DON E GANEM

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Virology. The X files--one step closer to closure
    D Ganem
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology, University of California, San Francisco, CA 94143, USA
    Science 294:2299-300. 2001
  2. pmc Experimental induction of proventricular dilatation disease in cockatiels (Nymphicus hollandicus) inoculated with brain homogenates containing avian bornavirus 4
    Ady Y Gancz
    The Exotic Clinic, Herzlyia, Israel
    Virol J 6:100. 2009
  3. pmc Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: identification of a candidate etiologic agent
    Amy L Kistler
    Departments of Biochemistry, Microbiology and Medicine, Howard Hughes Medical Institute, University of California, San Francisco, 94143, USA
    Virol J 5:88. 2008
  4. pmc The complete genome of klassevirus - a novel picornavirus in pediatric stool
    Alexander L Greninger
    Howard Hughes Medical Institute, Departments of Medicine, Biochemistry, and Microbiology, University of California, San Francisco, California 94143, USA
    Virol J 6:82. 2009
  5. pmc KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine
    Don Ganem
    Department of Medicine and Microbiology, University of California, 513 Parnassus Ave, San Francisco, CA 91413, USA
    J Clin Invest 120:939-49. 2010
  6. ncbi request reprint KSHV infection and the pathogenesis of Kaposi's sarcoma
    Don Ganem
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    Annu Rev Pathol 1:273-96. 2006
  7. pmc Cultivation and serological characterization of a human Theiler's-like cardiovirus associated with diarrheal disease
    C Y Chiu
    Department of Laboratory Medicine, University of California, San Francisco, 185 Berry Street, Box 0134, San Francisco, CA 94143 0134, USA
    J Virol 84:4407-14. 2010
  8. pmc DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promoters
    D M Lukac
    Howard Hughes Medical Institute and Department of Microbiology, University of California Medical Center, San Francisco, California 94143-0414, USA
    J Virol 75:6786-99. 2001
  9. pmc Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma
    W Zhong
    Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 93:6641-6. 1996
  10. ncbi request reprint A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution
    R Brazas
    Department of Microbiology, University of California, San Francisco, CA 94143, USA
    Science 274:90-4. 1996

Collaborators

  • Haiyan Wang
  • Laurence Huang
  • De Sheng Wang
  • W Zhong
  • D O Morgan
  • A L Burlingame
  • Alexander L Greninger
  • Joseph L Derisi
  • Amy L Kistler
  • D M Lukac
  • C Y Chiu
  • A Grundhoff
  • Ady Y Gancz
  • Sara Mechani
  • Avishai Lublin
  • Yigal Farnoushi
  • Susan Clubb
  • Charles Y Chiu
  • C S Sullivan
  • R Renne
  • R Brazas
  • A G Polson
  • Y T Liu
  • M Lagunoff
  • J Parsonnet
  • E Delwart
  • E C Chen
  • A L Greninger
  • J L DeRisi
  • T D Haggerty
  • Shmuel Perl
  • Asaf Berkowitz
  • Thomas Haggerty
  • Noa Perez
  • Julie Parsonnet
  • Charles Runckel
  • Alexander Greninger
  • Peter Skewes-Cox
  • Ady Gancz
  • Christopher C Wen
  • Scott B Karlene
  • Katherine Sorber
  • Kael Fischer
  • R Treisman
  • J M Pipas
  • S Tevethia
  • R C Desrosiers
  • K Schmidt
  • D Dittmer
  • D Kedes
  • P A Luciw
  • D Palmeri
  • L Garibyan
  • J R Kirshner
  • J D Blethrow
  • J N Engel

