Katheleen Gardiner

Summary

Affiliation: University of Denver
Country: USA

Publications

  1. pmc Gene-dosage effects in Down syndrome and trisomic mouse models
    Katheleen Gardiner
    Eleanor Roosevelt Institute at the University of Denver, Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, 1899 Gaylord Street, Denver, CO 80206, USA
    Genome Biol 5:244. 2004
  2. ncbi request reprint A-to-I editing of the 5HT2C receptor and behaviour
    Katheleen Gardiner
    Eleanor Roosevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA
    Brief Funct Genomic Proteomic 5:37-42. 2006
  3. ncbi request reprint Transcriptional dysregulation in Down syndrome: predictions for altered protein complex stoichiometries and post-translational modifications, and consequences for learning/behavior genes ELK, CREB, and the estrogen and glucocorticoid receptors
    Katheleen Gardiner
    Eleanor Roosevelt Institute at the University of Denver, CO 80045, USA
    Behav Genet 36:439-53. 2006
  4. ncbi request reprint Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions
    Katheleen Gardiner
    Eleanor Roosevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, CO 80206 1210, USA
    Gene 318:137-47. 2003
  5. ncbi request reprint Report on the 'Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype correlations in Down syndrome', held June 11-14, 2004, Washington D.C
    K Gardiner
    Eleanor Roosevelt Institute at the University of Denver, Denver, CO 80206, USA
    Cytogenet Genome Res 108:269-77. 2005
  6. ncbi request reprint A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons among inbred mouse strains
    Yunzhi Du
    Eleanor Roosevelt Institute at the University of Denver, CO 80206, USA
    Gene 382:39-46. 2006
  7. pmc The proteins of human chromosome 21
    Katheleen Gardiner
    Eleanor Roosevelt Institute, University of Denver, 1899 Gaylord Street, Denver, Colorado 80206, USA
    Am J Med Genet C Semin Med Genet 142:196-205. 2006
  8. ncbi request reprint Human chromosome 21/Down syndrome gene function and pathway database
    Oleksii Nikolaienko
    Eleanor Roosevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA
    Gene 364:90-8. 2005
  9. ncbi request reprint Building protein interaction maps for Down's syndrome
    Katheleen Gardiner
    Eleanor Roosevelt Institute, University of Denver, 2199 South University Blvd, Denver, Colorado 80208, USA
    Brief Funct Genomic Proteomic 3:142-56. 2004
  10. pmc The sequence of human chromosome 21 and implications for research into Down syndrome
    K Gardiner
    Eleanor Roosevelt Institute, Gaylord Street, Denver, Colorado 80206 1210, USA
    Genome Biol 1:REVIEWS0002. 2000

Collaborators

  • Alberto C S Costa
  • Cao Nguyen
  • Muriel Davisson
  • M L Yaspo
  • Rotraud Wieser
  • S E Antonarakis
  • Hong Zhang
  • Thomas D Schmittgen
  • Terry Elton
  • Ottavio Arancio
  • E Head
  • G J Nuovo
  • D Slavov
  • Oleksii Nikolaienko
  • Thanh Le
  • Sergey V Voronov
  • Donald E Kuhn
  • AVI MA'AYAN
  • Yunzhi Du
  • Lyudmyla Tsyba
  • Tom Altman
  • D Patterson
  • Christelle Borel
  • Gilbert Di Paolo
  • Elizabeth A Pollina
  • Pietro De Camilli
  • Geraldine E Malana
  • Mickey M Martin
  • Cecilia Schmidt
  • Laurent Cimasoni
  • Ellen C Akeson
  • David S Feldman
  • Jinmai Jiang
  • Samuel G Frere
  • Alvin V Terry
  • Silvia Giovedi
  • Markus R Wenk
  • Adam P Pleister
  • A Rynditch
  • Karen Kafadar
  • Ravi Iyengar
  • Krzysztof J Cios
  • Linda S Crinc
  • Inessa Skrypkina
  • Alla Rynditch
  • Andrew Fortna
  • Y Pekarsky
  • Ganna Ferenets
  • R Reinhardt
  • C Reimer
  • J Ramser
  • S Minoshima
  • M Hattori
  • J Kudoh
  • Y Sakaki
  • K Clancy
  • M Clark
  • A Rosenthal
  • N Shimizu
  • J Bleskan
  • J Bowersox
  • C Fonatsch

