Katheleen Gardiner

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc The proteins of human chromosome 21
    Katheleen Gardiner
    Eleanor Roosevelt Institute, University of Denver, 1899 Gaylord Street, Denver, Colorado 80206, USA
    Am J Med Genet C Semin Med Genet 142:196-205. 2006
  2. ncbi request reprint Of messages and meaning
    K Gardiner
    Eleanor Roosevelt Institute, Denver, CO 80206, USA
    Trends Genet 13:92-3. 1997
  3. ncbi request reprint Clonability and gene distribution on human chromosome 21: reflections of junk DNA content?
    K Gardiner
    Eleanor Roosevelt Institute, Denver, CO 80206, USA
    Gene 205:39-46. 1997
  4. pmc The sequence of human chromosome 21 and implications for research into Down syndrome
    K Gardiner
    Eleanor Roosevelt Institute, Gaylord Street, Denver, Colorado 80206 1210, USA
    Genome Biol 1:REVIEWS0002. 2000
  5. ncbi request reprint Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis
    Katheleen Gardiner
    Eleanor Roosevelt Institute, 1899 Gaylord Street, Denver, CO 80206, USA
    Genomics 79:833-43. 2002
  6. ncbi request reprint Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions
    Katheleen Gardiner
    Eleanor Roosevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, CO 80206 1210, USA
    Gene 318:137-47. 2003
  7. ncbi request reprint A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons among inbred mouse strains
    Yunzhi Du
    Eleanor Roosevelt Institute at the University of Denver, CO 80206, USA
    Gene 382:39-46. 2006
  8. doi request reprint HIGEDA: a hierarchical gene-set genetics based algorithm for finding subtle motifs in biological sequences
    Thanh Le
    Department of Computer Science and Engineering, Computational Biosciences Program, University of Colorado, Denver, CO, USA
    Bioinformatics 26:302-9. 2010
  9. ncbi request reprint Human chromosome 21/Down syndrome gene function and pathway database
    Oleksii Nikolaienko
    Eleanor Roosevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA
    Gene 364:90-8. 2005
  10. pmc Gene-dosage effects in Down syndrome and trisomic mouse models
    Katheleen Gardiner
    Eleanor Roosevelt Institute at the University of Denver, Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, 1899 Gaylord Street, Denver, CO 80206, USA
    Genome Biol 5:244. 2004

Collaborators

  • Cao Nguyen
  • Alberto C S Costa
  • Muriel Davisson
  • S E Antonarakis
  • Thomas D Schmittgen
  • Hong Zhang
  • G J Nuovo
  • E Head
  • Thanh Le
  • Donald E Kuhn
  • Sergey V Voronov
  • AVI MA'AYAN
  • Yunzhi Du
  • Oleksii Nikolaienko
  • Tom Altman
  • Ottavio Arancio
  • Geraldine E Malana
  • Cecilia Schmidt
  • Alvin V Terry
  • Gilbert Di Paolo
  • Pietro De Camilli
  • Terry S Elton
  • Silvia Giovedi
  • Markus R Wenk
  • Christelle Borel
  • Elizabeth A Pollina
  • Laurent Cimasoni
  • Ellen C Akeson
  • Samuel G Frere
  • Adam P Pleister
  • Mickey M Martin
  • David S Feldman
  • Jinmai Jiang
  • Ravi Iyengar
  • Karen Kafadar
  • Linda S Crinc
  • Krzysztof J Cios

