Tomas Ganz

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Copy number polymorphisms are not a common feature of innate immune genes
    Rose M Linzmeier
    Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1690, USA
    Genomics 88:122-6. 2006
  2. pmc Hepcidin and iron homeostasis
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Biochim Biophys Acta 1823:1434-43. 2012
  3. pmc Iron metabolism: interactions with normal and disordered erythropoiesis
    Tomas Ganz
    Department of Medicine and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Cold Spring Harb Perspect Med 2:a011668. 2012
  4. ncbi request reprint Macrophages and systemic iron homeostasis
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Innate Immun 4:446-53. 2012
  5. pmc The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders
    Tomas Ganz
    Department of Pulmonary and Critical Care Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Hematology Am Soc Hematol Educ Program 2011:538-42. 2011
  6. ncbi request reprint Iron homeostasis and its disorders in mice and men: potential lessons for rhinos
    Tomas Ganz
    Departments of Medicine, David Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, California 90095 1690 USA
    J Zoo Wildl Med 43:S19-26. 2012
  7. pmc Iron in innate immunity: starve the invaders
    Tomas Ganz
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, United States
    Curr Opin Immunol 21:63-7. 2009
  8. ncbi request reprint Hepcidin in iron metabolism
    Tomas Ganz
    Departments of Medicine and Pathology, David Geffen School of Medicine University of California, Los Angeles, California 90095 1690, USA
    Curr Opin Hematol 11:251-4. 2004
  9. ncbi request reprint Antimicrobial polypeptides
    Tomas Ganz
    David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    J Leukoc Biol 75:34-8. 2004
  10. ncbi request reprint Defensins: antimicrobial peptides of innate immunity
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 1690, USA
    Nat Rev Immunol 3:710-20. 2003

Research Grants

  1. INNATE HOST DEFENSE IN THE HUMAN VAGINA
    Tomas Ganz; Fiscal Year: 2004
  2. Hepcidin and Anemia of Inflammation
    Tomas Ganz; Fiscal Year: 2004
  3. Hepcidin and Anemia of Inflammation
    Tomas Ganz; Fiscal Year: 2005
  4. Hepcidin and Anemia of Inflammation
    Tomas Ganz; Fiscal Year: 2006
  5. THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    Tomas Ganz; Fiscal Year: 2007
  6. The role of hemojuvelin in the regulation of iron metabolism
    Tomas Ganz; Fiscal Year: 2007
  7. Hepcidin and Anemia of Inflammation
    Tomas Ganz; Fiscal Year: 2007
  8. THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    Tomas Ganz; Fiscal Year: 2008
  9. Hepcidin and Anemia of Inflammation
    Tomas Ganz; Fiscal Year: 2008
  10. THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    Tomas Ganz; Fiscal Year: 2008

Detail Information

Publications120 found, 100 shown here

  1. ncbi request reprint Copy number polymorphisms are not a common feature of innate immune genes
    Rose M Linzmeier
    Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1690, USA
    Genomics 88:122-6. 2006
    ....
  2. pmc Hepcidin and iron homeostasis
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Biochim Biophys Acta 1823:1434-43. 2012
    ..Hepcidin, ferroportin and their regulators represent potential targets for the diagnosis and treatment of iron disorders and anemias. This article is part of a Special Issue entitled: Cell Biology of Metals...
  3. pmc Iron metabolism: interactions with normal and disordered erythropoiesis
    Tomas Ganz
    Department of Medicine and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Cold Spring Harb Perspect Med 2:a011668. 2012
    ..Finally, we discuss iron disorders that affect erythropoiesis as well as erythroid disorders that cause iron dysregulation...
  4. ncbi request reprint Macrophages and systemic iron homeostasis
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Innate Immun 4:446-53. 2012
    ..This review discusses the iron-scavenging function of macrophages in the context of iron homeostasis and host defense...
  5. pmc The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders
    Tomas Ganz
    Department of Pulmonary and Critical Care Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Hematology Am Soc Hematol Educ Program 2011:538-42. 2011
    ....
  6. ncbi request reprint Iron homeostasis and its disorders in mice and men: potential lessons for rhinos
    Tomas Ganz
    Departments of Medicine, David Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, California 90095 1690 USA
    J Zoo Wildl Med 43:S19-26. 2012
    ..This review summarizes the current knowledge in humans and mice regarding the physiology and molecular basis of iron overload, and it explores how it can be applied to the problem of iron overload in captive rhino populations...
  7. pmc Iron in innate immunity: starve the invaders
    Tomas Ganz
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, United States
    Curr Opin Immunol 21:63-7. 2009
    ..Specialized inflammation-regulated proteins chelate iron, trap siderophores, and transport iron or modulate its transport to alter its tissue distribution during infections...
