Svitlana Garbuzova-Davis

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint Positive effect of transplantation of hNT neurons (NTera 2/D1 cell-line) in a model of familial amyotrophic lateral sclerosis
    Svitlana Garbuzova-Davis
    Departments of Neurosurgery, Center for Aging and Brain Repair, Tampa, Florida 33612, USA
    Exp Neurol 174:169-80. 2002
  2. ncbi request reprint Novel cell therapy approaches for brain repair
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, College of Medicine, University of South Florida, MDC 78, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Prog Brain Res 157:207-22. 2006
  3. ncbi request reprint Multiple transplants of hNT cells into the spinal cord of SOD1 mouse model of familial amyotrophic lateral sclerosis
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Health Sciences Center, Tampa, FL 33612, USA
    Amyotroph Lateral Scler 7:221-6. 2006
  4. pmc Trophic factor induction of human umbilical cord blood cells in vitro and in vivo
    Ning Chen
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    J Neural Eng 4:130-45. 2007
  5. ncbi request reprint Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Brain Res 1157:126-37. 2007
  6. pmc Blood-brain barrier impairment in MPS III patients
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, 12901 Bruce B, Downs Blvd, Tampa, FL 33612, USA
    BMC Neurol 13:174. 2013
  7. pmc Blood-brain barrier alterations provide evidence of subacute diaschisis in an ischemic stroke rat model
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e63553. 2013
  8. ncbi request reprint Impaired blood-brain/spinal cord barrier in ALS patients
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612, USA
    Brain Res 1469:114-28. 2012
  9. pmc Multiple intravenous administrations of human umbilical cord blood cells benefit in a mouse model of ALS
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 7:e31254. 2012
  10. pmc Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 2:e1205. 2007

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Positive effect of transplantation of hNT neurons (NTera 2/D1 cell-line) in a model of familial amyotrophic lateral sclerosis
    Svitlana Garbuzova-Davis
    Departments of Neurosurgery, Center for Aging and Brain Repair, Tampa, Florida 33612, USA
    Exp Neurol 174:169-80. 2002
    ..These results suggest that hNT Neuron transplantation may be a promising therapeutic strategy for ALS...
  2. ncbi request reprint Novel cell therapy approaches for brain repair
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, College of Medicine, University of South Florida, MDC 78, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Prog Brain Res 157:207-22. 2006
    ..These protective effects may prove essential to maintaining restored tissue integrity over the course of various diseases or injuries...
  3. ncbi request reprint Multiple transplants of hNT cells into the spinal cord of SOD1 mouse model of familial amyotrophic lateral sclerosis
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Health Sciences Center, Tampa, FL 33612, USA
    Amyotroph Lateral Scler 7:221-6. 2006
    ..Therefore, we suggest that the observed postponement of motor deficit symptoms in G93A mice was not a result of neuritic outgrowth from the implanted hNT cells...
  4. pmc Trophic factor induction of human umbilical cord blood cells in vitro and in vivo
    Ning Chen
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    J Neural Eng 4:130-45. 2007
    ....
  5. ncbi request reprint Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Brain Res 1157:126-37. 2007
    ..Capillary rupture was observed in brainstem in early symptomatic G93A mice. Capillary ultrastructure revealed that endothelial cell membrane and/or basement membrane damage occurred, followed by vascular leakage...
  6. pmc Blood-brain barrier impairment in MPS III patients
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, 12901 Bruce B, Downs Blvd, Tampa, FL 33612, USA
    BMC Neurol 13:174. 2013
    ..Since neuropathological manifestations are common to all MPS III types, determining blood-brain barrier (BBB) condition may be critical to understand potential additional disease mechanisms...
  7. pmc Blood-brain barrier alterations provide evidence of subacute diaschisis in an ischemic stroke rat model
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e63553. 2013
    ..The present study investigated subacute diaschisis in a focal ischemic stroke rat model. Specific focuses were BBB integrity and related pathogenic processes in contralateral brain areas...
  8. ncbi request reprint Impaired blood-brain/spinal cord barrier in ALS patients
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612, USA
    Brain Res 1469:114-28. 2012
    ..Pervasive barrier damage discovered in ALS may have implications for disease pathogenesis and progression, as well as for uncovering novel therapeutic targets...
  9. pmc Multiple intravenous administrations of human umbilical cord blood cells benefit in a mouse model of ALS
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 7:e31254. 2012
    ..The aim of the present pre-clinical translation study was therefore to evaluate the effects of multiple low dose systemic injections of MNC hUCB cell into G93A SOD1 mice at different disease stages...
  10. pmc Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 2:e1205. 2007
    ..However, the effect of these alterations upon barrier function in ALS is still unclear. The aim of this study was to determine the functional competence of the BSCB in G93A mice at different stages of disease...
  11. doi request reprint Intravenous administration of human umbilical cord blood cells in an animal model of MPS III B
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    J Comp Neurol 515:93-101. 2009
    ..Our results demonstrate the advantages of intravenously administering hUCB cells into a mouse model of Sanfilippo Syndrome type B, the advantages probably a result of Naglu delivery to enzyme-deficient organs...
  12. pmc Human umbilical cord blood treatment in a mouse model of ALS: optimization of cell dose
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 3:e2494. 2008
    ..Three different doses of MNC hUCB cells, 10x10(6), 25x10(6) and 50x10(6), were administered intravenously into pre-symptomatic G93A mice. Motor function tests and various assays to determine cell effects were performed on these mice...
  13. pmc Reduction of circulating endothelial cells in peripheral blood of ALS patients
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 5:e10614. 2010
    ..Since circulating endothelial cells (CECs) in the peripheral blood are associated with endothelium damage, being detached dysfunctional endothelial cells, we hypothesized that CEC levels may reflect endothelium condition in ALS patients...
