Clement E Furlong

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Pharmacogenomic considerations of the paraoxonase polymorphisms
    Clement E Furlong
    Department of genome Services, University of Washington, Seattle, WA 98195, USA
    Pharmacogenomics 3:341-8. 2002
  2. ncbi request reprint Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism
    Toby B Cole
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195 7720, USA
    Pharmacogenet Genomics 15:589-98. 2005
  3. ncbi request reprint Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1)
    C E Furlong
    Department of Genetics, University of Washington, Seattle 98195 7360, USA
    Neurotoxicology 21:91-100. 2000
  4. ncbi request reprint Paraoxonase 1 (PON1) status and risk of insecticide exposure
    Clement E Furlong
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195 7720, USA
    J Biochem Mol Toxicol 19:182-3. 2005
  5. ncbi request reprint PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity
    Clement E Furlong
    Department of Genome Sciences, Division of Medical Genetics, University of Washington, Seattle, Washington 98195 7720, USA
    Pharmacogenet Genomics 16:183-90. 2006
  6. ncbi request reprint Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds
    Clement E Furlong
    Department of Medicine, Division of Medical Genetics, and Genome Sciences, University of Washington, Seattle, WA 98195, USA
    J Biochem Mol Toxicol 21:197-205. 2007
  7. ncbi request reprint Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants
    Clement E Furlong
    Genome Sciences and Medicine, Division of Medical Genetics, University of Washington, Box 357720, Seattle, WA 98195 7720, USA
    Neurotoxicology 26:651-9. 2005
  8. pmc Human PON1, a biomarker of risk of disease and exposure
    C E Furlong
    University of Washington, Department of Medicine Div of Medical Genetics, Seattle, WA, United States
    Chem Biol Interact 187:355-61. 2010
  9. ncbi request reprint The PON1 gene and detoxication
    C E Furlong
    Department of Genetics, University of Washington, Seattle, USA
    Neurotoxicology 21:581-7. 2000
  10. pmc Paraoxonase 1 status as a risk factor for disease or exposure
    Rebecca J Richter
    Departments of Medicine Division of Medical Genetics and Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Adv Exp Med Biol 660:29-35. 2010

Research Grants

  1. Structure & Function of the Human PON1 Polymorphism
    Clement Furlong; Fiscal Year: 2007
  2. STRUCTURE/FUNCTION OF THE HUMAN PON1 POLYMORPHISM
    Clement Furlong; Fiscal Year: 2001
  3. Structure and Function of the Human PON1 Polymorphism
    Clement E Furlong; Fiscal Year: 2010

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Pharmacogenomic considerations of the paraoxonase polymorphisms
    Clement E Furlong
    Department of genome Services, University of Washington, Seattle, WA 98195, USA
    Pharmacogenomics 3:341-8. 2002
    ....
  2. ncbi request reprint Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism
    Toby B Cole
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195 7720, USA
    Pharmacogenet Genomics 15:589-98. 2005
    ..The current study examined the relevance of these observations for in-vivo exposures to chlorpyrifos and chlorpyrifos oxon...
  3. ncbi request reprint Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1)
    C E Furlong
    Department of Genetics, University of Washington, Seattle 98195 7360, USA
    Neurotoxicology 21:91-100. 2000
    ..A number of recent reports have also indicated that the PON1R192 isoform may be a risk factor for cardiovascular disease. Studies with PON1 knockout mice are also consistent with a role of PON1 in preventing vascular disease...
  4. ncbi request reprint Paraoxonase 1 (PON1) status and risk of insecticide exposure
    Clement E Furlong
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195 7720, USA
    J Biochem Mol Toxicol 19:182-3. 2005
  5. ncbi request reprint PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity
    Clement E Furlong
    Department of Genome Sciences, Division of Medical Genetics, University of Washington, Seattle, Washington 98195 7720, USA
    Pharmacogenet Genomics 16:183-90. 2006
    ..Of particular concern are exposures of pregnant mothers and newborns with low PON1 status...
