Research Topics
Genomes and Genes | Fen Biao GaoSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Publications
MicroRNA-9a ensures the precise specification of sensory organ precursors in DrosophilaYan Li
Gladstone Institute of Neurological Disease and Department of Neurology, University of California at San Francisco, San Francisco, California 94158, USA
Genes Dev 20:2793-805. 2006..These results indicate that miR-9a ensures the generation of the precise number of neuronal precursor cells during development...- Posttranscriptional control of neuronal development by microRNA networksFen Biao Gao
Gladstone Institute of Neurological Disease, Department of Neurology, Neuroscience Graduate Program, University of California, 1650 Owens Street, San Francisco, CA 94158, USA
Trends Neurosci 31:20-6. 2008..Further dissection of the in vivo physiological functions of individual miRNAs promises to offer novel mechanistic insights into the gene regulatory networks that ensure the precise assembly of a functional nervous system... 
Transcriptional control of dendritic patterning in Drosophila neuronsMichel Tassetto
Gladstone Institute of Neurological Disease, and Department of Neurology, University of California, San Francisco, CA 94158, USA
Genome Biol 7:225. 2006..A recent in vivo genome-wide screen based on RNA interference identified a large number of transcriptional factors that regulate the stereotyped growth and branching of dendrites on some Drosophila sensory neurons...- Molecular and cellular mechanisms of dendritic morphogenesisFen Biao Gao
Gladstone Institute of Neurological Disease, and Department of Neurology, University of California, San Francisco, CA 94158, United States
Curr Opin Neurobiol 17:525-32. 2007..Those exciting findings have enhanced significantly our understanding of dendritic morphogenesis and revealed the magnitude of complexity in the underlying molecular regulatory networks... 
Genetic control of dendritic morphogenesis in DrosophilaFen Biao Gao
Gladstone Institute of Neurological Disease, Neuroscience Graduate Program, University of California, San Francisco, CA 94141 9100, USA
Trends Neurosci 26:262-8. 2003....- Understanding fragile X syndrome: insights from retarded fliesFen Biao Gao
Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94141, USA
Neuron 34:859-62. 2002..The relevance of these studies to our understanding of fragile X syndrome is discussed... - Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1Alan Lee
Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94141 9100, USA
Development 130:5543-52. 2003..These findings demonstrate that Fmr1 affects dendritic development and that Rac1 is partially responsible for mediating this effect... - Genetic manipulation of single neurons in vivo reveals specific roles of flamingo in neuronal morphogenesisNeal T Sweeney
Gladstone Institute of Neurological Disease, University of California, San Francisco, 94141 9100, USA
Dev Biol 247:76-88. 2002..These results demonstrate that Flamingo plays a role in early neuronal differentiation and exerts specific effects on dendrites and axons... - BTB/POZ-zinc finger protein abrupt suppresses dendritic branching in a neuronal subtype-specific and dosage-dependent mannerWenjun Li
Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94141, USA
Neuron 43:823-34. 2004..These results demonstrate that dendritic branching can be suppressed by neuronal subtype-specific transcription factors in a cell-autonomous and dosage-dependent manner... - The fragile X-related gene affects the crawling behavior of Drosophila larvae by regulating the mRNA level of the DEG/ENaC protein pickpocket1Kanyan Xu
Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94103 USA
Curr Biol 14:1025-34. 2004..It remains largely unknown what proteins encoded by mRNAs in the FMR1-messenger ribonuclear protein (mRNP) complex are most relevant to the affected physiological processes... - Actin filament-stabilizing protein tropomyosin regulates the size of dendritic fieldsWenjun Li
Gladstone Institute of Neurological Disease, Neuroscience Program, University of California, San Francisco, San Francisco, California 94141 9100, USA
J Neurosci 23:6171-5. 2003..TmII encodes multiple isoforms of a protein that stabilizes actin filaments. Our findings suggest that tropomyosin helps control the size of dendritic fields by regulating actin cytoskeletal dynamics... - ESCRT-III dysfunction causes autophagosome accumulation and neurodegenerationJin A Lee
Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94158, USA
Curr Biol 17:1561-7. 2007.... - The steady-state level of the nervous-system-specific microRNA-124a is regulated by dFMR1 in DrosophilaXia Lian Xu
Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94158, USA
J Neurosci 28:11883-9. 2008..This effect could be explained in part by the reduced abundance of the Dicer-1-Ago1 complex in the absence of dFMR1. These findings suggest a modulatory role for dFMR1 to maintain proper levels of miRNAs during neuronal development... - Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in DrosophilaWenjun Li
Gladstone Institute of Neurological Disease, San Francisco, California, USA
Dev Dyn 234:512-22. 2005..These results suggest that Ena is a key regulator of dendritic branching and that different regulators of the actin cytoskeleton exert distinct effects on dendritic morphogenesis... - The Drosophila homologue of the Angelman syndrome ubiquitin ligase regulates the formation of terminal dendritic branchesYubing Lu
Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
Hum Mol Genet 18:454-62. 2009..These findings suggest that dendritic pathology may contribute to neurological deficits in patients with Angelman syndrome... - Roles of ESCRT in autophagy-associated neurodegenerationJin A Lee
Gladstone Institute of Neurological Disease and Department of Neurology, Neuroscience Graduate Program, University of California, San Francisco, San Francisco, California 94158, USA
Autophagy 4:230-2. 2008..This study suggests that defects in the late steps of the autophagy pathway may contribute to the pathogenesis of FTD and potentially other neurodegenerative diseases... - MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitorsCeline Delaloy
