Brandon L Garcia

Summary

Affiliation: University of Missouri-Kansas City
Country: USA

Publications

  1. pmc Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b
    Brandon L Garcia
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, 5100 Rockhill Road, Kansas City, MO 64110, USA
    J Mol Biol 402:17-29. 2010
  2. pmc Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins
    Brandon L Garcia
    School of Biological Sciences, University of Missouri, Kansas City, MO 64110, USA
    Adv Exp Med Biol 946:113-33. 2012
  3. pmc Diversity in the C3b [corrected] contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family
    Brandon L Garcia
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, Kansas City, Missouri 64110, USA
    J Biol Chem 287:628-40. 2012
  4. pmc A structurally dynamic N-terminal helix is a key functional determinant in staphylococcal complement inhibitor (SCIN) proteins
    Brandon L Garcia
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri, Kansas City, Missouri 64110, USA
    J Biol Chem 288:2870-81. 2013

Detail Information

Publications4

  1. pmc Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b
    Brandon L Garcia
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, 5100 Rockhill Road, Kansas City, MO 64110, USA
    J Mol Biol 402:17-29. 2010
    ..In the future, this may suggest templates for the design of novel complement inhibitors based upon the SCIN structure...
  2. pmc Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins
    Brandon L Garcia
    School of Biological Sciences, University of Missouri, Kansas City, MO 64110, USA
    Adv Exp Med Biol 946:113-33. 2012
    ..This chapter summarizes recent advances toward understanding the structure, function, and mechanism of the SCIN and Efb families, and suggests potential directions for the field over the coming years...
  3. pmc Diversity in the C3b [corrected] contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family
    Brandon L Garcia
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, Kansas City, Missouri 64110, USA
    J Biol Chem 287:628-40. 2012
    ..Together, these studies provide a more thorough understanding of immune evasion by S. aureus and enhance potential use of SCIN proteins as templates for design of complement targeted therapeutics...
  4. pmc A structurally dynamic N-terminal helix is a key functional determinant in staphylococcal complement inhibitor (SCIN) proteins
    Brandon L Garcia
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri, Kansas City, Missouri 64110, USA
    J Biol Chem 288:2870-81. 2013
    ..aureus. The work presented here provides detailed structure-activity relationships and improves our understanding of how S. aureus circumvents human innate immunity...