Research Topics
Genomes and Genes | Zoran GalicSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Generation of T lineage cells from human embryonic stem cells in a feeder free systemZoran Galic
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
Stem Cells 27:100-7. 2009....
Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cellsTae Sub Park
Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA, USA
Stem Cells 27:783-95. 2009....- The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigensScott G Kitchen
Department of Medicine, and UCLA AIDS Institute, David Geffen School of Medicine, University of California-Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 102:3794-9. 2005..Therefore, CD4 expression on CD8 T lymphocytes modulates cytotoxic T lymphocyte function and is critical in vivo for optimal cell-mediated immunity to viral and alloantigens... - T lineage differentiation from human embryonic stem cellsZoran Galic
Department of Medicine, UCLA AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1678, USA
Proc Natl Acad Sci U S A 103:11742-7. 2006..Stable transgene expression was maintained at high levels throughout differentiation, suggesting that genetically manipulated hESC hold potential to treat several T cell disorders... - A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse modelSaki Shimizu
Department of Medicine, Division of Hematology Oncology, UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
Blood 115:1534-44. 2010..These results demonstrate that lentiviral vector delivery of shRNA into human HPSCs could stably down-regulate CCR5 in systemic lymphoid organs in vivo... 
Controlling false-negative errors in microarray differential expression analysis: a PRIM approachSteve W Cole
Department of Medicine, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
Bioinformatics 19:1808-16. 2003....- Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient miceScott G Kitchen
Division of Hematology Oncology, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 4:e8208. 2009.... - Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cellsDimitrios N Vatakis
Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine at the University of California, Los Angeles CA 90095, USA
Proc Natl Acad Sci U S A 108:E1408-16. 2011..These studies present a potential therapeutic approach and an important tool to understand better and to optimize the human immune response to melanoma and, potentially, to other types of cancer... - A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumorsGustavo A Miranda-Carboni
Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
Genes Dev 22:3121-34. 2008..CUL4A and CUL4B are therefore components of a conserved Wnt-induced proteasome targeting (WIPT) complex that regulates p27(KIP1) levels and cell cycle progression in mammalian cells... - A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumorsAnne E Conway
Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, USA
Stem Cells 27:18-28. 2009.... - beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTAMargaret Chang
Department of Microbiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1678, USA
J Virol 79:13538-47. 2005..These findings also suggest novel therapeutic strategies for controlling the activity of this oncogenic gammaherpesvirus in vivo... - Expression-based monitoring of transcription factor activity: the TELiS databaseSteve W Cole
UCLA Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
Bioinformatics 21:803-10. 2005..TELiS thus provides a simple, rapid and sensitive tool for identifying transcription control pathways mediating observed gene expression dynamics... - CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infectionScott G Kitchen
Department of Medicine and Microbiology, David Geffen School of Medicine, University of California, 11-934 Factor Building, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 101:8727-32. 2004..Thus, the CD4 molecule plays a direct role in CD8 T cell function, and infection of these cells by HIV provides an additional reservoir for the virus and also may contribute to the immunodeficiency seen in HIV disease... - Combinatorial regulation of the murine RAG-2 promoter by Sp1 and distinct lymphocyte-specific transcription factorsGustavo A Miranda
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles 405 Hilgard Ave, Los Angeles, CA 90095 1606, USA
Mol Immunol 38:1151-9. 2002..Apart from showing that Sp1 interacts within the RAG-2 promoter, we also demonstrate that the Sp1-binding site is necessary for the high-level activation of this promoter...