  6. ncbi request reprint Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds
    Clement E Furlong
    Department of Medicine, Division of Medical Genetics, and Genome Sciences, University of Washington, Seattle, WA 98195, USA
    J Biochem Mol Toxicol 21:197-205. 2007
    ..The availability of PON1 null mice provides an opportunity to examine the contribution of other enzymes in the OP detoxication pathways without PON1 interference...
  7. ncbi request reprint Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants
    Clement E Furlong
    Genome Sciences and Medicine, Division of Medical Genetics, University of Washington, Box 357720, Seattle, WA 98195 7720, USA
    Neurotoxicology 26:651-9. 2005
    ..Our studies indicate that children less than 2 years old, especially those homozygous for PON1Q192, would be predicted to be particularly susceptible to CPO toxicity...
  8. pmc Human PON1, a biomarker of risk of disease and exposure
    C E Furlong
    University of Washington, Department of Medicine Div of Medical Genetics, Seattle, WA, United States
    Chem Biol Interact 187:355-61. 2010
    ..Immunolocalization studies of PONs 1, 2 and 3 in nearly all mouse tissues suggest that the functions of PONs 1 and 3 extend beyond the plasma and the HDL particle...
  9. ncbi request reprint The PON1 gene and detoxication
    C E Furlong
    Department of Genetics, University of Washington, Seattle, USA
    Neurotoxicology 21:581-7. 2000
    ....
  10. pmc Paraoxonase 1 status as a risk factor for disease or exposure
    Rebecca J Richter
    Departments of Medicine Division of Medical Genetics and Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Adv Exp Med Biol 660:29-35. 2010
    ..We have developed a new two-substrate assay/analysis protocol that provides PON1 status without use of toxic OP substrates. Factors were determined for inter-converting rates of hydrolysis of different substrates...
  11. pmc Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds
    Karen L Jansen
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
    Toxicol Appl Pharmacol 236:142-53. 2009
    ..Potentiation by PO was equivalent among all four genotypes. These results indicate that PON1 status can have a major influence on CaE-mediated detoxication of OP compounds...
  12. pmc The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status
    Toby B Cole
    Department of Medicine and Genome Sciences, University of Washington, Seattle, WA, USA
    Adv Exp Med Biol 660:47-60. 2010
    ..PON1 status can also impact the capacity to metabolize drugs or other CaE substrates following insecticide exposure...
  13. pmc Engineering human PON1 in an E. coli expression system
    Stephanie M Suzuki
    Departments of Medicine Div of Medical Genetics and Genome Sciences, University of Washington, Seattle, Washington, USA
    Adv Exp Med Biol 660:37-45. 2010
    ..The ease of mutagenesis in bacterial systems will also allow for the generation and screening of rHuPON1 variants with enhanced catalytic efficiencies against nerve agents and other OP compounds...
  14. pmc Paraoxonase 1 (PON1) status and substrate hydrolysis
    Rebecca J Richter
    Department of Medicine Division of Medical Genetics, Box 357720, University of Washington, Seattle, WA 98195 7720, USA
    Toxicol Appl Pharmacol 235:1-9. 2009
    ..Conversion factors were generated for rates of hydrolysis of different substrates...
  15. pmc Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State
    Jonathan N Hofmann
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Occup Environ Med 67:375-86. 2010
    ..To identify potential risk factors for serum cholinesterase (BuChE) inhibition among agricultural pesticide handlers exposed to organophosphate (OP) and N-methyl-carbamate (CB) insecticides...
  16. pmc Novel gene-by-environment interactions: APOB and NPC1L1 variants affect the relationship between dietary and total plasma cholesterol
    Daniel S Kim
    Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA
    J Lipid Res 54:1512-20. 2013
    ..These GxE interactions may account for part of the "missing heritability" not accounted for by genetic associations...
  17. pmc Protein adducts as biomarkers of exposure to organophosphorus compounds
    Judit Marsillach
    Departments of Medicine Division of Medical Genetics and Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Toxicology 307:46-54. 2013
    ..MS analysis of biomarker proteins also provides information about the OP that has caused inhibition. Other useful biomarker proteins include other serine hydrolases, albumin, tubulin and transferrin...
  18. doi request reprint Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures
    Judit Marsillach
    Dept of Medicine Division of Medical Genetics, University of Washington, 98195 Seattle, WA, USA
    Chem Biol Interact 203:85-90. 2013
    ..These analyses also provide some information about the nature of the OP adduct. Our aim is to develop high-throughput protocols for monitoring OP exposures using mass spectrometry...
