Deborah Galson

Summary

Affiliation: University of Pittsburgh
Location: Pittsburgh, USA

Publications

  1. pmc Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment
    Sonia D'Souza
    Department of Medicine, Division of Hematology Oncology and Bone Biology Center of University of Pittsburgh Medical Center, University of Pittsburgh and Veterans Administration Healthcare System, Pittsburgh, PA, USA
    Blood 119:1888-96. 2012
  2. pmc Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts
    Xiaoyan Zhang
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Cell Biochem 105:885-95. 2008
  3. doi CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro
    Yi Lu
    Department of Medicine, Pittsburgh VA Healthcare System, Research and Development, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Mol Cancer Res 6:546-54. 2008
  4. pmc General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2
    Shibing Yu
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Biol Chem 283:5542-53. 2008
  5. ncbi PTHrP-induced MCP-1 production by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation and prostate cancer cell proliferation and invasion in vitro
    Yi Lu
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Int J Cancer 121:724-33. 2007
  6. pmc Phosphorylation of IRF8 in a pre-associated complex with Spi-1/PU.1 and non-phosphorylated Stat1 is critical for LPS induction of the IL1B gene
    Sebnem Unlu
    University of Pittsburgh, School of Medicine, Department of Molecular Genetics and Biochemistry, Pittsburgh, PA 15261, USA
    Mol Immunol 44:3364-79. 2007
  7. pmc Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing in osteoclast precursors expression of LFA-1 and ICAM-1
    Veronica Garcia-Palacios
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh, Pittsburgh, PA, USA
    Bone 40:316-22. 2007
  8. ncbi Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion
    Yi Lu
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    Prostate 66:1311-8. 2006
  9. ncbi TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src
    Kent Z Q Wang
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Cell Sci 119:1579-91. 2006
  10. doi Epigallocatechin-3-gallate diminishes CCL2 expression in human osteoblastic cells via up-regulation of phosphatidylinositol 3-Kinase/Akt/Raf-1 interaction: a potential therapeutic benefit for arthritis
    Sze Kwan Lin
    National Taiwan University Hospital, Department of Veterinary Medicine, College of Bio Resources and Agriculture, National Taiwan University, Taipei, Taiwan
    Arthritis Rheum 58:3145-56. 2008

