Dmitry I Gabrilovich

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. doi Combined modality immunotherapy and chemotherapy: a new perspective
    Rupal Ramakrishnan
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Immunol Immunother 57:1523-9. 2008
  2. pmc Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells
    Cesar A Corzo
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, 33612, USA
    J Immunol 182:5693-701. 2009
  3. ncbi Dendritic cell vaccines for cancer treatment
    Dmitry I Gabrilovich
    H Lee Moffitt Cancer Center, University of South Florida, Tampa 33612, USA
    Curr Opin Mol Ther 4:452-8. 2002
  4. pmc HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    Cesar A Corzo
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    J Exp Med 207:2439-53. 2010
  5. pmc Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
    Pingyan Cheng
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Exp Med 205:2235-49. 2008
  6. pmc Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center, Tampa, Florida 33647, USA
    Clin Cancer Res 16:1812-23. 2010
  7. pmc Lipid accumulation and dendritic cell dysfunction in cancer
    Donna L Herber
    Department of Immunology, H Lee Moffitt Cancer Center, Tampa, Florida, USA
    Nat Med 16:880-6. 2010
  8. ncbi Immature myeloid cells and cancer-associated immune suppression
    Sergei Kusmartsev
    H Lee Moffitt Cancer Center, University of South Florida, MRC 2, Room 2067, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Immunol Immunother 51:293-8. 2002
  9. pmc Mechanism of T cell tolerance induced by myeloid-derived suppressor cells
    Srinivas Nagaraj
    Department of Immunology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Immunol 184:3106-16. 2010
  10. pmc Notch and wingless signaling cooperate in regulation of dendritic cell differentiation
    Jie Zhou
    Department of Immunology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Immunity 30:845-59. 2009

Collaborators

Detail Information

Publications53

  1. doi Combined modality immunotherapy and chemotherapy: a new perspective
    Rupal Ramakrishnan
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Immunol Immunother 57:1523-9. 2008
    ..In clinical trials, immune responses elicited by cancer vaccines appear to augment the effectiveness of subsequent conventional cancer therapies...
  2. pmc Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells
    Cesar A Corzo
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, 33612, USA
    J Immunol 182:5693-701. 2009
    ..These findings expand our fundamental understanding of the biology of MDSC and may also open new opportunities for therapeutic regulation of these cells in cancer...
  3. ncbi Dendritic cell vaccines for cancer treatment
    Dmitry I Gabrilovich
    H Lee Moffitt Cancer Center, University of South Florida, Tampa 33612, USA
    Curr Opin Mol Ther 4:452-8. 2002
    ..We will discuss requirements for DC activation as pre-requisite for the success of cancer immunotherapy...
  4. pmc HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    Cesar A Corzo
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    J Exp Med 207:2439-53. 2010
    ....
  5. pmc Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
    Pingyan Cheng
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Exp Med 205:2235-49. 2008
    ..This study demonstrates that tumor-induced up-regulation of S100A9 protein is critically important for accumulation of MDSCs and reveals a novel molecular mechanism of immunological abnormalities in cancer...
  6. pmc Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center, Tampa, Florida 33647, USA
    Clin Cancer Res 16:1812-23. 2010
    ..Myeloid-derived suppressor cells (MDSC) are one of the major factors responsible for immune suppression in cancer. Therefore, it would be important to identify effective therapeutic means to modulate these cells...
  7. pmc Lipid accumulation and dendritic cell dysfunction in cancer
    Donna L Herber
    Department of Immunology, H Lee Moffitt Cancer Center, Tampa, Florida, USA
    Nat Med 16:880-6. 2010
    ..These findings suggest that immune responses in cancer can be improved by manipulating the lipid levels in DCs...
  8. ncbi Immature myeloid cells and cancer-associated immune suppression
    Sergei Kusmartsev
    H Lee Moffitt Cancer Center, University of South Florida, MRC 2, Room 2067, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Immunol Immunother 51:293-8. 2002
    ..This review examines recent findings on the contribution of immature myeloid cells (ImC) to cancer-induced immune suppression...
  9. pmc Mechanism of T cell tolerance induced by myeloid-derived suppressor cells
    Srinivas Nagaraj
    Department of Immunology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Immunol 184:3106-16. 2010
    ..MDSCs caused dissociation between TCR and CD3zeta molecules, disrupting TCR complexes on T cells. Thus, these data describe a novel mechanism of Ag-specific CD8(+) T cell tolerance in cancer...
