CHRISTINE K GARCIA

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Inherited interstitial lung disease
    Christine Kim Garcia
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Building NB10 210A, Mail Code 8591, Dallas, TX 75390, USA
    Clin Chest Med 25:421-33, v. 2004
  2. pmc Idiopathic pulmonary fibrosis: update on genetic discoveries
    Christine Kim Garcia
    University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Proc Am Thorac Soc 8:158-62. 2011
  3. pmc Interactions between smoking, pulmonary surfactant protein B, and atherosclerosis in the general population: the Dallas Heart Study
    Ann B Nguyen
    Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Arterioscler Thromb Vasc Biol 31:2136-43. 2011
  4. pmc Telomere shortening in familial and sporadic pulmonary fibrosis
    Jennifer T Cronkhite
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Am J Respir Crit Care Med 178:729-37. 2008
  5. pmc Subclinical lung disease, macrocytosis, and premature graying in kindreds with telomerase (TERT) mutations
    Alberto Diaz de Leon
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, 75390 8591, USA
    Chest 140:753-63. 2011
  6. pmc Human diseases of telomerase dysfunction: insights into tissue aging
    Christine Kim Garcia
    McDermott Center for Human Growth and Development, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Nucleic Acids Res 35:7406-16. 2007
  7. pmc Adult-onset pulmonary fibrosis caused by mutations in telomerase
    Kalliopi D Tsakiri
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:7552-7. 2007
  8. pmc Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress
    Meenakshi Maitra
    Eugene McDermott Center for Human Growth and Development, Dallas, Texas 75390, USA
    J Biol Chem 285:22103-13. 2010
  9. pmc Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations
    Alberto Diaz de Leon
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e10680. 2010
  10. ncbi request reprint Familial spontaneous pneumothorax
    Hsienchang Thomas Chiu
    Department of Internal Medicine, Division of Pulmonary Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8591, USA
    Curr Opin Pulm Med 12:268-72. 2006

Research Grants

  1. The Molecular Basis of Familial Spontaneous Pneumothorax
    Christine Garcia; Fiscal Year: 2007
  2. Pulmonary Fibrosis and Telomerase Dysfunction
    Christine Kim Garcia; Fiscal Year: 2010
  3. Pulmonary Fibrosis and Telomerase Dysfunction
    Christine Kim Garcia; Fiscal Year: 2010

Collaborators

  • G Raghu
  • Craig S Glazer
  • Anna Luise A Katzenstein
  • Jennifer T Cronkhite
  • Chao Xing
  • Alberto Diaz de Leon
  • Randall L Rosenblatt
  • Yongyu Wang
  • Ann B Nguyen
  • Meenakshi Maitra
  • Fernando Torres
  • Phillip J Kuan
  • Kalliopi D Tsakiri
  • Hsienchang Thomas Chiu
  • Jarett D Berry
  • Connie C W Hsia
  • Cecelia Brewington
  • Darren K McGuire
  • Amit Khera
  • James A de Lemos
  • Richard Wang
  • Anand Rohatgi
  • Colby R Ayers
  • Sandeep R Das
  • Cuneyt Yilmaz
  • Susan G Lakoski
  • Edward R Garrity
  • Carole R Mendelson
  • Robert D Gerard
  • Carlos E Girod
  • J David Godwin
  • Lisa N Kinch
  • Nick V Grishin
  • J Michael Dimaio
  • Kelly M Chin
  • Jerry W Shay
  • Jonathan C Weissler

Detail Information

Publications11

  1. ncbi request reprint Inherited interstitial lung disease
    Christine Kim Garcia
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Building NB10 210A, Mail Code 8591, Dallas, TX 75390, USA
    Clin Chest Med 25:421-33, v. 2004
    ..The reader is directed to recent reviews on human genetic predisposition of sarcoidosis, environmental-related, drug-related, connective tissue related pulmonary fibrosis, and genetic predisposition of fibrosis in animal models...
  2. pmc Idiopathic pulmonary fibrosis: update on genetic discoveries
    Christine Kim Garcia
    University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Proc Am Thorac Soc 8:158-62. 2011
    ..These results have potentially predictive and therapeutic value...
  3. pmc Interactions between smoking, pulmonary surfactant protein B, and atherosclerosis in the general population: the Dallas Heart Study
    Ann B Nguyen
    Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Arterioscler Thromb Vasc Biol 31:2136-43. 2011
    ..We hypothesized that SP-B may serve as a marker of the vascular effects of smoking and would thus be associated with subclinical measures of atherosclerosis...
  4. pmc Telomere shortening in familial and sporadic pulmonary fibrosis
    Jennifer T Cronkhite
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Am J Respir Crit Care Med 178:729-37. 2008
    ..Heterozygous mutations in the coding regions of the telomerase genes, TERT and TERC, have been found in familial and sporadic cases of idiopathic interstitial pneumonia. All affected patients with mutations have short telomeres...
  5. pmc Subclinical lung disease, macrocytosis, and premature graying in kindreds with telomerase (TERT) mutations
    Alberto Diaz de Leon
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, 75390 8591, USA
    Chest 140:753-63. 2011
    ..The subclinical phenotypes of asymptomatic members of these families have not been evaluated with respect to TERT mutation status or telomere length...
  6. pmc Human diseases of telomerase dysfunction: insights into tissue aging
    Christine Kim Garcia
    McDermott Center for Human Growth and Development, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Nucleic Acids Res 35:7406-16. 2007
    ..Understanding the biological effects of these mutations may ultimately lead to novel treatments for these patients...
  7. pmc Adult-onset pulmonary fibrosis caused by mutations in telomerase
    Kalliopi D Tsakiri
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:7552-7. 2007
    ..Thus, mutations in TERT or TERC that result in telomere shortening over time confer a dramatic increase in susceptibility to adult-onset IPF...
  8. pmc Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress
    Meenakshi Maitra
    Eugene McDermott Center for Human Growth and Development, Dallas, Texas 75390, USA
    J Biol Chem 285:22103-13. 2010
    ....
  9. pmc Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations
    Alberto Diaz de Leon
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e10680. 2010
    ..Here we examine the telomere lengths and pulmonary fibrosis phenotype seen in multiple kindreds with heterozygous TERT mutations...
  10. ncbi request reprint Familial spontaneous pneumothorax
    Hsienchang Thomas Chiu
    Department of Internal Medicine, Division of Pulmonary Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8591, USA
    Curr Opin Pulm Med 12:268-72. 2006
    ..Until recently the molecular underpinning of this disease was unknown...
  11. pmc Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer
    Yongyu Wang
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Am J Hum Genet 84:52-9. 2009
    ..These data are consistent with SFTPA2 germline mutations that interfere with protein trafficking and cause familial IPF and lung cancer...

Research Grants7

  1. The Molecular Basis of Familial Spontaneous Pneumothorax
    Christine Garcia; Fiscal Year: 2007
    ..In addition, the combination of advanced training in patient-oriented research and in-depth study of an important clinical problem will prepare the candidate for a long-term career as an independent investigator. ..
  2. Pulmonary Fibrosis and Telomerase Dysfunction
    Christine Kim Garcia; Fiscal Year: 2010
    ..In this grant we will investigate the link between telomerase dysfunction and pulmonary fibrosis through an integrated, clinical and genetic approach to patients and their families with this devastating disorder. ..
  3. Pulmonary Fibrosis and Telomerase Dysfunction
    Christine Kim Garcia; Fiscal Year: 2010
    ..In this grant we will investigate the link between telomerase dysfunction and pulmonary fibrosis through an integrated, clinical and genetic approach to patients and their families with this devastating disorder. ..