Allen C Gao

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Stat5a/b in Prostate Cancer Metastasis
    Allen C Gao
    Department of Urology, Comprehensive Cancer Center, University of California Davis, Sacramento, California Electronic address
    Am J Pathol 185:2351-3. 2015
  2. pmc NF-κB2/p52:c-Myc:hnRNPA1 Pathway Regulates Expression of Androgen Receptor Splice Variants and Enzalutamide Sensitivity in Prostate Cancer
    Nagalakshmi Nadiminty
    Department of Urology, University of California at Davis, Sacramento, California
    Mol Cancer Ther 14:1884-95. 2015
  3. pmc Inhibition of ABCB1 expression overcomes acquired docetaxel resistance in prostate cancer
    Yezi Zhu
    Corresponding Author Allen C Gao, Department of Urology, University of California Davis Medical Center, 4645 2nd Ave, Research III, Suite 1300, Sacramento, CA 95817
    Mol Cancer Ther 12:1829-36. 2013
  4. pmc Interleukin-6 regulates androgen synthesis in prostate cancer cells
    Jae Yeon Chun
    Department of Urology, Graduate Program of Pharmacology and Toxicology, and Department of Biological Chemistry, and Cancer Center, University of California at Davis, Sacramento, CA 95817, USA
    Clin Cancer Res 15:4815-22. 2009
  5. pmc Functional p53 determines docetaxel sensitivity in prostate cancer cells
    Chengfei Liu
    Department of Urology, University of California at Davis, Sacramento, California 95817, USA
    Prostate 73:418-27. 2013
  6. pmc RhoGDIα suppresses growth and survival of prostate cancer cells
    Yezi Zhu
    Department of Urology, University of California at Davis, Sacramento, California 95817, USA
    Prostate 72:392-8. 2012
  7. pmc MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth
    Nagalakshmi Nadiminty
    Department of Urology, University of California Davis, Sacramento, California, United States of America
    PLoS ONE 7:e32832. 2012
  8. pmc Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion
    Meng Sun
    Department of Urology, University of California at Davis, Sacramento, California, USA
    Prostate 72:82-9. 2012
  9. pmc MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells
    Nagalakshmi Nadiminty
    Department of Urology, University of California at Davis, Sacramento, California 95817, USA
    J Biol Chem 287:1527-37. 2012
  10. pmc NF-κB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variants
    Nagalakshmi Nadiminty
    Department of Urology, University of California at Davis, Sacramento, CA, USA
    Mol Cancer Ther 12:1629-37. 2013

Collaborators

Detail Information

Publications41

  1. doi request reprint Stat5a/b in Prostate Cancer Metastasis
    Allen C Gao
    Department of Urology, Comprehensive Cancer Center, University of California Davis, Sacramento, California Electronic address
    Am J Pathol 185:2351-3. 2015
    ..This commentary highlights the article by Talati et al that describes novel mechanisms promoting metastasis in prostate cancer. ..
  2. pmc NF-κB2/p52:c-Myc:hnRNPA1 Pathway Regulates Expression of Androgen Receptor Splice Variants and Enzalutamide Sensitivity in Prostate Cancer
    Nagalakshmi Nadiminty
    Department of Urology, University of California at Davis, Sacramento, California
    Mol Cancer Ther 14:1884-95. 2015
    ..These findings may provide a rationale for cotargeting these pathways to achieve better efficacy through AR blockade...
  3. pmc Inhibition of ABCB1 expression overcomes acquired docetaxel resistance in prostate cancer
    Yezi Zhu
    Corresponding Author Allen C Gao, Department of Urology, University of California Davis Medical Center, 4645 2nd Ave, Research III, Suite 1300, Sacramento, CA 95817
    Mol Cancer Ther 12:1829-36. 2013
    ....
  4. pmc Interleukin-6 regulates androgen synthesis in prostate cancer cells
    Jae Yeon Chun
    Department of Urology, Graduate Program of Pharmacology and Toxicology, and Department of Biological Chemistry, and Cancer Center, University of California at Davis, Sacramento, CA 95817, USA
    Clin Cancer Res 15:4815-22. 2009
    ..In this study, we investigate whether IL-6 regulates intraprostatic androgen synthesis in prostate cancer cells...
  5. pmc Functional p53 determines docetaxel sensitivity in prostate cancer cells
    Chengfei Liu
    Department of Urology, University of California at Davis, Sacramento, California 95817, USA
    Prostate 73:418-27. 2013
    ..However, docetaxel resistance rapidly develops. Identifying the critical mechanisms giving rise to docetaxel resistance is the major challenge in advanced prostate cancer...
