Affiliation: University of Washington
- Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strainsLaurence Rohmer
Department of Genome Sciences, University of Washington, Campus Box 357710, 1705 NE Pacific Street Seattle, Washington 98195, USA
Genome Biol 8:R102. 2007....
- Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002B Gallis
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 274:30101-8. 1999..Finally, PKB phosphorylated eNOS in vitro at the same site phosphorylated in the cell and increased eNOS enzymatic activity by 15-20-fold...
- TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cellsF Kim
Department of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
Am J Physiol Cell Physiol 280:C1057-65. 2001..This study suggests one potential mechanism for the development of endothelial dysfunction in disease states with alterations in insulin regulation and increased TNF-alpha levels...
- A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-MplY Miyakawa
Divisions of Hematology and Cardiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
J Biol Chem 275:32214-9. 2000..However, the mutation of Ser-18 to Ala nearly abrogates TPO-induced proliferation and co-precipitation of JAK2 with Mpl. This study provides the first systematic analysis of the role of Ser residues in c-Mpl signaling...