Research Topics
| David R GangSummaryAffiliation: University of Arizona Country: USA Publications
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Detail Information
Publications
Characterization of phenylpropene O-methyltransferases from sweet basil: facile change of substrate specificity and convergent evolution within a plant O-methyltransferase familyDavid R Gang
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048, USA
Plant Cell 14:505-19. 2002..This prediction was confirmed by site-directed mutagenesis, in which the appropriate mutants of CVOMT1 (F260S) and EOMT1 (S261F) were produced that exhibited the opposite substrate preference relative to the respective native enzyme...- The biochemical and molecular basis for the divergent patterns in the biosynthesis of terpenes and phenylpropenes in the peltate glands of three cultivars of basilYoko Iijima
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048, USA
Plant Physiol 136:3724-36. 2004..The relative levels of geranyl diphosphate synthase and farnesyl diphosphate synthase activities did not correlate with the total amount of terpenes produced, but showed some correlation with the ratio of monoterpenes to sesquiterpenes... 
Huperzine A from Huperzia species--an ethnopharmacolgical reviewXiaoqiang Ma
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China
J Ethnopharmacol 113:15-34. 2007..A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented...- Differential production of meta hydroxylated phenylpropanoids in sweet basil peltate glandular trichomes and leaves is controlled by the activities of specific acyltransferases and hydroxylasesDavid R Gang
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
Plant Physiol 130:1536-44. 2002..Finally, additional hydroxylase activities were identified in basil peltate glands that convert p-coumaroyl 4-hydroxyphenyllactic acid to its caffeoyl derivative and p-coumaric acid to caffeic acid... - Evolution of flavors and scentsDavid R Gang
Department of Plant Sciences and BIO5 Institute, University of Arizona, Tucson, Arizona 85721 0036, USA
Annu Rev Plant Biol 56:301-25. 2005..Examples of these processes in these gene families are found in roses, Clarkia breweri, and sweet basil, among others. Finally, evolution of volatile emission will be an exciting field of study for the foreseeable future... - Evolution of Cinnamate/p-coumarate carboxyl methyltransferases and their role in the biosynthesis of methylcinnamateJeremy Kapteyn
Department of Plant Sciences and BIO5 Institute for Collaborative Bioresearch, University of Arizona, Tucson, Arizona 85721, USA
Plant Cell 19:3212-29. 2007..Site-directed mutagenesis of specific residues confirmed these findings... 
A systems biology investigation of the MEP/terpenoid and shikimate/phenylpropanoid pathways points to multiple levels of metabolic control in sweet basil glandular trichomesZhengzhi Xie
Department of Plant Sciences and BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA
Plant J 54:349-61. 2008..Additionally, precursors for different classes of terpenoids, including mono- and sesquiterpenoids, appear to be almost exclusively supplied by the MEP pathway, and not the mevalonate pathway, in basil glandular trichomes...- Metabolic profiling of turmeric (Curcuma longa L.) plants derived from in vitro micropropagation and conventional greenhouse cultivationXiaoqiang Ma
Department of Plant Sciences and BIO5 Institute, 303 Forbes Building, The University of Arizona, Tucson, AZ 85721-0036, USA
J Agric Food Chem 54:9573-83. 2006..However, this analysis indicated that no significant differences existed between growth treatments (conventional greenhouse-grown vs in vitro propagation derived plants)... - Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol esterTakao Koeduka
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 830 North University Street, Ann Arbor, MI 48109-1048, USA
Proc Natl Acad Sci U S A 103:10128-33. 2006..The basil and petunia phenylpropene-forming enzymes belong to a structural family of NADPH-dependent reductases that also includes pinoresinol-lariciresinol reductase, isoflavone reductase, and phenylcoumaran benzylic ether reductase... - Biosynthesis of curcuminoids and gingerols in turmeric (Curcuma longa) and ginger (Zingiber officinale): identification of curcuminoid synthase and hydroxycinnamoyl-CoA thioesterasesMaria del Carmen Ramirez-Ahumada
Arizona Center for Phytomedicine Research and Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721-0036, USA
Phytochemistry 67:2017-29. 2006..These activities may shunt phenylpropanoid pathway intermediates away from the production of curcuminoids and gingerols, thereby potentially playing a regulatory role in the biosynthesis of these compounds... - Characterization of geraniol synthase from the peltate glands of sweet basilYoko Iijima
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048, USA
Plant Physiol 134:370-9. 2004.... - Modules of co-regulated metabolites in turmeric (Curcuma longa) rhizome suggest the existence of biosynthetic modules in plant specialized metabolismZhengzhi Xie
Department of Plant Sciences and BIO5 Institute, 1657 E Helen Street, University of Arizona, Tucson, AZ 85721, USA
J Exp Bot 60:87-97. 2009..Similar conclusions about terpenoid biosynthesis could also be made. Thus, discovery and analysis of metabolite modules can be a powerful predictive tool in efforts to understand metabolism in plants... - Metabolic, genomic, and biochemical analyses of glandular trichomes from the wild tomato species Lycopersicon hirsutum identify a key enzyme in the biosynthesis of methylketonesEyal Fridman
Department of Molecular, Cellular, and Developmental Biology, University of Michigan An Arbor, Michigan 48109 1048, USA
Plant Cell 17:1252-67. 2005..Levels of MKS1 transcript, protein, and enzymatic activity were correlated with levels of methylketones and gland density in a variety of tomato accessions and in different plant organs... - Characterization and identification of diarylheptanoids in ginger (Zingiber officinale Rosc.) using high-performance liquid chromatography/electrospray ionization mass spectrometryHongliang Jiang
