcifications can be added to the growing list of disorders associated with LMNA mutations...
  54. ncbi Effect of a high-carbohydrate versus a high--cis-monounsaturated fat diet on blood pressure in patients with type 2 diabetes
    Meena Shah
    Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75235-9052, USA
    Diabetes Care 28:2607-12. 2005
    ....
  55. ncbi Adipocyte biology and adipocytokines
    Wasim A Haque
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Clin Lab Med 24:217-34. 2004
    ..Abnormal synthesis of these secretory products may be related to the pathogenesis of insulin resistance and its complications in patients who have adipose tissue disorders, such as obesity and lipodvstrophies...
  56. ncbi Adipose tissue distribution pattern in patients with familial partial lipodystrophy (Dunnigan variety)
    A Garg
    Department of Internal Medicine, Center for Human Nutrition, The University of Texas Southwestern Medical Center at Dallas, 75235 9052, USA
    J Clin Endocrinol Metab 84:170-4. 1999
    ..The pattern of fat distribution in the male and females was similar. We conclude that FPLD results in a characteristic absence of sc fat from the extremities, with preservation of intermuscular fat stores...
  57. ncbi Skeletal muscle morphology and exercise response in congenital generalized lipodystrophy
    A Garg
    Department of Internal Medicine, The Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas 75390 9052, USA
    Diabetes Care 23:1545-50. 2000
    ..We investigated whether insulin resistance in CGL patients is associated with abnormal muscle morphology and whether increased muscularity imparts increased muscle strength and exercise capacity..
  58. ncbi The role of diet, exercise and smoking in dyslipidaemia in HIV-infected patients with lipodystrophy
    M Shah
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine and Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 76129, USA
    HIV Med 6:291-8. 2005
    ..Lipodystrophy in HIV-infected (LDHIV) patients receiving protease inhibitors (PIs) is associated with dyslipidaemia. Whether lifestyle factors play a role in dyslipidaemia in LDHIV subjects on PIs is not well characterized...
  59. ncbi Inherited lipodystrophies and hypertriglyceridemia
    Vinaya Simha
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Curr Opin Lipidol 20:300-8. 2009
    ..We review the new insights in the pathophysiology and treatment of these disorders based on the current understanding of the biologic role of these lipodystrophy genes...
  60. ncbi The effect of dietary intervention on serum lipid levels in type 2 diabetes mellitus
    Nilo B Cater
    Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9052, USA
    Curr Diab Rep 2:289-94. 2002
    ....
  61. ncbi Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes
    Meena Shah
    Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Diabetes Care 30:2993-8. 2007
    ..The objective of this study was to study the effect of fatty acids on postprandial insulin, glucose, and triglyceride responses...
  62. ncbi Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy
    Víctor A Cortés
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell Metab 9:165-76. 2009
    ..These observations suggest that both dietary fat and hepatic triglyceride biosynthesis via a monoacylglycerol pathway may contribute to hepatic steatosis in Agpat2(-/-) mice...
  63. ncbi Congenital generalized lipodystrophy, type 4 (CGL4) associated with myopathy due to novel PTRF mutations
    Savitha Shastry
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Am J Med Genet A 152:2245-53. 2010
    ..It is unclear how mutations in PTRF, which plays an essential role in formation of caveolae, affect a wide variety of tissues resulting in a variable phenotype...
  64. ncbi Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy
    Wasim Haque
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Biochem Biophys Res Commun 327:446-53. 2005
    ..We suggest that reduction in AGPAT2 enzymatic activity underlies the loss of adipose tissue in CGL. Our observations reveal an important role of various carboxy-terminal residues in determining the enzymatic activity of AGPAT2...
  65. ncbi Effect of a high-fiber diet compared with a moderate-fiber diet on calcium and other mineral balances in subjects with type 2 diabetes
    Meena Shah
    Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Diabetes Care 32:990-5. 2009
    ..It is not clear, however, how high levels of fiber affect mineral balance...
  66. ncbi Lipodystrophy: lessons in lipid and energy metabolism
    Vinaya Simha
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine and the Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Curr Opin Lipidol 17:162-9. 2006
    ....
  67. ncbi Effect of subcutaneous leptin replacement therapy on bone metabolism in patients with generalized lipodystrophy
    Vinaya Simha
    Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Clin Endocrinol Metab 87:4942-5. 2002
    ..Our preliminary data suggest that sc leptin replacement in hypoleptinemic patients with generalized lipodystrophy has no effect on the mature adult skeleton...
  68. ncbi Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy
    Vinaya Simha
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9052, USA
    Diabetes Care 26:30-5. 2003
    ..CONCLUSIONS: Reduction in IMCL and intrahepatic lipid content may partly explain leptin-induced improvement in insulin sensitivity in patients with generalized lipodystrophy...
  69. ncbi Mislocalization of prelamin A Tyr646Phe mutant to the nuclear pore complex in human embryonic kidney 293 cells
    Yong Pan
    Department of Internal Medicine and Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biochem Biophys Res Commun 355:78-84. 2007
    ..The toxicity of prenylated prelamin A may be due to its association and/or accumulation at the nuclear pore complex which could be partially reversed by farnesyl transferase inhibitors...
  70. ncbi Genetic disorders of adipose tissue development, differentiation, and death
    Anil K Agarwal
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine and the Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9052, USA
    Annu Rev Genomics Hum Genet 7:175-99. 2006
    ..In this review, we focus on the molecular basis of inherited lipodystrophies as they relate to adipocyte biology and their associated phenotypic manifestations...