Detail Information

Publications16

  1. pmc The proteins of human chromosome 21
    Katheleen Gardiner
    Eleanor Roosevelt Institute, University of Denver, 1899 Gaylord Street, Denver, Colorado 80206, USA
    Am J Med Genet C Semin Med Genet 142:196-205. 2006
    ....
  2. ncbi request reprint Of messages and meaning
    K Gardiner
    Eleanor Roosevelt Institute, Denver, CO 80206, USA
    Trends Genet 13:92-3. 1997
  3. ncbi request reprint Clonability and gene distribution on human chromosome 21: reflections of junk DNA content?
    K Gardiner
    Eleanor Roosevelt Institute, Denver, CO 80206, USA
    Gene 205:39-46. 1997
    ..Thus, data from a variety of approaches suggest that a large part of 21q very likely has neither coding capacity nor associated regulatory function. By these criteria, it is a good candidate for a repository of junk DNA...
  4. pmc The sequence of human chromosome 21 and implications for research into Down syndrome
    K Gardiner
    Eleanor Roosevelt Institute, Gaylord Street, Denver, Colorado 80206 1210, USA
    Genome Biol 1:REVIEWS0002. 2000
    ....
  5. ncbi request reprint Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis
    Katheleen Gardiner
    Eleanor Roosevelt Institute, 1899 Gaylord Street, Denver, CO 80206, USA
    Genomics 79:833-43. 2002
    ..These data have implications for generating complete transcript maps of chromosome 21 and for the entire human genome, and for defining expression abnormalities in Down syndrome and mouse models...
  6. ncbi request reprint Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions
    Katheleen Gardiner
    Eleanor Roosevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, CO 80206 1210, USA
    Gene 318:137-47. 2003
    ..Together, these data point out the potential for existing mouse models to produce extraneous phenotypes and to fail to produce DS-relevant phenotypes...
  7. ncbi request reprint A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons among inbred mouse strains
    Yunzhi Du
    Eleanor Roosevelt Institute at the University of Denver, CO 80206, USA
    Gene 382:39-46. 2006
    ..These findings suggest that genetic background contributes to subtle variation in 5HT2CR mRNA editing patterns which may have consequences for pharmacological treatments and behavioral testing...
  8. doi request reprint HIGEDA: a hierarchical gene-set genetics based algorithm for finding subtle motifs in biological sequences
    Thanh Le
    Department of Computer Science and Engineering, Computational Biosciences Program, University of Colorado, Denver, CO, USA
    Bioinformatics 26:302-9. 2010
    ..Availability and implementation: Source code and test datasets are available for download at http://ouray.cudenver.edu/~tnle/, implemented in C++ and supported on Linux and MS Windows...
  9. ncbi request reprint Human chromosome 21/Down syndrome gene function and pathway database
    Oleksii Nikolaienko
    Eleanor Roosevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA
    Gene 364:90-8. 2005
    ..Here we describe the current status of data collection and the immediate future plans for this first human chromosome-specific database...
  10. pmc Gene-dosage effects in Down syndrome and trisomic mouse models
    Katheleen Gardiner
    Eleanor Roosevelt Institute at the University of Denver, Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, 1899 Gaylord Street, Denver, CO 80206, USA
    Genome Biol 5:244. 2004
    ..Now, several groups have shown this to be generally the case, but some inter-individual variability and other exceptions were found...
  11. ncbi request reprint Building protein interaction maps for Down's syndrome
    Katheleen Gardiner
    Eleanor Roosevelt Institute, University of Denver, 2199 South University Blvd, Denver, Colorado 80208, USA
    Brief Funct Genomic Proteomic 3:142-56. 2004
    ..Once pathway perturbations have been identified, the potential for rational design of therapeutics becomes practical...
  12. ncbi request reprint Transcriptional dysregulation in Down syndrome: predictions for altered protein complex stoichiometries and post-translational modifications, and consequences for learning/behavior genes ELK, CREB, and the estrogen and glucocorticoid receptors
    Katheleen Gardiner
    Eleanor Roosevelt Institute at the University of Denver, CO 80045, USA
    Behav Genet 36:439-53. 2006
    ..Each of these proteins is relevant to learning, behavior and/or development and therefore perturbation of their activation may contribute to the Down syndrome phenotype...
  13. pmc The cognitive phenotype of Down syndrome: insights from intracellular network analysis
    AVI MA'AYAN
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    NeuroRx 3:396-406. 2006
    ..We propose how these methods could be integrated with creation and manipulation of mouse models of DS to advance our understanding of the perturbed cell signaling pathways in DS. This understanding could lead to potential therapeutics...
  14. ncbi request reprint A comprehensive human chromosome 21 database
    Cao Nguyen
    University of Colorado at Denver and Health Sciences Center, 80217 3364, USA
    IEEE Eng Med Biol Mag 26:86-93. 2007
  15. pmc Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts
    Donald E Kuhn
    Davis Heart and Lung Research Institute, The Ohio State University, DHLRI 515, 473 West 12th Avenue, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 370:473-7. 2008
    ..Importantly, Hsa21-derived miRNAs may provide novel therapeutic targets in the treatment of individuals with DS...
  16. pmc Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
    Sergey V Voronov
    Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:9415-20. 2008
    ....