Research Topics
| David K GaffneySummaryAffiliation: University of Utah Country: USA Publications
| Collaborators
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Detail Information
Publications
Prognostic significance of histology and positive lymph node involvement following radical hysterectomy in carcinoma of the cervixO Kenneth Macdonald
Department of Radiation Oncology, Mayo Clinic, Desk R, 200 First St SW, Rochester, MN 55905, USA
Am J Clin Oncol 32:411-6. 2009..We queried a large database to analyze the importance of number of positive LN and histology in relation to survival after radical hysterectomy and lymphadenectomy...- Advances in clinical research in gynecologic radiation oncology: an RTOG symposiumDavid Gaffney
Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, UT, USA
Int J Gynecol Cancer 22:667-74. 2012.... 
A Phase II study of acute toxicity for Celebrex (celecoxib) and chemoradiation in patients with locally advanced cervical cancer: primary endpoint analysis of RTOG 0128David K Gaffney
Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, UT 84132, USA
Int J Radiat Oncol Biol Phys 67:104-9. 2007..To determine treatment-related acute toxicity rates in patients with locally advanced cervical cancer treated by oral celecoxib, i.v. cisplatin and 5-FU, and concurrent pelvic radiation therapy...- Practice patterns of radiotherapy in cervical cancer among member groups of the Gynecologic Cancer Intergroup (GCIG)David K Gaffney
Radiation Therapy Oncology Group, Salt Lake City, UT 84112, USA
Int J Radiat Oncol Biol Phys 68:485-90. 2007..The aim of this study was to describe radiotherapeutic practice of the treatment of cervical cancer in member groups of the Gynecologic Cancer Intergroup (GCIG)... - Patterns of care for radiotherapy in vulvar cancer: a Gynecologic Cancer Intergroup studyDavid K Gaffney
Radiation Therapy Oncology Group, Department of Radiation Oncology, Huntsman Cancer Hospital, 1950 Circle of Hope, Rm 1570, Salt Lake City, UT 84112, USA
Int J Gynecol Cancer 19:163-7. 2009..This study aimed to describe radiotherapeutic practice in the treatment of vulvar cancer in member study groups of the Gynecologic Cancer Intergroup (GCIG)... - Efficacy and patterns of failure for locally advanced cancer of the cervix treated with celebrex (celecoxib) and chemoradiotherapy in RTOG 0128David K Gaffney
Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, UT 84132, USA
Int J Radiat Oncol Biol Phys 69:111-7. 2007..To determine the efficacy and patterns of initial failure for oral celecoxib, intravenous cisplatin, and 5-fluorouracil and concurrent pelvic radiotherapy in patients with locally advanced cancer of the cervix... 
Local therapy in BRCA1 and BRCA2 mutation carriers with operable breast cancer: comparison of breast conservation and mastectomyLori J Pierce
Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive Room 4308, Ann Arbor, MI 48109, USA
Breast Cancer Res Treat 121:389-98. 2010..However, women undergoing BCT have an elevated risk of a second in-breast event that is significantly reduced in the presence of chemotherapy. Contralateral breast cancer events are very common...- Does brachytherapy improve survival in addition to external beam radiation therapy in patients with high risk stage I and II endometrial carcinoma?Marcus A Crosby
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, USA
Am J Clin Oncol 33:364-9. 2010..We evaluated the effect of adjuvant EBRT and combined EBRT + BT on overall survival and relative survival within a large US population database... - Are increased tumor aneuploidy and heightened cell proliferation along with heterogeneity associated with patient outcome for carcinomas of the uterine cervix? A combined analysis of subjects treated in RTOG 9001 and a single-institution trialAaron H Wolfson
Department of Radiation Oncology, University of Miami Miller School of Medicine, 1475 NW 12th Avenue, D 31, Miami, FL 33136, USA
Int J Radiat Oncol Biol Phys 70:111-7. 2008.... - Correlation between human epidermal growth factor receptor family (EGFR, HER2, HER3, HER4), phosphorylated Akt (P-Akt), and clinical outcomes after radiation therapy in carcinoma of the cervixChristopher M Lee
