David M Gamm
Affiliation: University of Wisconsin
- Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1David M Gamm
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53705, USA
Stem Cells 26:3182-93. 2008....
- Human retinal progenitor cells grown as neurospheres demonstrate time-dependent changes in neuronal and glial cell fate potentialDavid M Gamm
Department of Opthalmology and Visual Sciences, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53705 2280, USA
Ann N Y Acad Sci 1049:107-17. 2005..This provides information for optimizing culture systems aimed at the study of human retinal development and the generation of specific retinal cell types for therapeutic use or drug testing...
- Protection of visual functions by human neural progenitors in a rat model of retinal diseaseDavid M Gamm
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, United States of America
PLoS ONE 2:e338. 2007..Based on these reports, we explored the potential of hNPC transplantation to rescue visual function in an animal model of retinal degeneration, the Royal College of Surgeons rat...
- A novel serum-free method for culturing human prenatal retinal pigment epithelial cellsDavid M Gamm
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, T607 Waisman Center, Madison, WI 53705, USA
Invest Ophthalmol Vis Sci 49:788-99. 2008..Therefore, this study was conducted to develop a simple, serum-free system to propagate and sustain human RPE in vitro...
- Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatmentJason S Meyer
Waisman Center, University of Wisconsin, Madison, Wisconsin, USA
Stem Cells 29:1206-18. 2011..The production of OV-like populations from human pluripotent stem cells should facilitate the study of human retinal development and disease and advance the use of hiPSCs in personalized medicine...
- Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapsesM Joseph Phillips
Waisman Center, University of Wisconsin Madison, Madison, Wisconsin, USA
Invest Ophthalmol Vis Sci 53:2007-19. 2012..We sought to determine if human induced pluripotent stem cells (iPSCs) derived from blood could produce optic vesicle-like structures (OVs) with the capacity to stratify and express markers of intercellular communication...
- Modeling early retinal development with human embryonic and induced pluripotent stem cellsJason S Meyer
Stem Cell Research Program, Waisman Center, Departments of Anatomy and Neurology, University of Wisconsin Madison, 1500 Highland Avenue, Madison, WI 53705, USA
Proc Natl Acad Sci U S A 106:16698-703. 2009..These findings should aid in the investigation of the molecular events governing retinal specification from human pluripotent stem cells...
- iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degenerationRuchira Singh
Hum Mol Genet 22:593-607. 2013..In a larger context, this report demonstrates the potential to use patient-specific hiPSCs to model and study maculopathies, an important class of blinding disorders in humans...
- Vitamin D analogs, a new treatment for retinoblastoma: The first Ellsworth LectureDaniel M Albert
Department of Ophthalmology and Visual Sciences, School of Medicine, Madison, WI 53792 3284, USA
Ophthalmic Genet 23:137-56. 2002..We identified vitamin D receptors in retinoblastoma and examined the effectiveness and mechanism of action of these analogs...
- Long-term vision rescue by human neural progenitors in a rat model of photoreceptor degenerationShaomei Wang
Casey Eye Institute, Oregon Health and Sciences University, Portland, Oregon 97239, USA
Invest Ophthalmol Vis Sci 49:3201-6. 2008....
- Culture and Transplantation of Human Retinal SpheresDAVID GAMM; Fiscal Year: 2007..Together, these experiments are designed to build on recent advances in the burgeoning field of stem cell biology and apply them to the basic and clinical science of ophthalmology. ..
- Mechanisms of Retinogenesis in Human Stem CellsDavid M Gamm; Fiscal Year: 2010..Such a model will have great value in the study of basic mechanisms of retinal development and the causes of inherited eye diseases, and will complement our efforts to develop cell-based therapies for degenerative retinal disorders. ..