Affiliation: University of Pittsburgh
Gaffen S. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 2009;9:556-67 pubmed publisher
Gaffen S. The role of interleukin-17 in the pathogenesis of rheumatoid arthritis. Curr Rheumatol Rep. 2009;11:365-70 pubmed
..This article discusses the history of the discovery of Th17 cells, the potential mechanisms of action of IL-17 in autoimmunity, and perspectives for IL-17-targeted cytokine therapy. ..
Gaffen S, Hernández Santos N, Peterson A. IL-17 signaling in host defense against Candida albicans. Immunol Res. 2011;50:181-7 pubmed publisher
..Although immunity to Candida albicans was long considered to be mediated by Th1 cells, new data in both rodent models and in humans have revealed an essential role for the Th17 lineage, and in particular its signature cytokine IL-17. ..
Conti H, Peterson A, Brane L, Huppler A, HernÃ¡ndez Santos N, Whibley N, et al
. Oral-resident natural Th17 cells and Î³Î´ T cells control opportunistic Candida albicans infections. J Exp Med. 2014;211:2075-84 pubmed publisher
..These findings indicate that nTh17 and Î³Î´ T cells, but not ILCs, are key mucosal sentinels that control oral pathogens. ..
Bishu S, Su E, Wilkerson E, Reckley K, Jones D, McGeachy M, et al
. Rheumatoid arthritis patients exhibit impaired Candida albicans-specific Th17 responses. Arthritis Res Ther. 2014;16:R50 pubmed publisher
..70). RA subjects exhibit detectable impairments in oral immune responses to C. albicans, a strongly Th17-dependent opportunistic pathogen, despite an overall elevated baseline production of IL-17A. ..