Department of Radiation Oncology, Huntsman Cancer Hospital and University of Utah Medical Center, 1950 Circle of Hope, Salt Lake City, UT 84112, USA
Gynecol Oncol 99:415-21. 2005..To investigate prognostic significance of and correlations between HER1 (EGFR), HER2 (c-erb-B2), HER3 (c-erb-B3), HER4 (c-erb-B4), and phosphorylated Akt (P-Akt) in patients treated with radiation for cervical carcinoma... - Adjuvant radiotherapy and survival outcomes in early-stage endometrial cancer: a multi-institutional analysis of 608 womenO Kenneth Macdonald
Department of Radiation Oncology, Huntsman Cancer Hospital at the University of Utah, Salt Lake City, UT 84112-5560, USA
Gynecol Oncol 103:661-6. 2006..These findings suggest that adjuvant radiotherapy has a significant benefit in reducing mortality and disease progression in early-stage carcinoma of the uterine corpus... - The impact of involved field radiation therapy in the treatment of relapsed or refractory non-Hodgkin lymphoma with high-dose chemotherapy followed by hematopoietic progenitor cell transplantMerideth M M Wendland
Department of Radiation Oncology, Huntsman Cancer Hospital and the University of Utah, Salt Lake City, Utah 84112, USA
Am J Clin Oncol 30:156-62. 2007..We examined the role of involved field radiation therapy (IFRT) in this setting... - An analysis of simulation for adjuvant intracavitary high-dose-rate brachytherapy in early-stage endometrial cancerBrandon M Barney
Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, 1950 Circle of Hope, Salt Lake City, UT 84112, USA
Brachytherapy 6:201-6. 2007..Secondary endpoints included assessment of acute and late treatment toxicity, medication requirements, and charges related to the HDR-BT simulation and procedure... - Malignant phyllodes tumor of the female breast: association of primary therapy with cause-specific survival from the Surveillance, Epidemiology, and End Results (SEER) programO Kenneth Macdonald
Department of Radiation Oncology, Huntsman Cancer Hospital at the University of Utah, Salt Lake City, Utah 84112 5560, USA
Cancer 107:2127-33. 2006..The current study used a large population database to determine prognostic factors that predict cause-specific survival (CSS)... - Descriptive nomograms of adjuvant radiotherapy use and patterns of care analysis for stage I and II endometrial adenocarcinoma: A surveillance, epidemiology, and end results population studyChristopher M Lee
Department of Radiation Oncology, Huntsman Cancer Hospital and University of Utah Medical Center, Salt Lake City, Utah 99202, USA
Cancer 110:2092-100. 2007.... - Survival of men with clinically localized prostate cancer treated with prostatectomy, brachytherapy, or no definitive treatment: impact of age at diagnosisJonathan D Tward
Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, Utah 84112, USA
Cancer 107:2392-400. 2006..The optimal treatment for men with early stage prostate cancer remains undefined. Survival of such patients after surgery, brachytherapy, or no definitive therapy was investigated specifically to determine the impact of age at diagnosis... - Expression of HER2neu (c-erbB-2) and epidermal growth factor receptor in cervical cancer: prognostic correlation with clinical characteristics, and comparison of manual and automated imaging analysisChristopher M Lee
Department of Radiation Oncology, University of Utah, Salt Lake City, UT 84132, USA
Gynecol Oncol 93:209-14. 2004..We also found strong correlation of results between manually and automated imaging methods... - Postoperative radiotherapy use and patterns of care analysis for node positive or parametria positive cervical cancerAmol J Ghia
Huntsman Cancer Institute, University of Utah, USA
Gynecol Oncol 119:411-6. 2010..The objective of this study is to perform a patterns of care analysis for post-hysterectomy patients with node positive (LN+) or parametria positive cervical cancer... - Does the entire uterus need to be treated in cancer of the cervix? Role of adaptive brachytherapyChristopher J Anker
Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, UT 84112 5560, USA
