S L Gaffen

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. ncbi request reprint Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17
    Xikui K Liu
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    J Biol Chem 279:52762-71. 2004
  2. ncbi request reprint Signaling domains of the interleukin 2 receptor
    S L Gaffen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY14214, USA
    Cytokine 14:63-77. 2001
  3. ncbi request reprint Overview of interleukin-2 function, production and clinical applications
    Sarah L Gaffen
    University at Buffalo, State University of New York, Department of Oral Biology and Department of Microbiology, 3435 Main Street, Buffalo, NY 14214, USA
    Cytokine 28:109-23. 2004
  4. pmc Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection
    B Feinen
    Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, New York, USA
    Mucosal Immunol 3:312-21. 2010
  5. doi request reprint IL-17 and the Th17 lineage in systemic lupus erythematosus
    Lee Ann Garrett-Sinha
    Department of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    Curr Opin Rheumatol 20:519-25. 2008
  6. pmc Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis
    Sarah L Gaffen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, USA
    Arthritis Res Ther 6:240-7. 2004
  7. pmc Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy
    Fang Shen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    Cytokine 41:92-104. 2008
  8. ncbi request reprint Signaling through the murine T cell receptor induces IL-17 production in the absence of costimulation, IL-23 or dendritic cells
    Xikui K Liu
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    Mol Cells 20:339-47. 2005
  9. pmc Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway
    Matthew J Lindemann
    Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:14100-8. 2008
  10. pmc An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals
    Jeffrey J Yu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA
    Blood 109:3794-802. 2007

Research Grants

  1. INTERLEUKIN-17 RECEPTOR SIGNALING IN BONE
    SARAH GAFFEN; Fiscal Year: 2005

Collaborators

  • Zihua Hu
  • B Feinen
  • A E Jerse
  • Jay K Kolls
  • W Ouyang
  • S Kasayama
  • Keith Kirkwood
  • LAWRENCE KANE
  • Lee Ann Garrett-Sinha
  • James L Clements
  • Pamela J Baker
  • Susan Swain
  • Richard Locksley
  • Andrea Cooper
  • L Haynes
  • Fang Shen
  • Jeffrey J Yu
  • Heather R Conti
  • Matthew J Ruddy
  • Jill M Kramer
  • Allen W Ho
  • Matthew J Lindemann
  • Xikui K Liu
  • Amarnath Maitra
  • Marta Benczik
  • Jaya Goswami
  • Nydiaris Hern├índez-Santos
  • Joel Tocker
  • David Swart
  • Walter Hanel
  • Shabaana A Khader
  • Tian Jin
  • Grace C Wong
  • Jeffrey B Smith
  • Nayan Patel
  • Alanna C Peterson
  • Erin E Childs
  • Justine Hoda Hai
  • Luis A Zuniga
  • Ji Won Jung
  • Jianing N Sun
  • Eileen Stocum
  • Namrata Nayyar
  • Mira Edgerton
  • Patricia Masso-Welch
  • Scott G Filler
  • Kanitsak Boonanantanasarn
  • Kathleen D Liu
  • Sheri M Eaton
  • Nilgun Isik
  • Javier Rangel-Moreno
  • James P Malone
  • Troy D Randall
  • Jeffrey J Fountain
  • Guy K Bell
  • Richard T Evans
  • Garth E Cilley
  • Karen Mossman
  • John E Pearl
  • Cornelia Sfintescu
  • Wade Sigurdson
  • Ling Yi
  • Xuanmao Jiao
  • Pascale Plamondon
  • Hiroyasu Yamamoto
  • Ashu Sharma
  • Xin Lin

