R C Gallo

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint HIV infection and pathogenesis: what about chemokines?
    R C Gallo
    University of Maryland Biotechnology Institute, University of Maryland, Baltimore 21201 1192, USA
    J Clin Immunol 19:293-9. 1999
  2. ncbi request reprint Targeting Tat and IFN(alpha) as a therapeutic AIDS vaccine
    R C Gallo
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201 1192, USA
    DNA Cell Biol 21:611-8. 2002
  3. ncbi request reprint HIV-1: a look back from 20 years
    Robert C Gallo
    Institute of Human Virology, University of Maryland Biotechnology Institute and Department of Microbiology, University of Maryland Baltimore, 725 W Lombard Street, Baltimore, MD 21201, USA
    DNA Cell Biol 23:191-2. 2004
  4. ncbi request reprint Human retroviruses after 20 years: a perspective from the past and prospects for their future control
    Robert C Gallo
    Institute of Human Virology, Department of Microbiology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Immunol Rev 185:236-65. 2002
  5. ncbi request reprint Progressive and persistent downregulation of surface CXCR4 in CD4(+) T cells infected with human herpesvirus 7
    P Secchiero
    Institute of Human Virology, University of Maryland, Baltimore, MD and the Human Anatomy Section, Department of Morphology and Embriology, University of Ferrara, Ferrara, Italy
    Blood 92:4521-8. 1998
  6. ncbi request reprint Engagement of CD28 modulates CXC chemokine receptor 4 surface expression in both resting and CD3-stimulated CD4+ T cells
    P Secchiero
    Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA
    J Immunol 164:4018-24. 2000
  7. ncbi request reprint IFN-alpha 2b reduces IL-2 production and IL-2 receptor function in primary CD4+ T cells
    D Zella
    Institute of Human Virology, University of Maryland Biotechnology Institute and University of Maryland Medical Center, Baltimore, MD 21201, USA
    J Immunol 164:2296-302. 2000
  8. pmc Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication
    P Secchiero
    Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, S307, Baltimore, MD 21201 1192, USA
    Proc Natl Acad Sci U S A 97:14620-5. 2000
  9. pmc A Tat subunit vaccine confers protective immunity against the immune-modulating activity of the human immunodeficiency virus type-1 Tat protein in mice
    S M Agwale
    Division of Vaccine Research, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 99:10037-41. 2002
  10. ncbi request reprint HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells
    F F Weichold
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore 21201, USA
    J Hum Virol 2:261-9. 1999

Detail Information

Publications59

  1. ncbi request reprint HIV infection and pathogenesis: what about chemokines?
    R C Gallo
    University of Maryland Biotechnology Institute, University of Maryland, Baltimore 21201 1192, USA
    J Clin Immunol 19:293-9. 1999
    ..In this review we summarize the results of such studies and their promising implications for HIV infection...
  2. ncbi request reprint Targeting Tat and IFN(alpha) as a therapeutic AIDS vaccine
    R C Gallo
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201 1192, USA
    DNA Cell Biol 21:611-8. 2002
    ..Both Tat Toxoid and IFN(alpha) kinoid were well tolerated and elicited specific neutralizing antibodies (Abs) in mice, monkeys, and seronegative and HIV-1-infected individuals...
  3. ncbi request reprint HIV-1: a look back from 20 years
    Robert C Gallo
    Institute of Human Virology, University of Maryland Biotechnology Institute and Department of Microbiology, University of Maryland Baltimore, 725 W Lombard Street, Baltimore, MD 21201, USA
    DNA Cell Biol 23:191-2. 2004
  4. ncbi request reprint Human retroviruses after 20 years: a perspective from the past and prospects for their future control
    Robert C Gallo
    Institute of Human Virology, Department of Microbiology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Immunol Rev 185:236-65. 2002
    ....
  5. ncbi request reprint Progressive and persistent downregulation of surface CXCR4 in CD4(+) T cells infected with human herpesvirus 7
    P Secchiero
    Institute of Human Virology, University of Maryland, Baltimore, MD and the Human Anatomy Section, Department of Morphology and Embriology, University of Ferrara, Ferrara, Italy
    Blood 92:4521-8. 1998
    ....
  6. ncbi request reprint Engagement of CD28 modulates CXC chemokine receptor 4 surface expression in both resting and CD3-stimulated CD4+ T cells
    P Secchiero
    Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA
    J Immunol 164:4018-24. 2000
    ....