  71. ncbi Congenital generalized lipodystrophy: significance of triglyceride biosynthetic pathways
    Anil K Agarwal
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Trends Endocrinol Metab 14:214-21. 2003
    ..Here, we discuss the significance of these in energy storage, in addition to the normal functioning of cell membranes...
  72. ncbi Thiazolidinedione-associated congestive heart failure and pulmonary edema
    Asra Kermani
    Department of Veterans Affairs Medical Center, Dallas, Tex, USA
    Mayo Clin Proc 78:1088-91. 2003
    ..CONCLUSION: We conclude that thiazolidinediones can cause or exacerbate heart failure and pulmonary edema and should be avoided in patients with left ventricular dysfunction or chronic renal insufficiency...
  73. ncbi Lipodystrophies: rare disorders causing metabolic syndrome
    Abhimanyu Garg
    Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9052, USA
    Endocrinol Metab Clin North Am 33:305-31. 2004
    ..This article reviews these recent advances in our knowledge of the clinical features, metabolic abnormalities, and pathogenetic or other bases of various types of lipodystrophies...
  74. ncbi Seipin: a mysterious protein
    Anil K Agarwal
    Division of Nutrition and Metabolic Diseases, the Department of Internal Medicine and the Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Trends Mol Med 10:440-4. 2004
  75. ncbi Serum adiponectin and leptin levels in patients with lipodystrophies
    Wasim A Haque
    Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 87:2395. 2002
    ..001). Our results indicate that serum adiponectin and leptin levels are extremely low in patients with generalized lipodystrophies and may be related to severe insulin resistance and its metabolic complications in lipodystrophies...
  76. ncbi LMNA mutations in atypical Werner's syndrome
    Lishan Chen
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Lancet 362:440-5. 2003
    ..Some features of this disorder are also present in laminopathies caused by mutant LMNA encoding nuclear lamin A/C. Because of this similarity, we sequenced LMNA in individuals with atypical Werner's syndrome (wild-type WRN)...
  77. ncbi Leptin-replacement therapy for lipodystrophy
    Elif Arioglu Oral
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1770, USA
    N Engl J Med 346:570-8. 2002
    ..Since severe lipodystrophy is associated with leptin deficiency, insulin resistance, hypertriglyceridemia, and hepatic steatosis, we assessed whether leptin replacement would ameliorate this condition...
  78. ncbi Hepatic steatosis, insulin resistance, and adipose tissue disorders
    Abhimanyu Garg
    J Clin Endocrinol Metab 87:3019-22. 2002
  79. ncbi Mutations in the seipin and AGPAT2 genes clustering in consanguineous families with Berardinelli-Seip congenital lipodystrophy from two separate geographical regions of Brazil
    Karina Braga Gomes
    Department of Human Genetics, Instituto de Patologia Clinica Hermes Pardini, Belo Horizonte, Minas Gerais, 30140-070 Brazil
    J Clin Endocrinol Metab 89:357-61. 2004
    ..Our finding of a single mutation in the Seipin and AGPAT2 genes in the pedigrees from the northeastern and southeastern regions, respectively, will be useful in genetic counseling of subjects from these large pedigrees from Brazil...
  80. ncbi Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications
    Marion J Franz
    Nutrition Concepts by Franz, Inc, Minneapolis, Minnesota 55439, USA
    Diabetes Care 25:148-98. 2002
  81. ncbi Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications
    Marion J Franz
    Diabetes Care 26:S51-61. 2003
  82. ncbi Nutrition principles and recommendations in diabetes
    Marion J Franz
    Diabetes Care 27:S36-46. 2004

Research Grants31

  1. Novel Therapies for Metabolic Complications in Patients with Lipodystrophies
    Abhimanyu Garg; Fiscal Year: 2007
    ..Additionally, the findings may be applicable to treating metabolic complications in patients with obesity and type 2 diabetes. ..
  2. Therapeutic Approaches to HAART-Induced Lipodystrophy
    Abhimanyu Garg; Fiscal Year: 2006
    ..Additionally, the study may help prevent these problems in HIV-infected patients being initiated on PI-containing HAART. ..
  3. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2007
    ....
  4. Phase II study of cholic acid for hepatic steatosis in *
    Abhimanyu Garg; Fiscal Year: 2007
    ..The effectiveness of cholic acid in reducing hepatic steatosis in humans remains unknown. ..
  5. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2009
    ....
  6. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2010
    ....
  7. Novel Therapies for Metabolic Complications in Patients with Lipodystrophies
    Abhimanyu Garg; Fiscal Year: 2010
    ..Additionally, the findings may be applicable to treating metabolic complications in patients with obesity and type 2 diabetes. ..
  8. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2006
    ..abstract_text> ..
  9. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2002
    ..abstract_text> ..
  10. MECHANISMS OF LIPODYSTROPHY IN HIV INFECTED PATIENTS
    Abhimanyu Garg; Fiscal Year: 2002
    ..Additionally, the study may prove effectiveness and reduced toxicity of alternative antiretroviral regimens without a PI. ..
  11. GENETIC AND METABOLIC BASIS OF FAMILIAL LIPODYSTROPHIES
    Abhimanyu Garg; Fiscal Year: 2010
    ....