Int J Radiat Oncol Biol Phys 76:704-12. 2010..To evaluate local control and toxicity by use of a method of adaptive cervical brachytherapy (ACB)... - The impact of involved field radiation therapy for patients receiving high-dose chemotherapy followed by hematopoietic progenitor cell transplant for the treatment of relapsed or refractory Hodgkin diseaseMerideth M M Wendland
Department of Radiation Oncology, Huntsman Cancer Hospital and the University of Utah, Salt Lake City, UT, USA
Am J Clin Oncol 29:189-95. 2006..The potential benefit of IFRT may be underestimated because of the heterogeneity of the treatment groups. The use of IFRT was not associated with an increase in the risk of acute mortality or late events... - A population-based study of subsequent primary malignancies after endometrial cancer: genetic, environmental, and treatment-related associationsAaron P Brown
Department of Radiation Oncology, University of Utah, Salt Lake City, UT 84112, USA
Int J Radiat Oncol Biol Phys 78:127-35. 2010..To examine the risk of subsequent primary malignancies (SPMs) in women diagnosed with endometrial cancer... - Primary vaginal cancer and chemoradiotherapy: a patterns-of-care analysisAmol J Ghia
Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA
Int J Gynecol Cancer 21:378-84. 2011..We sought to describe the utilization rate of CRT and evaluate the potential survival benefit of CRT over radiotherapy alone in VC... - The impact of adjuvant radiation therapy on survival in women with uterine carcinosarcomaD Clayton Smith
Department of Radiation Oncology, Huntsman Cancer Hospital at the University of Utah, UT 84119, USA
Radiother Oncol 88:227-32. 2008..Uterine carcinosarcoma is an aggressive neoplasm and the benefit of adjuvant radiation therapy (RT) is unclear. This retrospective study analyzes the influence of RT on survival using a large population database... - Does radiotherapy or lymphadenectomy improve survival in endometrial stromal sarcoma?Brandon Barney
Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, UT 84112, USA
Int J Gynecol Cancer 19:1232-8. 2009..The roles of radiation therapy (RT) and lymphadenectomy (LAD) remain unclear. Using a large population database, we retrospectively evaluated the addition of RT and LAD to surgery for survival impact... - Transient dephosphorylation of p53 serine 376 as an early response to ionizing radiationRaymond L Warters
Department of Radiation Oncology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Radiat Res 171:725-34. 2009..The data suggest that dephosphorylation of serine 376 on constitutive nuclear p53 is a sensitive and early signaling event in the response of cells to DNA damage induced by ionizing radiation... - Survival and recurrence in nonmycosis fungoides primary cutaneous lymphomaJonathan D Tward
University of Utah and Huntsman Cancer Institute, Salt Lake City, UT, USA
Cancer J 15:87-92. 2009..To evaluate overall and relapse-free survival (RFS) in patients with nonmycosis fungoides (non-MF) primary cutaneous lymphoma (PCL)... - Incidence, mortality, and prognostic factors of small cell carcinoma of the cervixJergin Chen
Department of Radiation Oncology, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA
Obstet Gynecol 111:1394-402. 2008..To compare the incidence, mortality, and presentation of small cell carcinoma of the cervix with other histologies... - Frequency and effect of adjuvant radiation therapy among women with stage I endometrial adenocarcinomaChristopher M Lee
Department of Radiation Oncology, Huntsman Cancer Hospital and University of Utah Medical Center, Salt Lake City 84112-5560, USA
JAMA 295:389-97. 2006..Future work is needed to continue to delineate clinical and biological factors, which can guide treatment decisions and account for disparities in outcome between varied subsets of patients... - Time interval to the development of breast carcinoma after treatment for Hodgkin diseaseMerideth M M Wendland
Department of Radiation Oncology, The Huntsman Cancer Institute, Salt Lake City, Utah, USA
