Karen L Gamble

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. doi request reprint Circadian biology: the early bird catches the morning shift
    Karen L Gamble
    Division of Behavioral Neurobiology, Department of Psychiatry, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA Electronic address
    Curr Biol 25:R269-71. 2015
  2. pmc Gastrin-releasing peptide modulates fast delayed rectifier potassium current in Per1-expressing SCN neurons
    Karen L Gamble
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama, Birmingham, USA
    J Biol Rhythms 26:99-106. 2011
  3. pmc Chronic ethanol consumption disrupts diurnal rhythms of hepatic glycogen metabolism in mice
    Uduak S Udoh
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama
    Am J Physiol Gastrointest Liver Physiol 308:G964-74. 2015
  4. pmc Chronic ethanol consumption disrupts the core molecular clock and diurnal rhythms of metabolic genes in the liver without affecting the suprachiasmatic nucleus
    Ashley N Filiano
    Department of Pathology Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 8:e71684. 2013
  5. pmc Neuropeptide Y-induced phase shifts of PER2::LUC rhythms are mediated by long-term suppression of neuronal excitability in a phase-specific manner
    Rachel C Besing
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Chronobiol Int 29:91-102. 2012
  6. doi request reprint The Molecular Circadian Clock and Alcohol-Induced Liver Injury
    Uduak S Udoh
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Biomolecules 5:2504-37. 2015
  7. doi request reprint GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin
    Lauren M Hablitz
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, and
    J Neurosci 35:14957-65. 2015
  8. pmc Metabolism as an integral cog in the mammalian circadian clockwork
    Karen L Gamble
    Division of Behavioral Neurobiology, Department of Psychiatry, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Crit Rev Biochem Mol Biol 48:317-31. 2013
  9. doi request reprint Adults with ADHD-without insomnia history have subclinical sleep disturbance but not circadian delay: an ADHD phenotype?
    Rachel E Fargason
    1University of Alabama, Birmingham, USA
    J Atten Disord 17:583-8. 2013
  10. pmc Circadian clock control of endocrine factors
    Karen L Gamble
    Division of Behavioural Neurobiology, Department of Psychiatry, Department of Medicine, University of Alabama at Birmingham, 703 19th Street South, Birmingham, AL 35294, USA
    Nat Rev Endocrinol 10:466-75. 2014

Collaborators

  • Martin E Young
  • Shannon M Bailey
  • Takashi Kudo
  • Uduak S Udoh
  • Lauren M Hablitz
  • Ashley N Filiano
  • Rebecca A Prosser
  • Rachel E Fargason
  • Rachel C Besing
  • Jennifer A Valcin
  • Joanna M Cooper
  • Telisha M Swain
  • Kathryn E Abrahamsson
  • Hylton E Molzof
  • Abigail Fernandez Hollar
  • Telisha Millender-Swain
  • Russell Johnson
  • Samantha White
  • Russell L Johnson
  • Jodi R Paul

Detail Information

Publications11

  1. doi request reprint Circadian biology: the early bird catches the morning shift
    Karen L Gamble
    Division of Behavioral Neurobiology, Department of Psychiatry, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA Electronic address
    Curr Biol 25:R269-71. 2015
    ..A new study suggests that this 'social jet lag' can be remedied by a 'personalized schedule', an intervention that may help reduce circadian misalignment and pathologies in shift workers...
  2. pmc Gastrin-releasing peptide modulates fast delayed rectifier potassium current in Per1-expressing SCN neurons
    Karen L Gamble
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama, Birmingham, USA
    J Biol Rhythms 26:99-106. 2011
    ..Furthermore, these findings implicate fDR currents in the ionic basis for GRP-mediated entrainment of the primary mammalian circadian pacemaker...
  3. pmc Chronic ethanol consumption disrupts diurnal rhythms of hepatic glycogen metabolism in mice
    Uduak S Udoh
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama
    Am J Physiol Gastrointest Liver Physiol 308:G964-74. 2015
    ..Chronic ethanol-induced disruption in these daily rhythms likely contributes to glycogen depletion and disruption of hepatic energy homeostasis, a recognized risk factor in the etiology of alcoholic liver disease. ..
  4. pmc Chronic ethanol consumption disrupts the core molecular clock and diurnal rhythms of metabolic genes in the liver without affecting the suprachiasmatic nucleus
    Ashley N Filiano
    Department of Pathology Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 8:e71684. 2013
    ..Importantly, these results suggest that chronic ethanol consumption, at levels sufficient to cause steatosis, disrupts the core hepatic clock as well as the diurnal rhythms of key lipid metabolism genes. ..
  5. pmc Neuropeptide Y-induced phase shifts of PER2::LUC rhythms are mediated by long-term suppression of neuronal excitability in a phase-specific manner
    Rachel C Besing
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Chronobiol Int 29:91-102. 2012
    ..This model is consistent with findings in other brain regions that NPY-induced persistent hyperpolarization underlies mechanisms of energy homeostasis, anxiety-related behavior, and thalamocortical synchronous firing...
  6. doi request reprint The Molecular Circadian Clock and Alcohol-Induced Liver Injury
    Uduak S Udoh
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Biomolecules 5:2504-37. 2015
    ..Illuminating the mechanistic connections between the circadian clock and alcohol will be critical to the development of new preventative and pharmacological treatments for alcohol use disorders and alcohol-mediated organ diseases. ..
  7. doi request reprint GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin
    Lauren M Hablitz
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, and
    J Neurosci 35:14957-65. 2015
    ..This study suggests that GIRK channels may be an alternative therapeutic target for diseases with evidence of circadian disruption, including aberrant melatonin signaling...
  8. pmc Metabolism as an integral cog in the mammalian circadian clockwork
    Karen L Gamble
    Division of Behavioral Neurobiology, Department of Psychiatry, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Crit Rev Biochem Mol Biol 48:317-31. 2013
    ....
  9. doi request reprint Adults with ADHD-without insomnia history have subclinical sleep disturbance but not circadian delay: an ADHD phenotype?
    Rachel E Fargason
    1University of Alabama, Birmingham, USA
    J Atten Disord 17:583-8. 2013
    ..To explore the potential ADHD phenotype of ADHD-without reported insomnia in comparison with controls and their tolerance of stimulants in a cohort rigorously screened for comorbidities...
  10. pmc Circadian clock control of endocrine factors
    Karen L Gamble
    Division of Behavioural Neurobiology, Department of Psychiatry, Department of Medicine, University of Alabama at Birmingham, 703 19th Street South, Birmingham, AL 35294, USA
    Nat Rev Endocrinol 10:466-75. 2014
    ..Collectively, these observations suggest that strategies designed to realign normal circadian rhythmicities hold potential for the treatment of various endocrine-related disorders. ..
  11. doi request reprint Delayed sleep timing and symptoms in adults with attention-deficit/hyperactivity disorder: a controlled actigraphy study
    Karen L Gamble
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Chronobiol Int 30:598-606. 2013
    ..In addition, ADHD adults with combined hyperactive-impulsive and inattentive symptoms have decreased sleep quality as well as the delayed sleep timing of predominately inattentive subtypes...