  7. ncbi request reprint IFN-alpha 2b reduces IL-2 production and IL-2 receptor function in primary CD4+ T cells
    D Zella
    Institute of Human Virology, University of Maryland Biotechnology Institute and University of Maryland Medical Center, Baltimore, MD 21201, USA
    J Immunol 164:2296-302. 2000
    ....
  8. pmc Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication
    P Secchiero
    Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, S307, Baltimore, MD 21201 1192, USA
    Proc Natl Acad Sci U S A 97:14620-5. 2000
    ..These results add to the concept that decreasing Tat activity is an important addition to anti-HIV-1 therapy, and they suggest a target for anti-HIV-1 chemotherapy, phosphodiesterase 4...
  9. pmc A Tat subunit vaccine confers protective immunity against the immune-modulating activity of the human immunodeficiency virus type-1 Tat protein in mice
    S M Agwale
    Division of Vaccine Research, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 99:10037-41. 2002
    ..The effect of Tat was completely blocked, however, by immunization with inactivated Tat protein before vaccination with the bicistronic gp120-Tat DNA vaccine...
  10. ncbi request reprint HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells
    F F Weichold
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore 21201, USA
    J Hum Virol 2:261-9. 1999
    ..This disconnection between viral load and CD4 counts led us to investigate how the PI ritonavir directly affects leukocyte activation in vitro, using peripheral blood mononuclear cell (PBMC) fractions derived from normal donors...
  11. pmc Role of the extracellular domain of human herpesvirus 7 glycoprotein B in virus binding to cell surface heparan sulfate proteoglycans
    P Secchiero
    Institute of Human Virology, Medical Biotechnology Center, University of Maryland at Baltimore, 21201, USA
    J Virol 71:4571-80. 1997
    ....
  12. pmc Higher macrophage inflammatory protein (MIP)-1alpha and MIP-1beta levels from CD8+ T cells are associated with asymptomatic HIV-1 infection
    F Cocchi
    Institute of Human Virology, University of Maryland Biotechnology Institute, University of Maryland, 725 West Lombard Street, Baltimore, MD 21201 1192, USA
    Proc Natl Acad Sci U S A 97:13812-7. 2000
    ..These findings suggest that constitutive beta-chemokine production may play an important role in the outcome of HIV-1 infection...
  13. pmc Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV beta-chemokines: an approach to suppress R5 strains of HIV-1
    A Heredia
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 100:10411-6. 2003
    ..In addition, RAPA enhanced the antiviral activity of the CCR5 antagonist TAK-779. These results suggest that low concentrations of RAPA may have a role in both the treatment and prevention of HIV-1 infection...
  14. pmc Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta
    R Kamin-Lewis
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 98:9283-8. 2001
    ..These results demonstrate substantial subset heterogeneity of MIP-1beta synthesis among CD8(+) T cells and suggest that these subsets should be evaluated as correlates of protective immunity against HIV-1...
  15. ncbi request reprint Some recent results on HIV pathogenesis with implications for therapy and vaccines
    R C Gallo
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore 21201, USA
    Cell Mol Biol (Noisy-le-grand) 47:1101-4. 2001
    ..Studies from others and ourselves have shown that these two approaches are now ready to the leave experimental bench and move into clinical testing...
  16. ncbi request reprint Extracellular HIV-1 tat protein up-regulates the expression of surface CXC-chemokine receptor 4 in resting CD4+ T cells
    P Secchiero
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore 21201, USA
    J Immunol 162:2427-31. 1999
    ..As Tat protein is actively released by HIV-1 infected cells, our data indicate a potentially important role for extracellular Tat in rendering bystander CD4+ T cells more susceptible to infection with X4-tropic HIV-1 isolates...
  17. ncbi request reprint The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
    F Cocchi
    Institute of Human Virology, University of Maryland Biotechnology Institute and School of Medicine, Baltimore, Maryland 21201, USA
    Nat Med 2:1244-7. 1996
    ..The ability of the chemokines to block the early steps of HIV infection could be exploited to develop novel therapeutic approaches for AIDS...
  18. ncbi request reprint Induction of programmed cell death in Kaposi's sarcoma cells by preparations of human chorionic gonadotropin
    F Samaniego
    Institute of Human Virology, Medical Biotechnology Center and Greenebaum Cancer Center, University of Maryland, Baltimore 21201 1192, USA
    J Natl Cancer Inst 91:135-43. 1999
    ..While several clinical benefits of HAF are clearly evident, the basis for its anti-KS properties remains unknown. We investigated the apoptosis-inducing effects of HAF and the expression of apoptosis-related proteins in KS cells...
