Research Topics
Genomes and GenesSpecies | Manuela Gago-DominguezSummaryAffiliation: University of Southern California Country: USA Publications
Research Grants
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Detail Information
Publications
Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2Manuela Gago-Dominguez
USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033 0800, USA
Carcinogenesis 24:483-9. 2003..On the other hand, individuals of NAT1*10 genotype exhibited no such associations...- Role of lipid peroxidation in the epidemiology and prevention of breast cancerManuela Gago-Dominguez
USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9181, USA
Cancer Epidemiol Biomarkers Prev 14:2829-39. 2005.... - Lipid peroxidation and the protective effect of physical exercise on breast cancerManuela Gago-Dominguez
USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033 0800, United States
Med Hypotheses 68:1138-43. 2007.... 
Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesisManuela Gago-Dominguez
USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033 0800, USA
Breast Cancer Res 9:201. 2007..We also review the epidemiological evidence supporting a modifying effect of oxidative stress genes in dietary factor-breast cancer relationships...- Marine n-3 fatty acid intake, glutathione S-transferase polymorphisms and breast cancer risk in post-menopausal Chinese women in SingaporeManuela Gago-Dominguez
USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033 0800, USA
Carcinogenesis 25:2143-7. 2004..36, 95% CI = 0.14, 0.94). A similar relationship was observed among women with the combined GSTT1 null and GSTP1 AB/BB genotypes (OR = 0.26, 95% CI = 0.08, 0.78)... - Opposing effects of dietary n-3 and n-6 fatty acids on mammary carcinogenesis: The Singapore Chinese Health StudyM Gago-Dominguez
USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9181, USA
Br J Cancer 89:1686-92. 2003..06-3.27); the corresponding RR for advanced breast cancer was 2.45 (95% CI=1.20-4.97, P for trend=0.01). To our knowledge, these are the first prospective findings linking the intake of marine n-3 fatty acids to breast cancer protection... 
Role of lipid peroxidation and oxidative stress in the association between thyroid diseases and breast cancerManuela Gago-Dominguez
USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033 0800, United States
Crit Rev Oncol Hematol 68:107-14. 2008..e., from its ability to generate oxidative stress-induced apoptosis. Conversely, the increased risk from hypothyroidism may derive from its ability to inhibit this stress-mediated apoptotic process...- Lipid peroxidation and renal cell carcinoma: further supportive evidence and new mechanistic insightsManuela Gago-Dominguez
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 9176, USA
Free Radic Biol Med 40:721-33. 2006.... - Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control studyManuela Gago-Dominguez
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 9175, USA
Carcinogenesis 32:197-202. 2011..26; 95% CI, 1.04-1.54; P = 0.017). Our results support 5p15 and 15q25 as susceptibility regions for bladder cancer risk... - Hypertension, diuretics and antihypertensives in relation to bladder cancerXuejuan Jiang
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Carcinogenesis 31:1964-71. 2010..7 pg/g Hb) compared with individuals without hypertension (79.8 pg/g Hb) (P = 0.009). In conclusion, untreated hypertension was associated with a reduced risk of bladder cancer... - Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control studyMariana C Stern
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA
Cancer Epidemiol Biomarkers Prev 18:3057-61. 2009..045). Our results suggest that a TP63 gene variant may increase susceptibility for the development of urinary bladder tumors with low risk of progression... - Lipid peroxidation: a novel and unifying concept of the etiology of renal cell carcinoma (United States)Manuela Gago-Dominguez
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9176, USA
Cancer Causes Control 13:287-93. 2002..Our hypothesis may also explain the roles of other risk (oophorectomy/hysterectomy, parity, smoking, diabetes) and protective factors (dietary antioxidants) for renal cell cancer... - Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control studyVictoria K Cortessis
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, MC 9175, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 19:3150-6. 2010..Recent genome-wide association studies of urinary bladder cancer report risk to be associated with the T allele of rs9642880 on 8q24 among individuals of European descent... - Carotenoids/vitamin C and smoking-related bladder cancerJ Esteban Castelao
USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9181, USA
Int J Cancer 110:417-23. 2004..The carotenoid-bladder cancer association was not affected by the GSTM1, GSTT1 and GSTP1 genotypes... - Cigarette smoking and subtypes of bladder cancerXuejuan Jiang
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Int J Cancer 130:896-901. 2012..Our results indicate that cigarette smoking was more strongly associated with increased risk of invasive bladder cancer than with low-grade superficial bladder cancer... - Alcohol consumption and risk of bladder cancer in Los Angeles CountyXuejuan Jiang
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Int J Cancer 121:839-45. 2007..Alcohol consumption was strongly associated with a reduced risk of bladder cancer. The effect was modified by the type of alcoholic beverage, cigarette smoking and frequency of urination... - Lower risk in parous women suggests that hormonal factors are important in bladder cancer etiologyCarol A Davis-Dao
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 20:1156-70. 2011..Our objective was to determine whether hormonal and reproductive factors are involved in female bladder cancer... - Family history and breast cancer hormone receptor status in a Spanish cohortXuejuan Jiang
Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of America
PLoS ONE 7:e29459. 2012..Differences in genetic composition, lifestyles, reproductive factors, or environmental exposures may contribute to the differential presentation of breast cancer among Hispanic women... - Urinary tract infections and reduced risk of bladder cancer in Los AngelesX Jiang
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90089, USA