Collaborators

Detail Information

Publications41

  1. pmc Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment
    Sonia D'Souza
    Department of Medicine, Division of Hematology Oncology and Bone Biology Center of University of Pittsburgh Medical Center, University of Pittsburgh and Veterans Administration Healthcare System, Pittsburgh, PA, USA
    Blood 119:1888-96. 2012
    ..These results demonstrate that AXII and AXIIR play important roles in MM and that targeting the AXII/AXIIR axis may be a novel therapeutic approach for MM...
  2. pmc Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts
    Xiaoyan Zhang
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Cell Biochem 105:885-95. 2008
    ..Taken together, these results for the first time demonstrate that ATF4 is a critical regulator of proliferation and survival in BMSCs and osteoblasts in vitro and in vivo...
  3. doi CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro
    Yi Lu
    Department of Medicine, Pittsburgh VA Healthcare System, Research and Development, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Mol Cancer Res 6:546-54. 2008
    ..CXCL16 was found to promote prostate cancer cell migration and invasion in vitro. Therefore, we concluded that CXCL16 functions, through CXCR6, as a novel chemotactic factor for prostate cancer cells...
  4. pmc General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2
    Shibing Yu
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Biol Chem 283:5542-53. 2008
    ..This study shows that a general transcription factor, TFIIA gamma, facilitates osteoblast-specific gene expression through interactions with two important bone transcription factors ATF4 and Runx2...
  5. ncbi PTHrP-induced MCP-1 production by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation and prostate cancer cell proliferation and invasion in vitro
    Yi Lu
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Int J Cancer 121:724-33. 2007
    ..We conclude that PTHrP-induced MCP-1 production by HBME and hFOB cells promotes osteoclast differentiation in vitro and such induction may play a critical role in PCa development in the bone microenvironment...
  6. pmc Phosphorylation of IRF8 in a pre-associated complex with Spi-1/PU.1 and non-phosphorylated Stat1 is critical for LPS induction of the IL1B gene
    Sebnem Unlu
    University of Pittsburgh, School of Medicine, Department of Molecular Genetics and Biochemistry, Pittsburgh, PA 15261, USA
    Mol Immunol 44:3364-79. 2007
    ..Phosphorylation of chromatin pre-associated factors like IRF8 may be an important strategy for the rapid transcriptional activation of genes involved in innate immunity...
  7. pmc Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing in osteoclast precursors expression of LFA-1 and ICAM-1
    Veronica Garcia-Palacios
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh, Pittsburgh, PA, USA
    Bone 40:316-22. 2007
    ..Taken together, these results demonstrate that ECF-L enhances RANKL and 1,25-(OH)2D3-induced OCL formation by increasing adhesive interactions between OCL precursors through increased expression of ICAM-1 and LFA-1...
  8. ncbi Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion
    Yi Lu
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    Prostate 66:1311-8. 2006
    ..Increased MCP-1 serum levels in patients with various cancers were correlated with advanced stage. Here, we evaluated the role of MCP-1 on prostate cancer (CaP) cell proliferation and invasion...
  9. ncbi TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src
    Kent Z Q Wang
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Cell Sci 119:1579-91. 2006
    ..Although a key factor in TRAF6-dependent activation of PI 3-kinase, ectopic expression of Src was insufficient for NF-kappaB activation and, in contrast to NF-kappaB, was not inhibited by IRAK2...
  10. doi Epigallocatechin-3-gallate diminishes CCL2 expression in human osteoblastic cells via up-regulation of phosphatidylinositol 3-Kinase/Akt/Raf-1 interaction: a potential therapeutic benefit for arthritis
    Sze Kwan Lin
    National Taiwan University Hospital, Department of Veterinary Medicine, College of Bio Resources and Agriculture, National Taiwan University, Taipei, Taiwan
    Arthritis Rheum 58:3145-56. 2008
    ..The therapeutic effect of EGCG on collagen-induced arthritis (CIA) in rats was also studied...
  11. doi Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: an implication for the pathogenesis of arthritis
    Sang Heng Kok
    School fo Dentistry, College of Medicine, National Taiwan University, and National Taiwan University Hospital, Taipei, Taiwan
    Arthritis Rheum 60:1451-62. 2009
    ..To examine the roles of STATs 1 and 3 in CCL2 production in human osteoblastic cells and their influences on arthritis development...
  12. pmc Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease
    Sonia D'Souza
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh, PA, USA
    Blood 118:6871-80. 2011
    ..Thus, Gfi1 may have an important role in prolonged MM-induced OB suppression and provide a new therapeutic target for MM bone disease...
  13. pmc Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells
    Feng Ming Wang
    Department of Medicine Hematology Oncology and the Center for Bone Biology of UPMC, School of Medicine, University of Pittsburgh, PA, USA
    Exp Hematol 39:999-1006. 2011
    ..We investigated the molecular action of resveratrol on IRE1α/XBP1 axis in human MM cells...
