Francis B Gabbai
Affiliation: University of California
- Relationship between ambulatory BP and clinical outcomes in patients with hypertensive CKDFrancis B Gabbai
VA San Diego Healthcare System and Department of Medicine, University of California San Diego, CA 92161, USA
Clin J Am Soc Nephrol 7:1770-6. 2012..This study assessed the relationship of baseline ABP profiles with CKD progression and subsequent cardiovascular outcomes to determine the prognostic value of ABP beyond that of clinic BP measurements...
- Production of arginine by the kidney is impaired in a model of sepsis: early events following LPSMark J Lortie
Division of Nephrology and Hypertension, School of Medicine, University of California San Diego, San Diego, CA 92093, USA
Am J Physiol Regul Integr Comp Physiol 287:R1434-40. 2004..These studies demonstrate that the major factor responsible for the rapid decrease in extracellular arginine content following LPS is impaired production by the kidney, a phenomenon that appears linked to reduced renal perfusion...
- Early diabetes as a model for testing the regulation of juxtaglomerular NOS IScott C Thomson
Department of Medicine, Division of Nephrology Hypertension, University of California and Veterans Affairs San Diego Health Care System, San Diego, CA 92161, USA
Am J Physiol Renal Physiol 287:F732-8. 2004..In conclusion, normally, salt delivered to the macula densa (MD) exerts immediate control over MD NOS I activity. In diabetes, there is ongoing overactivity of NOS I that is not regulated by MD salt...
- Effect of acute iNOS inhibition on glomerular function in tubulointerstitial nephritisFrancis B Gabbai
Division of Nephrology Hypertension 9111 H, University of California San Diego School of Medicine, La Jolla, CA, USA
Kidney Int 61:851-4. 2002..These studies were designed to examine the changes in glomerular hemodynamics 7 and 21 days after induction of TIN and to evaluate the effect of acute iNOS blockade on glomerular function in the early stages of this model...
- The complex role of nitric oxide in the regulation of glomerular ultrafiltrationRoland C Blantz
Division of Nephrology Hypertension, Department of Medicine, University of California, San Diego, CA 92161, USA
Kidney Int 61:782-5. 2002..Future studies will determine whether NMDA receptor is also an important regulator of bNOS activity and the TGF system...
- Mechanisms of glomerular immune injury: effects of antioxidant treatmentSriram S Narsipur
Division of Nephrology, CWB 343, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
J Am Soc Nephrol 14:1748-55. 2003..The specific mechanisms whereby antioxidant therapy ameliorates glomerular hemodynamic effects will be defined in additional studies and is likely to involve either enhanced vasodilator or diminished vasoconstrictor activity...
- L-arginine-induced glomerular hyperfiltration response: the roles of insulin and ANG IIMario Ruiz
Division of Nephrology Hypertension, VA San Diego Healthcare System and the University of California, San Diego School of Medicine, La Jolla, CA 92161, USA
Am J Physiol Regul Integr Comp Physiol 294:R1744-51. 2008....
- Effects on kidney filtration rate by agmatine requires activation of ryanodine channels for nitric oxide generationJoseph Satriano
Division of Nephrology Hypertension, Univ of California, San Diego and Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, M C 9111 H, San Diego, CA 92161, USA
Am J Physiol Renal Physiol 294:F795-800. 2008..In conclusion, we show that agmatine-induced effects require activation of cADPR and RyR calcium release channels for NO generation, vasodilation, and increased filtration rate...
- Effect of combining an ACE inhibitor and an angiotensin II receptor blocker on plasma and kidney tissue angiotensin II levelsNorikuri Komine
Division of Nephrology Hypertension, VA San Diego Healthcare System and University of California, San Diego, La Jolla, CA 92161, USA
Am J Kidney Dis 39:159-64. 2002..The reduction in AIIk with ACE inhibitor plus ARB may have important implications in long-term organ protection in hypertension and renal disease...
- Protein intake regulates the vasodilatory function of the kidney and NMDA receptor expressionLarry A Slomowitz
Department of Medicine, University of California San Diego, Veterans Administration San Diego Healthcare System, 92161, USA
Am J Physiol Regul Integr Comp Physiol 287:R1184-9. 2004..Kidney NMDA receptor expression is conditioned by protein intake, and this receptor may play an important role in the kidney vasodilatory response to glycine infusion and protein feeding in rats...
- Kidney oxygen consumption, carbonic anhydrase, and proton secretionAihua Deng
Division of Nephrology Hypertension, Univ of California, San Diego and VASDHS, 3350 La Jolla Village Drive 9111 H San Diego, CA 92161, USA
Am J Physiol Renal Physiol 290:F1009-15. 2006..Instead, increased cost may be incurred within the proximal tubule as the result of increased active chloride transport...
- Long-term effects of renin-angiotensin system-blocking therapy and a low blood pressure goal on progression of hypertensive chronic kidney disease in African AmericansLawrence J Appel
Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins Institutions, Johns Hopkins University, Baltimore, MD 21205 2223, USA
Arch Intern Med 168:832-9. 2008..A low blood pressure (BP) goal (BP, <130/80 mm Hg) is also recommended. The objective of this study was to determine the long-term effects of currently recommended BP therapy in 1094 African Americans with hypertensive CKD...
- Changing the timing of antihypertensive therapy to reduce nocturnal blood pressure in CKD: an 8-week uncontrolled trialRoberto Minutolo
Department of Nephrology, Second University of Naples, Naples, Italy
Am J Kidney Dis 50:908-17. 2007..We examined whether shifting 1 antihypertensive drug from morning to evening restores the circadian rhythm of blood pressure in nondipper patients with CKD...