  8. ncbi request reprint Hepcidin in iron metabolism
    Tomas Ganz
    Departments of Medicine and Pathology, David Geffen School of Medicine University of California, Los Angeles, California 90095 1690, USA
    Curr Opin Hematol 11:251-4. 2004
    ..Connecting iron metabolism to innate immunity, hepcidin is a key mediator of hypoferremia of inflammation...
  9. ncbi request reprint Antimicrobial polypeptides
    Tomas Ganz
    David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    J Leukoc Biol 75:34-8. 2004
    ..Since then, a number of additional antimicrobial components have been identified, and there is increasing insight into their complex interactions. This review is an update of my previous summary of this area...
  10. ncbi request reprint Defensins: antimicrobial peptides of innate immunity
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 1690, USA
    Nat Rev Immunol 3:710-20. 2003
    ..This review, inspired by a spate of recent studies of defensins in human diseases and animal models, focuses on the biological function of defensins...
  11. ncbi request reprint Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, 10833 Le Conte Ave, CHS 37 055, University of California, Los Angeles, CA 90095 1690, USA
    Blood 102:783-8. 2003
    ..The discovery of hepcidin and its role in iron metabolism could lead to new therapies for hemochromatosis and anemia of inflammation...
  12. ncbi request reprint The role of hepcidin in iron sequestration during infections and in the pathogenesis of anemia of chronic disease
    Tomas Ganz
    Departments of Medicine and Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Isr Med Assoc J 4:1043-5. 2002
    ....
  13. pmc Epithelia: not just physical barriers
    Tomas Ganz
    Department of Medicine, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:3357-8. 2002
  14. pmc Hepcidin and iron regulation, 10 years later
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Blood 117:4425-33. 2011
    ..This response also restricts the iron supply to erythropoietic precursors and may cause or contribute to the anemia associated with infections and inflammatory disorders...
  15. doi request reprint Immunoassay for human serum hepcidin
    Tomas Ganz
    Intrinsic LifeSciences LLC, La Jolla, CA, USA
    Blood 112:4292-7. 2008
    ..The new serum hepcidin enzyme-linked immunosorbent assay yields accurate and reproducible measurements that appropriately reflect physiologic, pathologic, and genetic influences, and is informative about the etiology of iron disorders...
  16. ncbi request reprint Immunology. Versatile defensins
    Tomas Ganz
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 298:977-9. 2002
  17. ncbi request reprint Increased inflammation in lysozyme M-deficient mice in response to Micrococcus luteus and its peptidoglycan
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095 1690, USA
    Blood 101:2388-92. 2003
    ..Our data indicate that tissue injury is normally limited by prompt degradation of bacterial macromolecules that trigger innate immunity and inflammation...
  18. ncbi request reprint Defensins: antimicrobial peptides of vertebrates
    Tomas Ganz
    CHS 37 055, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    C R Biol 327:539-49. 2004
    ..The main focus is on vertebrate defensins, a family of cysteine-rich antimicrobial peptides abundantly represented in human cells and tissues...
  19. doi request reprint Iron homeostasis: fitting the puzzle pieces together
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1690, USA
    Cell Metab 7:288-90. 2008
    ....
  20. ncbi request reprint Hepcidin--a peptide hormone at the interface of innate immunity and iron metabolism
    T Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90095 1690, USA
    Curr Top Microbiol Immunol 306:183-98. 2006
    ..The decrease in extracellular iron concentrations due to hepcidin probably limits iron availability to invading microorganisms, thus contributing to host defense...
  21. ncbi request reprint Regulation of iron acquisition and iron distribution in mammals
    Tomas Ganz
    Department of Medicine and Pathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1690, USA
    Biochim Biophys Acta 1763:690-9. 2006
    ..Deficiency of hepcidin is the unifying cause of hereditary hemochromatoses, and excessive cytokine-stimulated hepcidin production causes hypoferremia and contributes to anemia of inflammation...
  22. pmc Iron sequestration and anemia of inflammation
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Semin Hematol 46:387-93. 2009
    ..The supply of iron to hemoglobin synthesis becomes limiting, eventually resulting in anemia. Depending on the details of the underlying disease, other inflammation-related mechanisms may also contribute to anemia...
  23. ncbi request reprint Iron imports. IV. Hepcidin and regulation of body iron metabolism
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
    Am J Physiol Gastrointest Liver Physiol 290:G199-203. 2006
    ..Hepcidin deficiency due to the dysregulation of its synthesis causes most known forms of hemochromatosis...
  24. ncbi request reprint Molecular pathogenesis of anemia of chronic disease
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Pediatr Blood Cancer 46:554-7. 2006
    ..Hepcidin blocks the release of iron from macrophages, hepatocytes, and enterocytes, causing the characteristic hypoferremia associated with this anemia and iron-deprivation of the developing erythrocytes...