  6. pmc RhoGDIα suppresses growth and survival of prostate cancer cells
    Yezi Zhu
    Department of Urology, University of California at Davis, Sacramento, California 95817, USA
    Prostate 72:392-8. 2012
    ..We have previously generated LNCaP-IL6+ cells by treating LNCaP cells chronically with interleukin-6 (IL-6), which have acquired the ability to grow in androgen-deprived conditions...
  7. pmc MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth
    Nagalakshmi Nadiminty
    Department of Urology, University of California Davis, Sacramento, California, United States of America
    PLoS ONE 7:e32832. 2012
    ..Prostate cancer (PCa) is characterized by deregulated expression of several tumor suppressor or oncogenic miRNAs. The objective of this study was the identification and characterization of miR-let-7c as a potential tumor suppressor in PCa...
  8. pmc Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion
    Meng Sun
    Department of Urology, University of California at Davis, Sacramento, California, USA
    Prostate 72:82-9. 2012
    ..Sanguinarine, a benzophenanthridine alkaloid derived primarily from the bloodroot plant, was identified previously as a novel inhibitor of survivin that selectively kills prostate cancer cells over "normal" prostate epithelial cells...
  9. pmc MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells
    Nagalakshmi Nadiminty
    Department of Urology, University of California at Davis, Sacramento, California 95817, USA
    J Biol Chem 287:1527-37. 2012
    ..These results suggest that reconstitution of miR-let-7c may aid in targeting enhanced and hypersensitive AR in advanced prostate cancer...
  10. pmc NF-κB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variants
    Nagalakshmi Nadiminty
    Department of Urology, University of California at Davis, Sacramento, CA, USA
    Mol Cancer Ther 12:1629-37. 2013
    ..These results collectively demonstrate that resistance to enzalutamide may be mediated by NF-κB2/p52 via activation of AR and its splice variants...
  11. pmc Lin28 promotes growth of prostate cancer cells and activates the androgen receptor
    Ramakumar Tummala
    Department of Urology, University of California at Davis, Sacramento, California 95817, USA
    Am J Pathol 183:288-95. 2013
    ..Lin28 induced expression of the AR and its target genes such as PSA and NKX3.1. Collectively, our findings demonstrate a novel role for Lin28 in CaP development and activation of the AR axis...
  12. doi request reprint Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex
    Zhijian Duan
    Cancer Center Basic Sciences, University of California at Davis, Sacramento, California 95817, USA
    Prostate 73:455-66. 2013
    ..However, how their expression is regulated in the tumors and whether they play a role in prostate development remains unclear...
  13. pmc Interleukin-4 activates androgen receptor through CBP/p300
    Soo Ok Lee
    Department of Urology and Cancer Center, University of California Davis Medical Center, Sacramento, California 95817, USA
    Prostate 69:126-32. 2009
    ..However, the mechanism of IL-4 mediated AR activation has not yet been revealed...
  14. pmc Inhibition of constitutively active Stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells
    Chengfei Liu
    Department of Urology, University of California at Davis, Sacramento, California
    Prostate 74:201-9. 2014
    ..However, resistance to enzalutamide can develop frequently in initial responders. This study aimed to test whether overexpression of IL-6 and constitutive activation of Stat3 in prostate cancer cells increase resistance to enzalutamide...
  15. pmc Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer
    Chengfei Liu
    Department of Urology, University of California at Davis, Sacramento, CA, USA
    Genes Cancer 2:151-9. 2011
    ..Thus, andrographolide can be developed as a potential therapeutic agent for prostate cancer by inhibition of androgen receptor signaling...
  16. pmc Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2
    Siting Feng
    Department of Urology and Cancer Center, University of California at Davis Medical Center Research III, Suite 1300, 4645 2nd Avenue, Sacramento, CA 95817, USA
    Mol Cancer Ther 8:665-71. 2009
    ..Our studies suggest that bicalutamide-IL-6-targeted adjunctive therapy may lead to a more effective intervention than bicalutamide alone...
  17. pmc Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth
    Jae Yeon Chun
    Department of Urology, University of California at Davis, Davis, CA, USA
    Genes Cancer 1:868-76. 2010
    ....