Cancer 101:1275-82. 2004..01). CONCLUSIONS: Use of the PHPH model indicated that the use of radiotherapy in the treatment of HD resulted in an increased long-term risk for the subsequent development of breast carcinoma, but conferred a short-term reduction... - Does the FIGO 2009 endometrial cancer staging system more accurately correlate with clinical outcome in different histologies? Revised staging, endometrial cancer, histologyBrandi R Page
Department of Radiation Oncology, University of Utah Huntsman Cancer Hospital, Salt Lake City, UT 84112, USA
Int J Gynecol Cancer 22:593-8. 2012..Different histologies were examined in a large population database. The FIGO 1988 and 2009 staging systems were compared for stage at presentation, differences in patient populations, and disease-specific survival (DSS)... - Cyclooxygenase-2 expression correlates with diminished survival in invasive breast cancer treated with mastectomy and radiotherapyJames Avent
Department of Radiation Oncology, University of Utah, Salt Lake City, UT 84132, USA
Int J Radiat Oncol Biol Phys 58:1034-40. 2004..Younger patients with invasive breast cancer may have a greater percentage of COX-2 expression in their tumors... - Does the revised International Federation of Gynecology and Obstetrics staging system for endometrial cancer lead to increased discrimination in patient outcomes?Ellen W Cooke
Department of Radiation Oncology, University of Utah Huntsman Cancer Hospital, Salt Lake City, Utah 84112, USA
Cancer 117:4231-7. 2011..The objective of this study was to compare survival outcomes for patients who were staged according to the 1988 FIGO staging system versus the 2009 FIGO staging system... - Rapid involution and mobility of carcinoma of the cervixChristopher M Lee
Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, 50 N. Medical Drive, Salt Lake City, UT 84132, USA
Int J Radiat Oncol Biol Phys 58:625-30. 2004..These data indicate that the cervix gross tumor volume changes rapidly in a systematic fashion during chemoradiotherapy and, together with the mobility of the cervix, urge caution in nonbrachytherapy boost planning... - Differential gene expression in primary human skin keratinocytes and fibroblasts in response to ionizing radiationRaymond L Warters
Department of Radiation Oncology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Radiat Res 172:82-95. 2009..Both Q-PCR and Western blot analysis experiments validated these transcription changes. Our results are consistent with changes in the expression of p53 target genes as indicating the magnitude of cell responses to ionizing radiation... - Does oncologic specialization influence outcomes following surgery in early stage adenocarcinoma of the endometrium?O Kenneth Macdonald
Department of Radiation Oncology, Huntsman Cancer Hospital at the University of Utah, 1950 Circle of Hope, Salt Lake City, UT 84112 5560, USA
Gynecol Oncol 99:730-5. 2005..To evaluate treatment outcomes in women with early-stage endometrial cancer (FIGO IA, IB, IC, or IIA) surgically managed by a general gynecologist (GYN) or a gynecologic oncologist (GYO)... - Phosphatidylinositol 3-kinase inhibition by LY294002 radiosensitizes human cervical cancer cell linesChristopher M Lee
Department of Radiation Oncology, University of Utah School of Medicine and Huntsman Cancer Hospital, Salt Lake City, Utah, USA
Clin Cancer Res 12:250-6. 2006..These findings support future investigation of PI3K inhibitors in combination with radiation therapy for carcinoma of the cervix... - Ten-year multi-institutional results of breast-conserving surgery and radiotherapy in BRCA1/2-associated stage I/II breast cancerLori J Pierce
Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI 48109 0010, USA
J Clin Oncol 24:2437-43. 2006..We compared the outcome of breast-conserving surgery and radiotherapy in BRCA1/2 mutation carriers with breast cancer versus that of matched sporadic controls... - The risk of secondary malignancies over 30 years after the treatment of non-Hodgkin lymphomaJonathan D Tward
Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, Utah 84112 5560, USA
