Glenn FurutaSummaryAffiliation: University of Colorado Country: USA Publications
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Publications
Eosinophilic esophagitis: update on clinicopathological manifestations and pathophysiologyGlenn T Furuta
Digestive Health Institute, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Gastrointestinal Eosinophilic Diseases Program, The Children s Hospital, National Jewish Health, Mucosal Inflammation Program, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
Curr Opin Gastroenterol 27:383-8. 2011..Over the course of the last year, a number of studies have brought new insights into the clinical presentation, pathogenesis, and treatment of eosinophilic esophagitis, some of which will be summarized here...- Eosinophilic esophagitisGlenn T Furuta
The Children s Hospital, Denver, National Jewish Health, University of Colorado, Denver, School of Medicine, Aurora, CO 80045, USA
Dig Dis 27:122-8. 2009..Effective treatments include topical and systemic corticosteroids and dietary restrictions... 
Eosinophilic gastrointestinal diseases (EGIDs)Glenn T Furuta
Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children's Hospital Denver, University of Colorado Denver, School of Medicine, 13123 E 16th Ave, B290, Aurora, CO 80045, USA
J Pediatr Gastroenterol Nutr 47:234-8. 2008- Eosinophils in the gastrointestinal tractEsi S N Lamousé-Smith
Children s Hospital Boston, 300 Longwood Avenue, Hunnewell Ground Floor, Boston, MA 02115, USA
Curr Gastroenterol Rep 8:390-5. 2006.... - Emerging questions regarding eosinophil's role in the esophago-gastrointestinal tractGlenn T Furuta
Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Curr Opin Gastroenterol 22:658-63. 2006..Whichever is the case, clinical needs to meet this new challenge include establishing diagnostic criteria, identifying the natural history and determining effective, tolerable treatments... - Integrated approach to treatment of children and adults with eosinophilic esophagitisSeema S Aceves
Division of Allergy, Immunology, Rady Children s Hospital, San Diego, Pediatrics University of California, 3020 Childrens Way, San Diego, CA 92123, USA
Gastrointest Endosc Clin N Am 18:195-217; xi. 2008..In this article, three authors from diverse backgrounds combine their resources to propose treatment paths with justification based on their clinical experience and interpretation of the literature... - Eructations from eosinophilsGlenn T Furuta
Gastroenterology 131:1629-31. 2006 - Upper gastrointestinal tract eosinophilic disorders: pathobiology and managementJessica J Lee
Harvard Medical School, Children's Hospital Boston, 300 Longwood Avenue, Hunnewell Ground Floor, Boston, MA 02115, USA
Curr Gastroenterol Rep 8:439-42. 2006..This review addresses recent studies that define clinical features, genetic predisposition, pathogenetic mechanisms, and treatment options for eosinophilic esophagitis... - Summary of the First International Gastrointestinal Eosinophil Research SymposiumChris A Liacouras
J Pediatr Gastroenterol Nutr 45:370-91. 2007 - Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatmentGlenn T Furuta
Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, Denver, University of Colorado Medical School, Denver, Colorado, USA
Gastroenterology 133:1342-63. 2007..Since EE is a relatively new disease, the intent of this report is to provide current recommendations for care of affected patients and defining gaps in knowledge for future research studies... 
Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibitionAndreas Robinson
Mucosal Inflammation Program, Division of Gastroenterology, University of Colorado Health Sciences Center, Denver, CO, USA
Gastroenterology 134:145-55. 2008..Here, we hypothesized that pharmacologic activation of HIF would similarly provide a protective adaptation to murine colitic disease...- 4. Gastrointestinal mucosal immunityBarry K Wershil
Albert Einstein College of Medicine, the Division of Pediatric Gastroenterology and Nutrition, The Children s Hospital at Montefiore, Bronx, NY, USA
J Allergy Clin Immunol 121:S380-3; quiz S415. 2008..The system has unique cellular components and functional aspects that permit it to carry out this dual role... - Idiopathic eosinophilic disorders of the gastrointestinal tract in childrenVincent A Mukkada
University of Colorado School of Medicine, Department of Pediatrics, The Children s Hospital, Denver, CO, USA
Best Pract Res Clin Gastroenterol 22:497-509. 2008..Many areas remain unanswered in the management of patients with EGIDs, including identification of optimal treatment protocol, development of appropriate non-invasive monitoring, and choice of appropriate therapeutic endpoints... - Allergic eosinophilic esophagitis: a primer for pathologistsDonald A Antonioli
Department of Pathology, Beth Israel Deaconess Medical Center and Children s Hospital, Boston, Massachusetts 02215 5491, USA
Semin Diagn Pathol 22:266-72. 2005..In this review, we evaluate current information on the clinical, endoscopic, and pathologic features of this condition and summarize the most useful parameters that support its diagnosis... - Eosinophils in the esophagus--peptic or allergic eosinophilic esophagitis? Case series of three patients with esophageal eosinophiliaPeter Ngo