Detail Information

Publications31

  1. ncbi request reprint Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17
    Xikui K Liu
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    J Biol Chem 279:52762-71. 2004
    ..Together, these data show that NFAT is the crucial sensor of TCR signaling in the IL-17 promoter...
  2. ncbi request reprint Signaling domains of the interleukin 2 receptor
    S L Gaffen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY14214, USA
    Cytokine 14:63-77. 2001
    ....
  3. ncbi request reprint Overview of interleukin-2 function, production and clinical applications
    Sarah L Gaffen
    University at Buffalo, State University of New York, Department of Oral Biology and Department of Microbiology, 3435 Main Street, Buffalo, NY 14214, USA
    Cytokine 28:109-23. 2004
    ..Despite the wealth of information generated about IL-2 from in vitro culture systems, in vivo mouse knockout models, and clinical trials in humans, fascinating new aspects of its functions in the immune system continue to emerge...
  4. pmc Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection
    B Feinen
    Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, New York, USA
    Mucosal Immunol 3:312-21. 2010
    ..gonorrhoeae. These results imply a crucial role for IL-17 and Th17 cells in the immune response to N. gonorrhoeae...
  5. doi request reprint IL-17 and the Th17 lineage in systemic lupus erythematosus
    Lee Ann Garrett-Sinha
    Department of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    Curr Opin Rheumatol 20:519-25. 2008
    ..In particular, the T-cell components that contribute to systemic lupus erythematosus pathogenesis are incompletely defined...
  6. pmc Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis
    Sarah L Gaffen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, USA
    Arthritis Res Ther 6:240-7. 2004
    ..In addition, IL-17 synergizes potently with other cytokines, placing it in the center of the inflammatory network. Strikingly, IL-17 has been associated with several bone pathologies, most notably rheumatoid arthritis...
  7. pmc Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy
    Fang Shen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    Cytokine 41:92-104. 2008
    ..However, in the last year important new insights into the composition and dynamics of the receptor complex and mechanisms of downstream signal transduction have been made, which will be reviewed here...
  8. ncbi request reprint Signaling through the murine T cell receptor induces IL-17 production in the absence of costimulation, IL-23 or dendritic cells
    Xikui K Liu
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    Mol Cells 20:339-47. 2005
    ....
  9. pmc Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway
    Matthew J Lindemann
    Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:14100-8. 2008
    ..Thus, there are intrinsic signaling differences between IL-2 and IL-15 that can be attributed to differences in activation of the PI3K pathway...
  10. pmc An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals
    Jeffrey J Yu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA
    Blood 109:3794-802. 2007
    ..These results indicate a nonredundant role for IL-17 in mediating host defense via neutrophil mobilization...
  11. ncbi request reprint Interleukin-17: a new paradigm in inflammation, autoimmunity, and therapy
    Jill M Kramer
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14212, USA
    J Periodontol 78:1083-93. 2007
    ..Therapeutics that antagonize inflammatory cytokines ameliorate inflammation and bone loss and may have broader implications for individuals with systemic diseases in which inflammation and autoimmunity predominate...
  12. ncbi request reprint Interleukin-17: a novel inflammatory cytokine that bridges innate and adaptive immunity
    Jeffrey J Yu
    Department of Microbiology and Immunology, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA
    Front Biosci 13:170-7. 2008
    ..IL-17 sits at the center of many complex diseases that integrate innate and adaptive immune mechanisms and requires careful study to maximize host protective effects and minimize host deleterious effects...
  13. ncbi request reprint Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells
    Fang Shen
    Department of Oral Biology, University at Buffalo, State University of New York, 36 Foster Hall, 3435 Main Street, Buffalo, NY 14214, USA
    J Leukoc Biol 77:388-99. 2005
    ..This study provides a profile of genes regulated by IL-17 and TNF-alpha in osteoblasts and suggests that in bone, the major function of IL-17 is to cooperate and/or synergize with other cytokines to amplify inflammation...
  14. pmc A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss
    Jaya Goswami
    Department of Microbiology and Immunology, University at Buffalo, SUNY, Buffalo, NY, USA
    Eur J Immunol 39:2831-9. 2009
    ..Accordingly, these data show that IL-17A negatively regulates adipogenesis and subsequent leptin expression, which correlates with increased bone destruction during OVX...
  15. ncbi request reprint Interleukin-17 regulates expression of the CXC chemokine LIX/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment
    Matthew J Ruddy
    Department of Microbiology and Immunology, University at Buffalo, SUNY, 36 Foster Hall, 3435 Main Street, Buffalo, NY 14214, USA
    J Leukoc Biol 76:135-44. 2004
    ..This study is the first demonstration of LIX expression in bone cells and has implications for inflammatory bone diseases such as arthritis and periodontal disease...
  16. pmc IL-17RC: a partner in IL-17 signaling and beyond
    Allen W Ho
    Department of Oral Biology, State University of New York, Buffalo, 14214, USA
    Semin Immunopathol 32:33-42. 2010
    ..This review will examine what is known regarding IL-17RC function and provide a framework for future work on this subunit and its impact on human health...
