David M Gamm

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi Human retinal progenitor cells grown as neurospheres demonstrate time-dependent changes in neuronal and glial cell fate potential
    David M Gamm
    Department of Opthalmology and Visual Sciences, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53705 2280, USA
    Ann N Y Acad Sci 1049:107-17. 2005
  2. pmc Protection of visual functions by human neural progenitors in a rat model of retinal disease
    David M Gamm
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 2:e338. 2007
  3. doi A novel serum-free method for culturing human prenatal retinal pigment epithelial cells
    David M Gamm
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, T607 Waisman Center, Madison, WI 53705, USA
    Invest Ophthalmol Vis Sci 49:788-99. 2008
  4. pmc Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1
    David M Gamm
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53705, USA
    Stem Cells 26:3182-93. 2008
  5. pmc Functional analysis of serially expanded human iPS cell-derived RPE cultures
    Ruchira Singh
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin
    Invest Ophthalmol Vis Sci 54:6767-78. 2013
  6. pmc Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment
    Jason S Meyer
    Waisman Center, University of Wisconsin, Madison, Wisconsin, USA
    Stem Cells 29:1206-18. 2011
  7. pmc Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses
    M Joseph Phillips
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin, USA
    Invest Ophthalmol Vis Sci 53:2007-19. 2012
  8. pmc Modeling early retinal development with human embryonic and induced pluripotent stem cells
    Jason S Meyer
    Stem Cell Research Program, Waisman Center, Departments of Anatomy and Neurology, University of Wisconsin Madison, 1500 Highland Avenue, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 106:16698-703. 2009
  9. pmc Modeling human retinal development with patient-specific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2
    M Joseph Phillips
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin, USA McPherson Eye Research Institute, University of Wisconsin Madison, Madison, Wisconsin, USA
    Stem Cells 32:1480-92. 2014
  10. pmc Induced pluripotent stem cells as custom therapeutics for retinal repair: progress and rationale
    Lynda S Wright
    Waisman Center, University of Wisconsin, Madison, WI, USA McPherson Eye Research Institute, University of Wisconsin, Madison, WI, USA
    Exp Eye Res 123:161-72. 2014

Research Grants

Collaborators

Detail Information

Publications13

  1. ncbi Human retinal progenitor cells grown as neurospheres demonstrate time-dependent changes in neuronal and glial cell fate potential
    David M Gamm
    Department of Opthalmology and Visual Sciences, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53705 2280, USA
    Ann N Y Acad Sci 1049:107-17. 2005
    ..This provides information for optimizing culture systems aimed at the study of human retinal development and the generation of specific retinal cell types for therapeutic use or drug testing...
  2. pmc Protection of visual functions by human neural progenitors in a rat model of retinal disease
    David M Gamm
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 2:e338. 2007
    ..Based on these reports, we explored the potential of hNPC transplantation to rescue visual function in an animal model of retinal degeneration, the Royal College of Surgeons rat...
  3. doi A novel serum-free method for culturing human prenatal retinal pigment epithelial cells
    David M Gamm
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, T607 Waisman Center, Madison, WI 53705, USA
    Invest Ophthalmol Vis Sci 49:788-99. 2008
    ..Therefore, this study was conducted to develop a simple, serum-free system to propagate and sustain human RPE in vitro...
  4. pmc Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1
    David M Gamm
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53705, USA
    Stem Cells 26:3182-93. 2008
    ....
  5. pmc Functional analysis of serially expanded human iPS cell-derived RPE cultures
    Ruchira Singh
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin
    Invest Ophthalmol Vis Sci 54:6767-78. 2013
    ..To determine the effects of serial expansion on the cellular, molecular, and functional properties of human iPS cell (hiPSC)-derived RPE cultures...
  6. pmc Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment
    Jason S Meyer
    Waisman Center, University of Wisconsin, Madison, Wisconsin, USA
    Stem Cells 29:1206-18. 2011
    ..The production of OV-like populations from human pluripotent stem cells should facilitate the study of human retinal development and disease and advance the use of hiPSCs in personalized medicine...
  7. pmc Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses
    M Joseph Phillips
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin, USA
    Invest Ophthalmol Vis Sci 53:2007-19. 2012
    ..We sought to determine if human induced pluripotent stem cells (iPSCs) derived from blood could produce optic vesicle-like structures (OVs) with the capacity to stratify and express markers of intercellular communication...
  8. pmc Modeling early retinal development with human embryonic and induced pluripotent stem cells
    Jason S Meyer
    Stem Cell Research Program, Waisman Center, Departments of Anatomy and Neurology, University of Wisconsin Madison, 1500 Highland Avenue, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 106:16698-703. 2009
    ..These findings should aid in the investigation of the molecular events governing retinal specification from human pluripotent stem cells...
  9. pmc Modeling human retinal development with patient-specific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2
    M Joseph Phillips
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin, USA McPherson Eye Research Institute, University of Wisconsin Madison, Madison, Wisconsin, USA
    Stem Cells 32:1480-92. 2014
    ..Our results establish hiPSC-OVs as versatile model systems to study retinal development at stages not previously accessible in humans and support the bona fide nature of hiPSC-OV-derived retinal progeny...
  10. pmc Induced pluripotent stem cells as custom therapeutics for retinal repair: progress and rationale
    Lynda S Wright
    Waisman Center, University of Wisconsin, Madison, WI, USA McPherson Eye Research Institute, University of Wisconsin, Madison, WI, USA
    Exp Eye Res 123:161-72. 2014
    ..The selection of appropriate hiPSC-derived donor cell type(s) for transplantation will be discussed, as will the caveats and prerequisite steps to formulating a clinical Good Manufacturing Practice (cGMP) product for clinical trials...
  11. pmc iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration
    Ruchira Singh
    Waisman Center, University of Wisconsin, Madison, WI 53705, USA
    Hum Mol Genet 22:593-607. 2013
    ..In a larger context, this report demonstrates the potential to use patient-specific hiPSCs to model and study maculopathies, an important class of blinding disorders in humans...
  12. ncbi Vitamin D analogs, a new treatment for retinoblastoma: The first Ellsworth Lecture
    Daniel M Albert
    Department of Ophthalmology and Visual Sciences, School of Medicine, Madison, WI 53792 3284, USA
    Ophthalmic Genet 23:137-56. 2002
    ..We identified vitamin D receptors in retinoblastoma and examined the effectiveness and mechanism of action of these analogs...
  13. pmc Long-term vision rescue by human neural progenitors in a rat model of photoreceptor degeneration
    Shaomei Wang
    Casey Eye Institute, Oregon Health and Sciences University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 49:3201-6. 2008
    ....

Research Grants3

  1. Culture and Transplantation of Human Retinal Spheres
    DAVID GAMM; Fiscal Year: 2007
    ..Together, these experiments are designed to build on recent advances in the burgeoning field of stem cell biology and apply them to the basic and clinical science of ophthalmology. ..
  2. Mechanisms of Retinogenesis in Human Stem Cells
    David M Gamm; Fiscal Year: 2010
    ..Such a model will have great value in the study of basic mechanisms of retinal development and the causes of inherited eye diseases, and will complement our efforts to develop cell-based therapies for degenerative retinal disorders. ..