  19. ncbi request reprint Recombinant IFN-alpha (2b) increases the expression of apoptosis receptor CD95 and chemokine receptors CCR1 and CCR3 in monocytoid cells
    D Zella
    Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA
    J Immunol 163:3169-75. 1999
    ..Taken together, these data add important information for the rational application of IFN-alpha (2b) in immune and cancer therapies...
  20. ncbi request reprint Inflammatory cytokines induce endothelial cells to produce and release basic fibroblast growth factor and to promote Kaposi's sarcoma-like lesions in nude mice
    F Samaniego
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore 21201, USA
    J Immunol 158:1887-94. 1997
    ....
  21. pmc An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction
    W Reid
    Animal Model Division and Divisions of Basic Science, University of Maryland, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 98:9271-6. 2001
    ....
  22. ncbi request reprint Indirubin-3'-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication
    Alonso Heredia
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    AIDS 19:2087-95. 2005
    ..To evaluate the effects of the cyclin dependent kinase (CDK) inhibitor Indirubin-3'-monoxime (IM) on Tat-mediated transactivation function, a step of the HIV-1 cycle that is not currently targeted in antiviral therapy...
  23. pmc Preclinical evaluation of synthetic -2 RANTES as a candidate vaginal microbicide to target CCR5
    Tina M Kish-Catalone
    Division of Basic Sciences, Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, S622, Baltimore, MD 21201, USA
    Antimicrob Agents Chemother 50:1497-509. 2006
    ..Overall, these preclinical studies suggest that -2 RANTES is suitable for further testing as a candidate anti-HIV-1 microbicide...
  24. ncbi request reprint International NeuroAIDS: prospects of HIV-1 associated neurological complications
    J Roberto Trujillo
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    Cell Res 15:962-9. 2005
    ....
  25. ncbi request reprint Commentary on "Prevalence and evolution of drug resistance HIV-1 variants in Henan, China"
    Bruce L Gilliam
    Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA
    Cell Res 15:850-1. 2005
  26. ncbi request reprint Commentary remarks on "HIV/AIDS in China"
    Robert C Gallo
    Institute of Human Virology, University of Maryland, USA
    Cell Res 15:823. 2005
  27. ncbi request reprint The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years
    Robert C Gallo
    Institute of Human Virology, University of Maryland Biotechnology Institute, University of Maryland Baltimore, Baltimore, MD, USA
    Lancet 366:1894-8. 2005
  28. ncbi request reprint HIV/AIDS research after HAART
    Robert C Gallo
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland, USA
    Res Initiat Treat Action 11:39-41. 2005
  29. ncbi request reprint HIV-1 transgenic rat CD4+ T cells develop decreased CD28 responsiveness and suboptimal Lck tyrosine dephosphorylation following activation
    Anjana Yadav
    Division of Basic Science, Institute of Human Virology, University of Maryland, Rm S616, 725, West Lombard Street, Baltimore, MD 21201, USA
    Virology 353:357-65. 2006
    ..These events likely lead to defects in antigen-specific signaling and may help explain the disruption of Th1 responses and the generation of specific effector/memory subsets in transgenic CD4+ T cells...
  30. pmc A reflection on HIV/AIDS research after 25 years
    Robert C Gallo
    Institute of Human Virology, University of Maryland Biotechnology Institute and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Retrovirology 3:72. 2006
    ..Dr. Robert C. Gallo provides a personal reflection on the 25 year history of AIDS...
  31. doi request reprint [Kinoids: a novel generation of specific immune therapy against cytokines]
    Armand Bensussan
    Institut National de la Sante et de la Recherche Medicale, INSERM U841, Creteil, France
    Med Sci (Paris) 24:306-13. 2008
    ..After validation by clinical trials, kinoid vaccines could represent a second generation of specific immune therapy to be used to combat ectopic cytokines...
  32. pmc Antibodies to CD4-induced sites in HIV gp120 correlate with the control of SHIV challenge in macaques vaccinated with subunit immunogens
    Anthony Devico
    Basic Research and Vaccine and Epidemiology Divisions, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 104:17477-82. 2007
    ..Collectively, these data suggest that antibodies to CD4i epitopes may play a role in controlling SHIV infection and provide insights for HIV vaccine development...