  17. pmc An overview of IL-17 function and signaling
    Sarah L Gaffen
    University at Buffalo, State University of New York, Department of Oral Biology, Buffalo, NY 14214, USA
    Cytokine 43:402-7. 2008
    ..This review will focus on interleukin (IL)-17, the founding member of the newest subclass of cytokines, which has received considerable attention in the last several years due to its central role in the Th17 system...
  18. pmc Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
    Heather R Conti
    Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo, NY 14201, USA
    J Exp Med 206:299-311. 2009
    ..Thus, the Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors...
  19. pmc IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail
    Allen W Ho
    Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    J Immunol 185:1063-70. 2010
    ..Insight into the mechanisms by which IL-17RC signals helps shed light on IL-17-dependent inflammatory responses and may ultimately provide an avenue for therapeutic intervention in IL-17-mediated diseases...
  20. pmc Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression
    Amarnath Maitra
    Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    Proc Natl Acad Sci U S A 104:7506-11. 2007
    ..This structure-function analysis of a IL-17 superfamily receptor reveals important differences in IL-17RA compared with IL-1/TLR receptors...
  21. ncbi request reprint Anti-apoptotic signaling by the interleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common gamma (gamma c) receptor subunit
    Matthew J Lindemann
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 278:10239-49. 2003
    ..Thus, gammac mediates an anti-apoptotic signaling pathway through Akt which cooperates with signals from its partner chain, IL-2Rbeta...
  22. ncbi request reprint The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes
    Marta Benczik
    Department of Oral Biology, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    Immunol Invest 33:109-42. 2004
    ..The details of these pathways as they apply to the IL-2 family of cytokines is discussed, with a focus on their roles in proliferation and survival signaling...
  23. pmc Evidence for ligand-independent multimerization of the IL-17 receptor
    Jill M Kramer
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    J Immunol 176:711-5. 2006
    ..Strikingly, treatment with IL-17A or IL-17F markedly reduced FRET efficiency, suggesting that IL-17RA subunits within the IL-17R complex undergo a conformational change upon ligand binding...
  24. pmc A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17
    S L Gaffen
    Department of Oral Biology, School of Dental Medicine, 36 Foster Hall, 3435 Main St, State University of New York, Buffalo, NY 14214, USA
    J Dent Res 87:817-28. 2008
    ..Moreover, with the advent of anti-cytokine biologic drugs that target the Th1 and Th17 pathways in autoimmunity, the potential consequences to periodontal disease susceptibility in humans need to be understood...
  25. ncbi request reprint Identification of common transcriptional regulatory elements in interleukin-17 target genes
    Fang Shen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 281:24138-48. 2006
    ..Analysis of IL-17 target gene regulation is key for understanding this important host-defense molecule and also contributes to an understanding of upstream signaling mechanisms used by IL-17, either alone or in concert with TNFalpha...
  26. ncbi request reprint The IL-17 cytokine family
    Sarah L Gaffen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    Vitam Horm 74:255-82. 2006
    ..This chapter describes the major molecular properties, biological activities, and known signaling pathways of the IL-17 family, with an emphasis on IL-17A and IL-17RA...
  27. pmc The interleukin-17 receptor plays a gender-dependent role in host protection against Porphyromonas gingivalis-induced periodontal bone loss
    Jeffrey J Yu
    Department of Microbiology and Immunology, University at Buffalo, SUNY, Buffalo, New York, USA
    Infect Immun 76:4206-13. 2008
    ..This study demonstrates a gender-dependent effect of IL-17 signaling and indicates that gender differences should be taken into account in the preclinical and clinical safety testing of anti-IL-17 biologic therapies...
  28. ncbi request reprint Functional cooperation between interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein family members
    Matthew J Ruddy
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University of Buffalo, Buffalo, NY 14214, USA
    J Biol Chem 279:2559-67. 2004
    ..Thus, C/EBP family members, particularly C/EBPdelta, appear to be important for the functional cooperation between IL-17 and TNFalpha...
  29. pmc Host responses to Candida albicans: Th17 cells and mucosal candidiasis
    Heather R Conti
    University at Buffalo, SUNY, Department of Oral Biology, Buffalo, NY, USA
    Microbes Infect 12:518-27. 2010
    ..However, emerging data indicate that the newly-defined Th17 compartment appears to play the predominant role in mucosal candidiasis...
  30. pmc Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor
    Jill M Kramer
    Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    J Immunol 179:6379-83. 2007
    ..However, the FN1 domain is also required for high affinity interactions with IL-17. Therefore, although the PLAD is located entirely within FN2, effective ligand binding also involves contributions from the linker and FN1...
  31. ncbi request reprint IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
    ....

Research Grants3

  1. INTERLEUKIN-17 RECEPTOR SIGNALING IN BONE
    SARAH GAFFEN; Fiscal Year: 2005
    ..Collectively, these studies will shed light on the function of a novel family of cytokine receptors, as represented by the IL-17R. ..