P R Galassetti

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Aspects of inflammation and oxidative stress in pediatric obesity and type 1 diabetes: an overview of ten years of studies
    Brian Tran
    Insitute for Clinical and Translational Science, University of California, 843 Health Science Road, Irvine, CA 92697, USA
    Exp Diabetes Res 2012:683680. 2012
  2. doi request reprint Exercise and type 1 diabetes (T1DM)
    Pietro Galassetti
    Department of Pediatrics, University of California Irvine, Irvine, California, USA
    Compr Physiol 3:1309-36. 2013
  3. ncbi request reprint Inflammatory cytokine, growth factor and counterregulatory responses to exercise in children with type 1 diabetes and healthy controls
    Pietro R Galassetti
    Department of Pediatrics, University of California Irvine General Clinical Research Center, Orange, CA, USA
    Pediatr Diabetes 7:16-24. 2006
  4. ncbi request reprint Effect of a high-fat meal on the growth hormone response to exercise in children
    Pietro Galassetti
    General Clinical Research Center and Department of Pediatrics, University of California Irvine School of Medicine, USA
    J Pediatr Endocrinol Metab 19:777-86. 2006
  5. ncbi request reprint Effect of prior hyperglycemia on IL-6 responses to exercise in children with type 1 diabetes
    P R Galassetti
    U C Irvine General Clinical Research Center, Bldg 25, 2 Floor, 101 The City Drive, Orange, CA 92868, USA
    Am J Physiol Endocrinol Metab 290:E833-9. 2006
  6. ncbi request reprint Breath ethanol and acetone as indicators of serum glucose levels: an initial report
    Pietro R Galassetti
    Center for the Study of Health Effects of Exercise in Children, University of California, Irvine, College of Medicine, Orange, California 92868, USA
    Diabetes Technol Ther 7:115-23. 2005
  7. ncbi request reprint Dietary effects on oxidation of low-density lipoprotein and atherogenesis
    Pietro Galassetti
    Department of Pediatrics and General Clinical Research Center, University of California at Irvine, Building 25, 2nd Floor, 101 The City Drive, Orange, CA 92868, USA
    Curr Atheroscler Rep 8:523-9. 2006
  8. ncbi request reprint Nutrient intake and body composition variables in Prader-Willi syndrome--effect of growth hormone supplementation and genetic subtype
    P Galassetti
    General Clinical Research Center, University of California at Irvine Medical Center, Orange, CA 92868, USA
    J Pediatr Endocrinol Metab 20:491-500. 2007
  9. ncbi request reprint Exercise, caloric restriction, and systemic oxidative stress
    Pietro R Galassetti
    University of California Irvine School of Medicine, Irvine, CA, USA
    J Investig Med 54:67-75. 2006
  10. ncbi request reprint Reciprocity of hypoglycaemia and exercise in blunting respective counterregulatory responses: possible role of cortisol as a mediator
    P Galassetti
    Division of Endocrinology Diabetes Metabolism, Vanderbilt University School of Medicine, Nashville, TN 37232 6303, USA
    Diabetes Nutr Metab 15:341-7; discussion 347-8, 362. 2002

