Glenn Furuta

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. doi request reprint Eosinophilic esophagitis: update on clinicopathological manifestations and pathophysiology
    Glenn T Furuta
    Digestive Health Institute, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Gastrointestinal Eosinophilic Diseases Program, The Children s Hospital, National Jewish Health, Mucosal Inflammation Program, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Curr Opin Gastroenterol 27:383-8. 2011
  2. doi request reprint Eosinophilic esophagitis
    Glenn T Furuta
    The Children s Hospital, Denver, National Jewish Health, University of Colorado, Denver, School of Medicine, Aurora, CO 80045, USA
    Dig Dis 27:122-8. 2009
  3. doi request reprint Eosinophilic gastrointestinal diseases (EGIDs)
    Glenn T Furuta
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital Denver, University of Colorado Denver, School of Medicine, 13123 E 16th Ave, B290, Aurora, CO 80045, USA
    J Pediatr Gastroenterol Nutr 47:234-8. 2008
  4. ncbi request reprint Eosinophils in the gastrointestinal tract
    Esi S N Lamousé-Smith
    Children s Hospital Boston, 300 Longwood Avenue, Hunnewell Ground Floor, Boston, MA 02115, USA
    Curr Gastroenterol Rep 8:390-5. 2006
  5. ncbi request reprint Emerging questions regarding eosinophil's role in the esophago-gastrointestinal tract
    Glenn T Furuta
    Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Curr Opin Gastroenterol 22:658-63. 2006
  6. ncbi request reprint Integrated approach to treatment of children and adults with eosinophilic esophagitis
    Seema S Aceves
    Division of Allergy, Immunology, Rady Children s Hospital, San Diego, Pediatrics University of California, 3020 Childrens Way, San Diego, CA 92123, USA
    Gastrointest Endosc Clin N Am 18:195-217; xi. 2008
  7. ncbi request reprint Eructations from eosinophils
    Glenn T Furuta
    Gastroenterology 131:1629-31. 2006
  8. ncbi request reprint Upper gastrointestinal tract eosinophilic disorders: pathobiology and management
    Jessica J Lee
    Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Hunnewell Ground Floor, Boston, MA 02115, USA
    Curr Gastroenterol Rep 8:439-42. 2006
  9. ncbi request reprint Summary of the First International Gastrointestinal Eosinophil Research Symposium
    Chris A Liacouras
    J Pediatr Gastroenterol Nutr 45:370-91. 2007
  10. ncbi request reprint Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment
    Glenn T Furuta
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, Denver, University of Colorado Medical School, Denver, Colorado, USA
    Gastroenterology 133:1342-63. 2007

Research Grants

Collaborators

  • Seema S Aceves
  • Simon P Hogan
  • Sandeep K Gupta
  • A Straumann
  • Chris A Liacouras
  • S J Spechler
  • Victor L Fox
  • Samuel Nurko
  • Peter Ngo
  • Jorn Karhausen
  • Sean P Colgan
  • Kamran Badizadegan
  • Jonathan E Teitelbaum
  • Donald A Antonioli
  • Andreas Robinson
  • Barry K Wershil
  • Vincent A Mukkada
  • Jessica J Lee
  • Esi S N Lamousé-Smith
  • Tusar K Desai
  • Qian Yuan
  • Henrik Kohler
  • Kristin Synnestvedt
  • So Young Lee
  • Mark E Gerich
  • Simon Keely
  • Jonathan A Phillips
  • Punitha Ramalingam
  • Veslav Stecevic
  • Chung Ho Chang
  • Neal S Goldstein
  • Donald Antonioli
  • Randall S Johnson
  • Carlo Buonomo
  • Christine Fortunato
  • John E Tomaszewski
  • Volker H Haase
  • Khaled Husain
  • Jonathan Glickman
  • Frank J Twarog
  • Nancy Louis
  • Holger K Eltzschig
  • Ashima Madan
  • Katrina M Comerford
  • Gerald Gleich
  • Linda F Thompson
  • Karl R Hansen
  • Don Antonioli
  • Eric Sibley

