SARAH GAFFEN

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc An overview of IL-17 function and signaling
    Sarah L Gaffen
    University at Buffalo, State University of New York, Department of Oral Biology, Buffalo, NY 14214, USA
    Cytokine 43:402-7. 2008
  2. pmc Structure and signalling in the IL-17 receptor family
    Sarah L Gaffen
    University of Pittsburgh, Department of Medicine, Division of Rheumatology and Clinical Immunology, Pittsburgh, Pennsylvania 15261, USA
    Nat Rev Immunol 9:556-67. 2009
  3. pmc The role of interleukin-17 in the pathogenesis of rheumatoid arthritis
    Sarah L Gaffen
    Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Curr Rheumatol Rep 11:365-70. 2009
  4. pmc IL-17 signaling in host defense against Candida albicans
    Sarah L Gaffen
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, BST S703, 3500 Terrace St, Pittsburgh, PA 15216, USA
    Immunol Res 50:181-7. 2011
  5. pmc A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17
    S L Gaffen
    Department of Oral Biology, School of Dental Medicine, 36 Foster Hall, 3435 Main St, State University of New York, Buffalo, NY 14214, USA
    J Dent Res 87:817-28. 2008
  6. pmc Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis
    Sarah L Gaffen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, USA
    Arthritis Res Ther 6:240-7. 2004
  7. ncbi request reprint Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells
    Fang Shen
    Department of Oral Biology, University at Buffalo, State University of New York, 36 Foster Hall, 3435 Main Street, Buffalo, NY 14214, USA
    J Leukoc Biol 77:388-99. 2005
  8. pmc Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy
    Fang Shen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    Cytokine 41:92-104. 2008
  9. ncbi request reprint Interleukin-17: a novel inflammatory cytokine that bridges innate and adaptive immunity
    Jeffrey J Yu
    Department of Microbiology and Immunology, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA
    Front Biosci 13:170-7. 2008
  10. ncbi request reprint Interleukin-17: a new paradigm in inflammation, autoimmunity, and therapy
    Jill M Kramer
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14212, USA
    J Periodontol 78:1083-93. 2007

Research Grants

Collaborators

  • Jay Kolls
  • W Ouyang
  • Kathleen D Liu
  • Y Iwakura
  • LAWRENCE KANE
  • Pamela J Baker
  • John F Alcorn
  • Fang Shen
  • Allen W Ho
  • Jill M Kramer
  • Heather R Conti
  • Jeffrey J Yu
  • Matthew J Ruddy
  • Reiko M Onishi
  • Xikui K Liu
  • Matthew J Lindemann
  • Jaya Goswami
  • Amarnath Maitra
  • Nydiaris Hern├índez-Santos
  • Yinyao Lin
  • Walter Hanel
  • Lee Ann Garrett-Sinha
  • Zihua Hu
  • Tian Jin
  • Grace C Wong
  • Jeffrey B Smith
  • Nayan Patel
  • Erin E Childs
  • Sangmi J Park
  • Alanna C Peterson
  • Troy D Randall
  • Reiko Onishi
  • Namrata Nayyar
  • Luis A Zuniga
  • Michael J Walter
  • Samantha Slight
  • Ji Won Jung
  • Justine Hoda Hai
  • Shabaana A Khader
  • Jianing N Sun
  • Nikki Nyugen
  • Michelle Messmer
  • Shane Ritchea
  • Sang Mi Park
  • Javier Rangel-Moreno
  • Alison Logar
  • Eileen Stocum
  • Lokesh Guglani
  • Heather Strawbridge
  • Scott G Filler
  • Mira Edgerton
  • Derek Pociask
  • Patricia Masso-Welch
  • Marta Benczik
  • Shinu John
  • Cornelia Sfintescu
  • Nilgun Isik
  • Wade Sigurdson
  • Joel Tocker
  • Richard T Evans
  • James P Malone
  • David Swart
  • Xuanmao Jiao
  • Ling Yi
  • Pascale Plamondon
  • James L Clements
  • Xin Lin
  • Soji Kasayama
  • Hiroyasu Yamamoto
  • Ashu Sharma
  • Keith L Kirkwood

