CHRISTINE K GARCIASummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Inherited interstitial lung diseaseChristine Kim Garcia
Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Building NB10 210A, Mail Code 8591, Dallas, TX 75390, USA
Clin Chest Med 25:421-33, v. 2004..The reader is directed to recent reviews on human genetic predisposition of sarcoidosis, environmental-related, drug-related, connective tissue related pulmonary fibrosis, and genetic predisposition of fibrosis in animal models...
Idiopathic pulmonary fibrosis: update on genetic discoveriesChristine Kim Garcia
University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
Proc Am Thorac Soc 8:158-62. 2011..These results have potentially predictive and therapeutic value...- Interactions between smoking, pulmonary surfactant protein B, and atherosclerosis in the general population: the Dallas Heart StudyAnn B Nguyen
Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
Arterioscler Thromb Vasc Biol 31:2136-43. 2011..We hypothesized that SP-B may serve as a marker of the vascular effects of smoking and would thus be associated with subclinical measures of atherosclerosis... - Telomere shortening in familial and sporadic pulmonary fibrosisJennifer T Cronkhite
Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
Am J Respir Crit Care Med 178:729-37. 2008..Heterozygous mutations in the coding regions of the telomerase genes, TERT and TERC, have been found in familial and sporadic cases of idiopathic interstitial pneumonia. All affected patients with mutations have short telomeres... - Subclinical lung disease, macrocytosis, and premature graying in kindreds with telomerase (TERT) mutationsAlberto Diaz de Leon
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, 75390 8591, USA
Chest 140:753-63. 2011..The subclinical phenotypes of asymptomatic members of these families have not been evaluated with respect to TERT mutation status or telomere length... 
Human diseases of telomerase dysfunction: insights into tissue agingChristine Kim Garcia
McDermott Center for Human Growth and Development, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Nucleic Acids Res 35:7406-16. 2007..Understanding the biological effects of these mutations may ultimately lead to novel treatments for these patients...- Adult-onset pulmonary fibrosis caused by mutations in telomeraseKalliopi D Tsakiri
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 104:7552-7. 2007..Thus, mutations in TERT or TERC that result in telomere shortening over time confer a dramatic increase in susceptibility to adult-onset IPF... - Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stressMeenakshi Maitra
Eugene McDermott Center for Human Growth and Development, Dallas, Texas 75390, USA
J Biol Chem 285:22103-13. 2010.... - Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutationsAlberto Diaz de Leon
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
PLoS ONE 5:e10680. 2010..Here we examine the telomere lengths and pulmonary fibrosis phenotype seen in multiple kindreds with heterozygous TERT mutations... - Familial spontaneous pneumothoraxHsienchang Thomas Chiu
Department of Internal Medicine, Division of Pulmonary Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8591, USA
Curr Opin Pulm Med 12:268-72. 2006..SUMMARY: A significant fraction of families with familial spontaneous pneumothorax have mutations in the folliculin gene and should be considered a forme fruste of Birt-Hogg-Dubé syndrome... - Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancerYongyu Wang
Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Am J Hum Genet 84:52-9. 2009..These data are consistent with SFTPA2 germline mutations that interfere with protein trafficking and cause familial IPF and lung cancer...
Research Grants
- The Molecular Basis of Familial Spontaneous PneumothoraxChristine Garcia; Fiscal Year: 2007..In addition, the combination of advanced training in patient-oriented research and in-depth study of an important clinical problem will prepare the candidate for a long-term career as an independent investigator. ..
- Pulmonary Fibrosis and Telomerase DysfunctionChristine Kim Garcia; Fiscal Year: 2010..In this grant we will investigate the link between telomerase dysfunction and pulmonary fibrosis through an integrated, clinical and genetic approach to patients and their families with this devastating disorder. ..
- Pulmonary Fibrosis and Telomerase DysfunctionChristine Kim Garcia; Fiscal Year: 2010..In this grant we will investigate the link between telomerase dysfunction and pulmonary fibrosis through an integrated, clinical and genetic approach to patients and their families with this devastating disorder. ..