  25. ncbi request reprint Molecular control of iron transport
    Tomas Ganz
    Departments of Medicine and Pathology, David Geffen School of Medicine, 10833 Le Conte Avenue, CHS 37 055, University of California, Los Angeles, CA 90095 1690, USA
    J Am Soc Nephrol 18:394-400. 2007
    ..Hepcidin deficiency plays a central role in most iron overload disorders. The role of hepcidin abnormalities in anemias that are associated with renal disease and in resistance to erythropoietic therapies remains to be elucidated...
  26. doi request reprint Hepcidin and disorders of iron metabolism
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Annu Rev Med 62:347-60. 2011
    ..The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias...
  27. ncbi request reprint Defensins and other antimicrobial peptides: a historical perspective and an update
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
    Comb Chem High Throughput Screen 8:209-17. 2005
    ....
  28. ncbi request reprint Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophages
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
    Best Pract Res Clin Haematol 18:171-82. 2005
    ..At the opposite extreme, early studies indicate that hepcidin deficiency--due to the dysregulation of its synthesis or mutations in the hepcidin gene itself--is the immediate cause of most forms of hemochromatosis...
  29. ncbi request reprint Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation
    Alice Y Liu
    Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
    J Invest Dermatol 118:275-81. 2002
    ..Defensins and other antimicrobial peptides of inflamed epidermis are likely to play an important antimicrobial role in host defense against cutaneous pathogens...
  30. pmc Reduction of serum hepcidin by hemodialysis in pediatric and adult patients
    Joshua Zaritsky
    Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Clin J Am Soc Nephrol 5:1010-4. 2010
    ....
  31. pmc Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload
    Gloria C Preza
    Department of Pathology, UCLA, Los Angeles, California, USA
    J Clin Invest 121:4880-8. 2011
    ..Moreover, liver iron concentrations were lower in mice chronically treated with minihepcidins than those in mice treated with solvent alone. Minihepcidins may be useful for the treatment of iron overload disorders...
  32. pmc The hepcidin-binding site on ferroportin is evolutionarily conserved
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Cell Metab 8:146-56. 2008
    ..The affinity of hepcidin for the HBD permits a rapid, sensitive assay of hepcidin from all species and yields insights into the evolution of hepcidin...
  33. ncbi request reprint Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, and the West Los Angeles Veterans Administration Hospital, University of California, Los Angeles 90095, USA
    Blood 101:2461-3. 2003
    ..The linkage of hepcidin induction to inflammation in humans supports its proposed role as a key mediator of anemia of inflammation...
  34. pmc The molecular mechanism of hepcidin-mediated ferroportin down-regulation
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Mol Biol Cell 18:2569-78. 2007
    ..Depletion of proteins involved in multivesicular body trafficking (Endosome Sorting Complex Required for Transport proteins), by small-interfering RNA, reduces the trafficking of Fpn-green fluorescent to the lysosome...
  35. ncbi request reprint Involvement of hepcidin in the anemia of multiple myeloma
    Sanjai Sharma
    West Los Angeles VA University of California Los Angeles Medical Center, Los Angeles, CA 90073, USA
    Clin Cancer Res 14:3262-7. 2008
    ..Because interleukin (IL)-6 is a potent inducer of hepcidin expression and its levels are elevated in multiple myeloma, we studied the role of hepcidin in the anemia of multiple myeloma...
  36. pmc IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, California, USA
    J Clin Invest 113:1271-6. 2004
    ....
  37. pmc Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae
    Haa Yung Lee
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California 90057, USA
    BMC Infect Dis 4:12. 2004
    ....
  38. pmc Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination
    Bo Qiao
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 15:918-24. 2012
    ..Our study demonstrates that ubiquitination is the functionally relevant signal for hepcidin-induced ferroportin endocytosis...
  39. pmc Hepcidin--a potential novel biomarker for iron status in chronic kidney disease
    Joshua Zaritsky
    Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Clin J Am Soc Nephrol 4:1051-6. 2009
    ..Hepcidin is a key regulator of iron homeostasis, but its study in the setting of chronic kidney disease (CKD) has been hampered by the lack of validated serum assays...
  40. pmc The molecular basis of hepcidin-resistant hereditary hemochromatosis
    Augustine Fernandes
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Blood 114:437-43. 2009
    ..Our observations explain why the mutations in C326 Fpn residue produce a severe form of hemochromatosis with iron overload at an early age...
  41. ncbi request reprint Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
    Seth Rivera
    Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Blood 105:1797-802. 2005
    ..Hepcidin contributes to AI by shunting iron away from erythropoiesis and sequestering it in the liver, predominantly in hepatocytes...
  42. ncbi request reprint Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Science 306:2090-3. 2004
    ..The posttranslational regulation of ferroportin by hepcidin may thus complete a homeostatic loop: Iron regulates the secretion of hepcidin, which in turn controls the concentration of ferroportin on the cell surface...
