Nichola C Garbett

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. doi request reprint Detection of cervical cancer biomarker patterns in blood plasma and urine by differential scanning calorimetry and mass spectrometry
    Nichola C Garbett
    James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 9:e84710. 2014
  2. pmc Calorimetric analysis of the plasma proteome: identification of type 1 diabetes patients with early renal function decline
    Nichola C Garbett
    James Graham Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA
    Biochim Biophys Acta 1830:4675-80. 2013
  3. pmc Thermodynamic studies for drug design and screening
    Nichola C Garbett
    Biophysics Core Facility, University of Louisville, James Graham Brown Cancer Center, Clinical and Translational Research Building, 505 South Hancock Street, Louisville, KY 40202, USA
    Expert Opin Drug Discov 7:299-314. 2012
  4. doi request reprint Differential scanning calorimetry of blood plasma for clinical diagnosis and monitoring
    Nichola C Garbett
    James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Exp Mol Pathol 86:186-91. 2009
  5. pmc Calorimetric analysis of the plasma proteome
    Nichola C Garbett
    James Graham Brown Cancer Center, Department of Medicine, University of Louisville Health Sciences Center, Louisville, KY 40202, USA
    Semin Nephrol 27:621-6. 2007
  6. pmc Calorimetry outside the box: a new window into the plasma proteome
    Nichola C Garbett
    James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Biophys J 94:1377-83. 2008
  7. doi request reprint Effect of O6-methylguanine on the stability of G-quadruplex DNA
    Chongkham S Mekmaysy
    James Graham Brown Cancer Center and University of Louisville, 529 South Jackson Street, Louisville, Kentucky 40202, USA
    J Am Chem Soc 130:6710-1. 2008
  8. ncbi request reprint Circular dichroism to determine binding mode and affinity of ligand-DNA interactions
    Nichola C Garbett
    James Graham Brown Cancer Center, Health Sciences Campus, University of Louisville, 529 S Jackson Street, Louisville, Kentucky 40202, USA
    Nat Protoc 2:3166-72. 2007
  9. ncbi request reprint Binding: a polemic and rough guide
    Nichola C Garbett
    James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Methods Cell Biol 84:3-23. 2008
  10. pmc Sedimentation velocity ultracentrifugation analysis for hydrodynamic characterization of G-quadruplex structures
    Nichola C Garbett
    James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
    Methods Mol Biol 608:97-120. 2010

Collaborators

Detail Information

Publications12

  1. doi request reprint Detection of cervical cancer biomarker patterns in blood plasma and urine by differential scanning calorimetry and mass spectrometry
    Nichola C Garbett
    James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 9:e84710. 2014
    ....
  2. pmc Calorimetric analysis of the plasma proteome: identification of type 1 diabetes patients with early renal function decline
    Nichola C Garbett
    James Graham Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA
    Biochim Biophys Acta 1830:4675-80. 2013
    ..This method provides an alternate physical basis with which to study disease-associated changes in the bulk plasma proteome...
  3. pmc Thermodynamic studies for drug design and screening
    Nichola C Garbett
    Biophysics Core Facility, University of Louisville, James Graham Brown Cancer Center, Clinical and Translational Research Building, 505 South Hancock Street, Louisville, KY 40202, USA
    Expert Opin Drug Discov 7:299-314. 2012
    ..Thermodynamic characterization provides information about the balance of energetic forces driving binding interactions and is essential for understanding and optimizing molecular interactions...
  4. doi request reprint Differential scanning calorimetry of blood plasma for clinical diagnosis and monitoring
    Nichola C Garbett
    James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Exp Mol Pathol 86:186-91. 2009
    ..Our application of the DSC method has provided a potential tool for the early diagnosis, monitoring and screening of cancer patients...
  5. pmc Calorimetric analysis of the plasma proteome
    Nichola C Garbett
    James Graham Brown Cancer Center, Department of Medicine, University of Louisville Health Sciences Center, Louisville, KY 40202, USA
    Semin Nephrol 27:621-6. 2007
    ..Some initial results are reported that indicate the potential clinical utility of the assay...
  6. pmc Calorimetry outside the box: a new window into the plasma proteome
    Nichola C Garbett
    James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Biophys J 94:1377-83. 2008
    ..These results signal a novel use for calorimetry as a diagnostic tool...
  7. doi request reprint Effect of O6-methylguanine on the stability of G-quadruplex DNA
    Chongkham S Mekmaysy
    James Graham Brown Cancer Center and University of Louisville, 529 South Jackson Street, Louisville, Kentucky 40202, USA
    J Am Chem Soc 130:6710-1. 2008
    ..The extent of destabilization is critically dependent on the exact position of the modified base within the quadruplex structure...
  8. ncbi request reprint Circular dichroism to determine binding mode and affinity of ligand-DNA interactions
    Nichola C Garbett
    James Graham Brown Cancer Center, Health Sciences Campus, University of Louisville, 529 S Jackson Street, Louisville, Kentucky 40202, USA
    Nat Protoc 2:3166-72. 2007
    ..This protocol outlines methods to determine the binding mode and affinity of ligand-DNA interactions and takes approximately 7.5 h...
  9. ncbi request reprint Binding: a polemic and rough guide
    Nichola C Garbett
    James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Methods Cell Biol 84:3-23. 2008
    ..The purpose of this chapter is to aid the reader in understanding how to apply the available technologies in extracting meaningful thermodynamic information for binding systems...
  10. pmc Sedimentation velocity ultracentrifugation analysis for hydrodynamic characterization of G-quadruplex structures
    Nichola C Garbett
    James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
    Methods Mol Biol 608:97-120. 2010
    ..We discuss the application of three of the most commonly used data analysis programs, DCDT+, Sedfit, and SedAnal, to the interpretation of SV data obtained in our laboratory on two GQ systems...
  11. ncbi request reprint Interrogation of the plasma proteome with differential scanning calorimetry
    Nichola C Garbett
    James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40292, USA
    Clin Chem 53:2012-4. 2007
  12. ncbi request reprint Competition dialysis: a method for the study of structural selective nucleic acid binding
    Patricia A Ragazzon
    James Graham Brown Cancer Center, University of Louisville, 529 S Jackson St, Louisville, KY 40202, USA
    Methods 42:173-82. 2007
    ..In this format, we have been able to greatly expand the array of nucleic acid structures studied, and now can routinely study the interactions of a ligand of interest with 46 different structures and sequences...