Detail Information

Publications23

  1. pmc Gene-dosage effects in Down syndrome and trisomic mouse models
    Katheleen Gardiner
    Eleanor Roosevelt Institute at the University of Denver, Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, 1899 Gaylord Street, Denver, CO 80206, USA
    Genome Biol 5:244. 2004
    ..Now, several groups have shown this to be generally the case, but some inter-individual variability and other exceptions were found...
  2. ncbi request reprint A-to-I editing of the 5HT2C receptor and behaviour
    Katheleen Gardiner
    Eleanor Roosevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA
    Brief Funct Genomic Proteomic 5:37-42. 2006
    ....
  3. ncbi request reprint Transcriptional dysregulation in Down syndrome: predictions for altered protein complex stoichiometries and post-translational modifications, and consequences for learning/behavior genes ELK, CREB, and the estrogen and glucocorticoid receptors
    Katheleen Gardiner
    Eleanor Roosevelt Institute at the University of Denver, CO 80045, USA
    Behav Genet 36:439-53. 2006
    ..Each of these proteins is relevant to learning, behavior and/or development and therefore perturbation of their activation may contribute to the Down syndrome phenotype...
  4. ncbi request reprint Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions
    Katheleen Gardiner
    Eleanor Roosevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, CO 80206 1210, USA
    Gene 318:137-47. 2003
    ..Together, these data point out the potential for existing mouse models to produce extraneous phenotypes and to fail to produce DS-relevant phenotypes...
  5. ncbi request reprint Report on the 'Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype correlations in Down syndrome', held June 11-14, 2004, Washington D.C
    K Gardiner
    Eleanor Roosevelt Institute at the University of Denver, Denver, CO 80206, USA
    Cytogenet Genome Res 108:269-77. 2005
  6. ncbi request reprint A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons among inbred mouse strains
    Yunzhi Du
    Eleanor Roosevelt Institute at the University of Denver, CO 80206, USA
    Gene 382:39-46. 2006
    ..These findings suggest that genetic background contributes to subtle variation in 5HT2CR mRNA editing patterns which may have consequences for pharmacological treatments and behavioral testing...
  7. pmc The proteins of human chromosome 21
    Katheleen Gardiner
    Eleanor Roosevelt Institute, University of Denver, 1899 Gaylord Street, Denver, Colorado 80206, USA
    Am J Med Genet C Semin Med Genet 142:196-205. 2006
    ....
  8. ncbi request reprint Human chromosome 21/Down syndrome gene function and pathway database
    Oleksii Nikolaienko
    Eleanor Roosevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA
    Gene 364:90-8. 2005
    ..Here we describe the current status of data collection and the immediate future plans for this first human chromosome-specific database...
  9. ncbi request reprint Building protein interaction maps for Down's syndrome
    Katheleen Gardiner
    Eleanor Roosevelt Institute, University of Denver, 2199 South University Blvd, Denver, Colorado 80208, USA
    Brief Funct Genomic Proteomic 3:142-56. 2004
    ..Once pathway perturbations have been identified, the potential for rational design of therapeutics becomes practical...
  10. pmc The sequence of human chromosome 21 and implications for research into Down syndrome
    K Gardiner
    Eleanor Roosevelt Institute, Gaylord Street, Denver, Colorado 80206 1210, USA
    Genome Biol 1:REVIEWS0002. 2000
    ....
  11. doi request reprint HIGEDA: a hierarchical gene-set genetics based algorithm for finding subtle motifs in biological sequences
    Thanh Le
    Department of Computer Science and Engineering, Computational Biosciences Program, University of Colorado, Denver, CO, USA
    Bioinformatics 26:302-9. 2010
    ..The effectiveness of EM algorithms in motif finding can be improved by incorporating methods that choose different sets of initial parameters to enable escape from local optima, and that allow gapped alignments within motif models...
  12. ncbi request reprint Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis
