James C Garbutt

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Baclofen for alcoholism
    James C Garbutt
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Lancet 370:1884-5. 2007
  2. pmc Sweet liking phenotype, alcohol craving and response to naltrexone treatment in alcohol dependence
    James C Garbutt
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Alcohol Alcohol 44:293-300. 2009
  3. ncbi request reprint The state of pharmacotherapy for the treatment of alcohol dependence
    James C Garbutt
    University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Subst Abuse Treat 36:S15-23; quiz S24-5. 2009
  4. ncbi request reprint Efficacy and tolerability of naltrexone in the management of alcohol dependence
    James C Garbutt
    Department of Psychiatry and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, North Carolina 27599 7160, USA
    Curr Pharm Des 16:2091-7. 2010
  5. ncbi request reprint Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial
    James C Garbutt
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    JAMA 293:1617-25. 2005
  6. pmc Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trial
    James C Garbutt
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Alcohol Clin Exp Res 34:1849-57. 2010
  7. ncbi request reprint Efficacy of extended-release naltrexone in alcohol-dependent patients who are abstinent before treatment
    STEPHANIE S O'MALLEY
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06519, USA
    J Clin Psychopharmacol 27:507-12. 2007
  8. ncbi request reprint Sweet preference predicts mood altering effect of and impaired control over eating sweet foods
    Alexey B Kampov-Polevoy
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Eat Behav 7:181-7. 2006
  9. doi request reprint Sweet liking and high novelty seeking: independent phenotypes associated with alcohol-related problems
    Leslie A Lange
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Alcohol Alcohol 45:431-6. 2010
  10. pmc Unipolar depression does not moderate responses to the Sweet Taste Test
    Gabriel S Dichter
    Department of Psychiatry, Department of Psychiatry, University of North Carolina School of Medicine, 101 Manning Drive, Chapel Hill, NC 27599 3366, USA
    Depress Anxiety 27:859-63. 2010

