Research Topics
Genomes and Genes
Species | Marilie D GammonSummaryAffiliation: University of North Carolina Country: USA Publications
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Detail Information
Publications
The use of complete-case and multiple imputation-based analyses in molecular epidemiology studies that assess interaction effectsManisha Desai
Department of Medicine, Division of General Medical Disciplines, Stanford University, Palo Alto, CA, 94304, USA
Epidemiol Perspect Innov 8:5. 2011..abstract:..
Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer riskJing Shen
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 630 West 168th Street, New York, New York 10032, USA
Breast Cancer Res 8:R71. 2006..926, COX-2 .5209, and COX-2 .8473) may reduce overall breast cancer risk or risk for subtypes of breast cancer by modulating the inflammatory response and may interact with aspirin or any NSAID use...
Environmental tobacco smoke and breast cancer incidenceMarilie D Gammon
Department of Epidemiology, School of Public Health, University of North Carolina, CB 7435 McGavern Greenberg Hall, Chapel Hill, NC 27599 7435, USA
Environ Res 96:176-85. 2004..42 for ER+ PR+, 95% CI, 1.00, 2.00). Our data suggest that if there is an effect for ETS on breast cancer, that effect is restricted to selected subgroups of women, such as those with long-term exposure from a smoking spouse...
Nonsteroidal anti-inflammatory drug use associated with reduced incidence of adenocarcinomas of the esophagus and gastric cardia that overexpress cyclin D1: a population-based studyMarilie D Gammon
University of North Carolina, School of Public Health, Department of Epidemiology, Chapel Hill, North Carolina, USA
Cancer Epidemiol Biomarkers Prev 13:34-9. 2004..These data suggest that the reduction in risk associated with NSAID use may be restricted to those esophageal and gastric cardia adenocarcinomas that overexpress cyclin D1...
Polycyclic aromatic hydrocarbon-DNA adducts and breast cancer: a pooled analysisMarilie D Gammon
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Arch Environ Health 59:640-9. 2004..These data provide only modest support for an association between PAH-DNA adducts and breast cancer development...
PAH, genetic susceptibility and breast cancer risk: an update from the Long Island Breast Cancer Study ProjectMarilie D Gammon
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Eur J Cancer 44:636-40. 2008
Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomasMary Beth Terry
Mailman School of Public Health, Department of Epidemiology, Columbia University, 722 West 168th Street, Room 724A, New York, NY 10032, USA
Cancer Causes Control 18:1039-46. 2007..The alcohol dehydrogenase gene has several polymorphisms which may lead to faster conversion of ethanol to acetaldehyde, which may increase cancer risk...
Polymorphism in the DNA repair gene XPD, polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, and breast cancer riskMary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, PH 18 102, 600 West 168th Street, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 13:2053-8. 2004..Overall, this study suggests that those individuals with this polymorphism in the XPD gene may face an increased risk of breast cancer from PAH-DNA adducts and cigarette smoking...
Active and passive cigarette smoke and breast cancer survivalSharon K Sagiv
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Ann Epidemiol 17:385-93. 2007..The association between active and passive cigarette smoking before breast cancer diagnosis and survival was investigated among a cohort of invasive breast cancer cases (n = 1273) participating in a population-based case-control study...
General and abdominal obesity and survival among young women with breast cancerPage E Abrahamson
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Cancer Epidemiol Biomarkers Prev 15:1871-7. 2006..22; 95% CI, 1.45-3.40). This study provides evidence that breast cancer survival is reduced among younger women with general or abdominal obesity...
Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survivalRebecca J Cleveland
Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7461, USA
Breast Cancer Res Treat 120:745-52. 2010..In summary, our results show that a common variant in LEP may be associated with the risk of developing breast cancer supporting the hypothesis that leptin is involved in breast carcinogenesis...
Dietary flavonoid intake and breast cancer survival among women on Long IslandBrian N Fink
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
Cancer Epidemiol Biomarkers Prev 16:2285-92. 2007..However, the effects of flavonoids on survival are not known. In a population-based cohort of breast cancer patients, we investigated whether dietary flavonoid intake before diagnosis is associated with subsequent survival...
Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer riskKatherine D Crew
Department of Epidemiology, Mailman School of Public Health, Columbia University, 161 Fort Washington Avenue, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 16:2033-41. 2007..Overall, this study suggests that the risk of breast cancer may be elevated among women with polymorphisms in NER pathway genes and detectable PAH-DNA adducts...
Associations between breast cancer risk and the catalase genotype, fruit and vegetable consumption, and supplement useJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Am J Epidemiol 162:943-52. 2005..CC genotypes were prevalent in approximately 64% of controls; thus, the preventive potential for fruit consumption has widespread implications...
Polycyclic aromatic hydrocarbon-DNA adducts and survival among women with breast cancerSharon K Sagiv
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Environ Res 109:287-91. 2009..Results from this large population-based study do not provide strong support for an association between detectable PAH-DNA adducts and survival among women with breast cancer, except perhaps among those receiving radiation treatment...
MnSOD Val-9Ala genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New YorkMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, CB 7435, Chapel Hill, NC 27599 7435, USA
Cancer Causes Control 16:1225-34. 2005..This study provides little evidence that variation in Val-9Ala polymorphism of MnSOD alone or through substantial interaction with key exposures believed to be pro- or anti-oxidant properties influences breast cancer risk...
Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New YorkMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Breast Cancer Res Treat 108:93-9. 2008..p53 participates in cell cycle control, programmed cell death/apoptosis, and DNA repair, all pathways involved in carcinogenesis. TP53 variants may influence p53 function...
Weight gain prior to diagnosis and survival from breast cancerRebecca J Cleveland
Department of Epidemiology, University of North Carolina, CB 7435 McGavran Greenberg Hall, Chapel Hill, NC 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 16:1803-11. 2007....
Fat or fit: the joint effects of physical activity, weight gain, and body size on breast cancer riskLauren E McCullough
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
Cancer 118:4860-8. 2012..These include the minimum duration and intensity necessary for risk reduction and the optimal time period for occurrence, as well as subgroup effects, particularly with regard to tumor heterogeneity and body size...
IGF1 CA repeat polymorphisms, lifestyle factors and breast cancer risk in the Long Island Breast Cancer Study ProjectRebecca J Cleveland
Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Carcinogenesis 27:758-65. 2006..Our results demonstrate a role for alleles with fewer than (CA)19 repeats as a risk factor for breast cancer and also suggest that several traditional breast cancer risk factors modify the association of the IGF1 (CA)19 repeat genotype...
PAH-DNA adducts, cigarette smoking, GST polymorphisms, and breast cancer riskKathleen M McCarty
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Environ Health Perspect 117:552-8. 2009..Few breast cancer studies have investigated the joint effects of multiple GSTs and a PAH biomarker...
Residential environmental exposures and other characteristics associated with detectable PAH-DNA adducts in peripheral mononuclear cells in a population-based sample of adult femalesSumitra Shantakumar
Department of Epidemiology, CB 7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
J Expo Anal Environ Epidemiol 15:482-90. 2005..These data suggest that PAH-DNA adducts detected in a population-based sample of adult women with ambient exposure levels reflect some key residential PAH exposure sources assessed in this study, such as cigarette smoking...
Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adductsMarilie D Gammon
Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 11:677-85. 2002..These data indicate that PAH-DNA adduct formation may influence breast cancer development, although the association does not appear to be dose dependent and may have a threshold effect...
Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer riskJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Carcinogenesis 27:1876-82. 2006..These data indicate that GSTA1 genotypes related to reduced GSTA1 expression are associated with increased breast cancer primarily among women with lower consumption of cruciferous vegetables and among current smokers...
The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancerMarilie D Gammon
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
Breast Cancer Res Treat 74:235-54. 2002....
Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor statusMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 13:1485-94. 2004..Our results support an inverse association for fruit and vegetable intake among postmenopausal but not premenopausal breast cancer, which may be more pronounced among women with ER+ tumors...
The association of diabetes with breast cancer incidence and mortality in the Long Island Breast Cancer Study ProjectRebecca J Cleveland
Department of Medicine, University of North Carolina, Chapel Hill, 27599 7280, USA
Cancer Causes Control 23:1193-203. 2012..Importantly, prior investigations have rarely considered the influence of factors associated with diabetes such as obesity, age at diabetes diagnosis, duration of diabetes, or diabetes treatments...