Division of Pediatric Gastroenterology, Children s Hospital, Boston, Massachusetts 02115, USA
Am J Gastroenterol 101:1666-70. 2006..The aim of this case series is to demonstrate that features thought to be consistent with a diagnosis of allergic esophagitis are also observed in peptic esophagitis... - Collagen gel contraction assayPeter Ngo
Fellow in Pediatric Gastroenterology, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Methods Mol Biol 341:103-9. 2006..This model allows for investigation of the influence of specific agonists on the rate and extent of matrix contraction... - Eosinophilic esophagitis: an emerging clinicopathologic entityGlenn T Furuta
Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Curr Allergy Asthma Rep 2:67-72. 2002..The major importance of identifying eosinophilic esophagitis is that affected patients are receiving fundoplication for persistent symptoms when, in fact, corticosteroids or diet restriction is the treatment of choice... - Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionateJonathan E Teitelbaum
Pediatric Gastroenterology and Nutrition, Department of Pathology, and Division of Allergy and Immunology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Gastroenterology 122:1216-25. 2002..CONCLUSIONS: EE is characterized by immunologically active esophageal mucosa. FP, not DR, effectively relieves symptoms. FP significantly reduces mucosal inflammation associated with EE... - Eosinophilic esophagitis: it's not just kid's stuffVictor L Fox
Combined Program in Pediatric Gastroenterology and Nutrition, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Gastrointest Endosc 56:260-70. 2002 - More than food trafficks into the esophagusGlenn T Furuta
Gastroenterology 123:946-7. 2002 - Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epitheliaKristin Synnestvedt
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 110:993-1002. 2002..These results identify an HIF-1-dependent regulatory pathway for CD73 and indicate the likelihood that CD39/CD73 protects the epithelial barrier during hypoxia... - Insights into milk protein allergy: microenvironment mattersQian Yuan
Gastroenterology 124:259-61; author reply 261. 2003 - High-resolution EUS in children with eosinophilic "allergic" esophagitisVictor L Fox
Division of Gastroenterology and Nutrition, Department of Pediatrics, Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Gastrointest Endosc 57:30-6. 2003.... - Acute myeloid leukemia presenting as non-neutropenic colitis in an infantHenrik Kohler
Divison of Gastroenterology and Nutrition, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Pediatr Gastroenterol Nutr 37:631-3. 2003 - Association of Schatzki ring with eosinophilic esophagitis in childrenSamuel Nurko
Division of Gastroenterology, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Massachusetts, 02115, USA
J Pediatr Gastroenterol Nutr 38:436-41. 2004..To describe the clinicopathologic characteristics of children with Schatzki ring and to determine if Schatzki ring is associated with eosinophilic esophagitis... - Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitisJorn Karhausen
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Clin Invest 114:1098-106. 2004..Taken together, these studies provide insight into tissue microenvironmental changes during model inflammatory bowel disease and identify HIF-1 as a critical factor for barrier protection during mucosal insult... - Association of eosinophilic inflammation with esophageal food impaction in adultsTusar K Desai
Department of Medicine, Beaumont Hospital, Royal Oak, Michigan, USA
Gastrointest Endosc 61:795-801. 2005..CONCLUSIONS: More than half of patients with esophageal food impaction in a primary gastroenterology practice have >20 eosinophils/HPF. Based on clinicopathologic features, a significant number likely have eosinophilic esophagitis... - Eosinophils alter colonic epithelial barrier function: role for major basic proteinGlenn T Furuta
Combined Program in Pediatric Gastroenterology and Nutrition, Harvard Medical School, Boston, MA 02115, USA
Am J Physiol Gastrointest Liver Physiol 289:G890-7. 2005..In conclusion, MBP decreases epithelial barrier function and in this manner contributes to the pathogenesis of inflammatory bowel diseases... - Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cellsSo Young Lee
Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
Mol Genet Metab 75:65-9. 2002..We conclude that HIF-1 can activate the lactase promoter in intestinal epithelial cells exposed to hypoxia. Induction of lactase transcription may represent an adaptive response to gut hypoxia...
Research Grants
- EOSINOPHIL PROTEINS AND GASTROINTESTINAL DISEASEGlenn Furuta; Fiscal Year: 2003..EDGP stimulated epithelial cell chloride ion secretion and 3. EDGP stimulated neutrophil infiltration, changes in vascular permeability and fluid secretion in vivo. ..
- Gastrointestinal Eosinophil Research SymposiumGlenn Furuta; Fiscal Year: 2006....
- Role of eosinophils in intestinal epithelial dysfunctionGlenn Furuta; Fiscal Year: 2009..Long-term goals of these studies are the identification of specific diagnostic tests for EOGs and the development of novel eosinophil specific treatments. ..