Fen Biao Gao

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi The fragile X-related gene affects the crawling behavior of Drosophila larvae by regulating the mRNA level of the DEG/ENaC protein pickpocket1
    Kanyan Xu
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94103 USA
    Curr Biol 14:1025-34. 2004
  2. pmc MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila
    Yan Li
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California at San Francisco, San Francisco, California 94158, USA
    Genes Dev 20:2793-805. 2006
  3. pmc Posttranscriptional control of neuronal development by microRNA networks
    Fen Biao Gao
    Gladstone Institute of Neurological Disease, Department of Neurology, Neuroscience Graduate Program, University of California, 1650 Owens Street, San Francisco, CA 94158, USA
    Trends Neurosci 31:20-6. 2008
  4. pmc Molecular and cellular mechanisms of dendritic morphogenesis
    Fen Biao Gao
    Gladstone Institute of Neurological Disease, and Department of Neurology, University of California, San Francisco, CA 94158, United States
    Curr Opin Neurobiol 17:525-32. 2007
  5. ncbi Understanding fragile X syndrome: insights from retarded flies
    Fen Biao Gao
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94141, USA
    Neuron 34:859-62. 2002
  6. ncbi Genetic control of dendritic morphogenesis in Drosophila
    Fen Biao Gao
    Gladstone Institute of Neurological Disease, Neuroscience Graduate Program, University of California, San Francisco, CA 94141 9100, USA
    Trends Neurosci 26:262-8. 2003
  7. ncbi Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1
    Alan Lee
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94141 9100, USA
    Development 130:5543-52. 2003
  8. ncbi Genetic manipulation of single neurons in vivo reveals specific roles of flamingo in neuronal morphogenesis
    Neal T Sweeney
    Gladstone Institute of Neurological Disease, University of California, San Francisco, 94141 9100, USA
    Dev Biol 247:76-88. 2002
  9. ncbi BTB/POZ-zinc finger protein abrupt suppresses dendritic branching in a neuronal subtype-specific and dosage-dependent manner
    Wenjun Li
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94141, USA
    Neuron 43:823-34. 2004
  10. pmc Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation
    Yubing Lu
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 52:264-71. 2013

