Manuela Gago-Dominguez

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033 0800, USA
    Carcinogenesis 24:483-9. 2003
  2. ncbi request reprint Lipid peroxidation and renal cell carcinoma: further supportive evidence and new mechanistic insights
    Manuela Gago-Dominguez
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 9176, USA
    Free Radic Biol Med 40:721-33. 2006
  3. ncbi request reprint Marine n-3 fatty acid intake, glutathione S-transferase polymorphisms and breast cancer risk in post-menopausal Chinese women in Singapore
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033 0800, USA
    Carcinogenesis 25:2143-7. 2004
  4. pmc Opposing effects of dietary n-3 and n-6 fatty acids on mammary carcinogenesis: The Singapore Chinese Health Study
    M Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9181, USA
    Br J Cancer 89:1686-92. 2003
  5. ncbi request reprint Lipid peroxidation and the protective effect of physical exercise on breast cancer
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033 0800, United States
    Med Hypotheses 68:1138-43. 2007
  6. pmc Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033 0800, USA
    Breast Cancer Res 9:201. 2007
  7. doi request reprint Role of lipid peroxidation and oxidative stress in the association between thyroid diseases and breast cancer
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033 0800, United States
    Crit Rev Oncol Hematol 68:107-14. 2008
  8. ncbi request reprint Role of lipid peroxidation in the epidemiology and prevention of breast cancer
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9181, USA
    Cancer Epidemiol Biomarkers Prev 14:2829-39. 2005
  9. pmc Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study
    Manuela Gago-Dominguez
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 9175, USA
    Carcinogenesis 32:197-202. 2011
  10. pmc Hypertension, diuretics and antihypertensives in relation to bladder cancer
    Xuejuan Jiang
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Carcinogenesis 31:1964-71. 2010

Research Grants

  1. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2006
  2. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2007
  3. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2009

