Lorise C Gahring

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage
    Lorise C Gahring
    Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e57481. 2013
  2. pmc Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells
    Lorise C Gahring
    Geriatric Research Education and Clinical Center, Salt Lake City VAMC, Salt Lake City, Utah 84132, USA
    AAPS J 7:E885-94. 2005
  3. ncbi request reprint Pro-inflammatory cytokines modify neuronal nicotinic acetylcholine receptor assembly
    Lorise C Gahring
    Salt Lake City VA Geriatrics Research, Education and Clinical Center, Salt Lake City, UT 84132, USA
    J Neuroimmunol 166:88-101. 2005
  4. ncbi request reprint Mouse strain-specific changes in nicotinic receptor expression with age
    Lorise C Gahring
    Salt Lake City VA Geriatrics Research, Education and Clinical Center, Salt Lake City, UT 84148, USA
    Neurobiol Aging 26:973-80. 2005
  5. ncbi request reprint Mouse strain-specific nicotinic acetylcholine receptor expression by inhibitory interneurons and astrocytes in the dorsal hippocampus
    Lorise C Gahring
    Salt Lake City Veterans Administration Geriatrics Research, Education and Clinical Center, Salt Lake City, Utah 84132, USA
    J Comp Neurol 468:334-46. 2004
  6. ncbi request reprint Neuronal and astrocyte expression of nicotinic receptor subunit beta4 in the adult mouse brain
    Lorise C Gahring
    Salt Lake City Veterans Administration Geriatrics Research, Education and Clinical Center, Salt Lake City, Utah 84132, USA
    J Comp Neurol 468:322-33. 2004
  7. ncbi request reprint Nicotine-induced neuroprotection against N-methyl-D-aspartic acid or beta-amyloid peptide occur through independent mechanisms distinguished by pro-inflammatory cytokines
    Lorise C Gahring
    Geriatric Research, Education and Clinical Center, Salt Lake City VA, Salt Lake City, UT 84132, USA
    J Neurochem 87:1125-36. 2003
  8. pmc Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation
    Lorise C Gahring
    Geriatric Research, Education and Clinical Center, Salt Lake City VA Medical Center, USA
    J Neuroinflammation 7:38. 2010
  9. ncbi request reprint Autoimmunity to glutamate receptors in the central nervous system
    Lorise C Gahring
    Salt Lake City VA GRECC, University of Utah School of Medicine, Department of Internal Medicine, 84132, USA
    Crit Rev Immunol 22:295-316. 2002
  10. ncbi request reprint Tumor necrosis factor alpha enhances nicotinic receptor up-regulation via a p38MAPK-dependent pathway
    Lorise C Gahring
    Salt Lake City Veterans Affairs Geriatrics Research, Education, Clinical Center, Salt Lake City, Utah 84148, USA
    J Biol Chem 283:693-9. 2008