  33. ncbi request reprint Functional and morphologic characterization of human T cells continuously grown in vitro. J. Immunol. 1977. 119: 131-138
    Francis W Ruscetti
    J Immunol 179:1415-22. 2007
  34. ncbi request reprint CCR5 density levels on primary CD4 T cells impact the replication and Enfuvirtide susceptibility of R5 HIV-1
    Alonso Heredia
    Institute of Human Virology, University of Maryland, 725 W Lombard Street, Baltimore, MD 21201, USA
    AIDS 21:1317-22. 2007
    ..In the present study we evaluated the impact of differences in CCR5 levels among donor CD4 T cells on the infection efficiency and T-20 susceptibility of R5 HIV-1...
  35. pmc Rapamycin reduces CCR5 density levels on CD4 T cells, and this effect results in potentiation of enfuvirtide (T-20) against R5 strains of human immunodeficiency virus type 1 in vitro
    Alonso Heredia
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    Antimicrob Agents Chemother 51:2489-96. 2007
    ....
  36. pmc Human herpesvirus 6A accelerates AIDS progression in macaques
    Paolo Lusso
    Unit of Human Virology, San Raffaele Scientific Institute, 20132 Milan, Italy
    Proc Natl Acad Sci U S A 104:5067-72. 2007
    ..Rapid disease development in dually infected animals was heralded by an early depletion of both CD4(+) and CD8(+) T cells. These results provide in vivo evidence that HHV-6A may act as a promoting factor in AIDS progression...
  37. doi request reprint Increased interferon alpha expression in circulating plasmacytoid dendritic cells of HIV-1-infected patients
    Clara Lehmann
    First Department of Internal Medicine, University of Cologne, Cologne, Germany
    J Acquir Immune Defic Syndr 48:522-30. 2008
    ..On the other hand, high IFN alpha serum levels in HIV-1-infected individuals have been proposed to promote immune hyper-activation and disease progression...
  38. ncbi request reprint A perspective on human herpes virus 6 (HHV-6)
    Robert C Gallo
    Institute of Human Virology, University of Maryland, Baltimore, MD, USA
    J Clin Virol 37:S2. 2006
  39. pmc Persistence of HIV-1 structural proteins and glycoproteins in lymph nodes of patients under highly active antiretroviral therapy
    Mikulas Popovic
    Institute of Human Virology, University of Maryland Biotechnology Institute, University of Maryland, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 102:14807-12. 2005
    ....
  40. ncbi request reprint History of the discoveries of the first human retroviruses: HTLV-1 and HTLV-2
    Robert C Gallo
    Institute of Human Virology, Baltimore, MD, USA
    Oncogene 24:5926-30. 2005
    ..However, following our reports the same virus was isolated in Japan, and both groups provided evidence that HTLV-1 caused ATL, a subclassification of T-cell malignancies first recognized in Japan...
  41. ncbi request reprint Historical essay. The early years of HIV/AIDS
    Robert C Gallo
    Institute of Human Virology and Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
    Science 298:1728-30. 2002
  42. ncbi request reprint Historical essay. Prospects for the future
    Robert C Gallo
    Institute of Human Virology and Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
    Science 298:1730-1. 2002
  43. ncbi request reprint Robert C. Gallo, M.D. [Interview by Vicki P Glaser]
    Robert C Gallo
    J Hematother Stem Cell Res 11:751-7. 2002
  44. pmc HIV-1-suppressive factors are secreted by CD4+ T cells during primary immune responses
    Sayed F Abdelwahab
    Institute of Human Virology, Biotechnology Institute, and Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 100:15006-10. 2003
    ..The data also suggest that production of such factors should be considered in the design of vaccines against HIV-1 and as a mechanism whereby the host can control infections with this virus...
  45. ncbi request reprint Development of vaccination strategies that elicit broadly neutralizing antibodies against human immunodeficiency virus type 1 in both the mucosal and systemic immune compartments
    David M Hone
    Divisions of Basic Science and Vaccine Research, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    J Hum Virol 5:17-23. 2002
    ..This paper reviews recent advances made by the authors toward the development of an HIV-1 vaccine that elicits such antibodies in both the mucosal and systemic immune compartments...
  46. ncbi request reprint The discovery of HIV as the cause of AIDS
    Robert C Gallo
    Institute of Human Virology, University of Maryland Biotechnology Institute and University of Maryland, Baltimore, USA
    N Engl J Med 349:2283-5. 2003
  47. ncbi request reprint Public health. A sound rationale needed for phase III HIV-1 vaccine trials
    Dennis R Burton
    Scripps Research Institute, La Jolla, California, USA
    Science 303:316. 2004
  48. pmc HIV-1 matrix protein p17 increases the production of proinflammatory cytokines and counteracts IL-4 activity by binding to a cellular receptor
    Maria A De Francesco
    Institute of Microbiology, University of Brescia Medical School, 25123 Brescia, Italy
    Proc Natl Acad Sci U S A 99:9972-7. 2002
    ..Our results define a role for p17 in HIV-1 pathogenesis and contribute to our understanding of the molecular mechanism of HIV-1 infection and the development of additional antiviral therapeutic strategies...