  43. pmc Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
    Seth Rivera
    UCLA Department of Medicine, 10833 Le Conte Ave, CHS 37 131, Los Angeles, CA 90095, USA
    Blood 106:2196-9. 2005
    ..The rapid and sustained action of a single dose of hepcidin makes it an appealing agent for the prevention of iron accumulation in hereditary hemochromatosis...
  44. pmc Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis
    Emilio Ramos
    Department of Chemistry and Biochemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1690, USA
    Blood 120:3829-36. 2012
    ..Our study demonstrates that minihepcidins could be beneficial in iron overload disorders either used alone for prevention or possibly as adjunctive therapy with phlebotomy or chelation...
  45. pmc Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
    Lan Lin
    Departments of Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
    Blood 110:2182-9. 2007
    ..Fresh primary hepatocytes constitute a sufficient system for the regulation of hepcidin by physiologic iron stimuli and will greatly facilitate studies of major disorders of iron homeostasis...
  46. ncbi request reprint TGF-alpha regulates TLR expression and function on epidermal keratinocytes
    Lloyd S Miller
    Division of Dermatology, Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 174:6137-43. 2005
    ..These findings provide evidence that TGF-alpha up-regulates TLR expression and function, augmenting host defense mechanisms at epithelial surfaces...
  47. pmc Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site
    Lan Lin
    Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
    Blood Cells Mol Dis 40:122-31. 2008
    ..In this report, we investigate the proteinase involved in the release of s-hemojuvelin and show that s-hemojuvelin is released by a proprotein convertase through the cleavage at a conserved polybasic RNRR site...
  48. pmc Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice
    Emilio Ramos
    Chemistry and Biochemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Hepatology 53:1333-41. 2011
    ..BMP6, whose expression is also regulated by iron, may mediate hepcidin regulation by iron stores. None of the mutant strains (except Bmp6(-/-) mice) had impaired BMP6 mRNA response to chronic iron loading...
  49. pmc The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Blood 107:328-33. 2006
    ..G71D and K83R, substitutions previously described in humans, did not affect hepcidin activity. Apart from the essential nature of the N-terminus, hepcidin structure appears permissive for mutations...
  50. pmc High-throughput screening of small molecules identifies hepcidin antagonists
    Eileen Fung
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Mol Pharmacol 83:681-90. 2013
    ..Fursultiamine is a unique antagonist of hepcidin in vitro that could serve as a template for the development of drug candidates that inhibit the hepcidin-ferroportin interaction...
  51. pmc Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6
    Richard Rodriguez
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Infect Immun 82:745-52. 2014
    ..Our results support the key role of IL-6 in hepcidin regulation in response to a variety of infectious and inflammatory stimuli. ..
  52. pmc Cellular catabolism of the iron-regulatory peptide hormone hepcidin
    Gloria Cuevas Preza
    Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e58934. 2013
    ..Together these results show that the hormone hepcidin and its receptor ferroportin are internalized together and trafficked to lysosomes where both are degraded...
  53. pmc Inhibition of hepcidin transcription by growth factors
    Julia B Goodnough
    Department of Pathology, University of California, Los Angeles, CA 90095 1690, USA
    Hepatology 56:291-9. 2012
    ....
  54. pmc Suppression of hepcidin during anemia requires erythropoietic activity
    Mihwa Pak
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California UCLA, Los Angeles, USA
    Blood 108:3730-5. 2006
    ..The suppression of hepcidin necessary to match iron supply to erythropoietic demand thus requires increased erythropoiesis and is not directly mediated by anemia, tissue hypoxia, or erythropoietin...
  55. pmc Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin
    Erika V Valore
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1690, USA
    Blood Cells Mol Dis 40:132-8. 2008
    ..In conclusion, the hepatic prohormone convertase furin mediates the posttranslational processing of hepcidin. The proteolytic cleavage of prohepcidin to hepcidin is not regulated by iron-transferrin or the HIF pathway...
  56. ncbi request reprint Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
    Lan Lin
    Dept of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Blood 106:2884-9. 2005
    ..We propose that soluble and cell-associated hemojuvelin reciprocally regulate hepcidin expression in response to changes in extracellular iron concentration...
  57. ncbi request reprint Lysozyme levels in the nasal secretions of patients with perennial allergic rhinitis and recurrent sinusitis
    V Cuneyt Kalfa
    Division of Pediatric Immunology, Allergy, Rheumatology, Department of Pediatrics, University of California at Los Angeles, Los Angeles, California, USA
    Ann Allergy Asthma Immunol 93:288-92. 2004
    ..Anatomic abnormalities at the osteomeatal complex or ciliary dysfunction may play a significant role in some patients. However, for most patients with allergy, the determinants of RS are unknown...