Detail Information

Publications22

  1. pmc Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage
    Lorise C Gahring
    Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e57481. 2013
    ....
  2. pmc Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells
    Lorise C Gahring
    Geriatric Research Education and Clinical Center, Salt Lake City VAMC, Salt Lake City, Utah 84132, USA
    AAPS J 7:E885-94. 2005
    ..Understanding these processes may offer novel therapeutic strategies to approach inflammatory diseases, as well as precautions in the design of interventional drugs...
  3. ncbi request reprint Pro-inflammatory cytokines modify neuronal nicotinic acetylcholine receptor assembly
    Lorise C Gahring
    Salt Lake City VA Geriatrics Research, Education and Clinical Center, Salt Lake City, UT 84132, USA
    J Neuroimmunol 166:88-101. 2005
    ..These results show that the emerging rules governing assembly of nAChRs are subject to modification by the pro-inflammatory cytokine environment...
  4. ncbi request reprint Mouse strain-specific changes in nicotinic receptor expression with age
    Lorise C Gahring
    Salt Lake City VA Geriatrics Research, Education and Clinical Center, Salt Lake City, UT 84148, USA
    Neurobiol Aging 26:973-80. 2005
    ..These results suggest that mouse strains of different genetic backgrounds undergo dissimilar age-related changes in the expression of nAChRs...
  5. ncbi request reprint Mouse strain-specific nicotinic acetylcholine receptor expression by inhibitory interneurons and astrocytes in the dorsal hippocampus
    Lorise C Gahring
    Salt Lake City Veterans Administration Geriatrics Research, Education and Clinical Center, Salt Lake City, Utah 84132, USA
    J Comp Neurol 468:334-46. 2004
    ....
  6. ncbi request reprint Neuronal and astrocyte expression of nicotinic receptor subunit beta4 in the adult mouse brain
    Lorise C Gahring
    Salt Lake City Veterans Administration Geriatrics Research, Education and Clinical Center, Salt Lake City, Utah 84132, USA
    J Comp Neurol 468:322-33. 2004
    ....
  7. ncbi request reprint Nicotine-induced neuroprotection against N-methyl-D-aspartic acid or beta-amyloid peptide occur through independent mechanisms distinguished by pro-inflammatory cytokines
    Lorise C Gahring
    Geriatric Research, Education and Clinical Center, Salt Lake City VA, Salt Lake City, UT 84132, USA
    J Neurochem 87:1125-36. 2003
    ..These results provide insight into how nicotine imparts neuroprotection and modulates inflammatory responses...
  8. pmc Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation
    Lorise C Gahring
    Geriatric Research, Education and Clinical Center, Salt Lake City VA Medical Center, USA
    J Neuroinflammation 7:38. 2010
    ..Control of responses in this organ is, in part, modulated by the neuronal nicotinic acetylcholine receptor (nAChR) alpha7...
  9. ncbi request reprint Autoimmunity to glutamate receptors in the central nervous system
    Lorise C Gahring
    Salt Lake City VA GRECC, University of Utah School of Medicine, Department of Internal Medicine, 84132, USA
    Crit Rev Immunol 22:295-316. 2002
    ....
  10. ncbi request reprint Tumor necrosis factor alpha enhances nicotinic receptor up-regulation via a p38MAPK-dependent pathway
    Lorise C Gahring
    Salt Lake City Veterans Affairs Geriatrics Research, Education, Clinical Center, Salt Lake City, Utah 84148, USA
    J Biol Chem 283:693-9. 2008
    ..This finding extends the possibilities for nAChR-inflammatory interactions in normal physiological processes and offers novel insights into endogenous mechanisms that can modify up-regulation...
  11. pmc Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation
    Amber V Osborne-Hereford
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, United States
    J Neuroimmunol 193:130-9. 2008
    ..Altered pro-inflammatory responses correlated with changes in SOCS3 protein. These results demonstrate that nAChRalpha7 can participate in modulating a local pro-inflammatory response in the absence of parasympathetic innervation...
  12. pmc Mouse chromosome 11 harbors genetic determinants of hippocampal strain-specific nicotinic receptor expression
    Scott W Rogers
    SLC VA GRECC and University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Hippocampus 18:750-7. 2008
    ..These finding suggest that this chromosomal segment harbors genes that regulate strain distinct hippocampal morphology that is revealed by nAChR alpha 4 expression...
  13. pmc Choline promotes nicotinic receptor alpha4 + beta2 up-regulation
    Lorise C Gahring
    Salt Lake City Veterans Affairs Geriatrics Research, Education, and Clinical Center, Salt Lake City, Utah, USA
    J Biol Chem 285:19793-801. 2010
    ..These findings extend the view that up-regulation of alpha4 + beta2 nAChRs is a normal physiological response to altered metabolic and inflammatory conditions...
  14. ncbi request reprint Age-related loss of neuronal nicotinic receptor expression in the aging mouse hippocampus corresponds with cyclooxygenase-2 and PPAR gamma expression and is altered by long-term NS398 administration
    Lorise C Gahring
    Salt Lake City VA Geriatrics Research, Education and Clinical Center, Salt Lake City, Utah, USA
    J Neurobiol 62:453-68. 2005
    ..These results provide evidence that the interaction during aging between oral administration of nicotine and NSAIDs are not straightforward and could even be antagonistic when combined...
  15. pmc Nicotinic acetylcholine receptor expression in the hippocampus of 27 mouse strains reveals novel inhibitory circuitry
    Lorise C Gahring
    Salt Lake City VA Geriatrics Research, Education and Clinical Center, University of Utah, Salt Lake City, Utah 84132, USA
    Hippocampus 18:737-49. 2008
    ..These findings define a genetic frame-work in which the strain-specific responses to nicotine include underlying contributions by the varied anatomical context in which nAChRs are expressed...
  16. pmc Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure
    Scott W Rogers
    Salt Lake City VA Geriatric Research, Education and Clinical Center, Salt Lake City, Utah, USA
    Am J Med Genet A 158:1135-44. 2012
    ..These studies identify the Chrna7 cell lineage as participating in posterior neuropore closure and present a novel model of lower SB that can be substantially modified by the prenatal environment...
  17. ncbi request reprint Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase
    Erin L Meyer
    Salt Lake City Veteran s Affairs Geriatrics Research, Education and Clinical Center, University of Utah, Salt Lake City, Utah 84132, USA
    J Biol Chem 278:23786-96. 2003
    ..These results suggest that limited proteolysis is another post-translational mechanism through which functional diversity and specialization between closely related GluR subunits is accomplished...
  18. pmc Nicotinic receptor subunit alpha5 modifies assembly, up-regulation, and response to pro-inflammatory cytokines
    Lorise C Gahring
    Salt Lake City Veterans Affairs Geriatrics Research, Education and Clinical Center, University of Utah, Salt Lake City, Utah 84132, USA
    J Biol Chem 285:26049-57. 2010
    ..These findings suggest that alpha5 is an influential modulator of alpha4+beta2 nicotinic acetylcholine receptor assembly and stabilizes their expression in response to fluctuations in external conditions...
  19. pmc The expression of nicotinic receptor alpha7 during cochlear development
    Scott W Rogers
    Salt Lake City VA Geriatric Research, Education and Clinical Center, University of Utah Salt Lake City, Utah, 84132 Department of Neurobiology and Anatomy, University of Utah School of Medicine Salt Lake City, Utah, 84132
    Brain Behav 2:628-39. 2012
    ..Our findings suggest that alpha7 expression by both neuronal and non-neuronal cells has the potential to impact multiple auditory functions through mechanisms that are not traditionally attributed to this receptor...
  20. pmc Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy
    Scott W Rogers
    Geriatric Research, Education and Clinical Center, Veteran s Administration, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e36467. 2012
    ..These results demonstrate distinct and varied spatiotemporal expression of alpha7 during tooth development, and they suggest that dysfunction of this receptor would have diverse impacts upon the adult organ...
  21. ncbi request reprint Nicotine preconditioning antagonizes activity-dependent caspase proteolysis of a glutamate receptor
    Erin L Meyer
    Salt Lake City Veterans Affairs Geriatrics Research, Education, and Clinical Center and the University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Biol Chem 277:10869-75. 2002
    ..The modulation of GluR1 agonist-initiated caspase-mediated cleavage by nicotine preconditioning offers a novel insight into how this agent can impart its numerous effects on the nervous system...
  22. pmc A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction
    Robert B Weiss
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS Genet 4:e1000125. 2008
    ..The identification of an age-dependent susceptibility haplotype reinforces the importance of preventing early exposure to tobacco through public health policies...