    Katheleen Gardiner
    Eleanor Roosevelt Institute, 1899 Gaylord Street, Denver, CO 80206, USA
    Genomics 79:833-43. 2002
    ..These data have implications for generating complete transcript maps of chromosome 21 and for the entire human genome, and for defining expression abnormalities in Down syndrome and mouse models...
  13. ncbi request reprint Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia
    Y Pekarsky
    Eleanor Roosevelt Institute, Denver, Colorado 80206, USA
    Cancer Res 57:3914-9. 1997
    ..The Ribophorin I-EVI1 fusion in particular may be a common occurrence in t(3;3)...
  14. ncbi request reprint Clonability and gene distribution on human chromosome 21: reflections of junk DNA content?
    K Gardiner
    Eleanor Roosevelt Institute, Denver, CO 80206, USA
    Gene 205:39-46. 1997
    ..Thus, data from a variety of approaches suggest that a large part of 21q very likely has neither coding capacity nor associated regulatory function. By these criteria, it is a good candidate for a repository of junk DNA...
  15. ncbi request reprint Human phosphoribosylformylglycineamide amidotransferase (FGARAT): regional mapping, complete coding sequence, isolation of a functional genomic clone, and DNA sequence analysis
    D Patterson
    Eleanor Roosevelt Institute, 1899 Gaylord Street, Denver, CO 80206, USA
    Gene 239:381-91. 1999
    ..The isolation of this gene means that DNA clones for all the 10 steps of IMP synthesis have been isolated from humans or other mammals...
  16. ncbi request reprint Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21
    D Slavov
    Eleanor Roosevelt Institute, 1899 Gaylord Street, Denver, CO 80206, USA
    Gene 247:215-32. 2000
    ..They also doubled the number of potential genes within the region...
  17. ncbi request reprint Comparative analysis of the RED1 and RED2 A-to-I RNA editing genes from mammals, pufferfish and zebrafish
    D Slavov
    Eleanor Roosevelt Institute, Denver, CO 80206 1210, USA
    Gene 250:41-51. 2000
    ..Different levels of conservation among domains of different functional roles may reflect differences in editase substrate specificity and/or substrate sequence conservation...
  18. ncbi request reprint Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns
    D Slavov
    The Eleanor Roosevelt Institute, 1899 Gaylord Street, Denver, CO 80206, USA
    Gene 299:83-94. 2002
    ..Patterns and levels of editing and alternative splicing vary among organisms, and include novel N-terminal exons and splicing events...
  19. pmc The cognitive phenotype of Down syndrome: insights from intracellular network analysis
    AVI MA'AYAN
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    NeuroRx 3:396-406. 2006
    ..We propose how these methods could be integrated with creation and manipulation of mouse models of DS to advance our understanding of the perturbed cell signaling pathways in DS. This understanding could lead to potential therapeutics...
  20. pmc Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts
    Donald E Kuhn
    Davis Heart and Lung Research Institute, The Ohio State University, DHLRI 515, 473 West 12th Avenue, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 370:473-7. 2008
    ..Importantly, Hsa21-derived miRNAs may provide novel therapeutic targets in the treatment of individuals with DS...
  21. pmc Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
    Sergey V Voronov
    Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:9415-20. 2008
    ....
  22. ncbi request reprint A comprehensive human chromosome 21 database
    Cao Nguyen
    University of Colorado at Denver and Health Sciences Center, 80217 3364, USA
    IEEE Eng Med Biol Mag 26:86-93. 2007
  23. ncbi request reprint Alternative splicing of mammalian Intersectin 1: domain associations and tissue specificities
    Lyudmyla Tsyba
    Institute of Molecular Biology and Genetics, 150 Zabolotnogo, Kyiv 03143, Ukraine
    Genomics 84:106-13. 2004
    ..Eight and 16 protein variants of the short and long ITSN1 isoforms, respectively, are predicted. These isoforms likely serve to modulate the many complex protein interactions and functions of ITSN1...