  58. pmc Animal models of anemia of inflammation
    Seth Rivera
    Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA
    Semin Hematol 46:351-7. 2009
    ..We review many of the models reported in the literature or developed in our laboratory, and discuss their respective merits and drawbacks...
  59. ncbi request reprint Differential regulation of beta-defensin expression in human skin by microbial stimuli
    Ole E Sørensen
    Host Defense Laboratory, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 174:4870-9. 2005
    ..Thus during inflammation, epidermal expression of beta-defensins is mediated by at least three different mechanisms...
  60. ncbi request reprint Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2
    Cheryl J Hertz
    Division of Dermatology, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 171:6820-6. 2003
    ..Together, these data suggest that TLRs monitor epithelial surfaces to enhance host defense by inducing the production of an antimicrobial peptide...
  61. ncbi request reprint Regulation of iron metabolism by hepcidin
    Elizabeta Nemeth
    Departments of Medicine and Pathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Annu Rev Nutr 26:323-42. 2006
    ..The emergence of hepcidin as the pathogenic factor in most systemic iron disorders should provide important opportunities for improving their diagnosis and treatment...
  62. ncbi request reprint Cationic polypeptides are required for antibacterial activity of human airway fluid
    Alexander M Cole
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, and Will Rogers Institute Pulmonary Research Laboratory, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 169:6985-91. 2002
    ..aeruginosa...
  63. pmc A model for antimicrobial gene therapy: demonstration of human beta-defensin 2 antimicrobial activities in vivo
    George T J Huang
    Division of Associated Clinical Specialties, Section of Endodontics, 23 087 CHS, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Hum Gene Ther 13:2017-25. 2002
    ..8 +/- 3.3% viable bacteria. On the basis of this demonstration of HBD-2 in vivo antimicrobial activity, enhancement of antibacterial host defense by HBD-2 gene therapy may be feasible...
  64. pmc Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis
    Eric Bachman
    Department of Medicine, Boston University School of Medicine, 670 Albany Street, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 95:4743-7. 2010
    ..The mechanisms by which testosterone increases hemoglobin and hematocrit are unknown...
  65. pmc Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis
    Erika V Valore
    Department of Medicine, CHS 37 055, David Geffen School of Medicine, Los Angeles, CA 90095 1690, USA
    Infect Immun 74:5693-702. 2006
    ..The loss of normal immunostimulatory flora in bacterial vaginosis is thus associated with a local deficiency of multiple innate immune factors, and this deficiency could predispose individuals to sexually transmitted diseases...
  66. ncbi request reprint Antibacterial activity of peptides derived from envelope glycoproteins of HIV-1
    Alexander M Cole
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, 10833 Le Conte Ave, Room CHS 37 055, Los Angeles, CA 90095 1690, USA
    FEBS Lett 535:195-9. 2003
    ..The strategies employed herein could uncover additional antimicrobial peptides from envelope proteins of other lytic viruses...
  67. ncbi request reprint Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells
    Sung Kyun Moon
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Biochim Biophys Acta 1590:41-51. 2002
    ..Moreover, we demonstrate that the transcriptional activation of hBD-2 gene by IL-1 alpha is mediated through an Src-dependent Raf-MEK1/2-ERK signaling pathway...
  68. pmc Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers
    Karin M Aberg
    Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, California, USA
    J Invest Dermatol 128:917-25. 2008
    ..These studies demonstrate that (1) the permeability and antimicrobial barriers are coordinately regulated by permeability barrier requirements and (2) CRAMP is required for permeability barrier homeostasis...
  69. ncbi request reprint Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens
    Belinda H Tan
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 177:1864-71. 2006
    ....
  70. ncbi request reprint Antimicrobial components of vaginal fluid
    Erika V Valore
    Department of Medicine and Pathology, School of Medicine, University of California, Los Angeles 90095 1690, USA
    Am J Obstet Gynecol 187:561-8. 2002
    ..We examined the antimicrobial activity and composition of vaginal fluid...
  71. ncbi request reprint By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide
    Lide Liu
    Will Rogers Pulmonary Research Laboratory, Department of Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
    J Immunol 170:575-80. 2003
    ..This pattern of responses establishes a key role for both IL-1 and HBD-2 in the host defense reaction of the epidermis...
  72. pmc The role of hepcidin in iron metabolism
    Elizabeta Nemeth
    David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Acta Haematol 122:78-86. 2009
    ..Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory...
  73. pmc Reduced Paneth cell alpha-defensins in ileal Crohn's disease
    Jan Wehkamp
    Department of Microbiology and Immunology, School of Medicine, University of California, Davis, 95616, USA
    Proc Natl Acad Sci U S A 102:18129-34. 2005
    ..Thus, the specific deficiency of PC defensins that characterizes ileal CD may compromise innate immune defenses of the ileal mucosa and initiate and/or perpetuate this disease...