Detail Information

Publications37

  1. ncbi request reprint Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033 0800, USA
    Carcinogenesis 24:483-9. 2003
    ..On the other hand, individuals of NAT1*10 genotype exhibited no such associations...
  2. ncbi request reprint Lipid peroxidation and renal cell carcinoma: further supportive evidence and new mechanistic insights
    Manuela Gago-Dominguez
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 9176, USA
    Free Radic Biol Med 40:721-33. 2006
    ....
  3. ncbi request reprint Marine n-3 fatty acid intake, glutathione S-transferase polymorphisms and breast cancer risk in post-menopausal Chinese women in Singapore
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033 0800, USA
    Carcinogenesis 25:2143-7. 2004
    ..36, 95% CI = 0.14, 0.94). A similar relationship was observed among women with the combined GSTT1 null and GSTP1 AB/BB genotypes (OR = 0.26, 95% CI = 0.08, 0.78)...
  4. pmc Opposing effects of dietary n-3 and n-6 fatty acids on mammary carcinogenesis: The Singapore Chinese Health Study
    M Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9181, USA
    Br J Cancer 89:1686-92. 2003
    ..06-3.27); the corresponding RR for advanced breast cancer was 2.45 (95% CI=1.20-4.97, P for trend=0.01). To our knowledge, these are the first prospective findings linking the intake of marine n-3 fatty acids to breast cancer protection...
  5. ncbi request reprint Lipid peroxidation and the protective effect of physical exercise on breast cancer
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033 0800, United States
    Med Hypotheses 68:1138-43. 2007
    ....
  6. pmc Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033 0800, USA
    Breast Cancer Res 9:201. 2007
    ..We also review the epidemiological evidence supporting a modifying effect of oxidative stress genes in dietary factor-breast cancer relationships...
  7. doi request reprint Role of lipid peroxidation and oxidative stress in the association between thyroid diseases and breast cancer
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033 0800, United States
    Crit Rev Oncol Hematol 68:107-14. 2008
    ..e., from its ability to generate oxidative stress-induced apoptosis. Conversely, the increased risk from hypothyroidism may derive from its ability to inhibit this stress-mediated apoptotic process...
  8. ncbi request reprint Role of lipid peroxidation in the epidemiology and prevention of breast cancer
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9181, USA
    Cancer Epidemiol Biomarkers Prev 14:2829-39. 2005
    ....
  9. pmc Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study
    Manuela Gago-Dominguez
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 9175, USA
    Carcinogenesis 32:197-202. 2011
    ..26; 95% CI, 1.04-1.54; P = 0.017). Our results support 5p15 and 15q25 as susceptibility regions for bladder cancer risk...
  10. pmc Hypertension, diuretics and antihypertensives in relation to bladder cancer
    Xuejuan Jiang
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Carcinogenesis 31:1964-71. 2010
    ..7 pg/g Hb) compared with individuals without hypertension (79.8 pg/g Hb) (P = 0.009). In conclusion, untreated hypertension was associated with a reduced risk of bladder cancer...
  11. pmc Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA
    Cancer Epidemiol Biomarkers Prev 18:3057-61. 2009
    ..045). Our results suggest that a TP63 gene variant may increase susceptibility for the development of urinary bladder tumors with low risk of progression...
  12. pmc Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study
    Victoria K Cortessis
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, MC 9175, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 19:3150-6. 2010
    ..Recent genome-wide association studies of urinary bladder cancer report risk to be associated with the T allele of rs9642880 on 8q24 among individuals of European descent...
  13. ncbi request reprint Lipid peroxidation: a novel and unifying concept of the etiology of renal cell carcinoma (United States)
    Manuela Gago-Dominguez
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9176, USA
    Cancer Causes Control 13:287-93. 2002
    ..Our hypothesis may also explain the roles of other risk (oophorectomy/hysterectomy, parity, smoking, diabetes) and protective factors (dietary antioxidants) for renal cell cancer...
  14. ncbi request reprint Carotenoids/vitamin C and smoking-related bladder cancer
    J Esteban Castelao
    USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9181, USA
    Int J Cancer 110:417-23. 2004
    ..The carotenoid-bladder cancer association was not affected by the GSTM1, GSTT1 and GSTP1 genotypes...
  15. pmc Cigarette smoking and subtypes of bladder cancer
    Xuejuan Jiang
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Int J Cancer 130:896-901. 2012
    ..Our results indicate that cigarette smoking was more strongly associated with increased risk of invasive bladder cancer than with low-grade superficial bladder cancer...
  16. ncbi request reprint Alcohol consumption and risk of bladder cancer in Los Angeles County
    Xuejuan Jiang
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Int J Cancer 121:839-45. 2007
    ..Alcohol consumption was strongly associated with a reduced risk of bladder cancer. The effect was modified by the type of alcoholic beverage, cigarette smoking and frequency of urination...
  17. ncbi request reprint Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai
    Roman Corral
    Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA
    Int J Cancer 135:335-47. 2014
    ..A SNP that tags both the XRCC6 and SREBF2 genes strongly modifies the association between bladder cancer risk and smoking. ..
  18. pmc Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry
    Xuejuan Jiang
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    PLoS ONE 8:e60464. 2013
    ..Our objective was to confirm the association between SMAD7 SNPs and colorectal cancer risk in the multi-center Colon Cancer Family Registry...
  19. doi request reprint Dietary sources of N-nitroso compounds and bladder cancer risk: findings from the Los Angeles bladder cancer study
    Chelsea E Catsburg
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA
    Int J Cancer 134:125-35. 2014
    ..In addition, any effect of consuming these meats may be greater when accompanied by high nitrate intake. ..
  20. pmc Lower risk in parous women suggests that hormonal factors are important in bladder cancer etiology
    Carol A Davis-Dao
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 20:1156-70. 2011
    ..Our objective was to determine whether hormonal and reproductive factors are involved in female bladder cancer...
  21. pmc Family history and breast cancer hormone receptor status in a Spanish cohort
    Xuejuan Jiang
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 7:e29459. 2012
    ..Differences in genetic composition, lifestyles, reproductive factors, or environmental exposures may contribute to the differential presentation of breast cancer among Hispanic women...
