Affiliation: University of Colorado
- Eosinophilic esophagitis: update on clinicopathological manifestations and pathophysiologyGlenn T Furuta
Digestive Health Institute, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Gastrointestinal Eosinophilic Diseases Program, The Children s Hospital, National Jewish Health, Mucosal Inflammation Program, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
Curr Opin Gastroenterol 27:383-8. 2011..Over the course of the last year, a number of studies have brought new insights into the clinical presentation, pathogenesis, and treatment of eosinophilic esophagitis, some of which will be summarized here...
- Eosinophilic esophagitisGlenn T Furuta
The Children s Hospital, Denver, National Jewish Health, University of Colorado, Denver, School of Medicine, Aurora, CO 80045, USA
Dig Dis 27:122-8. 2009..Effective treatments include topical and systemic corticosteroids and dietary restrictions...
- Eosinophilic gastrointestinal diseases (EGIDs)Glenn T Furuta
Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children's Hospital Denver, University of Colorado Denver, School of Medicine, 13123 E 16th Ave, B290, Aurora, CO 80045, USA
J Pediatr Gastroenterol Nutr 47:234-8. 2008
- Eosinophils in the gastrointestinal tractEsi S N Lamousé-Smith
Children s Hospital Boston, 300 Longwood Avenue, Hunnewell Ground Floor, Boston, MA 02115, USA
Curr Gastroenterol Rep 8:390-5. 2006....
- Emerging questions regarding eosinophil's role in the esophago-gastrointestinal tractGlenn T Furuta
Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Curr Opin Gastroenterol 22:658-63. 2006..Whichever is the case, clinical needs to meet this new challenge include establishing diagnostic criteria, identifying the natural history and determining effective, tolerable treatments...
- Integrated approach to treatment of children and adults with eosinophilic esophagitisSeema S Aceves
Division of Allergy, Immunology, Rady Children s Hospital, San Diego, Pediatrics University of California, 3020 Childrens Way, San Diego, CA 92123, USA
Gastrointest Endosc Clin N Am 18:195-217; xi. 2008..In this article, three authors from diverse backgrounds combine their resources to propose treatment paths with justification based on their clinical experience and interpretation of the literature...
- Eructations from eosinophilsGlenn T Furuta
Gastroenterology 131:1629-31. 2006
- Upper gastrointestinal tract eosinophilic disorders: pathobiology and managementJessica J Lee
Harvard Medical School, Children's Hospital Boston, 300 Longwood Avenue, Hunnewell Ground Floor, Boston, MA 02115, USA
Curr Gastroenterol Rep 8:439-42. 2006..This review addresses recent studies that define clinical features, genetic predisposition, pathogenetic mechanisms, and treatment options for eosinophilic esophagitis...
- Summary of the First International Gastrointestinal Eosinophil Research SymposiumChris A Liacouras
J Pediatr Gastroenterol Nutr 45:370-91. 2007
- Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatmentGlenn T Furuta
Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, Denver, University of Colorado Medical School, Denver, Colorado, USA
Gastroenterology 133:1342-63. 2007..Since EE is a relatively new disease, the intent of this report is to provide current recommendations for care of affected patients and defining gaps in knowledge for future research studies...
- Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibitionAndreas Robinson
Mucosal Inflammation Program, Division of Gastroenterology, University of Colorado Health Sciences Center, Denver, CO, USA
Gastroenterology 134:145-55. 2008..Here, we hypothesized that pharmacologic activation of HIF would similarly provide a protective adaptation to murine colitic disease...
- 4. Gastrointestinal mucosal immunityBarry K Wershil
Albert Einstein College of Medicine, the Division of Pediatric Gastroenterology and Nutrition, The Children s Hospital at Montefiore, Bronx, NY, USA
J Allergy Clin Immunol 121:S380-3; quiz S415. 2008..The system has unique cellular components and functional aspects that permit it to carry out this dual role...
- Idiopathic eosinophilic disorders of the gastrointestinal tract in childrenVincent A Mukkada
University of Colorado School of Medicine, Department of Pediatrics, The Children s Hospital, Denver, CO, USA
Best Pract Res Clin Gastroenterol 22:497-509. 2008..Many areas remain unanswered in the management of patients with EGIDs, including identification of optimal treatment protocol, development of appropriate non-invasive monitoring, and choice of appropriate therapeutic endpoints...
- Allergic eosinophilic esophagitis: a primer for pathologistsDonald A Antonioli
Department of Pathology, Beth Israel Deaconess Medical Center and Children s Hospital, Boston, Massachusetts 02215 5491, USA
Semin Diagn Pathol 22:266-72. 2005..In this review, we evaluate current information on the clinical, endoscopic, and pathologic features of this condition and summarize the most useful parameters that support its diagnosis...