  49. ncbi request reprint HIV-1 transgenic rats develop T cell abnormalities
    William Reid
    Division of Basic Science, University of Maryland, Baltimore, MD 21201, USA
    Virology 321:111-9. 2004
    ....
  50. ncbi request reprint Control of HIV-1 infection by soluble factors of the immune response
    Anthony L DeVico
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
    Nat Rev Microbiol 2:401-13. 2004
  51. ncbi request reprint A journey with T cells, primate/human retroviruses and other persisting human T-cell tropic viruses
    Robert C Gallo
    Institute of Human Virology, University of Maryland Biotechnology Institute, Department of Microbiology and Immunology and Department of Medicine, School of Medicine, 725 W Lombard Street, Baltimore, MD 21201, USA
    Rev Clin Exp Hematol 7:329-35. 2003
    ..HTLV-1, 3. HTLV-2, 4. human immunodeficiency virus and 5. human herpes virus-6 (HHV-6). This report is a brief synopsis of the discoveries of the first human retroviruses, the HTLV...
  52. ncbi request reprint Differential polarization of immune responses by co-administration of antigens with chemokines
    Achim Frauenschuh
    Division of Basic Science, Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore, MD 21201, USA
    Vaccine 23:546-54. 2004
    ..These results are relevant towards the engineering of novel vaccine and immune-based therapies, and point to chemokines as candidate adjuvant and immunomodulatory molecules...
  53. pmc Sequence variation within the dominant amino terminus epitope affects antibody binding and neutralization of human immunodeficiency virus type 1 Tat protein
    Tracy J Ruckwardt
    Institute of Human Virology, University of Maryland Biotechnology Institute, 725 W Lombard St, Room N546, Baltimore, MD 21201, USA
    J Virol 78:13190-6. 2004
    ..Tat-neutralizing antibodies to the dominant amino terminus epitope are affected by HIV clade variation...
  54. pmc The discovery of the first human retrovirus: HTLV-1 and HTLV-2
    Robert C Gallo
    Institute of Human Virology University of Maryland Biotechnology Institute 701 E, Pratt Street Baltimore, MD 21202, USA
    Retrovirology 2:17. 2005
    ..These efforts finally yielded success following the discovery of IL-2 and its use to culture adult T cell lymphoma/leukemia cells...
  55. ncbi request reprint Epilogue: a journey with blood cells and viruses
    Robert C Gallo
    J Hematother Stem Cell Res 11:849-57. 2002
  56. ncbi request reprint HIV receptors on lymphocytes
    Alfredo Garzino-Demo
    Institute of Human Virology, University of Maryland Biotechnology Institute Baltimore, Maryland 21201, USA
    Curr Opin Hematol 10:279-83. 2003
    ..This article reviews the most exciting aspects of these novel findings and discusses their practical application in the fight against HIV infection...
  57. ncbi request reprint A plea for justice for jailed medical workers
    Sunil K Ahuja
    Science 314:924-5. 2006
  58. ncbi request reprint Anti-cytokine Ab immune therapy: present status and perspectives
    Daniel Zagury
    NEOVACS Université Pierre et Marie Curie, Paris VI, 15, rue de l Ecole de Medecine, 75006 Paris, France
    Drug Discov Today 9:72-81. 2004
    ..However, the induction of anti-idiotypic Abs may restrict the long-term use of anti-cytokine immunotherapy using allogenic or humanized/chimeric Abs. We propose that greater consideration should be given to active immunization protocols...
  59. pmc VEGF kinoid vaccine, a therapeutic approach against tumor angiogenesis and metastases
    Farhad Haghighi Rad
    INSERM U602 Microenvironnement et Physiopathologie de la Différenciation, Hopital Paul Brousse, 12 avenue Paul Vaillant Couturier, F 94807 Villejuif, France
    Proc Natl Acad Sci U S A 104:2837-42. 2007
    ..These experiments suggest that a therapeutic vaccine containing VEGF kinoid may represent a strategy for safely combating VEGF-dependent neovascularization and metastases occurring in malignant tumors...