Cooked meat and risk of breast cancer--lifetime versus recent dietary intakeSusan E Steck
Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Epidemiology 18:373-82. 2007..Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HCAs) are carcinogens formed in or on the surface of well-done meat, cooked at high temperature...
A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer riskKathryn E Talbott
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA
Breast Cancer Res Treat 111:481-7. 2008..The finding supports the potential role of variation in estrogen biosynthesis genes in premenopausal breast cancer risk...
ADIPOQ, ADIPOR1, and ADIPOR2 polymorphisms in relation to serum adiponectin levels and BMI in black and white womenSarah S Cohen
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
Obesity (Silver Spring) 19:2053-62. 2011....
Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypesSarah J Nyante
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
Breast Cancer Res Treat 129:593-606. 2011..Replication in additional studies where breast cancer subtypes have been defined is necessary to confirm these potential associations...
Postdiagnosis change in bodyweight and survival after breast cancer diagnosisPatrick T Bradshaw
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7535, USA
Epidemiology 23:320-7. 2012..Weight gain after diagnosis is common among women with breast cancer, yet results have been inconsistent among the few studies examining its effects on survival...
Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer riskJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
Cancer Res 64:7634-9. 2004....
Dietary flavonoid intake and breast cancer risk among women on Long IslandBrian N Fink
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Am J Epidemiol 165:514-23. 2007..These results suggest that US women can consume sufficient levels of flavonoids to benefit from their potential chemopreventive effects...
Reproductive factors and breast cancer risk among older womenSumitra Shantakumar
Department of Epidemiology, CB 7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, NC 27599 7435, USA
Breast Cancer Res Treat 102:365-74. 2007..Moreover, breastfeeding, one of the few potentially modifiable risk factors for breast cancer, was an important factor in decreasing risk among older parous postmenopausal women...
Association between reproductive factors and breast cancer survival in younger womenKatrina F Trivers
Department of Epidemiology, University of North Carolina at Chapel Hill, CB 7435, Chapel Hill, NC 27599 7435, USA
Breast Cancer Res Treat 103:93-102. 2007..These results may help elucidate breast cancer progression mechanisms and enable a better understanding of how reproductive characteristics influence breast cancer survival...
ADH3 genotype, alcohol intake and breast cancer riskMary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA, and Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Carcinogenesis 27:840-7. 2006..9, 95 % CI=1.2-7.1; postmenopausal women OR=1.8, 95% CI=0.9-3.8). These population-based data support the hypothesis that fast metabolizers of alcohol have a higher risk of breast cancer risk, from alcohol intake than slow metabolizers...
Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New YorkMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hil, NC 27516, USA
Breast Cancer Res Treat 99:235-40. 2006....
Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in bloodMarilie D Gammon
Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 11:686-97. 2002..These findings, based on the largest number of samples analyzed to date among primarily white women, do not support the hypothesis that organochlorines increase breast cancer risk among Long Island women...
Antioxidant intake and pancreatic cancer risk: the Vitamins and Lifestyle (VITAL) StudyXuesong Han
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Cancer 119:1314-20. 2013..In this study, the authors examined the intake of antioxidants from diet and supplements in relation to pancreatic cancer risk among participants of the Vitamins and Lifestyle (VITAL) Study...
Influence of prediagnostic recreational physical activity on survival from breast cancerRebecca J Cleveland
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7280, USA
Eur J Cancer Prev 21:46-54. 2012..no RPA, the HR=0.61; 95% CI=0.39-0.94 and HR=1.00; 95% CI=0.65-1.54, respectively). This study provides support that RPA prior to breast cancer diagnosis improves survival...
Fruits, vegetables, and micronutrient intake in relation to breast cancer survivalBrian N Fink
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Breast Cancer Res Treat 98:199-208. 2006..To determine whether fruit, vegetable, and micronutrient intake 1 year prior to breast cancer diagnosis is associated with a reduction in the subsequent risk of all-cause or breast cancer-specific mortality...