  18. pmc RhoGDIα downregulates androgen receptor signaling in prostate cancer cells
    Yezi Zhu
    Department of Urology and Cancer Center, University of California at Davis, Sacramento, California Graduate Program of Pharmacology and Toxicology, University of California at Davis, Sacramento, California
    Prostate 73:1614-22. 2013
    ..We have previously identified Rho GDP Dissociation Inhibitor alpha (GDIα) as a novel suppressor in prostate cancer. In this study, we examine the effect of GDIα on AR signaling in prostate cancer cells...
  19. pmc Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer
    Chengfei Liu
    Authors Affiliations Department of Urology Graduate Program in Pharmacology and Toxicology and UC Davis Comprehensive Cancer Center, University of California Davis, California
    Clin Cancer Res 20:3198-210. 2014
    ..This study was designed to identify inhibitors of AR variants and test its ability to overcome resistance to enzalutamide...
  20. pmc Intracrine Androgens and AKR1C3 Activation Confer Resistance to Enzalutamide in Prostate Cancer
    Chengfei Liu
    Department of Urology, University of California, Davis, California
    Cancer Res 75:1413-22. 2015
    ....
  21. pmc Sanguinarine suppresses prostate tumor growth and inhibits survivin expression
    Meng Sun
    Department of Urology, University of California at Davis, Davis, CA, USA
    Genes Cancer 1:283-92. 2010
    ..These results suggest that sanguinarine may be developed as an agent either alone or in combination with taxol for treatment of prostate cancer overexpressing survivin...
  22. doi request reprint Effect of the specific Src family kinase inhibitor saracatinib on osteolytic lesions using the PC-3 bone model
    Joy C Yang
    Department of Urology, University of California at Davis, Sacramento, California 95817, USA
    Mol Cancer Ther 9:1629-37. 2010
    ..The inhibition of Src thus targets multiple sites involved in prostate cancer bone metastasis, which may offer a therapeutic advantage in treating advanced prostate cancer...
  23. doi request reprint Microarray analysis reveals potential target genes of NF-kappaB2/p52 in LNCaP prostate cancer cells
    Nagalakshmi Nadiminty
    Department of Urology, University of California Davis Medical Center, Sacramento, California, USA
    Prostate 70:276-87. 2010
    ....
  24. doi request reprint Lin28 induces resistance to anti-androgens via promotion of AR splice variant generation
    Ramakumar Tummala
    Department of Urology, University of California at Davis, Sacramento, California
    Prostate 76:445-55. 2016
    ..Recent clinical observations point to the development of resistance to these therapies which may be mediated by constitutively active alternative splice variants of the androgen receptor (AR)...
  25. doi request reprint Interleukin-6 induces neuroendocrine differentiation (NED) through suppression of RE-1 silencing transcription factor (REST)
    Yezi Zhu
    Department of Urology, University of California Davis, Sacramento, California Graduate Program in Pharmacology and Toxicology, University of California Davis, Sacramento, California
    Prostate 74:1086-94. 2014
    ..However, little is known about the mechanisms underlying neuroendocrine differentiation induced by IL-6...
  26. pmc Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop
    Ping Yang
    UC Davis Cancer Center Basic Sciences, University of California at Davis, Sacramento, California, USA
    Mol Cell Biol 32:3121-31. 2012
    ....
  27. pmc Niclosamide enhances abiraterone treatment via inhibition of androgen receptor variants in castration resistant prostate cancer
    Chengfei Liu
    Department of Urology, University of California Davis, CA, USA
    Oncotarget 7:32210-20. 2016
    ....
  28. pmc Antiandrogens Inhibit ABCB1 Efflux and ATPase Activity and Reverse Docetaxel Resistance in Advanced Prostate Cancer
    Yezi Zhu
    Department of Urology, University of California at Davis, Sacramento, California Graduate Program in Pharmacology and Toxicology, University of California at Davis, Sacramento, California
    Clin Cancer Res 21:4133-42. 2015
    ..In this study, we examined whether antiandrogens, such as bicalutamide and enzalutamide, could inhibit ABCB1 activity and overcome resistance to docetaxel...
  29. pmc Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition
    Chengfei Liu
    Department of Urology, University of California at Davis, Sacramento, California
    Prostate 75:1341-53. 2015
    ..This study is aimed to target Stat3 activation and improve enzalutamide therapy...
  30. pmc Upregulation of glucose metabolism by NF-κB2/p52 mediates enzalutamide resistance in castration-resistant prostate cancer cells
    Yuanyuan Cui
    Department of Urology, University of California Davis Medical Center, 4645 2nd Avenue, Research, III, Suite 1300, Sacramento, California 95817, USA UC Davis Comprehensive Cancer Center, University of California Davis, California, USA
    Endocr Relat Cancer 21:435-42. 2014
    ..Co-targeting glucose metabolism together with AR axis synergistically inhibits cell growth and restores enzalutamide-resistant cells to enzalutamide treatment. ..