Detail Information

Publications18

  1. ncbi request reprint Virology. The X files--one step closer to closure
    D Ganem
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology, University of California, San Francisco, CA 94143, USA
    Science 294:2299-300. 2001
    ..As Ganem reveals in his Perspective, new findings (Bouchard et al.) show that this versatile viral protein is an activator of calcium-dependent Ras signaling, an observation that may explain many of its biological effects...
  2. pmc Experimental induction of proventricular dilatation disease in cockatiels (Nymphicus hollandicus) inoculated with brain homogenates containing avian bornavirus 4
    Ady Y Gancz
    The Exotic Clinic, Herzlyia, Israel
    Virol J 6:100. 2009
    ..However, it remains unclear whether ABV infection actually causes PDD. To address this question, we examined the impact of ABV inoculation on the cockatiel (Nymphicus hollandicus)...
  3. pmc Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: identification of a candidate etiologic agent
    Amy L Kistler
    Departments of Biochemistry, Microbiology and Medicine, Howard Hughes Medical Institute, University of California, San Francisco, 94143, USA
    Virol J 5:88. 2008
    ..For almost 40 years, a viral etiology for PDD has been suspected, but to date no candidate etiologic agent has been reproducibly linked to the disease...
  4. pmc The complete genome of klassevirus - a novel picornavirus in pediatric stool
    Alexander L Greninger
    Howard Hughes Medical Institute, Departments of Medicine, Biochemistry, and Microbiology, University of California, San Francisco, California 94143, USA
    Virol J 6:82. 2009
    ..Modern technologies, especially deep sequencing, allow rapid, high-throughput screening of clinical samples such as stool for new infectious agents associated with human disease...
  5. pmc KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine
    Don Ganem
    Department of Medicine and Microbiology, University of California, 513 Parnassus Ave, San Francisco, CA 91413, USA
    J Clin Invest 120:939-49. 2010
    ....
  6. ncbi request reprint KSHV infection and the pathogenesis of Kaposi's sarcoma
    Don Ganem
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    Annu Rev Pathol 1:273-96. 2006
    ..The studies also highlight mechanistic differences between oncogenesis caused by KSHV and that caused by its distant relative Epstein-Barr virus...
  7. pmc Cultivation and serological characterization of a human Theiler's-like cardiovirus associated with diarrheal disease
    C Y Chiu
    Department of Laboratory Medicine, University of California, San Francisco, 185 Berry Street, Box 0134, San Francisco, CA 94143 0134, USA
    J Virol 84:4407-14. 2010
    ..We also demonstrate an acute cardiovirus seroconversion event in a child with diarrhea and vomiting, thus reporting for the first time evidence linking cardiovirus infection to diarrheal disease in humans...
  8. pmc DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promoters
    D M Lukac
    Howard Hughes Medical Institute and Department of Microbiology, University of California Medical Center, San Francisco, California 94143-0414, USA
    J Virol 75:6786-99. 2001
    ..Expression of truncated versions of the ORF50 protein reveals that DNA binding is mediated by the amino-terminal 272 amino acids of the polypeptide...
  9. pmc Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma
    W Zhong
    Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 93:6641-6. 1996
    ..These findings have implications for the therapeutic utility of currently available antiviral drugs targeted against the lytic replication cycle...
  10. ncbi request reprint A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution
    R Brazas
    Department of Microbiology, University of California, San Francisco, CA 94143, USA
    Science 274:90-4. 1996
    ..These observations demonstrate that a host gene product can modulate HDV replication and suggest that HDV may have evolved from a primitive viroidlike RNA through capture of a cellular transcript...
  11. pmc Immunoreceptor tyrosine-based activation motif-dependent signaling by Kaposi's sarcoma-associated herpesvirus K1 protein: effects on lytic viral replication
    M Lagunoff
    Howard Hughes Medical Institute, Departments of Microbiology and Immunology and Medicine, University of California Medical Center, San Francisco, CA 94143-0414, USA
    J Virol 75:5891-8. 2001
    ..We conclude that ITAM-dependent signaling by K1 is not absolutely required for lytic reactivation but functions to modestly augment lytic replication in B cells, the natural reservoir of KSHV...
  12. pmc Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus
    A Grundhoff
    Howard Hughes Medical Institute, Department of Microbiology, University of California Medical Center, San Francisco, California 94143-0414, USA
    J Virol 75:1857-63. 2001
    ..Thus, two potential mechanisms exist for v-FLIP expression, but the evidence suggests that IRES-mediated internal translational initiation on latent polycistronic mRNAs is the principal source of v-FLIP in latency...
  13. pmc Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases
    A G Polson
    Departments of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143, USA
    J Virol 75:3175-84. 2001
    ..These studies indicate that K-bZIP is a substrate for CDKs and should inform further functional analyses of the protein...
  14. ncbi request reprint Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SIV-positive and SIV-negative rhesus macaques
    R Renne
    Departments of Medicine and Microbiology, Division of Hematology and Oncology, Case Western Reserve University, 10900 Euclid Avenue, BRB3 West, Cleveland, OH 44106 4937, USA
    J Med Primatol 33:1-9. 2004
    ..g. KS or lympho-proliferative disease). Hence, although KSHV replicates in rhesus macaques at very low levels, this non-human primate host is unlikely to provide a useful animal model for disease...
  15. pmc Deleterious effects of hepatitis delta virus replication on host cell proliferation
    D Wang
    Departments of Microbiology and Medicine and Howard Hughes Medical Institute, University of California Medical Center, San Francisco, California 94143, USA
    J Virol 75:3600-4. 2001
    ..This effect would not be expected to cause hepatitis in vivo but might contribute to impaired liver regeneration in the setting of ongoing hepatocellular injury...
  16. pmc Efficient hepatitis delta virus RNA replication in avian cells requires a permissive factor(s) from mammalian cells
    Y T Liu
    Howard Hughes Medical Institute and Departments of Microbiology and Immunology and Medicine, University of California Medical Center, San Francisco, California 94143-0414, USA
    J Virol 75:7489-93. 2001
    ..These results set the stage for the identification of such factors and also explain the failure of earlier efforts to transmit HDV infection to avian hosts harboring indigenous hepadnaviruses...
  17. ncbi request reprint Expression and function of microRNAs in viruses great and small
    C S Sullivan
    Howard Hughes Medical Institute, Department of Microbiology, University of California, San Francisco, California 94143, USA
    Cold Spring Harb Symp Quant Biol 71:351-6. 2006
    ..Here we review our computational and array-based approaches for viral miRNA discovery, and we discuss the structure and function of miRNAs identified by these approaches in polyomaviruses and herpesviruses...
  18. pmc A polymerase chain reaction-based approach to cloning sigma factors from eubacteria and its application to the isolation of a sigma-70 homolog from Chlamydia trachomatis
    J N Engel
    Department of Microbiology and Immunology, University of California, San Francisco 94143
    J Bacteriol 172:2447-55. 1990
    ..trachomatis. This PCR-based approach will be broadly applicable to the cloning of major sigma factors from other eubacteria...