Research Topics
| M I FurmanSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
| Collaborators
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Detail Information
Publications
Antithrombotic therapy in the cardiac catheterization laboratory: focus on antiplatelet agentsM I Furman
Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Curr Cardiol Rep 2:386-94. 2000..Despite the growing use of GP IIb/IIIa antagonists, much information remains unknown as to the proper dosing and the effects these agents have on other elements of the hemostatic and vascular systems...- Leukocyte-platelet aggregation, platelet surface P-selectin, and platelet surface glycoprotein IIIa after percutaneous coronary intervention: Effects of dalteparin or unfractionated heparin in combination with abciximabM I Furman
Center for Platelet Function Studies and the Division of Cardiovascular Medicine, Departments of Medicine, Pediatrics, and Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Am Heart J 142:790-8. 2001..Low-molecular-weight heparins have been reported to cause less platelet activation than unfractionated heparin... - GPIIb-IIIa antagonist-induced reduction in platelet surface factor V/Va binding and phosphatidylserine expression in whole bloodM I Furman
Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, PA 01655, USA
Thromb Haemost 84:492-8. 2000..Fibrinogen binding to GPIIb-IIIa is important in the generation of platelet procoagulant activity... - Indices of platelet activation and the stability of coronary artery diseaseM D Linden
Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Thromb Haemost 5:761-5. 2007..To determine whether indices of platelet activation are associated with the stability of coronary artery disease (CAD)... - The active metabolite of prasugrel inhibits adenosine diphosphate- and collagen-stimulated platelet procoagulant activitiesA L Frelinger
Center for Platelet Function Studies, and Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Thromb Haemost 6:359-65. 2008..We therefore examined whether R-138727 inhibits ADP- and collagen-triggered platelet procoagulant activities... - Evaluation of platelet function by flow cytometryA D Michelson
Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, Massachusetts, 01655, USA
Methods 21:259-70. 2000.... - GPIIb-IIIa antagonists reduce thromboinflammatory processes in patients with acute coronary syndromes undergoing percutaneous coronary interventionM I Furman
Cardiac Catheterization Laboratories, UMass Memorial Medical Center, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Thromb Haemost 3:312-20. 2005.... - Evidence that pre-existent variability in platelet response to ADP accounts for 'clopidogrel resistance'A D Michelson
Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Thromb Haemost 5:75-81. 2007..Clopidogrel is a widely used antithrombotic agent that inhibits the platelet P2Y(12) adenosine diphosphate (ADP) receptor. There is increasing interest in 'clopidogrel resistance'... - Circulating monocyte-platelet aggregates are an early marker of acute myocardial infarctionM I Furman
Center for Platelet Function Studies, Division of Cardiovascular Medicine, Worcester, Massachusetts 01655, USA
J Am Coll Cardiol 38:1002-6. 2001..We investigated whether elevated levels of circulating monocyte-platelet aggregates (MPA) can be used to identify patients with acute myocardial infarction (AMI)... - Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarctionA D Michelson
Center for Platelet Function Studies, Departments of Pediatrics and Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Circulation 104:1533-7. 2001..Platelet surface P-selectin is considered the "gold standard" marker of platelet activation. Degranulated, P-selectin-positive platelets, however, aggregate with leukocytes in vitro and rapidly lose surface P-selectin in vivo... - Dissociation of glycoprotein IIb/IIIa antagonists from platelets does not result in fibrinogen binding or platelet aggregationA L Frelinger
Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, MA 01655, USA
Circulation 104:1374-9. 2001..These apparently paradoxical results have been extensively referenced in the cardiology literature... - Laser scanning cytometry: a novel method for the detection of platelet--endothelial cell adhesionR B Claytor
Department of Surgery, Division of Vascular Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Cytometry 43:308-13. 2001..We report a novel method for in vitro detection of platelet-endothelial cell adhesion that allows endothelial cells to remain as an intact monolayer and for visualization of individual platelets... - Effects of platelet binding on whole blood flow cytometry assays of monocyte and neutrophil procoagulant activityM R Barnard
Center for Platelet Function Studies, University of Massachusettes Medical School, Worcester, MA 01655, USA
J Thromb Haemost 3:2563-70. 2005.... - Laboratory markers of platelet activation and their clinical significanceA D Michelson
Center for Platelet Function Studies, Department of Pediatrics, University of Massachusetts Medical School, Worcester 01655, USA
Curr Opin Hematol 6:342-8. 1999.... 
The cleaved peptide of the thrombin receptor is a strong platelet agonistM I Furman
Center for Platelet Function Studies, University of Massachusetts Medical Center, Worcester, MA 01655, USA
Proc Natl Acad Sci U S A 95:3082-7. 1998..TR1-41-induced platelet activation was synergistic with TR42-55. In summary, the cleaved peptide of the seven-transmembrane domain TR (TR1-41) is a strong platelet agonist...- Twenty-two year (1975 to 1997) trends in the incidence, in-hospital and long-term case fatality rates from initial Q-wave and non-Q-wave myocardial infarction: a multi-hospital, community-wide perspectiveM I Furman
Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
J Am Coll Cardiol 37:1571-80. 2001.... - Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)D I Simon
Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Exp Med 192:193-204. 2000..These observations provide a molecular target for disrupting leukocyte-platelet complexes that promote vascular inflammation in thrombosis, atherosclerosis, and angioplasty-related restenosis... - The control of actin nucleotide exchange by thymosin beta 4 and profilin. A potential regulatory mechanism for actin polymerization in cellsP J Goldschmidt-Clermont
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Mol Biol Cell 3:1015-24. 1992..Because ATP-actin subunits polymerize more readily than ADP-actin subunits, this ratio may play a key regulatory role in the assembly of cellular actin structures, particularly under circumstances of rapid filament turnover...