  74. ncbi request reprint Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation
    L Liu
    Departments of Medicine and Pathology and the Will Rogers Institute for Pulmonary Research, UCLA School of Medicine, Los Angeles, CA, USA
    Gene 222:237-44. 1998
    ..The HBD-2 gene is the first member of the human defensin family that is locally inducible by inflammation...
  75. ncbi request reprint Defensins of vertebrate animals
    Robert I Lehrer
    Department of Medicine Room CHS 37 062, and Molecular Biology Institute University of California at Los Angeles UCLA Center for the Health Sciences, Los Angeles, CA 90095, USA
    Curr Opin Immunol 14:96-102. 2002
    ..There is now convincing evidence that defensins augment adaptive immune responses...
  76. ncbi request reprint Cellular iron: ferroportin is the only way out
    Tomas Ganz
    Department of Medicine, David Gefen School of Medicine, Unvirsity of California, Los Angeles, California 90095, USA
    Cell Metab 1:155-7. 2005
    ..New studies of ferroportin knockout mice define a key role for this transporter in physiological iron balance...
  77. ncbi request reprint Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantation
    David J Ross
    Division of Pulmonary and Critical Care Medicine and the Will Rogers Institute for Pulmonary Research, David Geffen School of Medicine U C L A Medical Center, Los Angeles, CA 90095 1690, USA
    Transplantation 78:1222-4. 2004
    ..We therefore speculate that complex interactions between adaptive and innate immunity may contribute to the propagation of airway inflammation in BOS...
  78. ncbi request reprint Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors
    Ole E Sørensen
    Granulocyte Research Laboratory, Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Immunol 170:5583-9. 2003
    ..These findings offer an explanation for the expression of these peptides/polypeptides in the skin disease psoriasis and in wound healing and define a host defense role for growth factors in wound healing...
  79. ncbi request reprint Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23
    Rose M Linzmeier
    Department of Medicine and Department of Pathology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1690, USA
    Genomics 86:423-30. 2005
    ..The remarkable variability in defensin gene copy numbers could contribute to differences in individual resistance to infections...
  80. ncbi request reprint Cathelicidins: a family of endogenous antimicrobial peptides
    Robert I Lehrer
    Department of Medicine, Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California, USA
    Curr Opin Hematol 9:18-22. 2002
    ..Porcine protegrins are in stage III clinical trials to prevent oral mucositis caused by radiation or chemo-therapy...
  81. pmc Antimicrobial polypeptides in host defense of the respiratory tract
    Tomas Ganz
    University of California Los Angeles School of Medicine, Center for the Health Sciences, 10833 LeConte Avenue, 37 055, Los Angeles, CA 90095 1690, USA
    J Clin Invest 109:693-7. 2002
  82. ncbi request reprint Antimicrobial peptides in mammalian and insect host defence
    R I Lehrer
    Department of Medicine, The Molecular Biology Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Curr Opin Immunol 11:23-7. 1999
    ..Studies that examined the potential contributions of antimicrobial peptides to regional innate immunity gained in prominence. Efforts to design peptide analogues to prevent or treat infections continued...
  83. ncbi request reprint In human epidermis, beta-defensin 2 is packaged in lamellar bodies
    A Oren
    Department of Medicine and Pathology, Geffen School of Medicine at University of California, at Los Angeles, Los Angeles, CA 90095, USA
    Exp Mol Pathol 74:180-2. 2003
    ..These findings suggest that HBD-2 is released with the contents of the LBs. Along with other investigations, our findings indicate that the lipid "permeability" barrier of the skin contains antimicrobial substances...
  84. ncbi request reprint Calcitermin, a novel antimicrobial peptide isolated from human airway secretions
    A M Cole
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
    FEBS Lett 504:5-10. 2001
    ..4) and in the presence of micromolar concentrations of ZnCl(2). Analysis revealed a putative zinc-binding consensus sequence as well as an alpha-helical conformation in structure-promoting solvents...
  85. ncbi request reprint Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity
    A M Cole
    Department of Medicine, Division of Pulmonary and Critical Care, University of California School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 167:623-7. 2001
    ..IFN-gamma-inducible chemokines may directly inactivate microbes before attracting other host defense cells to the area of infection...
  86. ncbi request reprint Antimicrobial proteins and peptides in host defense
    T Ganz
    UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
    Semin Respir Infect 16:4-10. 2001
    ..Several peptides have properties that make them suitable for pharmaceutical development as topical or systemic antimicrobial agents...
  87. pmc Purification and antimicrobial properties of three defensins from rat neutrophils
    P B Eisenhauer
    Department of Medicine, University of California, Los Angeles
    Infect Immun 57:2021-7. 1989
    ..The existence of the defensin system in rats should facilitate investigations of the in vivo role of defensins in experimental infections...