Peroxisome proliferator-activated receptor-alpha (PPARA) genetic polymorphisms and breast cancer risk: a Long Island ancillary studyAmanda K Golembesky
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
Carcinogenesis 29:1944-9. 2008..Our results are the first to evaluate the relationship between PPARA and breast cancer incidence and suggest that replication in an independent cohort is warranted...
No association between glutathione peroxidase Pro198Leu polymorphism and breast cancer riskJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer Epidemiol Biomarkers Prev 14:2459-61. 2005
Age and menopausal effects of hormonal birth control and hormone replacement therapy in relation to breast cancer riskSumitra Shantakumar
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC, USA
Am J Epidemiol 165:1187-98. 2007..These results emphasize that timing of exogenous hormone use is important. Women who used these hormones before menopause had elevated risks, but the harmful effects began to decline with age after menopause...
Val153Met polymorphism of catechol-O-methyltransferase and prevalence of uterine leiomyomataKyna M Gooden
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Reprod Sci 14:117-20. 2007..This study suggests that variation in this polymorphism alone does not affect fibroid prevalence. Additional research is needed to examine other variations and haplotypes within the COMT gene...
Prevalence and predictors of antioxidant supplement use during breast cancer treatment: the Long Island Breast Cancer Study ProjectHeather Greenlee
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Cancer 115:3271-82. 2009..The authors of this report analyzed the prevalence of and factors associated with antioxidant supplement use during breast cancer (BC) treatment among women who participated in the Long Island Breast Cancer Study Project...
Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancersKatrina F Trivers
Department of Epidemiology, University of North Carolina at Chapel Hill, CB 7435, Chapel Hill, North Carolina 27599 7435, USA
Clin Gastroenterol Hepatol 3:225-30. 2005..Risk factors for subtypes of esophageal and gastric cancer recently have been identified, but their effect on survival is unknown...
Polymorphisms in oxidative stress genes, physical activity, and breast cancer riskLauren E McCullough
Department of Epidemiology, University of North Carolina, CB 7435, McGavran Greenberg Hall, Chapel Hill, NC 27599 7435, USA
Cancer Causes Control 23:1949-58. 2012..Given the paradoxical effects of physical activity, the oxidative stress pathway is of interest. Genetic variation in CAT or antioxidant-related polymorphisms may mediate the physical activity-breast cancer association...
Preeclampsia, pregnancy-related hypertension, and breast cancer riskMary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Am J Epidemiol 165:1007-14. 2007..These data suggest that pregnancy conditions related to hypertension, particularly preeclampsia, play a role in reducing breast cancer risk. Possible biologic mechanisms underpinning these associations should be further explored...
A Bayesian proportional hazards regression model with non-ignorably missing time-varying covariatesPatrick T Bradshaw
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Stat Med 29:3017-29. 2010..Our sensitivity analysis showed only slight differences between models with different assumptions on the missing data mechanism yet the complete-case analysis yielded markedly different results...
Consumption of sweet foods and breast cancer risk: a case-control study of women on Long Island, New YorkPatrick T Bradshaw
Department of Epidemiology, CB 7435 McGavran Greenberg Hall, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Cancer Causes Control 20:1509-15. 2009..These results are consistent with other studies that implicate insulin-related factors in breast carcinogenesis...
Body size changes in relation to postmenopausal breast cancer among women on Long Island, New YorkSybil M Eng
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10017, USA
Am J Epidemiol 162:229-37. 2005..55, 95% CI: 0.32, 0.96). These results add to the literature by focusing on the perimenopausal weight trajectory and support efforts urging women to avoid weight gain as they age...
Nutrient pathways and breast cancer risk: the Long Island Breast Cancer Study ProjectPatrick T Bradshaw
Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Nutr Cancer 65:345-54. 2013..Our study emphasizes the importance of accounting for multiple nutrient pathways when examining associations between dietary intake and breast cancer...
Oral contraceptive use and cyclin D1 overexpression in breast cancer among young womenMary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Cancer Epidemiol Biomarkers Prev 11:1100-3. 2002..2-4.0) but not for breast cancer without cyclin D1 overexpression (OR, 1.1; 95% CI, 0.7-1.8). If replicated, these findings suggest that early OC use may be associated with the subset of mammary tumors that overexpress cyclin D1...