Collaborators

Detail Information

Publications37

  1. ncbi The fragile X-related gene affects the crawling behavior of Drosophila larvae by regulating the mRNA level of the DEG/ENaC protein pickpocket1
    Kanyan Xu
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94103 USA
    Curr Biol 14:1025-34. 2004
    ..It remains largely unknown what proteins encoded by mRNAs in the FMR1-messenger ribonuclear protein (mRNP) complex are most relevant to the affected physiological processes...
  2. pmc MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila
    Yan Li
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California at San Francisco, San Francisco, California 94158, USA
    Genes Dev 20:2793-805. 2006
    ..These results indicate that miR-9a ensures the generation of the precise number of neuronal precursor cells during development...
  3. pmc Posttranscriptional control of neuronal development by microRNA networks
    Fen Biao Gao
    Gladstone Institute of Neurological Disease, Department of Neurology, Neuroscience Graduate Program, University of California, 1650 Owens Street, San Francisco, CA 94158, USA
    Trends Neurosci 31:20-6. 2008
    ..Further dissection of the in vivo physiological functions of individual miRNAs promises to offer novel mechanistic insights into the gene regulatory networks that ensure the precise assembly of a functional nervous system...
  4. pmc Molecular and cellular mechanisms of dendritic morphogenesis
    Fen Biao Gao
    Gladstone Institute of Neurological Disease, and Department of Neurology, University of California, San Francisco, CA 94158, United States
    Curr Opin Neurobiol 17:525-32. 2007
    ..Those exciting findings have enhanced significantly our understanding of dendritic morphogenesis and revealed the magnitude of complexity in the underlying molecular regulatory networks...
  5. ncbi Understanding fragile X syndrome: insights from retarded flies
    Fen Biao Gao
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94141, USA
    Neuron 34:859-62. 2002
    ..The relevance of these studies to our understanding of fragile X syndrome is discussed...
  6. ncbi Genetic control of dendritic morphogenesis in Drosophila
    Fen Biao Gao
    Gladstone Institute of Neurological Disease, Neuroscience Graduate Program, University of California, San Francisco, CA 94141 9100, USA
    Trends Neurosci 26:262-8. 2003
    ....
  7. ncbi Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1
    Alan Lee
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94141 9100, USA
    Development 130:5543-52. 2003
    ..These findings demonstrate that Fmr1 affects dendritic development and that Rac1 is partially responsible for mediating this effect...
  8. ncbi Genetic manipulation of single neurons in vivo reveals specific roles of flamingo in neuronal morphogenesis
    Neal T Sweeney
    Gladstone Institute of Neurological Disease, University of California, San Francisco, 94141 9100, USA
    Dev Biol 247:76-88. 2002
    ..These results demonstrate that Flamingo plays a role in early neuronal differentiation and exerts specific effects on dendrites and axons...
  9. ncbi BTB/POZ-zinc finger protein abrupt suppresses dendritic branching in a neuronal subtype-specific and dosage-dependent manner
    Wenjun Li
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94141, USA
    Neuron 43:823-34. 2004
    ..These results demonstrate that dendritic branching can be suppressed by neuronal subtype-specific transcription factors in a cell-autonomous and dosage-dependent manner...
  10. pmc Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation
    Yubing Lu
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 52:264-71. 2013
    ..These results suggest that STX13 is a genetic modifier of ESCRT-III dysfunction and participates in the maturation of phagophores into closed autophagosomes. ..
  11. ncbi Actin filament-stabilizing protein tropomyosin regulates the size of dendritic fields
    Wenjun Li
    Gladstone Institute of Neurological Disease, Neuroscience Program, University of California, San Francisco, San Francisco, California 94141 9100, USA
    J Neurosci 23:6171-5. 2003
    ..TmII encodes multiple isoforms of a protein that stabilizes actin filaments. Our findings suggest that tropomyosin helps control the size of dendritic fields by regulating actin cytoskeletal dynamics...
  12. pmc The FTD/ALS-associated RNA-binding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in Drosophila
    Zhaodong Li
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hum Mol Genet 22:218-25. 2013
    ..These findings reveal a novel role for endogenous TDP-43 in neuronal specification and suggest that the FTD/ALS-associated RNA-binding protein TDP-43 functions to ensure the robustness of genetic control programs...
  13. pmc The steady-state level of the nervous-system-specific microRNA-124a is regulated by dFMR1 in Drosophila
    Xia Lian Xu
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94158, USA
    J Neurosci 28:11883-9. 2008
    ..This effect could be explained in part by the reduced abundance of the Dicer-1-Ago1 complex in the absence of dFMR1. These findings suggest a modulatory role for dFMR1 to maintain proper levels of miRNAs during neuronal development...
  14. ncbi Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila
    Wenjun Li
    Gladstone Institute of Neurological Disease, San Francisco, California, USA
    Dev Dyn 234:512-22. 2005
    ..These results suggest that Ena is a key regulator of dendritic branching and that different regulators of the actin cytoskeleton exert distinct effects on dendritic morphogenesis...
  15. pmc Protocols for investigating microRNA functions in human neural progenitor cells
    Sandra Almeida
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 916:387-402. 2012
    ..These methods may be applicable to protein factors and neural progenitor cells derived from patient-specific induced pluripotent stem cells...
  16. pmc The Drosophila homologue of the Angelman syndrome ubiquitin ligase regulates the formation of terminal dendritic branches
    Yubing Lu
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Hum Mol Genet 18:454-62. 2009
    ..These findings suggest that dendritic pathology may contribute to neurological deficits in patients with Angelman syndrome...
  17. ncbi ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration
    Jin A Lee
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94158, USA
    Curr Biol 17:1561-7. 2007
    ....
  18. pmc MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors
    Celine Delaloy
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California San Francisco, CA 94158, USA
    Cell Stem Cell 6:323-35. 2010
    ..These results identify miR-9 as a novel regulator that coordinates the proliferation and migration of hNPCs...
  19. ncbi Roles of ESCRT in autophagy-associated neurodegeneration
    Jin A Lee