- Eosinophils in the esophagus--peptic or allergic eosinophilic esophagitis? Case series of three patients with esophageal eosinophiliaPeter Ngo
Division of Pediatric Gastroenterology, Children s Hospital, Boston, Massachusetts 02115, USA
Am J Gastroenterol 101:1666-70. 2006..The aim of this case series is to demonstrate that features thought to be consistent with a diagnosis of allergic esophagitis are also observed in peptic esophagitis...
- Collagen gel contraction assayPeter Ngo
Fellow in Pediatric Gastroenterology, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Methods Mol Biol 341:103-9. 2006..This model allows for investigation of the influence of specific agonists on the rate and extent of matrix contraction...
- Eosinophilic esophagitis: an emerging clinicopathologic entityGlenn T Furuta
Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Curr Allergy Asthma Rep 2:67-72. 2002..The major importance of identifying eosinophilic esophagitis is that affected patients are receiving fundoplication for persistent symptoms when, in fact, corticosteroids or diet restriction is the treatment of choice...
- Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionateJonathan E Teitelbaum
Pediatric Gastroenterology and Nutrition, Department of Pathology, and Division of Allergy and Immunology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Gastroenterology 122:1216-25. 2002..CONCLUSIONS: EE is characterized by immunologically active esophageal mucosa. FP, not DR, effectively relieves symptoms. FP significantly reduces mucosal inflammation associated with EE...
- Eosinophilic esophagitis: it's not just kid's stuffVictor L Fox
Combined Program in Pediatric Gastroenterology and Nutrition, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Gastrointest Endosc 56:260-70. 2002
- More than food trafficks into the esophagusGlenn T Furuta
Gastroenterology 123:946-7. 2002
- Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epitheliaKristin Synnestvedt
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 110:993-1002. 2002..These results identify an HIF-1-dependent regulatory pathway for CD73 and indicate the likelihood that CD39/CD73 protects the epithelial barrier during hypoxia...
- Insights into milk protein allergy: microenvironment mattersQian Yuan
Gastroenterology 124:259-61; author reply 261. 2003
- High-resolution EUS in children with eosinophilic "allergic" esophagitisVictor L Fox
Division of Gastroenterology and Nutrition, Department of Pediatrics, Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Gastrointest Endosc 57:30-6. 2003....
- Acute myeloid leukemia presenting as non-neutropenic colitis in an infantHenrik Kohler
Divison of Gastroenterology and Nutrition, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Pediatr Gastroenterol Nutr 37:631-3. 2003
- Association of Schatzki ring with eosinophilic esophagitis in childrenSamuel Nurko
Division of Gastroenterology, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Massachusetts, 02115, USA
J Pediatr Gastroenterol Nutr 38:436-41. 2004..To describe the clinicopathologic characteristics of children with Schatzki ring and to determine if Schatzki ring is associated with eosinophilic esophagitis...
- Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitisJorn Karhausen
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Clin Invest 114:1098-106. 2004..Taken together, these studies provide insight into tissue microenvironmental changes during model inflammatory bowel disease and identify HIF-1 as a critical factor for barrier protection during mucosal insult...
- Association of eosinophilic inflammation with esophageal food impaction in adultsTusar K Desai
Department of Medicine, Beaumont Hospital, Royal Oak, Michigan, USA
Gastrointest Endosc 61:795-801. 2005..CONCLUSIONS: More than half of patients with esophageal food impaction in a primary gastroenterology practice have >20 eosinophils/HPF. Based on clinicopathologic features, a significant number likely have eosinophilic esophagitis...
- Eosinophils alter colonic epithelial barrier function: role for major basic proteinGlenn T Furuta
Combined Program in Pediatric Gastroenterology and Nutrition, Harvard Medical School, Boston, MA 02115, USA
Am J Physiol Gastrointest Liver Physiol 289:G890-7. 2005..In conclusion, MBP decreases epithelial barrier function and in this manner contributes to the pathogenesis of inflammatory bowel diseases...
- Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cellsSo Young Lee
Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
Mol Genet Metab 75:65-9. 2002..We conclude that HIF-1 can activate the lactase promoter in intestinal epithelial cells exposed to hypoxia. Induction of lactase transcription may represent an adaptive response to gut hypoxia...
- EOSINOPHIL PROTEINS AND GASTROINTESTINAL DISEASEGlenn Furuta; Fiscal Year: 2003..EDGP stimulated epithelial cell chloride ion secretion and 3. EDGP stimulated neutrophil infiltration, changes in vascular permeability and fluid secretion in vivo. ..
- Gastrointestinal Eosinophil Research SymposiumGlenn Furuta; Fiscal Year: 2006....
- Role of eosinophils in intestinal epithelial dysfunctionGlenn Furuta; Fiscal Year: 2009..Long-term goals of these studies are the identification of specific diagnostic tests for EOGs and the development of novel eosinophil specific treatments. ..