KARIN L GAENSLER

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Role of antigen-specific regulatory CD4+CD25+ T cells in tolerance induction after neonatal IP administration of AAV-hF.IX
    Y Shi
    Department of Medicine, University of California, San Francisco, CA, USA
    Gene Ther 20:987-96. 2013
  2. pmc Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locus
    Karin M L Gaensler
    Department of Medicine and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 100:3374-9. 2003
  3. pmc KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo
    Priyadarshi Basu
    Department of Human Genetics, Virginia Commonwealth University, PO Box 980033, Richmond, VA 23298 0033, USA
    Blood 106:2566-71. 2005

Collaborators

  • Y Shi
  • Priyadarshi Basu
  • L Flebbe-Rehwaldt
  • R Falahati
  • J Zhang
  • Pamela E Morris
  • Joyce A Lloyd
  • Jack L Haar
  • Jerry B Lingrel
  • Maqsood A Wani

Detail Information

Publications3

  1. pmc Role of antigen-specific regulatory CD4+CD25+ T cells in tolerance induction after neonatal IP administration of AAV-hF.IX
    Y Shi
    Department of Medicine, University of California, San Francisco, CA, USA
    Gene Ther 20:987-96. 2013
    ..Neonatal gene transfer provides a useful approach for defining the ontogeny of immune responses and may suggest approaches for inducing tolerance in the context of genetic therapies...
  2. pmc Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locus
    Karin M L Gaensler
    Department of Medicine and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 100:3374-9. 2003
    ..These studies suggest that regulatory sequences required for activation and silencing of the human beta-globin gene family during ontogeny reside proximally to the genes and immediately 5' to the human gamma- and beta-globin genes...
  3. pmc KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo
    Priyadarshi Basu
    Department of Human Genetics, Virginia Commonwealth University, PO Box 980033, Richmond, VA 23298 0033, USA
    Blood 106:2566-71. 2005
    ..KLF2 also plays a role in the maturation and/or stability of erythroid cells in the yolk sac. KLF2-/- embryos have a significantly increased number of primitive erythroid cells undergoing apoptotic cell death...

Research Grants13

  1. Tolerance Induction by Neonatal Gene Delivery
    KARIN L GAENSLER; Fiscal Year: 2010
    ..Furthermore, for many genetic disorders, intervention in the perinatal period to correct the disorder would limit or abrogate the development of irrevocable, often lethal consequences of the disease. ..
  2. Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    Karin Gaensler; Fiscal Year: 2009
    ..We have developed a new approach combining gene therapy and stem cell transplantation that reduces or eliminates the need for toxic, high dose chemotherapy and immunosuppression used in current transplant protocols and procedures. ..
  3. Tolerance Induction by Neonatal Gene Delivery
    Karin Gaensler; Fiscal Year: 2009
    ..Furthermore, for many genetic disorders, intervention in the perinatal period to correct the disorder would limit or abrogate the development of irrevocable, often lethal consequences of the disease. ..
  4. Tolerance Induction by Neonatal Gene Delivery
    Karin Gaensler; Fiscal Year: 2007
    ..Furthermore, for many genetic disorders, intervention in the perinatal period to correct the disorder would limit or abrogate the development of irrevocable, often lethal consequences of the disease. ..
  5. In Vivo Stem Cell Selection in Neonatal Allo-Transplants
    Karin Gaensler; Fiscal Year: 2006
    ..This negative selection strategy may also abrogate autonomous clonal proliferation of transduced donor cells after forced enrichment and expansion in vivo, an important potential safety issue. ..
  6. Tolerance Induction by Neonatal Gene Delivery
    Karin Gaensler; Fiscal Year: 2006
    ..Furthermore, for many genetic disorders, intervention in the perinatal period to correct the disorder would limit or abrogate the development of irrevocable, often lethal consequences of the disease. ..
  7. Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    KARIN L GAENSLER; Fiscal Year: 2010
    ..We have developed a new approach combining gene therapy and stem cell transplantation that reduces or eliminates the need for toxic, high dose chemotherapy and immunosuppression used in current transplant protocols and procedures. ..