  10. pmc Notch and wingless signaling cooperate in regulation of dendritic cell differentiation
    Jie Zhou
    Department of Immunology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Immunity 30:845-59. 2009
    ..Thus, these data suggest a model of DC differentiation via cooperation between Wnt and Notch pathways...
  11. ncbi Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients
    Steven E Finkelstein
    H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
    Int J Radiat Oncol Biol Phys 82:924-32. 2012
    ....
  12. pmc Antigen-specific CD4(+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling
    Srinivas Nagaraj
    Department of Internal Medicine, University of South Florida, Tampa, Florida 33612, USA
    Cancer Res 72:928-38. 2012
    ....
  13. ncbi Myeloid-derived suppressor cells
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
    Adv Exp Med Biol 601:213-23. 2007
    ..In recent years, it has become increasingly evident that MDSCs bring about antigen-specific T cell tolerance by various mechanisms, which is the focus of this chapter...
  14. pmc Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, Florida 33647, USA
    Nat Med 13:828-35. 2007
    ..These data identify a previously unknown mechanism of T-cell tolerance in cancer that is also pertinent to many pathological conditions associated with accumulation of MDSCs...
  15. pmc Reciprocal relationship between myeloid-derived suppressor cells and T cells
    Srinivas Nagaraj
    Department of Internal Medicine, University of South Florida, Tampa, FL 33612, USA
    J Immunol 191:17-23. 2013
    ..In this review we discuss the nature of the complex relationship between MDSCs and the different populations of CD4(+) T cells. ..
  16. doi Therapeutic effect of intratumoral administration of DCs with conditional expression of combination of different cytokines
    Chun Huang
    Department of Immunology, H Lee Moffitt Cancer Center, MRC 2067, 12902 Magnolia Dr Tampa, Tampa, FL 33647, USA
    Cancer Immunol Immunother 61:573-9. 2012
    ..These results indicate that RTS can be a potent tool for conditional topical cytokine delivery, in combination with DC administration. However, combination of different cytokines may not necessarily improve the outcome of treatment...
  17. ncbi Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species
    Sergei Kusmartsev
    H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
    J Immunol 172:989-99. 2004
    ..This study demonstrates a new mechanism of Ag-specific T cell inhibition mediated by ROS produced by ImCs in cancer...
  18. ncbi Vascular endothelial growth factor-trap overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responses
    Ingo Fricke
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612, USA
    Clin Cancer Res 13:4840-8. 2007
    ..It has been proposed that inhibition of VEGF may result in improved immune responses. The goal of this study was to test this hypothesis...
  19. doi Tumor escape mechanism governed by myeloid-derived suppressor cells
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612, USA
    Cancer Res 68:2561-3. 2008
    ..Elucidation of this mechanism of T-cell tolerance offers new opportunities for therapeutic corrections of immune escape in cancer...
  20. ncbi Targeting of Jak/STAT pathway in antigen presenting cells in cancer
    Yulia Nefedova
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Curr Cancer Drug Targets 7:71-7. 2007
    ..The different approaches to pharmacological regulation of this pathway and their effects on DC function and antitumor immune responses will be discussed...
  21. pmc Myeloid-derived suppressor cells as regulators of the immune system
    Dmitry I Gabrilovich
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Nat Rev Immunol 9:162-74. 2009
    ..In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit...
  22. pmc Subsets of myeloid-derived suppressor cells in tumor-bearing mice
    Je In Youn
    H Lee Moffitt Cancer Center and Research Institute and Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, USA
    J Immunol 181:5791-802. 2008
    ..These data indicate that suppressive features of MDSC is caused not by expansion of a specific subset but more likely represent a functional state of these cells...
  23. pmc Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer
    Sergei Kusmartsev
    H Lee Moffitt Cancer Center, University of South Florida, MRC 2067, 12902 Magnolia Dr, Tampa, FL 33612, USA
    Cancer Metastasis Rev 25:323-31. 2006
    ..The role of reactive oxygen species as well as JAK/STAT signaling in mechanisms of the effects of tumor-derived factors on myeloid cells is also discussed...
  24. doi Mechanism of synergistic effect of chemotherapy and immunotherapy of cancer
    Rupal Ramakrishnan
    H Lee Moffitt Cancer Center, MRC 2067, 12902 Magnolia Dr, Tampa, FL 33612, USA
    Cancer Immunol Immunother 60:419-23. 2011
    ..However, the mechanism of this phenomenon is poorly understood. Here, we will discuss recent findings that suggest novel mechanisms of synergistic effect of cancer immunotherapy and chemotherapy...