Detail Information

Publications29

  1. pmc An overview of IL-17 function and signaling
    Sarah L Gaffen
    University at Buffalo, State University of New York, Department of Oral Biology, Buffalo, NY 14214, USA
    Cytokine 43:402-7. 2008
    ..This review will focus on interleukin (IL)-17, the founding member of the newest subclass of cytokines, which has received considerable attention in the last several years due to its central role in the Th17 system...
  2. pmc Structure and signalling in the IL-17 receptor family
    Sarah L Gaffen
    University of Pittsburgh, Department of Medicine, Division of Rheumatology and Clinical Immunology, Pittsburgh, Pennsylvania 15261, USA
    Nat Rev Immunol 9:556-67. 2009
    ....
  3. pmc The role of interleukin-17 in the pathogenesis of rheumatoid arthritis
    Sarah L Gaffen
    Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Curr Rheumatol Rep 11:365-70. 2009
    ..This article discusses the history of the discovery of Th17 cells, the potential mechanisms of action of IL-17 in autoimmunity, and perspectives for IL-17-targeted cytokine therapy...
  4. pmc IL-17 signaling in host defense against Candida albicans
    Sarah L Gaffen
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, BST S703, 3500 Terrace St, Pittsburgh, PA 15216, USA
    Immunol Res 50:181-7. 2011
    ..Although immunity to Candida albicans was long considered to be mediated by Th1 cells, new data in both rodent models and in humans have revealed an essential role for the Th17 lineage, and in particular its signature cytokine IL-17...
  5. pmc A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17
    S L Gaffen
    Department of Oral Biology, School of Dental Medicine, 36 Foster Hall, 3435 Main St, State University of New York, Buffalo, NY 14214, USA
    J Dent Res 87:817-28. 2008
    ..Moreover, with the advent of anti-cytokine biologic drugs that target the Th1 and Th17 pathways in autoimmunity, the potential consequences to periodontal disease susceptibility in humans need to be understood...
  6. pmc Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis
    Sarah L Gaffen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, USA
    Arthritis Res Ther 6:240-7. 2004
    ..In addition, IL-17 synergizes potently with other cytokines, placing it in the center of the inflammatory network. Strikingly, IL-17 has been associated with several bone pathologies, most notably rheumatoid arthritis...
  7. ncbi request reprint Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells
    Fang Shen
    Department of Oral Biology, University at Buffalo, State University of New York, 36 Foster Hall, 3435 Main Street, Buffalo, NY 14214, USA
    J Leukoc Biol 77:388-99. 2005
    ..This study provides a profile of genes regulated by IL-17 and TNF-alpha in osteoblasts and suggests that in bone, the major function of IL-17 is to cooperate and/or synergize with other cytokines to amplify inflammation...
  8. pmc Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy
    Fang Shen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    Cytokine 41:92-104. 2008
    ..However, in the last year important new insights into the composition and dynamics of the receptor complex and mechanisms of downstream signal transduction have been made, which will be reviewed here...
  9. ncbi request reprint Interleukin-17: a novel inflammatory cytokine that bridges innate and adaptive immunity
    Jeffrey J Yu
    Department of Microbiology and Immunology, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA
    Front Biosci 13:170-7. 2008
    ..IL-17 sits at the center of many complex diseases that integrate innate and adaptive immune mechanisms and requires careful study to maximize host protective effects and minimize host deleterious effects...
  10. ncbi request reprint Interleukin-17: a new paradigm in inflammation, autoimmunity, and therapy
    Jill M Kramer
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14212, USA
    J Periodontol 78:1083-93. 2007
    ..Therapeutics that antagonize inflammatory cytokines ameliorate inflammation and bone loss and may have broader implications for individuals with systemic diseases in which inflammation and autoimmunity predominate...
  11. pmc IL-17RC: a partner in IL-17 signaling and beyond
    Allen W Ho
    Department of Oral Biology, State University of New York, Buffalo, 14214, USA
    Semin Immunopathol 32:33-42. 2010
    ..This review will examine what is known regarding IL-17RC function and provide a framework for future work on this subunit and its impact on human health...
  12. ncbi request reprint The IL-17 cytokine family
    Sarah L Gaffen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    Vitam Horm 74:255-82. 2006
    ..This chapter describes the major molecular properties, biological activities, and known signaling pathways of the IL-17 family, with an emphasis on IL-17A and IL-17RA...
  13. pmc Host responses to Candida albicans: Th17 cells and mucosal candidiasis
    Heather R Conti
    University at Buffalo, SUNY, Department of Oral Biology, Buffalo, NY, USA
    Microbes Infect 12:518-27. 2010
    ..However, emerging data indicate that the newly-defined Th17 compartment appears to play the predominant role in mucosal candidiasis...
  14. pmc Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
    Reiko M Onishi
    Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Immunology 129:311-21. 2010
    ..Here, we summarize the major IL-17 target genes that mediate this cytokine's activities in both autoimmune and chronic diseases as well as during various types of infections...
  15. pmc A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss
    Jaya Goswami