Br J Cancer 100:834-9. 2009..Our results suggest that a history of bladder infection is associated with a reduced risk of bladder cancer among women. Cytotoxicity from antibiotics commonly used to treat bladder infections is proposed as one possible explanation... - Tobacco use in relation to renal cell carcinomaJ M Yuan
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles 90033 0800, USA
Cancer Epidemiol Biomarkers Prev 7:429-33. 1998..Seventeen percent of RCC (21% in men and 11% in women) in Los Angeles, California can be attributed to cigarette smoking... - Cruciferous vegetables in relation to renal cell carcinomaJ M Yuan
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90033, USA
Int J Cancer 77:211-6. 1998..Dietary nitrosamines and their precursors were not related to RCC risk... - Increased risk of renal cell carcinoma subsequent to hysterectomyM Gago-Dominguez
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles 90033 0800, USA
Cancer Epidemiol Biomarkers Prev 8:999-1003. 1999..We conjecture that unintentional injury to the ureter during the surgical procedure, which results in renal cell damage and consequent renal cell proliferation, may be a cause of the increased cancer risk in hysterectomized women... - Use of permanent hair dyes and bladder-cancer riskM Gago-Dominguez
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, M S 44, University of Southern California School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
Int J Cancer 91:575-9. 2001..Subjects who worked for 10 or more years as hairdressers or barbers experienced a 5-fold (95% CI = 1.3-19.2) increase in risk compared to individuals not exposed... - Gender- and smoking-related bladder cancer riskJ E Castelao
University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles 90089 9181, USA
J Natl Cancer Inst 93:538-45. 2001..Because smokers are also at risk for bladder cancer, we investigated possible sex differences in the susceptibility to bladder cancer among smokers... - Family history and risk of renal cell carcinomaM Gago-Dominguez
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles, California 90033 0800, USA
Cancer Epidemiol Biomarkers Prev 10:1001-4. 2001..A FH of urinary tract cancers other than kidney cancer was not associated with RCC risk (OR, 0.7; 95% CI, 0.3-1.7). A FH of nonurinary tract cancers also was unrelated to RCC risk (OR, 1.1; 95% CI, 0.9-1.5)... - Phenobarbital use and bladder cancer riskJ E Castelao
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9175, USA
Eur J Epidemiol 18:659-64. 2003..It was proposed that PB use protects against bladder cancer by inducing enzymes that participate in the detoxification of human bladder carcinogens, such as the aminobiphenyls and naphthylamines, which are found in cigarette smoke... - Genetic Variations in SMAD7 Are Associated with Colorectal Cancer Risk in the Colon Cancer Family RegistryXuejuan Jiang
Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of America
PLoS ONE 8:e60464. 2013..Our objective was to confirm the association between SMAD7 SNPs and colorectal cancer risk in the multi-center Colon Cancer Family Registry... - Risk factors for cardiovascular disease in women: relationship to lipid peroxidation and oxidative stressJ Esteban Castelao
USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033 0800, USA
Med Hypotheses 71:39-44. 2008..We also discuss how screening human populations for reactive oxygen species (ROS) levels could help identify groups with a high level of ROS that may be at risk of developing CVD... - The value of risk-factor ("black-box") epidemiologySander Greenland
Department of Epidemiology and Statistics, University of California Los Angeles, Los Angeles, California 90095, USA
Epidemiology 15:529-35. 2004.... - Regular use of analgesics is a risk factor for renal cell carcinomaM Gago Dominguez
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90033 0800, USA
Br J Cancer 81:542-8. 1999..Subjects who took one regular-strength (i.e. 325 mg) aspirin a day or less for cardiovascular disease prevention were not at an increased risk of RCC (OR = 0.9, 95% CI = 0.6-1.4)... - Hypertension, obesity and their medications in relation to renal cell carcinomaJ M Yuan
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90033 0800, USA
Br J Cancer 77:1508-13. 1998..4-2.8) and the risk increased with increasing dose of amphetamines. However, the fraction of cases possibly related to this exposure is small (population-attributable risk = 5%)... - Water intake and bladder cancer risk in Los Angeles CountyXuejuan Jiang
USC Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Int J Cancer 123:1649-56. 2008..Similarly, the protection from water intake was confined to women who did not experience nocturia and to men who did. Results from our study suggest that water intake may be associated with a slight reduction in bladder cancer risk... - Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancerMariana C Stern
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA
Cancer Res 69:6857-64. 2009..002) and was strongest for the highest levels of smoking dose and smoking duration. Overall, our study provides the strongest evidence to date for a role of common variants in DNA repair genes in bladder carcinogenesis... - Non-steroidal anti-inflammatory drugs and bladder cancer preventionJ E Castelao
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck University of Southern California School of Medicine, Los Angeles 90033 0800, USA
Br J Cancer 82:1364-9. 2000..Acetic acids seemed to exhibit the strongest protective effect, whereas aspirin/other salicylic acids and oxicam showed the weakest protection... - Alkylaniline-hemoglobin adducts and risk of non-smoking-related bladder cancerJinping Gan
Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
J Natl Cancer Inst 96:1425-31. 2004..Because arylamines may account for a substantial proportion of bladder cancers among the general population, identification of environmental sources of these compounds is needed...
Research Grants
- LIPID PEROXIDATION IN COLORECTAL CANCERManuela Gago Dominguez; Fiscal Year: 2007..4. To conduct a case-case association study to determine if morphological markers of apoptosis in tumor and surrounding free tissue differ among cases with varying exposure levels of a given putative environmental/genetic risk factor. ..
- LIPID PEROXIDATION IN COLORECTAL CANCERManuela Gago Dominguez; Fiscal Year: 2009....