Research Grants11

  1. Cholinergic Modulation of Inflammatory CNS Cytokines
    LORISE GAHRING; Fiscal Year: 2003
    ....
  2. Peripheral Nicotinic Cholinergic and Inflammatory Dysfunction in Aging
    LORISE GAHRING; Fiscal Year: 2009
    ..Further, we will determine if changes in nAChR expression shape the progression of normal aging of the skin through altering the important balance between normal and excessive inflammation. ..
  3. Peripheral Nicotinic Cholinergic and Inflammatory Dysfunction in Aging
    Lorise C Gahring; Fiscal Year: 2010
    ..Further, we will determine if changes in nAChR expression shape the progression of normal aging of the skin through altering the important balance between normal and excessive inflammation. ..
  4. Mechanisms of TNFa Enhancement of Nicotinic Receptor Upregulation
    LORISE GAHRING; Fiscal Year: 2009
    ..Understanding how the inflammatory system and response to nicotine interact will impact upon how we approach these problems with therapeutic agents. ..
  5. Peripheral Nicotinic Cholinergic and Inflammatory Dysfunction in Aging
    LORISE GAHRING; Fiscal Year: 2009
    ..Further, we will determine if changes in nAChR expression shape the progression of normal aging of the skin through altering the important balance between normal and excessive inflammation. ..
  6. Nicotine Modulation of Caspases in Non-Neuronal Cells
    LORISE GAHRING; Fiscal Year: 2006
    ....
  7. Cholinergic Modulation of Inflammatory CNS Cytokines
    LORISE GAHRING; Fiscal Year: 2006
    ..abstract_text> ..
  8. Mechanisms of TNFa Enhancement of Nicotinic Receptor Upregulation
    SCOTT WARREN ROGERS; Fiscal Year: 2010
    ..Understanding how the inflammatory system and response to nicotine interact will impact upon how we approach these problems with therapeutic agents. ..