Research Grants

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Baclofen for alcoholism
    James C Garbutt
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Lancet 370:1884-5. 2007
  2. pmc Sweet liking phenotype, alcohol craving and response to naltrexone treatment in alcohol dependence
    James C Garbutt
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Alcohol Alcohol 44:293-300. 2009
    ..To investigate the relationship between the sweet liking/sweet disliking phenotype (a putative probe of brain opioid function), craving for alcohol and response to treatment with naltrexone in individuals with alcohol dependence...
  3. ncbi request reprint The state of pharmacotherapy for the treatment of alcohol dependence
    James C Garbutt
    University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Subst Abuse Treat 36:S15-23; quiz S24-5. 2009
    ....
  4. ncbi request reprint Efficacy and tolerability of naltrexone in the management of alcohol dependence
    James C Garbutt
    Department of Psychiatry and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, North Carolina 27599 7160, USA
    Curr Pharm Des 16:2091-7. 2010
    ....
  5. ncbi request reprint Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial
    James C Garbutt
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    JAMA 293:1617-25. 2005
    ..However, adherence to daily oral pharmacotherapy can be problematic, and clinical acceptance and utility of oral naltrexone have been limited...
  6. pmc Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trial
    James C Garbutt
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Alcohol Clin Exp Res 34:1849-57. 2010
    ..However, the clinical trial data with baclofen is limited. The purpose of the present study was to test the efficacy and tolerability of baclofen in alcohol dependence in the United States...
  7. ncbi request reprint Efficacy of extended-release naltrexone in alcohol-dependent patients who are abstinent before treatment
    STEPHANIE S O'MALLEY
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06519, USA
    J Clin Psychopharmacol 27:507-12. 2007
    ..In conclusion, XR-NTX 380 mg prolonged abstinence and reduced the number of heavy drinking days and drinking days in patients who were abstinent for as few as 4 days before treatment initiation...
  8. ncbi request reprint Sweet preference predicts mood altering effect of and impaired control over eating sweet foods
    Alexey B Kampov-Polevoy
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Eat Behav 7:181-7. 2006
    ..The results of the present study support the hypothesis that hedonic response to sweet taste is associated with elevated sensitivity to mood altering effects of sweet foods and impaired control over eating sweets...
  9. doi request reprint Sweet liking and high novelty seeking: independent phenotypes associated with alcohol-related problems
    Leslie A Lange
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Alcohol Alcohol 45:431-6. 2010
    ....
  10. pmc Unipolar depression does not moderate responses to the Sweet Taste Test
    Gabriel S Dichter
    Department of Psychiatry, Department of Psychiatry, University of North Carolina School of Medicine, 101 Manning Drive, Chapel Hill, NC 27599 3366, USA
    Depress Anxiety 27:859-63. 2010
    ..However, STT response profiles in unipolar major depressive disorder (MDD), a disorder characterized by anhedonia, have been minimally investigated...
  11. ncbi request reprint A longitudinal study of serotonergic function in depression
    Robert N Golden
    Department of Psychiatry, University of North Carolina School of Medicine, Campus Box 7160, Chapel Hill, NC 27599 7160, USA
    Neuropsychopharmacology 26:653-9. 2002
    ..Blunted prolactin response to clomipramine challenge persists in depressed patients after recovery from acute illness, and may reflect an underlying biological vulnerability...
  12. ncbi request reprint Behavioral counseling after screening for alcohol misuse in primary care: a systematic review and meta-analysis for the U.S. Preventive Services Task Force
    Daniel E Jonas
    University of North Carolina at Chapel Hill, Department of Medicine, 5034 Old Clinic Building, CB 7110, Chapel Hill, NC 27599, USA
    Ann Intern Med 157:645-54. 2012
    ..Alcohol misuse, which includes the full spectrum from risky drinking to alcohol dependence, is a leading cause of preventable death in the United States...
  13. ncbi request reprint Family history of alcoholism and response to sweets
    Alexey B Kampov-Polevoy
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Alcohol Clin Exp Res 27:1743-9. 2003
    ..e., 0.83 M) as the most palatable during the standard sweet test...
  14. pmc Intranasal oxytocin blocks alcohol withdrawal in human subjects
    Cort A Pedersen
    Department of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
    Alcohol Clin Exp Res 37:484-9. 2013
    ..Numerous recent studies in human subjects indicate that OT administered by the intranasal route penetrates into and exerts effects within the brain...
  15. pmc Rates of ethanol metabolism decrease in sons of alcoholics following a priming dose of ethanol
    Blair U Bradford
    Department of Environmental Sciences and Engineering, University of North Carolina, 3207 Michael Hooker Research Center, CB 7431, Chapel Hill, NC 27599 7431, USA
    Alcohol 41:263-70. 2007
    ....
  16. ncbi request reprint Reduction in heavy drinking as a treatment outcome in alcohol dependence
    David R Gastfriend
    Alkermes, Cambridge, MA, USA
    J Subst Abuse Treat 33:71-80. 2007
    ....
  17. ncbi request reprint Medications for the treatment of alcohol dependence
    James C Garbutt
    Am Fam Physician 74:1836. 2006
  18. ncbi request reprint Baclofen for alcohol dependence: a preliminary open-label study
    Barbara A Flannery
    RTI International, Baltimore, Maryland 21224, USA
    Alcohol Clin Exp Res 28:1517-23. 2004
    ..This preliminary open-label investigation examined the tolerability and effect of a 30-mg daily baclofen dose for reducing drinking, subclinical anxiety and depressive symptoms, and craving in alcohol-dependent subjects...
  19. ncbi request reprint Paroxetine modulates psychological and sympathetic responses during public speaking
    Michael Golding
    J Clin Psychopharmacol 22:98-9. 2002

Research Grants1

  1. Efficacy and Safety of Baclofen for Alcohol Dependence
    James Garbutt; Fiscal Year: 2006
    ..Several studies also have found that baclofen reduces self-reported anxiety and craving; thus, the proposed study will assess baclofen's ability to reduce these symptoms as well. ..