  14. pmc IMiD immunomodulatory compounds block C/EBP{beta} translation through eIF4E down-regulation resulting in inhibition of MM
    Shirong Li
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Blood 117:5157-65. 2011
    ....
  15. pmc Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease
    Noriyoshi Kurihara
    University of Pittsburgh, Medicine Hem Onc, Pittsburgh, PA 15213, USA
    Cell Metab 13:23-34. 2011
    ..Mice coexpressing MVNP and p62(P394L) developed dramatic Paget's-like bone lesions. These results suggest that p62(P394L) and IL-6 induction by MVNP play key roles in PD...
  16. pmc ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo
    Hisako Ishizuka
    Department of Medicine Hematology Oncology and the Center for Bone Biology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Bone Miner Res 26:169-81. 2011
    ....
  17. pmc Activating transcription factor 4 regulates osteoclast differentiation in mice
    Huiling Cao
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Clin Invest 120:2755-66. 2010
    ..These results demonstrate that ATF4 plays a direct role in regulating OCL differentiation and suggest that it may be a therapeutic target for treating bone diseases associated with increased OCL activity...
  18. pmc TRAF6 is autoinhibited by an intramolecular interaction which is counteracted by trans-ubiquitination
    Kent Z Q Wang
    Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
    J Cell Biochem 110:763-71. 2010
    ..Although TRAF6 ubiquitination has emerged as a hallmark of activation, trans-ubiquitination induced by two TRAF6 muteins is insufficient for NF-kappaB activation...
  19. pmc C/EBPbeta regulates transcription factors critical for proliferation and survival of multiple myeloma cells
    Rekha Pal
    Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Blood 114:3890-8. 2009
    ..Targeting C/EBPbeta may provide a novel therapeutic strategy in the treatment of multiple myeloma...
  20. ncbi Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 279:26475-80. 2004
    ..These data indicate that lack of Nfatc1 expression is the cause of the differentiation block in Fos(-/-) osteoclast precursors and that transcriptional induction of Nfatc1 is a major function of c-Fos in osteoclast differentiation...
  21. pmc Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo
    Romain Dacquin
    Department of Molecular and Human Genetics and Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Room S921, Houston, TX 77030, USA
    J Cell Biol 164:509-14. 2004
    ..Thus, amylin is a physiological regulator of bone resorption that acts through an unidentified receptor...
  22. ncbi Estrogen receptor-related receptor alpha impinges on the estrogen axis in bone: potential function in osteoporosis
    Edith Bonnelye
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Endocrinology 143:3658-70. 2002
    ..These data suggest that ERRalpha is regulated by estrogen in bone in which it may play a functional role at several levels (osteoblasts, adipocytes, and osteoclasts) in E2 deficiency diseases such as osteoporosis...
  23. ncbi Comparison of the human and mouse erythropoietin genes shows extensive homology in the flanking regions
    D L Galson
    Division of Hematology Oncology, Brigham and Women s Hospital, Boston, MA 02115
    Blood 82:3321-6. 1993
    ..In addition, both species were found to have a high frequency of short interspersed (SINE) repetitive sequences that interrupt homologies in both the 5' flank and within the transcription unit...
  24. pmc Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis
    D L Galson
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Mol Cell Biol 13:2929-41. 1993
    ..This region has not yet been found to be associated with a human malignancy...
  25. ncbi Dual regulatory role of human cytomegalovirus immediate-early protein in IL1B transcription is dependent upon Spi-1/PU.1
    Zhiyong Yang
    The New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Biochem Biophys Res Commun 294:854-63. 2002
    ..Therefore, the relative expression of IE1 and IE2, which varies during HCMV infection, may provide a molecular mechanism by which IL1B can be repressed, thus, avoiding clearance by the host...
  26. ncbi Tissue-specific and ubiquitous promoters direct the expression of alternatively spliced transcripts from the calcitonin receptor gene
    O Anusaksathien
    New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Biol Chem 276:22663-74. 2001
    ..These transfection data confirm the osteoclast specificity of promoter P3 and provide the first evidence that the CTR gene is regulated in a tissue-specific manner by alternative promoter utilization...
  27. pmc The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption
    E M Gravallese
    Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Arthritis Res 3:6-12. 2001
    ....
  28. ncbi Expression of the transcription factor, Spi-1 (PU.1), in differentiating murine erythroleukemia cells Is regulated post-transcriptionally. Evidence for differential stability of transcription factor mRNAs following inducer exposure
    J O Hensold
    University Ireland Cancer Center, Department of Medicine and Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 271:3385-91. 1996
    ..The effect of Me2SO on the stability of Spi-1 mRNA provides a novel means of altering gene expression in these cells and is likely to have significance for the differentiation of these cells...