  88. ncbi request reprint Antimicrobial peptides of vertebrates
    T Ganz
    Department of Medicine, University of California School of Medicine, Los Angeles 90095 1690, USA
    Curr Opin Immunol 10:41-4. 1998
    ..Other highlights included new insights into the relative selectivity of antimicrobial peptides for microbial membranes, their primary site of action...
  89. ncbi request reprint Antibiotic peptides from higher eukaryotes: biology and applications
    T Ganz
    Dept of Medicine and the Will Rogers Institute for Pulmonary Research, UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
    Mol Med Today 5:292-7. 1999
    ....
  90. ncbi request reprint Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich antimicrobial peptides
    R I Lehrer
    Department of Medicine, UCLA Center for the Health Sciences 90095, USA
    Ann N Y Acad Sci 797:228-39. 1996
    ..Defensins and protegrin-like peptides are likely to play a considerable role in innate immunity and may provide molecular templates that can be used to generate novel antibiotics for topical and systemic use...
  91. ncbi request reprint Human antimicrobial peptides: analysis and application
    A M Cole
    Department of Medicine, UCLA School of Medicine 90095 1690, USA
    Biotechniques 29:822-6, 828, 830-1. 2000
    ....
  92. ncbi request reprint Antimicrobial peptides and proteins in the CF airway
    Alexander M Cole
    Department of Medicine, Will Rogers Institute Pulmonary Research Laboratory, UCLA School of Medicine, Los Angeles, CA, USA
    Methods Mol Med 70:447-64. 2002
  93. ncbi request reprint Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39
    C Zhao
    Department of Medicine, UCLA Center for the Health Sciences 90095 1678, USA
    FEBS Lett 376:130-4. 1995
    ....
  94. ncbi request reprint The structure of the rabbit macrophage defensin genes and their organ-specific expression
    T Ganz
    Will Rogers Institute of Pulmonary Research, UCLA, Los Angeles, CA 90024 1736
    J Immunol 143:1358-65. 1989
    ..In macrophages, the expression of MCPs appears to be a marker of lung-specific differentiation...
  95. pmc Human beta-defensin-1: an antimicrobial peptide of urogenital tissues
    E V Valore
    Department of Medicine, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Clin Invest 101:1633-42. 1998
    ..coli in unconcentrated (low conductance) urine, and the 36 aa form was microbicidal even in normal (high conductance) urine. Production of HBD-1 in the urogenital tract could contribute to local antimicrobial defense...
  96. ncbi request reprint Therapeutic effect of a pig-derived peptide antibiotic on porcine wound infections
    A V Ceccarelli
    Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
    Comp Med 51:75-9. 2001
    ..Therapeutics used in the same animal species from which they were derived are a promising means for preventing and treating localized infections...
  97. ncbi request reprint Defensins
    T Ganz
    Department of Medicine, University of California School of Medicine, Los Angeles 90024 1736, USA
    Pharmacol Ther 66:191-205. 1995
    ..They contribute to host defense against microbes and may participate in tissue inflammation and endocrine regulation during infection. Bioengineered defensins are potentially useful as prophylactic and therapeutic agents in infections...
  98. ncbi request reprint Defensins: antimicrobial and cytotoxic peptides of mammalian cells
    R I Lehrer
    Department of Medicine, University of California, Los Angeles 90024
    Annu Rev Immunol 11:105-28. 1993
    ..Defensins are a newly delineated family of effector molecules whose contribution to host defense, inflammation, and cytotoxicity may be considerable for humans, even though it is unlikely to be revealed by experimentation with mice...
  99. ncbi request reprint Posttranslational processing of defensins in immature human myeloid cells
    E V Valore
    Will Rogers Institute Pulmonary Research Laboratory, University of California, Los Angeles
    Blood 79:1538-44. 1992
    ..Further studies will be required to determine the role of this processing pathway in subcellular targeting to azurophil granules and avoidance of autocytotoxicity...
  100. ncbi request reprint Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    C H Park
    Departments of Medicine and Pathology, UCLA School of Medicine, Los Angeles, California 90059, USA
    J Biol Chem 276:7806-10. 2001
    ..Hepcidin may be a vertebrate counterpart of cysteine-rich antimicrobial peptides produced in the fat body of insects...

Research Grants32

  1. INNATE HOST DEFENSE IN THE HUMAN VAGINA
    Tomas Ganz; Fiscal Year: 2004
    ..abstract_text> ..
  2. Hepcidin and Anemia of Inflammation
    Tomas Ganz; Fiscal Year: 2004
    ..This work is important both for the fundamental understanding of iron metabolism and for its exciting translational potential in the treatment of anemia of inflammation and some forms of hemochromatosis. ..
  3. Hepcidin and Anemia of Inflammation
    Tomas Ganz; Fiscal Year: 2005
    ..This work is important both for the fundamental understanding of iron metabolism and for its exciting translational potential in the treatment of anemia of inflammation and some forms of hemochromatosis. ..