  31. doi request reprint Mechanisms of persistent activation of the androgen receptor in CRPC: recent advances and future perspectives
    Nagalakshmi Nadiminty
    Department of Urology and Cancer Center, University of California Davis Medical Center, 4645 2nd Ave, Research III, Suite 1300, Sacramento, CA 95817, USA
    World J Urol 30:287-95. 2012
    ..The re-activation of the androgen receptor (AR) in castration-resistant prostate cancer (CRPC) is now recognized as the central event in this process, and therapeutic modalities are being devised to combat it...
  32. pmc Effects of triclocarban on intact immature male rat: augmentation of androgen action
    Antoni J Duleba
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Davis, CA 95817, USA
    Reprod Sci 18:119-27. 2011
    ..In conclusion, TCC significantly affects intact male reproductive organs and potentiates androgen effects in prostate cancer cells...
  33. pmc Inhibition of AKR1C3 activation overcomes resistance to abiraterone in advanced prostate cancer
    Chengfei Liu
    Department of Urology, University of California Davis
    Mol Cancer Ther . 2016
    ..Furthermore, this study provides a preclinical proof-of-principle for clinical trials investigating the combination of targeting AKR1C3 using indomethacin with abiraterone for advanced prostate cancer...
  34. pmc ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer
    Junjian Wang
    Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Sacramento, California, USA
    Nat Med 22:488-96. 2016
    ..Taken together, these results establish ROR-γ as a key player in CRPC by acting upstream of AR and as a potential therapeutic target for advanced PCa. ..
  35. doi request reprint The interleukin 6 receptor is a direct transcriptional target of E2F3 in prostate tumor derived cells
    Stephen J Libertini
    Veterans Affairs Northern California Health Care System, Mather, California, USA
    Prostate 72:649-60. 2012
    ..E2F3 levels are elevated in prostate tumors and E2F3 overexpression independently predicts clinical outcome. The goals of this study were to identify direct transcriptional targets of E2F3 in prostate tumor derived cells...
  36. pmc Molecular mechanisms of castration-resistant prostate cancer progression
    Smitha S Dutt
    Department of Urology and Cancer Center, University of California School of Medicine at Davis, Sacramento, CA 95817, USA
    Future Oncol 5:1403-13. 2009
    ..A multicombinatorial drug treatment approach has been suggested to target these multiple pathways in an effort to reduce the possibility of recurrence of CRPC...
  37. pmc Targeting molecular resistance in castration-resistant prostate cancer
    Thenappan Chandrasekar
    Department of Urology, University of California, Davis, USA
    BMC Med 13:206. 2015
    ..We review current knowledge of mechanisms of resistance to the currently approved treatments, development of adjunctive therapies, and identification of new pathways being targeted for therapeutic purposes. ..
  38. doi request reprint Mechanisms of selenium chemoprevention and therapy in prostate cancer
    Nagalakshmi Nadiminty
    Department of Urology and Cancer Center, University of California School of Medicine at Davis, Sacramento, CA 95817, USA
    Mol Nutr Food Res 52:1247-60. 2008
    ....
  39. doi request reprint The N-terminal kinase suppressor of Ras complex has a weak nucleoside diphosphate kinase activity
    Xueqin Yang
    Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, ChinaCancer Center, Institute of Surgery Research and Daping Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Urology and Cancer Center, University of California Davis Medical Center, Sacramento, USA
    Thorac Cancer 1:109-115. 2010
    ..However, a few studies have reported that KSR1 can activate c-Raf-1. Therefore, whether KSR1 possesses a kinase activity has been an unresolved issue until now...
  40. ncbi request reprint Selective activation of members of the signal transducers and activators of transcription family in prostate carcinoma
    Zuyao Ni
    Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Urol 167:1859-62. 2002
    ..Constitutive activation of STATs has been found in a wide variety of human tumors. In this study we examined the activity of STATs in primary human prostate tissues...
  41. ncbi request reprint Regulation of androgen and vitamin d receptors by 1,25-dihydroxyvitamin D3 in human prostate epithelial and stromal cells
    Eddy S Leman
    Department of Urology, Cellular and Molecular Pathology Training Program, Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Urol 170:235-40. 2003
    ..We examined the interplay of 1,25 D and androgens on the epithelial and stromal cells of the prostate...