  19. pmc Dietary cholesterol increases paraoxonase 1 enzyme activity
    Daniel S Kim
    Department of Medicine and University of Washington School of Medicine, Seattle, WA, USA
    J Lipid Res 53:2450-8. 2012
    ..Identifying and understanding environmental factors that affect PON1 activity is necessary to understand its role and that of HDL in human disease...
  20. pmc Biomarkers of organophosphorus (OP) exposures in humans
    Judit Marsillach
    Department of Medicine, Division Medical Genetics, University of Washington, Seattle, WA 98195 7720, United States
    Neurotoxicology 32:656-60. 2011
    ..We have developed immunomagnetic bead-based single-step purification protocols for both BChE and APH and have characterized the active site serine adducts of BChE by MS...
  21. pmc Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression
    Toby B Cole
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
    Toxicol Sci 123:155-69. 2011
    ..These findings indicate that PON1 status plays a critical role in modulating the effects of neonatal CPO exposure in the developing brain...
  22. ncbi request reprint TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease
    Christopher S Carlson
    The Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, The University of Washington, Seattle, USA
    J Lipid Res 47:1014-24. 2006
    ....
  23. ncbi request reprint Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease
    Gail P Jarvik
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Wash, USA
    Arterioscler Thromb Vasc Biol 23:1465-71. 2003
    ..The effects of paraoxonase (PON1) activity and of genetic variation in the PON1 promoter and coding region on carotid artery disease (CAAD) were investigated...
  24. ncbi request reprint Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism
    Lucio G Costa
    Department of Environmental Health, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Med 54:371-92. 2003
    ..A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies...
  25. pmc Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL
    Daniel S Kim
    Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
    J Lipid Res 54:552-60. 2013
    ..We present novel findings that common and rare variants in FTO, SERPINA12, and ITGAL predict PON1 activity. These results further link PON1 to diabetes and inflammation and may inform the role of HDL in human disease...
  26. ncbi request reprint Expression of human paraoxonase (PON1) during development
    Toby B Cole
    Departments of Environmental Health, University of Washington, Seattle 98195 7720, USA
    Pharmacogenetics 13:357-64. 2003
    ..Since PON1 levels are important in determining resistance to specific organophosphorus compounds, the time course of appearance of PON1 in newborns is of great interest...
  27. pmc Identifying safer anti-wear triaryl phosphate additives for jet engine lubricants
    Paul E Baker
    Department of Medicine Division of Medical Genetics, University of Washington, Seattle, WA 98195, United States
    Chem Biol Interact 203:257-64. 2013
    ..The in vitro assay should provide a valuable tool for prescreening candidate TAP anti-wear additives, identifying safer additives and reducing the number of animals required for in vivo toxicity testing...
  28. pmc Identification and characterization of biomarkers of organophosphorus exposures in humans
    Jerry H Kim
    Department of Anesthesiology, University of Washington, Seattle, WA, USA
    Adv Exp Med Biol 660:61-71. 2010
    ..This research uses functional proteomics and enzyme activities to identify and characterize useful biomarkers of neurotoxic environmental and occupational OP exposures...
  29. ncbi request reprint Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates
    Lucio G Costa
    Department of Environmental Health, University of Washington, Seattle, Washington 98105 6099, USA
    J Toxicol Clin Toxicol 41:37-45. 2003
    ....
  30. pmc Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on
    Lucio G Costa
    Dept of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98105, USA
    Biochem Pharmacol 81:337-44. 2011
    ....
  31. ncbi request reprint Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity
    Lucio G Costa
    Department of Environmental Health, University of Washington, Seattle, Washington 98105 6099, USA
    Biomarkers 8:1-12. 2003
    ..Low PON1 activity may also contribute to the higher sensitivity of newborns to OP toxicity...
  32. pmc Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin: a mechanism of neuroprotection?
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA
    Neurochem Res 38:1809-18. 2013
    ..These findings suggest that induction of PON2 by quercetin represents an important mechanism by which this polyphenol may exert its neuroprotective action. ..