Department of Plant Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85721, USA
Rapid Commun Mass Spectrom 21:509-18. 2007.... - Ginger and turmeric expressed sequence tags identify signature genes for rhizome identity and development and the biosynthesis of curcuminoids, gingerols and terpenoidsHyun Jo Koo
School of Plant Sciences and BIO5 Institute, The University of Arizona, Tucson, AZ 85721, USA
BMC Plant Biol 13:27. 2013..Despite their importance, relatively little is known regarding gene expression in the rhizomes of ginger and turmeric... - Use of liquid chromatography-electrospray ionization tandem mass spectrometry to identify diarylheptanoids in turmeric (Curcuma longa L.) rhizomeHongliang Jiang
Arizona Center for Phytomedicine Research, College of Pharmacy, University of Arizona, Tucson, 85721, USA
J Chromatogr A 1111:21-31. 2006..Twelve of the identified diarylheptanoids have not been previously reported from turmeric and six of these are new compounds... - Comparative functional genomic analysis of Solanum glandular trichome typesEric T McDowell
BIO5 Institute, University of Arizona, Tucson, Arizona 85721, USA
Plant Physiol 155:524-39. 2011.... - Metabolic profiling of in vitro micropropagated and conventionally greenhouse grown ginger (Zingiber officinale)Xiaoqiang Ma
Department of Plant Sciences and BIO5 Institute, The University of Arizona, 303 Forbes Building, Tucson, 85721-0036, USA
Phytochemistry 67:2239-55. 2006..Further statistical analyses (ANOVA) confirmed these results. These findings suggest that the biochemical mechanisms used to produce the large array of compounds found in ginger are not affected by in vitro propagation... - Instrument dependence of electrospray ionization and tandem mass spectrometric fragmentation of the gingerolsHongliang Jiang
Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
Rapid Commun Mass Spectrom 20:3089-100. 2006.... - In vitro production of huperzine A, a promising drug candidate for Alzheimer's diseaseXiaoqiang Ma
Department of Plant Sciences and BIO5 Institute, The University of Arizona, Thomas W Keating Bioresearch Building, Tucson, AZ 85721, USA
Phytochemistry 69:2022-8. 2008..The in vitro propagated tissues produce even higher levels of HupA than the natural plant, and may represent an excellent source for HupA... - A survey of potential huperzine A natural resources in China: the HuperziaceaeXiaoqiang Ma
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China
J Ethnopharmacol 104:54-67. 2006.... - Is there a better source of huperzine A than Huperzia serrata? Huperzine A content of Huperziaceae species in ChinaXiaoqiang Ma
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People s Republic of China
J Agric Food Chem 53:1393-8. 2005..Finally, HupA content varied significantly by season, with the highest levels being found in mid fall and the lowest levels in early spring, suggesting that HupA is turned over in the plant... - Analysis of curcuminoids by positive and negative electrospray ionization and tandem mass spectrometryHongliang Jiang
Arizona Center for Phytomedicine Research, University of Arizona, Tucson 85721-0036, USA
Rapid Commun Mass Spectrom 20:1001-12. 2006..Major and diagnostic fragment ions were identified and their origins are proposed... - Characterization of gingerol-related compounds in ginger rhizome (Zingiber officinale Rosc.) by high-performance liquid chromatography/electrospray ionization mass spectrometryHongliang Jiang
Arizona Center for Phytomedicine Research, University of Arizona, Tucson, AZ 85721-0036, USA
Rapid Commun Mass Spectrom 19:2957-64. 2005..This study demonstrated that LC/ESI-MS/MS is a powerful on-line tool for identification of gingerol-related compounds, especially for thermally labile compounds that cannot be readily detected by GC/MS analysis... - Incorporation of non-natural nucleotides into template-switching oligonucleotides reduces background and improves cDNA synthesis from very small RNA samplesJeremy Kapteyn
School of Plant Sciences and BIO5 Institute, The University of Arizona, 1657 E Helen Street, Tucson, AZ 85721, USA
BMC Genomics 11:413. 2010..However, when applied to very small RNA samples, such as those obtained from tens or hundreds of cells, this approach leads to high background and low cDNA yield due to concatamerization of the TS oligo... - Suites of terpene synthases explain differential terpenoid production in ginger and turmeric tissuesHyun Jo Koo
Department of Plant Sciences and BIO5 Institute, The University of Arizona, Tucson, Arizona, United States of America
PLoS ONE 7:e51481. 2012.... - The Lycopodium alkaloidsXiaoqiang Ma
Department of Plant Sciences and BIO5 Institute, University of Arizona, 303 Forbes Building, Tucson, AZ 85721-0036, USA
Nat Prod Rep 21:752-72. 2004..The state of HupA availability and recent advances in in vitro propagation of HupA producing plants are outlined. Finally, hypotheses about Lycopodium alkaloid biosynthetic pathways are discussed... - Metabolic profiling and phylogenetic analysis of medicinal Zingiber species: Tools for authentication of ginger (Zingiber officinale Rosc)Hongliang Jiang
Arizona Center for Phytomedicine Research, College of Pharmacy, University of Arizona, USA
Phytochemistry 67:1673-85. 2006..Therefore, identification and quantification of the actual bioactive compounds are required to guarantee the bioactivity of a particular Zingiber sample even after performing authentication by molecular and/or chemical markers... - Chavicol formation in sweet basil (Ocimum basilicum): cleavage of an esterified C9 hydroxyl group with NAD(P)H-dependent reductionDaniel G Vassão
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
Org Biomol Chem 4:2733-44. 2006..The latter was shown to be the case using p-coumaryl esters as potential substrates for a NAD(P)H-dependent reductase to afford chavicol, which is then O-methylated to afford methylchavicol...