Construction of a flavonoid database for assessing intake in a population-based sample of women on Long Island, New YorkBrian N Fink
Department of Epidemiology, School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Nutr Cancer 56:57-66. 2006..Each class of flavonoids and lignans exhibited a wide range of intake levels. This database is useful to quantify flavonoid and lignan intake for other observational studies conducted in the United States that utilize the Block FFQ...
Lifetime alcohol intake and breast cancer riskMary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Ann Epidemiol 16:230-40. 2006..Risk is confined to moderate intake and does not vary with the timing of use, with heavier doses, or with the type of alcohol consumed...
Association of frequency and duration of aspirin use and hormone receptor status with breast cancer riskMary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
JAMA 291:2433-40. 2004..67-1.40). CONCLUSION: These data add to the growing evidence that supports the regular use of aspirin and other NSAIDs (which may operate through inhibition of estrogen biosynthesis) as effective chemopreventive agents for breast cancer...
Types of fish consumed and fish preparation methods in relation to pancreatic cancer incidence: the VITAL Cohort StudyKa He
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Am J Epidemiol 177:152-60. 2013..LC-PUFAs, particularly docosahexaenoic acid, and nonfried fish, but not shellfish or fried fish, may be beneficial in the primary prevention of pancreatic cancer...
Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumorsIrina Mordukhovich
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
Environ Health Perspect 118:511-8. 2010..Objectives: We hypothesized that associations of PAH-related exposures with breast cancer would differ according to tumor p53 mutation status, effect, type, and number...
Recreational physical activity and survival among young women with breast cancerPage E Abrahamson
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
Cancer 107:1777-85. 2006..Most epidemiologic studies report a reduced risk of developing breast cancer associated with higher levels of recreational physical activity, but little is known regarding its effect on prognosis...
Dichlorodiphenyldichloroethane and polychlorinated biphenyls: intraindividual changes, correlations, and predictors in healthy women from the southeastern United StatesThao T Vo
Department of Epidemiology, School of Public Health, University of North Carolina in Chapel Hill, Chapel Hill, North Carolina, USA
Cancer Epidemiol Biomarkers Prev 17:2729-36. 2008....
Serum adiponectin in relation to body mass index and other correlates in black and white womenSarah S Cohen
Department of Epidemiology, University of North Carolina, Chapel Hill, USA
Ann Epidemiol 21:86-94. 2011..Adiponectin is a promising biomarker linking obesity and disease risk; however, limited data are available regarding adiponectin in black women among whom obesity is highly prevalent...
Exposure to fogger trucks and breast cancer incidence in the Long Island Breast Cancer Study Project: a case-control studyAlexandra J White
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
Environ Health 12:24. 2013..Self-reported acute exposure to a fogger truck, which sprayed DDT prior to 1972, was hypothesized to increase the risk of breast cancer, particularly among women exposed at a young age or diagnosed with ER+PR+ breast cancer...
Obesity before age 30 years and risk of advanced prostate cancerWhitney R Robinson
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Am J Epidemiol 161:1107-14. 2005....
The epidemiology of gastric cancerMary Beth Terry
Columbia University Mailman School of Public Health, Department of Epidemiology, New York, NY 10032, USA
Semin Radiat Oncol 12:111-27. 2002..Future epidemiologic studies that include information on site of origin as well as molecular markers promise to yield more homogeneous classification of case groups, which will enhance identification of underlying disease processes...
The association between oral contraceptive use and lobular and ductal breast cancer in young womenSarah J Nyante
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Int J Cancer 122:936-41. 2008..These results are similar to previous studies that report little difference in the effect of oral contraceptive use on breast cancer by histology...
Airborne emissions from 1961 to 2004 of benzo[a]pyrene from U.S. vehicles per km of travel based on tunnel studiesJan Beyea
Consulting in the Public Interest CIPI, Lambertville, New Jersey, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Environ Sci Technol 42:7315-20. 2008....
Perceptions of participation in an observational epidemiologic study of cancer among African AmericansKyna M Gooden
Department of Epidemiology, University of North Carolina at Chapel Hill, 2101 McGavran-Greenberg Hall, CB#7435, Chapel Hill, NC 26599, USA
Ethn Dis 15:68-75. 2005..However, culturally appropriate efforts to thoroughly inform them of study process and progress are deemed essential for successful recruitment and retention...