  4. Hepcidin and Anemia of Inflammation
    Tomas Ganz; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  5. THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    Tomas Ganz; Fiscal Year: 2007
    ..This study is designed to find how inflammation causes anemia in the elderly and how the disease processes are changed by available treatments. ..
  6. The role of hemojuvelin in the regulation of iron metabolism
    Tomas Ganz; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. Hepcidin and Anemia of Inflammation
    Tomas Ganz; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  8. THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    Tomas Ganz; Fiscal Year: 2008
    ..This study is designed to find how inflammation causes anemia in the elderly and how the disease processes are changed by available treatments. ..
  9. Hepcidin and Anemia of Inflammation
    Tomas Ganz; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    Tomas Ganz; Fiscal Year: 2008
    ..This study is designed to find how inflammation causes anemia in the elderly and how the disease processes are changed by available treatments. ..
  11. THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    Tomas Ganz; Fiscal Year: 2009
    ..This study is designed to find how inflammation causes anemia in the elderly and how the disease processes are changed by available treatments. ..
  12. Hepcidin, ferroportin and iron disorders
    Tomas Ganz; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: The proposed project will help understand and treat disorders of iron metabolism including hemochromatosis and thalassemias. ..
  13. THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    Tomas Ganz; Fiscal Year: 2010
    ..This study is designed to find how inflammation causes anemia in the elderly and how the disease processes are changed by available treatments. ..
  14. Hepcidin, ferroportin and iron disorders
    Tomas Ganz; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The proposed project will help understand and treat disorders of iron metabolism including hemochromatosis and thalassemias. ..
  15. THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    Tomas Ganz; Fiscal Year: 2010
    ..This study is designed to find how inflammation causes anemia in the elderly and how the disease processes are changed by available treatments. ..
  16. Human Defensins in Phagocytes and Epithelia
    Tomas Ganz; Fiscal Year: 2004
    ..In the aggregate, these studies will expand our understanding of is ubiquitous and multifunctional family of human host defense peptides, this time also in their role as effectors of innate immunity in epithelia. ..
  17. PRODUCTION OF ANTIMICROBIAL PEPTIDES BY HUMAN NEUTROPHIL
    Tomas Ganz; Fiscal Year: 1999
    ..Thus the overall goal of the proposal is to define a recently recognized human host defense mechanism that may be important in resistance to microbial infection. ..
  18. PRODUCTION OF DEFENSINS BY HUMAN GRANULOCYTES
    Tomas Ganz; Fiscal Year: 1993
    ..In the longer term, these studies may lead to therapeutic strategies for targeting exogenous microbicidal proteins into the cytoplasmic granules of human or animal neutrophils, monocytes and macrophages...
  19. INNATE HOST DEFENSE IN THE HUMAN VAGINA
    Tomas Ganz; Fiscal Year: 2000
    ..abstract_text> ..
  20. PRODUCTION OF ANTIMICROBIAL PEPTIDES BY HUMAN NEUTROPHIL
    Tomas Ganz; Fiscal Year: 2000
    ..Thus the overall goal of the proposal is to define a recently recognized human host defense mechanism that may be important in resistance to microbial infection. ..
  21. Human Defensins in Phagocytes and Epithelia
    Tomas Ganz; Fiscal Year: 2001
    ..In the aggregate, these studies will expand our understanding of is ubiquitous and multifunctional family of human host defense peptides, this time also in their role as effectors of innate immunity in epithelia. ..
  22. INNATE HOST DEFENSE IN THE HUMAN VAGINA
    Tomas Ganz; Fiscal Year: 2001
    ..abstract_text> ..
  23. INNATE HOST DEFENSE IN THE HUMAN VAGINA
    Tomas Ganz; Fiscal Year: 2002
    ..abstract_text> ..
  24. Human Defensins in Phagocytes and Epithelia
    Tomas Ganz; Fiscal Year: 2002
    ..In the aggregate, these studies will expand our understanding of is ubiquitous and multifunctional family of human host defense peptides, this time also in their role as effectors of innate immunity in epithelia. ..
  25. INNATE HOST DEFENSE IN THE HUMAN VAGINA
    Tomas Ganz; Fiscal Year: 2003
    ..abstract_text> ..
  26. Human Defensins in Phagocytes and Epithelia
    Tomas Ganz; Fiscal Year: 2003
    ..In the aggregate, these studies will expand our understanding of is ubiquitous and multifunctional family of human host defense peptides, this time also in their role as effectors of innate immunity in epithelia. ..
  27. Hepcidin, ferroportin and iron disorders
    Tomas Ganz; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The proposed project will help understand and treat disorders of iron metabolism including hemochromatosis and thalassemias. ..