  14. pmc Blood-brain barrier impairment in an animal model of MPS III B
    Svitlana Garbuzova-Davis
    College of Medicine, Center of Excellence for Aging and Brain Repair, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 6:e16601. 2011
    ..However, little is known about the competence of the blood-brain barrier (BBB) in MPS III B. BBB dysfunction in this devastating disorder could contribute to neuropathological disease manifestations...
  15. doi request reprint Amyotrophic lateral sclerosis: a neurovascular disease
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Brain Res 1398:113-25. 2011
    ..The BBB/BSCB is a promising research area in ALS and this review will reveal some aspects of microvascular pathology in ALS and hopefully provide ideas for the development of new therapeutic strategies...
  16. ncbi request reprint Umbilical cord blood-derived stem cells and brain repair
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, MDC 78, Tampa, FL 33612, USA
    Ann N Y Acad Sci 1049:67-83. 2005
    ..We discuss how transplantation of HUCB cells affects these disorders and we present recent clinical studies with promising outcome...
  17. ncbi request reprint Maternal transplantation of human umbilical cord blood cells provides prenatal therapy in Sanfilippo type B mouse model
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    FASEB J 20:485-7. 2006
    ....
  18. ncbi request reprint Transplantation of human umbilical cord blood cells benefits an animal model of Sanfilippo syndrome type B
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Stem Cells Dev 14:384-94. 2005
    ..A hUCB cell transplant may be an effective therapeutic strategy for enzyme delivery in Sanfilippo syndrome type B...
  19. ncbi request reprint Mouse model of Sanfilippo syndrome type B: relation of phenotypic features to background strain
    Sylvia I Gografe
    Department of Pathology, Division of Comparative Medicine, University of South Florida, College of Medicine, 12901 Bruce B Downs Blvd, MDC 78, Tampa, Florida, 33612, USA
    Comp Med 53:622-32. 2003
    ..Our observations may prove useful in studies of Naglu mutant mice. The necessity for distinguishing background anomalies from signs of the modeled disease is apparent...
  20. ncbi request reprint Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair and Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    J Hematother Stem Cell Res 12:255-70. 2003
    ..Most likely, cord blood efficacy is partially due to neuroprotection by modulation of the autoimmune process...
  21. pmc Human umbilical cord blood progenitors: the potential of these hematopoietic cells to become neural
    Ning Chen
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, Florida 33612, USA
    Stem Cells 23:1560-70. 2005
    ....
  22. pmc Toward personalized cell therapies: autologous menstrual blood cells for stroke
    Maria Carolina O Rodrigues
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    J Biomed Biotechnol 2011:194720. 2011
    ..Practical aspects of clinical application of menstrual blood cells for stroke will be discussed, from cell harvesting and cryopreservation to administration to the patient...
  23. doi request reprint Neurovascular aspects of amyotrophic lateral sclerosis
    Maria Carolina O Rodrigues
    Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA
    Int Rev Neurobiol 102:91-106. 2012
    ..The impact of BBB/BSCB damage in ALS pathogenesis is a novel research topic, and this review will reveal some aspects of microvascular pathology involved in the disease and hopefully engender new therapeutic approaches...
  24. pmc Compromised blood-brain barrier competence in remote brain areas in ischemic stroke rats at the chronic stage
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, 33612 Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, 33612 Department of Molecular Pharmacology and Physiology, University of South Florida, Morsani College of Medicine, Tampa, Florida, 33612 Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, Florida, 33612
    J Comp Neurol 522:3120-37. 2014
    ..J. Comp. Neurol. 522:3120-3137, 2014. © 2014 Wiley Periodicals, Inc. ..
  25. doi request reprint The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA
    Cell Transplant 20:85-94. 2011
    ..Evidence of anti-inflammatory effects and secretion of specific cytokines and growth factors that promote cell survival, rather than cell replacement, have been detected in both transplanted cells...
  26. doi request reprint Recent progress in cell therapy for basal ganglia disorders with emphasis on menstrual blood transplantation in stroke
    Maria Carolina Oliveira Rodrigues
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, USA
    Neurosci Biobehav Rev 36:177-90. 2012
    ..We highlight the availability, proliferative capacity, pluripotentiality and angiogenic features of these cells and explore their present and future experimental and clinical applications...
  27. ncbi request reprint Evaluation of humoral immune response in adaptive immunity in ALS patients during disease progression
    Islam A Saleh
    Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    J Neuroimmunol 215:96-101. 2009
    ..Serum IgM was within normal range. Results suggest a humoral immune response initiating adaptive immunity in ALS, however, cellular immune response needs verification...
  28. doi request reprint Routes of stem cell administration in the adult rodent
    Alison E Willing
    Center for Aging and Brain Repair Cell Biology, University of South Florida College of Medicine, Tampa, FL, USA
    Methods Mol Biol 438:383-401. 2008
    ..The second, which in our hands has proven to be superior in some instances, is introduction of the stem cells into the circulatory system...
  29. pmc Novel pathologic findings associated with urinary retention in a mouse model of mucopolysaccharidosis type IIIB
    Sylvia I Gografe
    Center for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, Florida, USA
    Comp Med 59:139-46. 2009
    ..The novel finding of an unexpected mononuclear cell infiltrate in the urinary tract in the knockout mice B6.129S6- Naglu(tm1Efn)/J is reported...
  30. ncbi request reprint Routes of stem cell administration in the adult rodent
    Alison E Willing
    Center for Aging and Brain Repair, Departments of Neurosurgery and Anatomy, College of Medicine, University of South Florida, Tampa, FL, USA
    Methods Mol Biol 198:357-74. 2002