Detail Information

Publications29

  1. doi request reprint Eosinophilic esophagitis: update on clinicopathological manifestations and pathophysiology
    Glenn T Furuta
    Digestive Health Institute, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Gastrointestinal Eosinophilic Diseases Program, The Children s Hospital, National Jewish Health, Mucosal Inflammation Program, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
    Curr Opin Gastroenterol 27:383-8. 2011
    ..Over the course of the last year, a number of studies have brought new insights into the clinical presentation, pathogenesis, and treatment of eosinophilic esophagitis, some of which will be summarized here...
  2. doi request reprint Eosinophilic esophagitis
    Glenn T Furuta
    The Children s Hospital, Denver, National Jewish Health, University of Colorado, Denver, School of Medicine, Aurora, CO 80045, USA
    Dig Dis 27:122-8. 2009
    ..Effective treatments include topical and systemic corticosteroids and dietary restrictions...
  3. doi request reprint Eosinophilic gastrointestinal diseases (EGIDs)
    Glenn T Furuta
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital Denver, University of Colorado Denver, School of Medicine, 13123 E 16th Ave, B290, Aurora, CO 80045, USA
    J Pediatr Gastroenterol Nutr 47:234-8. 2008
  4. ncbi request reprint Eosinophils in the gastrointestinal tract
    Esi S N Lamousé-Smith
    Children s Hospital Boston, 300 Longwood Avenue, Hunnewell Ground Floor, Boston, MA 02115, USA
    Curr Gastroenterol Rep 8:390-5. 2006
    ....
  5. ncbi request reprint Emerging questions regarding eosinophil's role in the esophago-gastrointestinal tract
    Glenn T Furuta
    Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Curr Opin Gastroenterol 22:658-63. 2006
    ..Whichever is the case, clinical needs to meet this new challenge include establishing diagnostic criteria, identifying the natural history and determining effective, tolerable treatments...
  6. ncbi request reprint Integrated approach to treatment of children and adults with eosinophilic esophagitis
    Seema S Aceves
    Division of Allergy, Immunology, Rady Children s Hospital, San Diego, Pediatrics University of California, 3020 Childrens Way, San Diego, CA 92123, USA
    Gastrointest Endosc Clin N Am 18:195-217; xi. 2008
    ..In this article, three authors from diverse backgrounds combine their resources to propose treatment paths with justification based on their clinical experience and interpretation of the literature...
  7. ncbi request reprint Eructations from eosinophils
    Glenn T Furuta
    Gastroenterology 131:1629-31. 2006
  8. ncbi request reprint Upper gastrointestinal tract eosinophilic disorders: pathobiology and management
    Jessica J Lee
    Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Hunnewell Ground Floor, Boston, MA 02115, USA
    Curr Gastroenterol Rep 8:439-42. 2006
    ..This review addresses recent studies that define clinical features, genetic predisposition, pathogenetic mechanisms, and treatment options for eosinophilic esophagitis...
  9. ncbi request reprint Summary of the First International Gastrointestinal Eosinophil Research Symposium
    Chris A Liacouras
    J Pediatr Gastroenterol Nutr 45:370-91. 2007
  10. ncbi request reprint Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment
    Glenn T Furuta
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, Denver, University of Colorado Medical School, Denver, Colorado, USA
    Gastroenterology 133:1342-63. 2007
    ..Since EE is a relatively new disease, the intent of this report is to provide current recommendations for care of affected patients and defining gaps in knowledge for future research studies...
  11. pmc Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition
    Andreas Robinson
    Mucosal Inflammation Program, Division of Gastroenterology, University of Colorado Health Sciences Center, Denver, CO, USA
    Gastroenterology 134:145-55. 2008
    ..Here, we hypothesized that pharmacologic activation of HIF would similarly provide a protective adaptation to murine colitic disease...
  12. doi request reprint 4. Gastrointestinal mucosal immunity
    Barry K Wershil
    Albert Einstein College of Medicine, the Division of Pediatric Gastroenterology and Nutrition, The Children s Hospital at Montefiore, Bronx, NY, USA
    J Allergy Clin Immunol 121:S380-3; quiz S415. 2008
    ..The system has unique cellular components and functional aspects that permit it to carry out this dual role...
  13. doi request reprint Idiopathic eosinophilic disorders of the gastrointestinal tract in children
    Vincent A Mukkada
    University of Colorado School of Medicine, Department of Pediatrics, The Children s Hospital, Denver, CO, USA
    Best Pract Res Clin Gastroenterol 22:497-509. 2008
    ..Many areas remain unanswered in the management of patients with EGIDs, including identification of optimal treatment protocol, development of appropriate non-invasive monitoring, and choice of appropriate therapeutic endpoints...
  14. ncbi request reprint Allergic eosinophilic esophagitis: a primer for pathologists
    Donald A Antonioli
    Department of Pathology, Beth Israel Deaconess Medical Center and Children s Hospital, Boston, Massachusetts 02215 5491, USA
    Semin Diagn Pathol 22:266-72. 2005
    ..In this review, we evaluate current information on the clinical, endoscopic, and pathologic features of this condition and summarize the most useful parameters that support its diagnosis...
  15. ncbi request reprint Eosinophils in the esophagus--peptic or allergic eosinophilic esophagitis? Case series of three patients with esophageal eosinophilia