Research Grants

Collaborators

Detail Information

Publications33

  1. pmc Aspects of inflammation and oxidative stress in pediatric obesity and type 1 diabetes: an overview of ten years of studies
    Brian Tran
    Insitute for Clinical and Translational Science, University of California, 843 Health Science Road, Irvine, CA 92697, USA
    Exp Diabetes Res 2012:683680. 2012
    ..This paper offers a concise overview of the salient results from this decade-long research effort...
  2. doi request reprint Exercise and type 1 diabetes (T1DM)
    Pietro Galassetti
    Department of Pediatrics, University of California Irvine, Irvine, California, USA
    Compr Physiol 3:1309-36. 2013
    ....
  3. ncbi request reprint Inflammatory cytokine, growth factor and counterregulatory responses to exercise in children with type 1 diabetes and healthy controls
    Pietro R Galassetti
    Department of Pediatrics, University of California Irvine General Clinical Research Center, Orange, CA, USA
    Pediatr Diabetes 7:16-24. 2006
    ..05). In conclusion, T1DM children displayed significant alterations in multiple aspects of their adaptive response to intense exercise...
  4. ncbi request reprint Effect of a high-fat meal on the growth hormone response to exercise in children
    Pietro Galassetti
    General Clinical Research Center and Department of Pediatrics, University of California Irvine School of Medicine, USA
    J Pediatr Endocrinol Metab 19:777-86. 2006
    ..A high-fat meal before exercise, therefore (a common event in Western societies), may reduce the growth factor response to exercise in children, with potential implications for growth and development...
  5. ncbi request reprint Effect of prior hyperglycemia on IL-6 responses to exercise in children with type 1 diabetes
    P R Galassetti
    U C Irvine General Clinical Research Center, Bldg 25, 2 Floor, 101 The City Drive, Orange, CA 92868, USA
    Am J Physiol Endocrinol Metab 290:E833-9. 2006
    ....
  6. ncbi request reprint Breath ethanol and acetone as indicators of serum glucose levels: an initial report
    Pietro R Galassetti
    Center for the Study of Health Effects of Exercise in Children, University of California, Irvine, College of Medicine, Orange, California 92868, USA
    Diabetes Technol Ther 7:115-23. 2005
    ..We hypothesized that the integrated analysis of breath ethanol and acetone would provide a good approximation of the blood glucose profile during a glucose load...
  7. ncbi request reprint Dietary effects on oxidation of low-density lipoprotein and atherogenesis
    Pietro Galassetti
    Department of Pediatrics and General Clinical Research Center, University of California at Irvine, Building 25, 2nd Floor, 101 The City Drive, Orange, CA 92868, USA
    Curr Atheroscler Rep 8:523-9. 2006
    ....
  8. ncbi request reprint Nutrient intake and body composition variables in Prader-Willi syndrome--effect of growth hormone supplementation and genetic subtype
    P Galassetti
    General Clinical Research Center, University of California at Irvine Medical Center, Orange, CA 92868, USA
    J Pediatr Endocrinol Metab 20:491-500. 2007
    ..We therefore compared GH-treated and nontreated patients, taking into account Tanner stage, gender, and genetic form...
  9. ncbi request reprint Exercise, caloric restriction, and systemic oxidative stress
    Pietro R Galassetti
    University of California Irvine School of Medicine, Irvine, CA, USA
    J Investig Med 54:67-75. 2006
    ....
  10. ncbi request reprint Reciprocity of hypoglycaemia and exercise in blunting respective counterregulatory responses: possible role of cortisol as a mediator
    P Galassetti
    Division of Endocrinology Diabetes Metabolism, Vanderbilt University School of Medicine, Nashville, TN 37232 6303, USA
    Diabetes Nutr Metab 15:341-7; discussion 347-8, 362. 2002
  11. ncbi request reprint Reduced exercise-associated response of the GH-IGF-I axis and catecholamines in obese children and adolescents
    Alon Eliakim
    Pediatric Exercise Research Center, Department of Pediatrics, University Children s Hospital, University of California, CA 92868
    J Appl Physiol 100:1630-7. 2006
    ..These abnormalities were compensated for, so that exercise was not associated with hypoglycemia, despite increased insulin levels in obese children...
  12. pmc Exhaled methyl nitrate as a noninvasive marker of hyperglycemia in type 1 diabetes
    B J Novak
    Department of Chemistry, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 104:15613-8. 2007
    ..003-0.001). Indeed, the kinetic profiles of the two variables paralleled each other in 16 of 18 experiments, including repeat subjects who at different times displayed either euglycemia or hyperglycemia...
  13. ncbi request reprint Effect of sex on counterregulatory responses to exercise after antecedent hypoglycemia in type 1 diabetes
    Pietro Galassetti
    715 PRB, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt Univ School of Medicine, Nashville, TN 37232 6303, USA
    Am J Physiol Endocrinol Metab 287:E16-24. 2004
    ..Preserved counterregulatory responses during exercise in T1DM women may confer greater protection against hypoglycemia than in men with T1DM...
  14. ncbi request reprint Effect of gender on counterregulatory responses to euglycemic exercise in type 1 diabetes
    Pietro Galassetti
    Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University School of Medicine, Nashville, TN 37232 6303, USA
    J Clin Endocrinol Metab 87:5144-50. 2002
    ..Other responses, including glucagon and EGP, were similar between genders, suggesting that the glucagon to insulin ratio may be the primary determinant of EGP during moderate intensity exercise in T1DM...
  15. ncbi request reprint Interaction of free fatty acids and epinephrine in regulating hepatic glucose production in conscious dogs
    Chang An Chu
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Endocrinol Metab 284:E291-301. 2003
    ..In conclusion, increased FFA markedly changed the mechanism by which EPI stimulated hepatic glucose production, suggesting that its overall lipolytic effect may be important in determining its effect on the liver...
  16. ncbi request reprint Prior exercise and the response to insulin-induced hypoglycemia in the dog
    Yoshiharu Koyama
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Am J Physiol Endocrinol Metab 282:E1128-38. 2002
    ..The primary site of this reduction is the liver...
  17. ncbi request reprint Exercise, stress, and inflammation in the growing child: from the bench to the playground