  25. ncbi Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species
    Sergei Kusmartsev
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Leukoc Biol 74:186-96. 2003
    ..Thus, this is a first demonstration that tumors may prevent differentiation of antigen-presenting cells by increasing the level of endogenous H(2)O(2) in immature myeloid cells...
  26. pmc Activation of dendritic cells via inhibition of Jak2/STAT3 signaling
    Yulia Nefedova
    Immunology Program, H Lee Moffitt Cancer Center, and the Department of Interdisciplinary Oncology, University of South Florida, Tampa, FL 33647, USA
    J Immunol 175:4338-46. 2005
    ..This indicates that Jak2/STAT3 play an important role in negative regulation of DC activation, and pharmacological inhibition of the Jak2/STAT3 pathway can be used to enhance DC function...
  27. pmc Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway
    Yulia Nefedova
    Department of Interdisciplinary Oncology, University of South Florida, Tampa, FL 33612, USA
    Cancer Res 65:9525-35. 2005
    ..This indicates that pharmacologic inhibition of the JAK2/STAT3 pathway can be an important new therapeutic strategy to enhance antitumor activity of cancer immunotherapy...
  28. pmc Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice
    Je In Youn
    H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Leukoc Biol 91:167-81. 2012
    ..These data suggest that in cancer, despite morphological and phenotypic similarities, G-MDSCs are functionally distinct from Neu and are comprised of pathologically activated precursors of Neu...
  29. pmc Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function
    Thomas Condamine
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Trends Immunol 32:19-25. 2011
    ..Here, we discuss recent findings that describe the molecular mechanisms that regulate the expansion and function of MDSCs, as well as recent attempts to use MDSCs in cell therapy for different pathologic conditions...
  30. doi Myeloid-derived suppressor cells in human cancer
    Srinivas Nagaraj
    Division of Translational Medicine, Department of Internal Medicine, University of South Florida, Tampa, FL, USA
    Cancer J 16:348-53. 2010
    ..Here, we give an overview of the myeloid-derived suppressor cells field focusing primarily on the studies in cancer patients and current and future therapeutic options targeting these cells...
  31. ncbi H1(0) histone and differentiation of dendritic cells. A molecular target for tumor-derived factors
    Dmitry I Gabrilovich
    H Lee Moffitt Cancer Center, University of South Florida, Tampa 33612, USA
    J Leukoc Biol 72:285-96. 2002
    ..Thus, H1(0) histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1(0) expression...
  32. ncbi STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion
    Sergei Kusmartsev
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Immunol 174:4880-91. 2005
    ..Using the analysis of STAT activity in combination with STAT knockout mice, we have determined that STAT1, but not STAT3 or STAT6, was responsible for TAM-suppressive activity...
  33. pmc Role of immature myeloid cells in mechanisms of immune evasion in cancer
    Sergei Kusmartsev
    H Lee Moffitt Cancer Center and Research Institute and The Department of Interdisciplinary Oncology, University of South Florida, MRC 2067, 12902 Magnolia Dr, Tampa, FL 33612, USA
    Cancer Immunol Immunother 55:237-45. 2006
    ....
  34. ncbi INGN 201 (Advexin): adenoviral p53 gene therapy for cancer
    Dmitry I Gabrilovich
    University of South Florida, H Lee Moffitt Cancer Center and the Department of Interdisciplinary Oncology, MRC 2067, 12902 Magnolia Dr, Tampa, FL 33612, USA
    Expert Opin Biol Ther 6:823-32. 2006
    ..In addition, there is now data to support the use of Advexin in cancer immunotherapy...
  35. pmc Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells
    Sergei Kusmartsev
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Immunol 175:4583-92. 2005
    ..Thus, this is a first demonstration that in tumor-bearing mice CD8+ T cell tolerance is induced primarily by ImC that may have direct implications for cancer immunotherapy...
  36. pmc All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients
    Noweeda Mirza
    H Lee Moffitt Cancer Center and the Department of Interdisciplinary Oncology, University of South Florida, Tampa, Florida 33612, USA
    Cancer Res 66:9299-307. 2006
    ..ATRA treatment did not result in significant toxicity and it could be tested in therapeutic combination with cancer vaccines...
  37. ncbi Dendritic cell-based full-length survivin vaccine in treatment of experimental tumors
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center and Department of Interdisciplinary Oncology, University of South Florida, Tampa, FL 33612, USA
    J Immunother 30:169-79. 2007
    ..Despite the fact that combination of 2 vaccines generated potent antigen specific T-cell responses against both molecules they did not result in the improvement of antitumor effect in any of the tested experimental tumor models...