    Peter Ngo
    Division of Pediatric Gastroenterology, Children s Hospital, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 101:1666-70. 2006
    ..The aim of this case series is to demonstrate that features thought to be consistent with a diagnosis of allergic esophagitis are also observed in peptic esophagitis...
  16. ncbi request reprint Collagen gel contraction assay
    Peter Ngo
    Fellow in Pediatric Gastroenterology, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 341:103-9. 2006
    ..This model allows for investigation of the influence of specific agonists on the rate and extent of matrix contraction...
  17. ncbi request reprint Eosinophilic esophagitis: an emerging clinicopathologic entity
    Glenn T Furuta
    Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Curr Allergy Asthma Rep 2:67-72. 2002
    ..The major importance of identifying eosinophilic esophagitis is that affected patients are receiving fundoplication for persistent symptoms when, in fact, corticosteroids or diet restriction is the treatment of choice...
  18. ncbi request reprint Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate
    Jonathan E Teitelbaum
    Pediatric Gastroenterology and Nutrition, Department of Pathology, and Division of Allergy and Immunology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 122:1216-25. 2002
    ..The aims of this study were to determine the immunopathologic features of EE and the effectiveness of antigen-specific diet restriction (DR) and topical immunosuppression...
  19. ncbi request reprint Eosinophilic esophagitis: it's not just kid's stuff
    Victor L Fox
    Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastrointest Endosc 56:260-70. 2002
  20. ncbi request reprint More than food trafficks into the esophagus
    Glenn T Furuta
    Gastroenterology 123:946-7. 2002
  21. pmc Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
    Kristin Synnestvedt
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 110:993-1002. 2002
    ..These results identify an HIF-1-dependent regulatory pathway for CD73 and indicate the likelihood that CD39/CD73 protects the epithelial barrier during hypoxia...
  22. ncbi request reprint Insights into milk protein allergy: microenvironment matters
    Qian Yuan
    Gastroenterology 124:259-61; author reply 261. 2003
  23. ncbi request reprint High-resolution EUS in children with eosinophilic "allergic" esophagitis
    Victor L Fox
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Gastrointest Endosc 57:30-6. 2003
    ..This study investigated possible anatomic alterations in children with eosinophilic esophagitis in comparison with healthy children by using high-resolution EUS to precisely measure individual tissue layers of the esophagus...
  24. ncbi request reprint Acute myeloid leukemia presenting as non-neutropenic colitis in an infant
    Henrik Kohler
    Divison of Gastroenterology and Nutrition, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Pediatr Gastroenterol Nutr 37:631-3. 2003
  25. ncbi request reprint Association of Schatzki ring with eosinophilic esophagitis in children
    Samuel Nurko
    Division of Gastroenterology, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Massachusetts, 02115, USA
    J Pediatr Gastroenterol Nutr 38:436-41. 2004
    ..To describe the clinicopathologic characteristics of children with Schatzki ring and to determine if Schatzki ring is associated with eosinophilic esophagitis...
  26. pmc Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
    Jorn Karhausen
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 114:1098-106. 2004
    ..Taken together, these studies provide insight into tissue microenvironmental changes during model inflammatory bowel disease and identify HIF-1 as a critical factor for barrier protection during mucosal insult...
  27. ncbi request reprint Association of eosinophilic inflammation with esophageal food impaction in adults
    Tusar K Desai
    Department of Medicine, Beaumont Hospital, Royal Oak, Michigan, USA
    Gastrointest Endosc 61:795-801. 2005
    ..The prevalence of eosinophilic esophagitis among patients with food impaction is unknown. To address this, we evaluated clinicopathologic features of adults with food impaction...
  28. ncbi request reprint Eosinophils alter colonic epithelial barrier function: role for major basic protein
    Glenn T Furuta
    Combined Program in Pediatric Gastroenterology and Nutrition, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 289:G890-7. 2005
    ..In conclusion, MBP decreases epithelial barrier function and in this manner contributes to the pathogenesis of inflammatory bowel diseases...
  29. ncbi request reprint Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cells
    So Young Lee
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
    Mol Genet Metab 75:65-9. 2002
    ..We conclude that HIF-1 can activate the lactase promoter in intestinal epithelial cells exposed to hypoxia. Induction of lactase transcription may represent an adaptive response to gut hypoxia...

Research Grants8

  1. EOSINOPHIL PROTEINS AND GASTROINTESTINAL DISEASE
    Glenn Furuta; Fiscal Year: 2003
    ..EDGP stimulated epithelial cell chloride ion secretion and 3. EDGP stimulated neutrophil infiltration, changes in vascular permeability and fluid secretion in vivo. ..
  2. Gastrointestinal Eosinophil Research Symposium
    Glenn Furuta; Fiscal Year: 2006
    ....
  3. Role of eosinophils in intestinal epithelial dysfunction
    Glenn Furuta; Fiscal Year: 2009
    ..Long-term goals of these studies are the identification of specific diagnostic tests for EOGs and the development of novel eosinophil specific treatments. ..