    Dan Michael Cooper
    Department of Pediatrics, Center for the Study of Health Effects of Exercise in Children, College of Medicine, University of California, Irvine, Orange, 92868, USA
    Curr Opin Pediatr 16:286-92. 2004
    ..New mechanistic insights have created the opportunity for a phase shift in understanding of the links between exercise and health in the context of the growing child...
  18. ncbi request reprint Effect of differing antecedent hypoglycemia on counterregulatory responses to exercise in type 1 diabetes
    Pietro Galassetti
    Division of Diabetes, Endocrinology and Metabolism, Vanderbilt Univ School of Medicine, Nashville, TN 37232 6303, USA
    Am J Physiol Endocrinol Metab 290:E1109-17. 2006
    ..9 mmol/l in patients with T1DM...
  19. ncbi request reprint Effect of antecedent hypoglycemia on counterregulatory responses to subsequent euglycemic exercise in type 1 diabetes
    Pietro Galassetti
    Departments of Medicine and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine and Nashville Veteran Affairs Medical Center, Nashville, Tennessee 37232 6303, USA
    Diabetes 52:1761-9. 2003
    ..These data indicate that counterregulatory failure may be a significant in vivo mechanism responsible for exercise-associated hypoglycemia in type 1 diabetes...
  20. ncbi request reprint Inclusion of low amounts of fructose with an intraportal glucose load increases net hepatic glucose uptake in the presence of relative insulin deficiency in dog
    Masakazu Shiota
    Dept of Molecular Physiology and Biophysics, Vanderbilt Univ School of Medicine, 702 Light Hall, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 288:E1160-7. 2005
    ..In conclusion, small amounts of fructose can markedly reduce hyperglycemia during intraportal glucose infusion by increasing NHGU even when insulin secretion is compromised...
  21. ncbi request reprint Negative energy balance plays a major role in the IGF-I response to exercise training
    Dan Nemet
    Center for the Study of Health Effects of Exeercise in Childdren, University of California Children s Hospital, College of Medicine, Irvine, CA 92868, USA
    J Appl Physiol (1985) 96:276-82. 2004
    ..Exercise-associated mechanisms may inhibit increases in IGF-I early in the course of a training protocol, even in overfed subjects...
  22. ncbi request reprint Cellular immunity and inflammatory mediator responses to intense exercise in overweight children and adolescents
    Robert G McMurray
    Pediatric Exercise Research Center, Department of Pediatrics, University Children s Hospital, University of California, Irvine, Irvine, CA, USA
    J Investig Med 55:120-9. 2007
    ..Obesity modifies inflammatory mediators, but little is known about how obesity modifies the inflammatory responses of exercising children. This study assessed the acute effect of exercise on inflammatory mediators in overweight children...
  23. ncbi request reprint Leptin responses to antecedent exercise and hypoglycemia in healthy and type 1 diabetes mellitus men and women
    Darleen A Sandoval
    Department of Medicine, Vanderbilt University School of Medicine and Nashville Veterans Affairs Medical Center, Nashville, TN 37232, USA
    J Diabetes Complications 17:301-6. 2003
    ..However, T1DM patients do have increased basal leptin levels compared to healthy man. Lastly, there is a marked sexual dimorphism in plasma leptin responses to repeated episodes of exercise...
  24. ncbi request reprint Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog
    Masakazu Shiota
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Diabetes 51:469-78. 2002
    ..As a result, postprandial hyperglycemia and insulin release by the pancreatic beta-cell were reduced. In conclusion, catalytic amounts of fructose have the ability to improve glucose tolerance...
  25. ncbi request reprint Glucoregulation during and after exercise in health and insulin-dependent diabetes
    Raul C Camacho
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Exerc Sport Sci Rev 33:17-23. 2005
    ..These mechanisms of glucoregulatory failure may cause hypoglycemia in insulin-dependent diabetics during and after exercise...
  26. ncbi request reprint Constitutive pro- and anti-inflammatory cytokine and growth factor response to exercise in leukocytes
    Frank Zaldivar
    Department of Pediatrics, Pediatric Exercise Research Center, University Children s Hospital, University of California, Irvine, USA
    J Appl Physiol 100:1124-33. 2006
    ....
  27. pmc Inflammatory cytokine profiles during exercise in obese, diabetic, and healthy children
    Jaime S Rosa
    University of California, Department of Pharmacology, Irvine, CA, USA
    J Clin Res Pediatr Endocrinol 3:115-21. 2011
    ..To date, exercise-induced alterations in immuno-modulatory mediators in Ob and T1DM children remain largely unknown...
  28. ncbi request reprint Effects of 30 min of aerobic exercise on gene expression in human neutrophils
    Shlomit Radom-Aizik
    Pediatric Exercise Research Center, Department of Pediatrics, University Children s Hospital, University of California Irvine, Orange, California, USA
    J Appl Physiol (1985) 104:236-43. 2008
    ..In summary, brief heavy exercise leads to a previously unknown substantial and significant alteration in neutrophil gene expression...
  29. pmc Evidence for microRNA involvement in exercise-associated neutrophil gene expression changes
    Shlomit Radom-Aizik
    Pediatric Exercise Research Center, Department of Pediatrics, University Children s Hospital, University of California Irvine, Orange, CA 92868, USA
    J Appl Physiol (1985) 109:252-61. 2010
    ..These data support the hypothesis that exercise-associated changes in neutrophil miRNA expression play a role in neutrophil gene expression in response to physical activity...
  30. ncbi request reprint Kinetic profiles of 18 systemic pro- and anti-inflammatory mediators during and following exercise in children
    Jaime S Rosa
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA, USA
    J Pediatr Endocrinol Metab 20:1293-305. 2007
    ....
  31. doi request reprint Sustained IL-1alpha, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus
    Jaime S Rosa
    Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Pediatr Diabetes 9:9-16. 2008
    ....
  32. pmc Prevention and treatment of type 2 diabetes: current role of lifestyle, natural product, and pharmacological interventions
    Nicholas P Hays
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States
    Pharmacol Ther 118:181-91. 2008
    ....