  38. pmc The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneity
    Je In Youn
    H Lee Moffitt Cancer Center, Tampa, FL, USA
    Eur J Immunol 40:2969-75. 2010
    ..In this review, we will discuss recent findings that help to better clarify these issues and to determine the place of MDSC within the myeloid cell lineage...
  39. pmc Regulation of dendritic-cell differentiation by bone marrow stroma via different Notch ligands
    Pingyan Cheng
    H Lee Moffitt Cancer Center, Department of Interdisciplinary Oncology, University of South Florida, MRC 2067, 12902 Magnolia Dr, Tampa, FL 33612, USA
    Blood 109:507-15. 2007
    ..Thus, this study not only revealed the different role of Notch ligands in DC differentiation but also may provide a new insight into regulation of DC differentiation by BMS...
  40. ncbi Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy
    Yulia Nefedova
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612, USA
    Blood 111:2220-9. 2008
    ..Thus, this study demonstrates that inhibition of Notch signaling prevents BM-mediated drug resistance and sensitizes myeloma cells to chemotherapy. This may represent a promising approach for therapeutic intervention in multiple myeloma...
  41. pmc Dendritic cells and tumor microenvironment: a dangerous liaison
    Ingo Fricke
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612, USA
    Immunol Invest 35:459-83. 2006
    ..The tumor microenvironment has emerged as an important component contributing to DC malfunction. In this review we will discuss the potential role of tumor microenvironment in DC dysfunction...
  42. ncbi Combination of chemotherapy and immunotherapy for cancer: a paradigm revisited
    Dmitry I Gabrilovich
    Department of Interdisciplinary Oncology and Molecular Medicine, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Lancet Oncol 8:2-3. 2007
  43. ncbi Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines
    Yulia Nefedova
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Blood 103:3503-10. 2004
    ..Thus, this is a first report demonstrating that Notch-1 signaling may be a primary mechanism mediating the BMS influence on hematologic malignant cell growth and survival...
  44. ncbi Full-length dominant-negative survivin for cancer immunotherapy
    Vladimir Pisarev
    University of Nebraska Medical Center Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Clin Cancer Res 9:6523-33. 2003
    ..The goal of this study is to investigate the possible utility of dendritic cells (DCs) transduced with the human full-length dominant-negative survivin for cancer immunotherapy...
  45. pmc Developing dendritic cells become 'lacy' cells packed with fat and glycogen
    Asher Maroof
    Antigen Presentation Research Group, Imperial College London, Harrow, UK
    Immunology 115:473-83. 2005
    ....
  46. ncbi Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy
    Ulrich Keilholz
    UKBF Free University, Berlin, Germany
    J Immunother 25:97-138. 2002
    ..At present, assays appear to be most useful as measures of vaccine potency. Careful immune monitoring in association with larger scale clinical trials ultimately may enable the correlation of monitoring results with clinical benefit...
  47. ncbi Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer
    Scott J Antonia
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Clin Cancer Res 12:878-87. 2006
    ....
  48. ncbi Molecular mechanisms and therapeutic reversal of immune suppression in cancer
    Dmitry I Gabrilovich
    Curr Cancer Drug Targets 7:1. 2007
  49. pmc MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis
    Matthew J Delano
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Exp Med 204:1463-74. 2007
    ..GR-1(+)CD11b(+) cells contribute to sepsis-induced T cell suppression and preferential Th2 polarization...
  50. ncbi Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells
    Yulia Nefedova
    H Lee Moffitt Cancer Center and University of South Florida, Tampa, Florida 33612, USA
    Cancer Res 67:11021-8. 2007
    ..This novel mechanism involves specific up-regulation of GSS and accumulation of GSH and could be used in developing and monitoring therapeutic application of ATRA...
  51. pmc Mechanism and therapeutic reversal of immune suppression in cancer
    Donna L Herber
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Cancer Res 67:5067-9. 2007
  52. ncbi VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression
    Joyce E Ohm
    Department of Cancer Biology and Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA
    Blood 101:4878-86. 2003
    ..These data demonstrate that at pathophysiologic concentrations, VEGF interferes with the development of T cells from early hematopoetic progenitor cells and this may contribute to tumor-associated immune deficiencies...
  53. pmc The terminology issue for myeloid-derived suppressor cells
    Dmitry I Gabrilovich
    Cancer Res 67:425; author reply 426. 2007