Cancer 107:108-15. 2006..Survivors of non-Hodgkin lymphoma (NHL) are at increased risk for developing secondary malignancies. For the current study, the authors quantitated this risk in a group of NHL survivors over 30 years of follow-up... - Diminished survival in patients with inner versus outer quadrant breast cancersDavid K Gaffney
Department of Radiation Oncology and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA
J Clin Oncol 21:467-72. 2003..To evaluate the role of breast tumor location on survival in patients with breast cancer... - Electron arc irradiation of the postmastectomy chest wall in locally recurrent and metastatic breast cancerDavid K Gaffney
Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84132, USA
Am J Clin Oncol 26:241-6. 2003.... - Is short-interval mammography necessary after breast conservation surgery and radiation treatment in breast cancer patients?Richard V Hymas
Department of Radiation Oncology, University of Utah, Salt Lake City, UT, USA
Int J Radiat Oncol Biol Phys 83:519-24. 2012..This retrospective study was undertaken to determine the cancer yield mammography during the first 2 years after BCT... - Impact of tumor size on survival in cancer of the cervix and validation of stage IIA1 and IIA2 subdivisionsAaron E Wagner
Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA
Gynecol Oncol 129:517-21. 2013..This study was designed to investigate the impact of size within stage I-IIIB cervical carcinoma, and to validate these changes... - Role of radiotherapy treatment of uterine sarcomaSagus Sampath
Department of Radiation Oncology, University of New Mexico, USA
Best Pract Res Clin Obstet Gynaecol 25:761-72. 2011..As distant failure rates decrease with improvements in systemic therapies, there may be a broader indication for adjuvant radiotherapy... - Is simulation necessary for each high-dose-rate tandem and ovoid insertion in carcinoma of the cervix?Nathan D Jones
Department of Radiation Oncology and Huntsman Cancer Institute, University of Utah Medical Center, 1950 Circle of Hope, Salt Lake City, UT 84112, USA
Brachytherapy 3:120-4. 2004..To evaluate the dose variation in high-dose-rate (HDR) intracavitary brachytherapy for cancer of the cervix when treatment planning is performed prior to each applicator insertion versus when the initial plan is used for each treatment... - Does radiotherapy around the time of pregnancy for Hodgkin's disease modify the risk of breast cancer?Jergin Chen
Department of Radiation Oncology, University of Utah, Salt Lake City, UT 84132, USA
Int J Radiat Oncol Biol Phys 58:1474-9. 2004..To determine whether the risk of secondary breast cancer after radiotherapy (RT) for Hodgkin's disease is greater among women who underwent RT around time of pregnancy... - Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) negatively affect overall survival in carcinoma of the cervix treated with radiotherapyDavid K Gaffney
Department of Radiation Oncology, University of Utah, Salt Lake City, UT 84132, USA
Int J Radiat Oncol Biol Phys 56:922-8. 2003..the natural history of the disease, (2). response to radiotherapy (RT), and (3). potential for new therapeutic strategies... - Intracranial extramedullary hematopoiesis: brief review of response to radiation therapyChristopher M Lee
Department of Radiation Oncology, Huntsman Cancer Institute and University of Utah, Salt Lake City, UT 84132, USA
Am J Hematol 78:151-2. 2005..Radiation therapy has proven to be an effective modality for treatment of this rare radiosensitive disease... - Topoisomerase II alpha expression correlates with diminished disease-free survival in invasive breast cancerJohn K O'Connor
Radiation Oncology, Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA, USA
Int J Radiat Oncol Biol Phys 65:1411-5. 2006..The purpose of this study was to evaluate the relationship between Topo II alpha expression and survival in patients with invasive breast cancer... - Facilitation of radiotherapeutic error by computerized record and verify systemsGregory A Patton
Northwest Cancer Specialists, PC, Portland, OR 97227, USA
Int J Radiat Oncol Biol Phys 56:50-7. 2003..To examine the impact of computerized record and verify (R&V) systems on types of radiotherapeutic error...