Research Grants5

  1. Hypoglycemia & exercise in children with type 1 diabetes
    Pietro Galassetti; Fiscal Year: 2003
    ..The results from our studies will hopefully provide the conceptual basis for new therapeutic strategies aimed at correcting the high incidence of hypoglycemia in children with diabetes. ..
  2. Mentored Patient-Oriented Research Career Development Award
    Pietro Galassetti; Fiscal Year: 2004
    ..The results from our studies will hopefully provide the conceptual basis for new therapeutic strategies aimed at correcting the high incidence of hypoglycemia in children with diabetes. ..
  3. Mentored Patient-Oriented Research Career Development Award
    Pietro Galassetti; Fiscal Year: 2005
    ..The results from our studies will hopefully provide the conceptual basis for new therapeutic strategies aimed at correcting the high incidence of hypoglycemia in children with diabetes. ..
  4. Mentored Patient-Oriented Research Career Development Award
    Pietro Galassetti; Fiscal Year: 2006
    ..The results from our studies will hopefully provide the conceptual basis for new therapeutic strategies aimed at correcting the high incidence of hypoglycemia in children with diabetes. ..
  5. Hypoglycemia & exercise in children with type 1 diabetes
    Pietro Galassetti; Fiscal Year: 2007
    ..The results from our studies will hopefully provide the conceptual basis for new therapeutic strategies aimed at correcting the high incidence of hypoglycemia in children with diabetes. ..