  22. ncbi request reprint Cruciferous vegetables in relation to renal cell carcinoma
    J M Yuan
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90033, USA
    Int J Cancer 77:211-6. 1998
    ..Dietary nitrosamines and their precursors were not related to RCC risk...
  23. ncbi request reprint Increased risk of renal cell carcinoma subsequent to hysterectomy
    M Gago-Dominguez
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles 90033 0800, USA
    Cancer Epidemiol Biomarkers Prev 8:999-1003. 1999
    ..We conjecture that unintentional injury to the ureter during the surgical procedure, which results in renal cell damage and consequent renal cell proliferation, may be a cause of the increased cancer risk in hysterectomized women...
  24. ncbi request reprint Tobacco use in relation to renal cell carcinoma
    J M Yuan
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles 90033 0800, USA
    Cancer Epidemiol Biomarkers Prev 7:429-33. 1998
    ..Seventeen percent of RCC (21% in men and 11% in women) in Los Angeles, California can be attributed to cigarette smoking...
  25. pmc Urinary tract infections and reduced risk of bladder cancer in Los Angeles
    X Jiang
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90089, USA
    Br J Cancer 100:834-9. 2009
    ..Our results suggest that a history of bladder infection is associated with a reduced risk of bladder cancer among women. Cytotoxicity from antibiotics commonly used to treat bladder infections is proposed as one possible explanation...
  26. ncbi request reprint Use of permanent hair dyes and bladder-cancer risk
    M Gago-Dominguez
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, M S 44, University of Southern California School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Int J Cancer 91:575-9. 2001
    ..Subjects who worked for 10 or more years as hairdressers or barbers experienced a 5-fold (95% CI = 1.3-19.2) increase in risk compared to individuals not exposed...
  27. ncbi request reprint Gender- and smoking-related bladder cancer risk
    J E Castelao
    University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles 90089 9181, USA
    J Natl Cancer Inst 93:538-45. 2001
    ..Because smokers are also at risk for bladder cancer, we investigated possible sex differences in the susceptibility to bladder cancer among smokers...
  28. ncbi request reprint Phenobarbital use and bladder cancer risk
    J E Castelao
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9175, USA
    Eur J Epidemiol 18:659-64. 2003
    ..It was proposed that PB use protects against bladder cancer by inducing enzymes that participate in the detoxification of human bladder carcinogens, such as the aminobiphenyls and naphthylamines, which are found in cigarette smoke...
  29. ncbi request reprint Family history and risk of renal cell carcinoma
    M Gago-Dominguez
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles, California 90033 0800, USA
    Cancer Epidemiol Biomarkers Prev 10:1001-4. 2001
    ..A FH of urinary tract cancers other than kidney cancer was not associated with RCC risk (OR, 0.7; 95% CI, 0.3-1.7). A FH of nonurinary tract cancers also was unrelated to RCC risk (OR, 1.1; 95% CI, 0.9-1.5)...
  30. ncbi request reprint The value of risk-factor ("black-box") epidemiology
    Sander Greenland
    Department of Epidemiology and Statistics, University of California Los Angeles, Los Angeles, California 90095, USA
    Epidemiology 15:529-35. 2004
    ....
  31. doi request reprint Risk factors for cardiovascular disease in women: relationship to lipid peroxidation and oxidative stress
    J Esteban Castelao
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033 0800, USA
    Med Hypotheses 71:39-44. 2008
    ..We also discuss how screening human populations for reactive oxygen species (ROS) levels could help identify groups with a high level of ROS that may be at risk of developing CVD...
  32. pmc Hypertension, obesity and their medications in relation to renal cell carcinoma
    J M Yuan
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90033 0800, USA
    Br J Cancer 77:1508-13. 1998
    ..4-2.8) and the risk increased with increasing dose of amphetamines. However, the fraction of cases possibly related to this exposure is small (population-attributable risk = 5%)...
  33. pmc Regular use of analgesics is a risk factor for renal cell carcinoma
    M Gago Dominguez
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90033 0800, USA
    Br J Cancer 81:542-8. 1999
    ..Subjects who took one regular-strength (i.e. 325 mg) aspirin a day or less for cardiovascular disease prevention were not at an increased risk of RCC (OR = 0.9, 95% CI = 0.6-1.4)...
  34. doi request reprint Water intake and bladder cancer risk in Los Angeles County
    Xuejuan Jiang
    USC Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Int J Cancer 123:1649-56. 2008
    ..Similarly, the protection from water intake was confined to women who did not experience nocturia and to men who did. Results from our study suggest that water intake may be associated with a slight reduction in bladder cancer risk...
  35. pmc Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA
    Cancer Res 69:6857-64. 2009
    ..002) and was strongest for the highest levels of smoking dose and smoking duration. Overall, our study provides the strongest evidence to date for a role of common variants in DNA repair genes in bladder carcinogenesis...
  36. pmc Non-steroidal anti-inflammatory drugs and bladder cancer prevention
    J E Castelao
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck University of Southern California School of Medicine, Los Angeles 90033 0800, USA
    Br J Cancer 82:1364-9. 2000
    ..Acetic acids seemed to exhibit the strongest protective effect, whereas aspirin/other salicylic acids and oxicam showed the weakest protection...
  37. ncbi request reprint Alkylaniline-hemoglobin adducts and risk of non-smoking-related bladder cancer
    Jinping Gan
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Natl Cancer Inst 96:1425-31. 2004
    ..Low levels of 4-ABP exposure have been associated with non-smoking-related bladder cancer. Other arylamine compounds coming from as yet unidentified environmental sources may also be human bladder carcinogens...

Research Grants4

  1. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2006
    ..4. To conduct a case-case association study to determine if morphological markers of apoptosis in tumor and surrounding free tissue differ among cases with varying exposure levels of a given putative environmental/genetic risk factor. ..
  2. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2007
    ..4. To conduct a case-case association study to determine if morphological markers of apoptosis in tumor and surrounding free tissue differ among cases with varying exposure levels of a given putative environmental/genetic risk factor. ..
  3. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2009
    ....