    Department of Microbiology and Immunology, University at Buffalo, SUNY, Buffalo, NY, USA
    Eur J Immunol 39:2831-9. 2009
    ..Accordingly, these data show that IL-17A negatively regulates adipogenesis and subsequent leptin expression, which correlates with increased bone destruction during OVX...
  16. pmc IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail
    Allen W Ho
    Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    J Immunol 185:1063-70. 2010
    ..Insight into the mechanisms by which IL-17RC signals helps shed light on IL-17-dependent inflammatory responses and may ultimately provide an avenue for therapeutic intervention in IL-17-mediated diseases...
  17. ncbi request reprint Interleukin-17 regulates expression of the CXC chemokine LIX/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment
    Matthew J Ruddy
    Department of Microbiology and Immunology, University at Buffalo, SUNY, 36 Foster Hall, 3435 Main Street, Buffalo, NY 14214, USA
    J Leukoc Biol 76:135-44. 2004
    ..This study is the first demonstration of LIX expression in bone cells and has implications for inflammatory bone diseases such as arthritis and periodontal disease...
  18. pmc Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis
    Yinyao Lin
    Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Immunity 31:799-810. 2009
    ..Together, these findings illustrate a biological function for IL-17A in regulating IL-12-Th1 cell immunity and host responses to an intracellular pathogen...
  19. pmc SEF/IL-17R (SEFIR) is not enough: an extended SEFIR domain is required for il-17RA-mediated signal transduction
    Reiko M Onishi
    Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 285:32751-9. 2010
    ..These studies provide new insight into the structure-function relationships of IL-17RA and reveal distinct signaling differences among IL-17R family members...
  20. pmc Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
    Heather R Conti
    Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo, NY 14201, USA
    J Exp Med 206:299-311. 2009
    ..Thus, the Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors...
  21. ncbi request reprint Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17
    Xikui K Liu
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    J Biol Chem 279:52762-71. 2004
    ..Together, these data show that NFAT is the crucial sensor of TCR signaling in the IL-17 promoter...
  22. pmc Evidence for ligand-independent multimerization of the IL-17 receptor
    Jill M Kramer
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    J Immunol 176:711-5. 2006
    ..Strikingly, treatment with IL-17A or IL-17F markedly reduced FRET efficiency, suggesting that IL-17RA subunits within the IL-17R complex undergo a conformational change upon ligand binding...
  23. ncbi request reprint Signaling through the murine T cell receptor induces IL-17 production in the absence of costimulation, IL-23 or dendritic cells
    Xikui K Liu
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    Mol Cells 20:339-47. 2005
    ....
  24. ncbi request reprint Identification of common transcriptional regulatory elements in interleukin-17 target genes
    Fang Shen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 281:24138-48. 2006
    ..Analysis of IL-17 target gene regulation is key for understanding this important host-defense molecule and also contributes to an understanding of upstream signaling mechanisms used by IL-17, either alone or in concert with TNFalpha...
  25. pmc An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals
    Jeffrey J Yu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA
    Blood 109:3794-802. 2007
    ..These results indicate a nonredundant role for IL-17 in mediating host defense via neutrophil mobilization...
  26. pmc Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor
    Jill M Kramer
    Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    J Immunol 179:6379-83. 2007
    ..However, the FN1 domain is also required for high affinity interactions with IL-17. Therefore, although the PLAD is located entirely within FN2, effective ligand binding also involves contributions from the linker and FN1...
  27. pmc Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway
    Matthew J Lindemann
    Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:14100-8. 2008
    ..Thus, there are intrinsic signaling differences between IL-2 and IL-15 that can be attributed to differences in activation of the PI3K pathway...
  28. doi request reprint IL-17 and the Th17 lineage in systemic lupus erythematosus
    Lee Ann Garrett-Sinha
    Department of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    Curr Opin Rheumatol 20:519-25. 2008
    ..In particular, the T-cell components that contribute to systemic lupus erythematosus pathogenesis are incompletely defined...
  29. ncbi request reprint Functional cooperation between interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein family members
    Matthew J Ruddy
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University of Buffalo, Buffalo, NY 14214, USA
    J Biol Chem 279:2559-67. 2004
    ..Thus, C/EBP family members, particularly C/EBPdelta, appear to be important for the functional cooperation between IL-17 and TNFalpha...

Research Grants9

  1. Structure-Function Relationships in the IL-17 Receptor
    Sarah L Gaffen; Fiscal Year: 2010
    ..Moreover, using that information, we aim to design specific blockers of the IL-17 receptor that might ultimately be used therapeutically to treat autoimmune conditions. ..
  2. Anti-Apoptotic Signaling by the IL-2/15 Receptor
    SARAH GAFFEN; Fiscal Year: 2006
    ....