    Gladstone Institute of Neurological Disease and Department of Neurology, Neuroscience Graduate Program, University of California, San Francisco, San Francisco, California 94158, USA
    Autophagy 4:230-2. 2008
    ..This study suggests that defects in the late steps of the autophagy pathway may contribute to the pathogenesis of FTD and potentially other neurodegenerative diseases...
  20. ncbi Autophagy defects contribute to neurodegeneration induced by dysfunctional ESCRT-III
    Jin A Lee
    Gladstone Institute of Neurological Disease, and Department of Neurology, University of California, San Francisco, CA 94158, USA
    Autophagy 5:1070-2. 2009
    ..These findings indicate that excess accumulation of autophagosomes is detrimental to neuronal survival, and dysfunctional ESCRT-III appears to cause neurodegeneration through multiple mechanisms...
  21. pmc Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia
    S Tariq Ahmad
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 106:12168-73. 2009
    ..This fly model will be useful to further dissect genetic pathways that are potentially relevant to the pathogenesis and treatment of FTD...
  22. pmc Regulation of Abeta pathology by beclin 1: a protective role for autophagy?
    Jin A Lee
    Gladstone Institute of Neurological Disease and Department of Neurology, UCSF, San Francisco, California 94158, USA
    J Clin Invest 118:2015-8. 2008
    ..These findings further support the notion that modulation of autophagy, in this case through beclin 1, may represent a novel therapeutic strategy for AD...
  23. doi Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS
    Paloma González-Pérez
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Neurobiol Dis 48:391-8. 2012
    ..Genetic variants in UBQLN1 gene have been linked to neurodegeneration and mutations in UBQLN2 have recently been identified as a rare cause of amyotrophic lateral sclerosis (ALS)...
  24. pmc MicroRNA-9: functional evolution of a conserved small regulatory RNA
    Yeliz Yuva-Aydemir
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    RNA Biol 8:557-64. 2011
    ..Thus, miR-9 is emerging as an important regulator in development and disease through its ability to modulate different targets in a manner dependent on the developmental stage and the cellular context...
  25. ncbi ESCRT, autophagy, and frontotemporal dementia
    Jin A Lee
    Department of Neurology, University of California, San Francisco, CA, USA
    BMB Rep 41:827-32. 2008
    ..Mutant CHMP2B proteins seem to disrupt the fusion of autophagosomes and lysosomes in cell culture models. These findings suggest a potential mechanism for the pathogenesis of FTD3 and possibly other neurodegenerative diseases as well...
  26. pmc FXR1P but not FMRP regulates the levels of mammalian brain-specific microRNA-9 and microRNA-124
    Xia Lian Xu
    Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA
    J Neurosci 31:13705-9. 2011
    ..These findings reveal differential roles of FMRP family proteins in controlling the expression levels of brain-specific miRNAs...
  27. pmc Transcriptional control of dendritic patterning in Drosophila neurons
    Michel Tassetto
    Gladstone Institute of Neurological Disease, and Department of Neurology, University of California, San Francisco, CA 94158, USA
    Genome Biol 7:225. 2006
    ..A recent in vivo genome-wide screen based on RNA interference identified a large number of transcriptional factors that regulate the stereotyped growth and branching of dendrites on some Drosophila sensory neurons...
  28. ncbi The coiled-coil protein shrub controls neuronal morphogenesis in Drosophila
    Neal T Sweeney
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California 94158, USA
    Curr Biol 16:1006-11. 2006
    ..Our findings demonstrate that the novel coiled-coil protein Shrub functions in the endosomal pathway and plays an essential role in neuronal morphogenesis...
  29. pmc Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching
    Yubing Lu
    Gladstone Institute of Neurological Disease, and Department of Neurology, University of California, San Francisco, CA 94158, USA
    Mol Brain 2:30. 2009
    ..In diseased neurons, TDP-43 is depleted in the nucleus, suggesting a loss-of-function pathogenic mechanism. However, the normal function of TDP-43 in postmitotic neurons is largely unknown...
  30. pmc Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia
    Jin A Lee
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94158, USA
    J Neurosci 29:8506-11. 2009
    ..These findings show that autophagic stress by excess accumulation of autophagosomes is detrimental to neuronal survival under certain neurodegenerative conditions...
  31. pmc Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons
    Sandra Almeida
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Acta Neuropathol 126:385-99. 2013
    ....
  32. pmc Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects
    Sandra Almeida
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Rep 2:789-98. 2012
    ..Our findings identify cell-autonomous, reversible defects in patient neurons with PGRN deficiency, and provide a compelling model for studying PGRN-dependent pathogenic mechanisms and testing potential therapies...
  33. pmc MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia
    Jian Jiao
    Gladstone Institute of Neurological Disease, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e10551. 2010
    ..These findings identify miR-29b as a novel posttranscriptional regulator of PGRN expression, raising the possibility that miR-29b or other miRNAs might be targeted therapeutically to increase hPGRN levels in some FTD patients...
  34. pmc Cause or Effect: Misregulation of microRNA Pathways in Neurodegeneration
    Eduardo Gascon
    Department of Neurology, University of Massachusetts Medical School Worcester, MA, USA
    Front Neurosci 6:48. 2012
    ..The precise causal relationships between specific miRNAs and neurodegeneration in humans need to be further investigated...
  35. doi microRNA-9 multitasking near organizing centers
    Celine Delaloy
    Nat Neurosci 11:625-6. 2008
  36. pmc Patterns and functions of STAT activation during Drosophila embryogenesis
    Jinghong Li
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Mech Dev 120:1455-68. 2003
    ..These results suggest that STAT activation is involved in proper differentiation and morphogenesis of multiple tissues during Drosophila embryogenesis...
  37. ncbi Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation
    Yasuhito M Tokumoto
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK
    Dev Biol 245:224-34. 2002
    ....

Research Grants5

  1. Genetic Analysis of Heavy Metals Neurotoxicity
    Fen Biao Gao; Fiscal Year: 2005
    ....
  2. Animal Models For Studying Angelman Syndrome, A Developmental Brain Disorder
    Fen Biao Gao; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page J Description, ..