John C Gant

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Action potential throughput in aged rat hippocampal neurons: regulation by selective forms of hyperpolarization
    John C Gant
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center UKMC, MS320, Lexington, KY 40503, United States
    Neurobiol Aging 30:2053-64. 2009
  2. pmc Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons
    John C Gant
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurosci 31:1693-703. 2011
  3. pmc Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store
    Olivier Thibault
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Aging Cell 6:307-17. 2007
  4. ncbi Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release
    John C Gant
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurosci 26:3482-90. 2006
  5. pmc Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy
    John C Gant
    Departments of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY, USA
    Epilepsia 50:629-45. 2009
  6. pmc Effects of long-term pioglitazone treatment on peripheral and central markers of aging
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky, United States of America
    PLoS ONE 5:e10405. 2010
  7. pmc Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease
    Jennifer L Furman
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Neurosci 32:16129-40. 2012

Detail Information

Publications7

  1. pmc Action potential throughput in aged rat hippocampal neurons: regulation by selective forms of hyperpolarization
    John C Gant
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center UKMC, MS320, Lexington, KY 40503, United States
    Neurobiol Aging 30:2053-64. 2009
    ..Together, these results are consistent with a model in which the source of the hyperpolarization is important in determining hippocampal spike throughput within the theta frequency range...
  2. pmc Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons
    John C Gant
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurosci 31:1693-703. 2011
    ..Thus, disruption of FKBP1b recapitulated much of the Ca(2+)-dysregulation aging phenotype in young rat hippocampus, supporting a novel hypothesis that declining FKBP function plays a major role in unhealthy brain aging...
  3. pmc Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store
    Olivier Thibault
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Aging Cell 6:307-17. 2007
    ..In turn, the increased transients result in dysregulation of multiple Ca2+-dependent processes and, through somewhat different pathways, in accelerated functional decline during aging and AD...
  4. ncbi Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release
    John C Gant
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurosci 26:3482-90. 2006
    ..Thus, this study provides the first evidence that altered CICR plays a role in driving the early and simultaneous emergence in hippocampus of multiple Ca2+-related biomarkers of aging...
  5. pmc Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy
    John C Gant
    Departments of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY, USA
    Epilepsia 50:629-45. 2009
    ..To further understand the role of NPN2 signaling in central nevous system (CNS) plasticity, structural and functional alterations were assessed in NPN2 deficient mice...
  6. pmc Effects of long-term pioglitazone treatment on peripheral and central markers of aging
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky, United States of America
    PLoS ONE 5:e10405. 2010
    ..Because aging is a common risk factor for both AD and T2DM, we investigated whether the TZD, pioglitazone could alter brain aging under non-pathological conditions...
  7. pmc Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease
    Jennifer L Furman
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Neurosci 32:16129-40. 2012
    ..The results confirm a deleterious role for activated astrocytes in AD and lay the groundwork for exploration of other novel astrocyte-based therapies...