Genetic polymorphisms in the apoptosis-associated genes FAS and FASL and breast cancer riskKatherine D Crew
Department of Medicine and the Herbert Irving Comprehensive Cancer Center, Columbia University, 161 Fort Washington Avenue, 10 1072, New York, NY 10032, USA
Carcinogenesis 28:2548-51. 2007..Overall, this study suggests that the risk of breast cancer may be elevated among women with polymorphisms in the FAS gene and detectable PAH-DNA adducts...
MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer riskJing Shen
Department of Environmental Health Sciences, Columbia University, New York, NY 10032, USA
Carcinogenesis 26:2131-7. 2005....
Reported residential pesticide use and breast cancer risk on Long Island, New YorkSusan L Teitelbaum
Department of Community Medicine, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
Am J Epidemiol 165:643-51. 2007..This study is the first known to suggest that self-reported use of residential pesticides may increase breast cancer risk. Further investigation in other populations is necessary to confirm these findings...
Population attributable risks of esophageal and gastric cancersLawrence S Engel
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
J Natl Cancer Inst 95:1404-13. 2003..Herein, we estimate the population attributable risks (PARs) for various risk factors observed in a multicenter population-based case-control study...
One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancerJia Chen
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA
Cancer Res 65:1606-14. 2005..96) or total folate intake (OR, 1.71; 95% CI, 1.08-2.71). From a public heath perspective, it is important to identify risk factors, such as low B vitamin consumption, that may guide an effective prevention strategy against the disease...
Polymorphisms in XRCC1 modify the association between polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, dietary antioxidants, and breast cancer riskJing Shen
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 14:336-42. 2005..Further understanding of the biological function of XRCC1 variants and their interactions with PAH-DNA adducts, antioxidants, and other genes in the pathway are needed...
Wire coding in the EMF and Breast Cancer on Long Island Study: relationship to magnetic fieldsErin S O'Leary
Department of Preventive Medicine, School of Medicine, Stony Brook University, Stony Brook, New York 11794 8036, USA
J Expo Anal Environ Epidemiol 13:283-93. 2003..Results also suggest that wire codes are a proxy measure, to some degree, for current in-home magnetic field measurements in this study...
Breast cancers among very young premenopausal women (United States)Michelle D Althuis
National Cancer Institute, Rockville, MD, USA
Cancer Causes Control 14:151-60. 2003..To assess risk factors for breast cancer among very young compared to older premenopausal women...
Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphismsEmad M El-Omar
Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Scotland
Gastroenterology 124:1193-201. 2003..The aim of this study was to evaluate the role of proinflammatory cytokine gene polymorphisms in gastric and esophageal cancers defined by anatomic subsite...
Increased risk of early-stage breast cancer related to consumption of sweet foods among women less than age 45 in the United StatesNancy Potischman
Division of Cancer Control and Population Studies, Centers for Disease Conztrol annd Prevention, Atlanta, GA, USA
Cancer Causes Control 13:937-46. 2002..To evaluate the associations of dietary macronutrients, food groups, and eating patterns with risk of breast cancer in a population-based case-control study...
Risk of breast cancer classified by joint estrogen receptor and progesterone receptor status among women 20-44 years of ageJulie A Britton
Division of Environmental Health Science, Mount Sinai School of Medicine, New York, NY 10029, USA
Am J Epidemiol 156:507-16. 2002..These findings only modestly support the hypothesis that hormonally related risk factors have differing relations with ER+PR+ versus ER-PR- tumors among younger women...
Improving organochlorine biomarker models for cancer researchMary S Wolff
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Cancer Epidemiol Biomarkers Prev 14:2224-36. 2005..e., PCB) or long discontinued (i.e., DDE)...
Carbonated soft drink consumption and risk of esophageal adenocarcinomaSusan T Mayne
Department of Epidemiology and Public Health, Yale University School of Medicine and Cancer Center, New Haven, CT 06520 8034, USA
J Natl Cancer Inst 98:72-5. 2006..These findings indicate that CSD consumption (especially diet CSD) is inversely associated with risk of esophageal adenocarcinoma, and thus it is not likely to have contributed to the rising incidence rates...
GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomasLouise Wideroff
Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, EPN 4005, 6130 Executive Boulevard, MSC 7344, Bethesda, MD 20892 7344, USA
Cancer Detect Prev 31:233-6. 2007..In a population-based case-control study, we examined risks in relation to polymorphisms of the following genes: GSTP1; GSTM1; GSTT1; NAT1; and CYP1A1...
Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic studyLesley M Butler
University of California Davis, Department of Public Health Sciences, Division of Epidemiology, Davis, CA 95616, USA
Mutat Res 638:162-74. 2008....
Xeroderma pigmentosum complementation group C genotypes/diplotypes play no independent or interaction role with polycyclic aromatic hydrocarbons-DNA adducts for breast cancer riskJing Shen
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 630 West 168th Street, P and S 19 418, New York, NY 10032, USA
Eur J Cancer 44:710-7. 2008..69). These data suggest that XPCs have neither independent effects nor interactions with cigarette smoking and PAH-DNA adducts for breast cancer risk. Further studies with multiple genetic polymorphisms in NER pathway are warranted...
Choline metabolism and risk of breast cancer in a population-based studyXinran Xu
Department of Community and Preventive Medicine, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
FASEB J 22:2045-52. 2008..We observed a significant interaction between dietary betaine intake and the PEMT rs7926 polymorphism (P(interaction)=0.04). Our findings suggest that choline metabolism may play an important role in breast cancer etiology...
Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study ProjectYu Chen
Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
Carcinogenesis 29:766-71. 2008..In conclusion, the findings suggest that the CYP17 variant C allele may increase breast cancer risk in conjunction with long-term HRT use and high BMI in postmenopausal women...
OGG1 polymorphisms and breast cancer riskPavel Rossner
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
Cancer Epidemiol Biomarkers Prev 15:811-5. 2006..In addition, data on functionality of these polymorphisms are crucial to understand if these modest differences are important...
A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin usersXinran Xu
Departments of Community and Preventive Medicine and Epidemiology and Medicine, Columbia University, New York, NY, USA
Am J Clin Nutr 85:1098-102. 2007..Folic acid from multivitamins needs to be reduced by DHFR before it participates in cellular reactions...
Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based studyXinran Xu
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Carcinogenesis 28:1504-9. 2007..Although the pathway is a network of interrelated enzymes, redundancy exists; evaluating the rate-limiting enzyme and its interaction with environment and other genes within the same pathway is critical in assessing breast cancer risk...
A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursorsGeorgina L Hold
Department of Medicine and Therapeutics, Aberdeen University, Aberdeen, Scotland
Gastroenterology 132:905-12. 2007..The TLR4+896A>G polymorphism linked with impaired reactivity to bacterial lipopolysaccharide may play a role in gastric carcinogenesis...
Validation and calibration of a model used to reconstruct historical exposure to polycyclic aromatic hydrocarbons for use in epidemiologic studiesJan Beyea
Consulting in the Public Interest, Lambertville, New Jersey, USA
Environ Health Perspect 114:1053-8. 2006..Here we report the results of four exercises to validate and calibrate the model...
Shift work, light at night, and breast cancer on Long Island, New YorkErin S O'Leary
Department of Preventive Medicine, School of Medicine, Stony Brook University, Stony Brook, NY 11794 8036, USA
Am J Epidemiol 164:358-66. 2006..Furthermore, overall and evening shift work were not significant factors, and analyses of overnight shift workers yielded reduced risk estimates. The study thus provides mixed evidence for the light-at-night hypothesis...
IGHMBP2 Thr671Ala polymorphism might be a modifier for the effects of cigarette smoking and PAH-DNA adducts to breast cancer riskJing Shen
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
Breast Cancer Res Treat 99:1-7. 2006..Additional studies focused on the biological function of the variant-G allele and interactions with other genetic polymorphisms are necessary to confirm our findings...
Occupation and risk of esophageal and gastric cardia adenocarcinomaLawrence S Engel
Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Ind Med 42:11-22. 2002..Adenocarcinomas of the esophagus and gastric cardia have risen dramatically in incidence over the past few decades, however, little research has been conducted on the occupational risk factors for these cancers...