Gladstone Institute of Neurological Disease and Department of Neurology, University of California San Francisco, CA 94158, USA
Cell Stem Cell 6:323-35. 2010..These results identify miR-9 as a novel regulator that coordinates the proliferation and migration of hNPCs... - Autophagy defects contribute to neurodegeneration induced by dysfunctional ESCRT-IIIJin A Lee
Gladstone Institute of Neurological Disease, and Department of Neurology, University of California, San Francisco, CA 94158, USA
Autophagy 5:1070-2. 2009..These findings indicate that excess accumulation of autophagosomes is detrimental to neuronal survival, and dysfunctional ESCRT-III appears to cause neurodegeneration through multiple mechanisms... - Regulation of Abeta pathology by beclin 1: a protective role for autophagy?Jin A Lee
Gladstone Institute of Neurological Disease and Department of Neurology, UCSF, San Francisco, California 94158, USA
J Clin Invest 118:2015-8. 2008..These findings further support the notion that modulation of autophagy, in this case through beclin 1, may represent a novel therapeutic strategy for AD... - Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementiaS Tariq Ahmad
Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 106:12168-73. 2009..This fly model will be useful to further dissect genetic pathways that are potentially relevant to the pathogenesis and treatment of FTD... - MicroRNA-9: functional evolution of a conserved small regulatory RNAYeliz Yuva-Aydemir
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
RNA Biol 8:557-64. 2011..Thus, miR-9 is emerging as an important regulator in development and disease through its ability to modulate different targets in a manner dependent on the developmental stage and the cellular context... - The coiled-coil protein shrub controls neuronal morphogenesis in DrosophilaNeal T Sweeney
Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California 94158, USA
Curr Biol 16:1006-11. 2006..Our findings demonstrate that the novel coiled-coil protein Shrub functions in the endosomal pathway and plays an essential role in neuronal morphogenesis... - ESCRT, autophagy, and frontotemporal dementiaJin A Lee
Department of Neurology, University of California, San Francisco, CA, USA
BMB Rep 41:827-32. 2008..Mutant CHMP2B proteins seem to disrupt the fusion of autophagosomes and lysosomes in cell culture models. These findings suggest a potential mechanism for the pathogenesis of FTD3 and possibly other neurodegenerative diseases as well... - FXR1P but not FMRP regulates the levels of mammalian brain-specific microRNA-9 and microRNA-124Xia Lian Xu
Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA
J Neurosci 31:13705-9. 2011..These findings reveal differential roles of FMRP family proteins in controlling the expression levels of brain-specific miRNAs... - The FTD/ALS-associated RNA-binding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in DrosophilaZhaodong Li
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Hum Mol Genet 22:218-25. 2013..These findings reveal a novel role for endogenous TDP-43 in neuronal specification and suggest that the FTD/ALS-associated RNA-binding protein TDP-43 functions to ensure the robustness of genetic control programs... - Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branchingYubing Lu
Gladstone Institute of Neurological Disease, and Department of Neurology, University of California, San Francisco, CA 94158, USA
Mol Brain 2:30. 2009..In diseased neurons, TDP-43 is depleted in the nucleus, suggesting a loss-of-function pathogenic mechanism. However, the normal function of TDP-43 in postmitotic neurons is largely unknown... - Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementiaJin A Lee
Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94158, USA
J Neurosci 29:8506-11. 2009..These findings show that autophagic stress by excess accumulation of autophagosomes is detrimental to neuronal survival under certain neurodegenerative conditions... - Protocols for investigating microRNA functions in human neural progenitor cellsSandra Almeida
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Methods Mol Biol 916:387-402. 2012..These methods may be applicable to protein factors and neural progenitor cells derived from patient-specific induced pluripotent stem cells... - MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementiaJian Jiao
Gladstone Institute of Neurological Disease, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 5:e10551. 2010..These findings identify miR-29b as a novel posttranscriptional regulator of PGRN expression, raising the possibility that miR-29b or other miRNAs might be targeted therapeutically to increase hPGRN levels in some FTD patients... 
Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALSPaloma González-Pérez
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Neurobiol Dis 48:391-8. 2012..Genetic variants in UBQLN1 gene have been linked to neurodegeneration and mutations in UBQLN2 have recently been identified as a rare cause of amyotrophic lateral sclerosis (ALS)...- Cause or Effect: Misregulation of microRNA Pathways in NeurodegenerationEduardo Gascon
Department of Neurology, University of Massachusetts Medical School Worcester, MA, USA
Front Neurosci 6:48. 2012..The precise causal relationships between specific miRNAs and neurodegeneration in humans need to be further investigated... - Patterns and functions of STAT activation during Drosophila embryogenesisJinghong Li
Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
Mech Dev 120:1455-68. 2003..These results suggest that STAT activation is involved in proper differentiation and morphogenesis of multiple tissues during Drosophila embryogenesis... - microRNA-9 multitasking near organizing centersCeline Delaloy
Nat Neurosci 11:625-6. 2008 - Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiationYasuhito M Tokumoto
Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK
Dev Biol 245:224-34. 2002....
Research Grants
- Genetic Analysis of Heavy Metals NeurotoxicityFen Biao Gao; Fiscal Year: 2005....
- Animal Models For Studying Angelman Syndrome, A Developmental Brain DisorderFen Biao Gao; Fiscal Year: 2007..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page J Description, ..