Affiliation: University of Wisconsin
Katzenberger R, Ganetzky B, Wassarman D. Age and Diet Affect Genetically Separable Secondary Injuries that Cause Acute Mortality Following Traumatic Brain Injury in Drosophila. G3 (Bethesda). 2016;6:4151-4166 pubmed publisher
..Our results indicate that the complexity of TBI outcomes is due in part to distinct, genetically controlled, age- and diet-regulated mechanisms that promote secondary injuries and that involve a subset of innate immune response genes. ..
Babcock D, Ganetzky B. Transcellular spreading of huntingtin aggregates in the Drosophila brain. Proc Natl Acad Sci U S A. 2015;112:E5427-33 pubmed publisher
..Finally we show that the release of aggregates requires N-ethylmalemide-sensitive fusion protein 1, demonstrating that active release and uptake of Htt aggregates are important elements of spreading and disease progression. ..
Ganetzky B, Wu C. Remembering Obaid Siddiqi, a pioneer in the study of temperature-sensitive paralytic mutants in Drosophila. J Biosci. 2014;39:547-53 pubmed
..We acknowledge our debt to Obaid Siddiqi and remember him fondly as an inspired and inspiring scientist, mentor, role model and human being. ..
Loewen C, Ganetzky B. Mito-Nuclear Interactions Affecting Lifespan and Neurodegeneration in a Drosophila Model of Leigh Syndrome. Genetics. 2018;208:1535-1552 pubmed publisher
..Thus, our work provides an in vivo demonstration of the phenotypic importance of mito-nuclear interactions in the context of mitochondrial disease. ..
Babcock D, Ganetzky B. An improved method for accurate and rapid measurement of flight performance in Drosophila. J Vis Exp. 2014;:e51223 pubmed publisher
..These improvements allow for the rapid, quantitative assessment of flight behavior, useful for large datasets and large-scale genetic screens. ..
Sudmeier L, Howard S, Ganetzky B. A Drosophila model to investigate the neurotoxic side effects of radiation exposure. Dis Model Mech. 2015;8:669-77 pubmed publisher
..This work demonstrates the usefulness of Drosophila to model the toxic effects of radiation during development, and has the potential to unravel underlying mechanisms and to facilitate the discovery of novel therapeutic interventions. ..
Sudmeier L, Samudrala S, Howard S, Ganetzky B. Persistent Activation of the Innate Immune Response in Adult Drosophila Following Radiation Exposure During Larval Development. G3 (Bethesda). 2015;5:2299-306 pubmed publisher
..These studies may facilitate the development of strategies to reduce the deleterious side effects of CRT. ..