  33. ncbi request reprint Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100 Seattle, WA 98105, USA
    Clin Chim Acta 352:37-47. 2005
    ..Documentation of exposure and of early health effects would be most relevant to increase the predictive value of the test...
  34. pmc Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease
    Daniel Seung Kim
    Departments of Genome Sciences and Medicine Division of Medical Genetics, University of Washington School of Medicine, Box 357720, University of Washington, Seattle, WA 98195 7720, USA
    Pharmacogenomics 14:1495-515. 2013
    ....
  35. pmc Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity
    Lucio G Costa
    Dept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Toxicology 307:115-22. 2013
    ..Evidence is slowly emerging that a low PON1 status may increase susceptibility to OP toxicity in humans. Low PON1 activity may also contribute to the developmental toxicity and neurotoxicity of OPs, as shown by animal and human studies...
  36. ncbi request reprint Modulation of paraoxonase (PON1) activity
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA
    Biochem Pharmacol 69:541-50. 2005
    ....
  37. pmc Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning
    Richard C Stevens
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195 7720, USA
    Proc Natl Acad Sci U S A 105:12780-4. 2008
    ..The injected rHuPON1 is nontoxic, persists in serum for at least 2 days after injection, and provides protection against DZO exposures of at least three times the median lethal dose value...
  38. doi request reprint Semi-automated, occupationally safe immunofluorescence microtip sensor for rapid detection of mycobacterium cells in sputum
    Shinnosuke Inoue
    Department of Mechanical Engineering, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 9:e86018. 2014
    ..The device and biosafe sputum liquefaction method opens the door to rapid detection of tuberculosis in settings with limited laboratory infrastructure. ..
  39. pmc Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon
    Toby B Cole
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Neurotoxicol Teratol 34:311-22. 2012
    ....
  40. pmc Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role?
    Gennaro Giordano
    Dept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Toxicol Appl Pharmacol 256:369-78. 2011
    ....
  41. pmc Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers
    Jonathan N Hofmann
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Environ Health Perspect 117:1402-8. 2009
    ..However, few human studies have investigated associations between PON1 status and intermediate end points, such as serum cholinesterase [butyrylcholinesterase (BuChE)] inhibition, among OP-exposed individuals...
  42. ncbi request reprint Novel paraoxonase (PON1) nonsense and missense mutations predicted by functional genomic assay of PON1 status
    Gail P Jarvik
    Department of Medicine, Division of Medical Genetics, The University of Washington, Seattle, Washington 98195 7720, USA
    Pharmacogenetics 13:291-5. 2003
    ....
  43. pmc Dietary fatty acid intake is associated with paraoxonase 1 activity in a cohort-based analysis of 1,548 subjects
    Daniel Seung Kim
    Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Box 357720, Seattle, WA 98195 7720, USA
    Lipids Health Dis 12:183. 2013
    ..Our previous work found associations between dietary cholesterol and vitamin C with PON1 activity. The goal of this study was to determine the effect of specific dietary fatty acid (DFA) intake on PON1 activity...
  44. ncbi request reprint Vitamin C and E intake is associated with increased paraoxonase activity
    Gail P Jarvik
    Department of Medicine, Division of Medical Genetics, University of Washington 98195, USA
    Arterioscler Thromb Vasc Biol 22:1329-33. 2002
    ..Vitamins C and E, dietary antioxidants, scavenge free-oxygen radical products that may depress PON1 activity. Therefore, we evaluated the relationship between dietary vitamin C and E intake and PON1 activity...
  45. ncbi request reprint Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease
    C P Zabetian
    Department of Neurology, University of Washington School of Medicine, Seattle, USA
    Neurology 67:697-9. 2006
    ..This suggests that G2019S originated from separate founders in Europe and Japan and is more widely dispersed than previously recognized...
  46. ncbi request reprint A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations
    C P Zabetian
    Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA
    Neurology 65:741-4. 2005
    ..6%) subjects, including two heterozygous for new putative pathogenic variants (R1441H, IVS31 + 3A-->G). These data confirm the important contribution of LRRK2 to PD susceptibility in a clinic-based population...
  47. ncbi request reprint Inflammatory response after influenza vaccination in men with and without carotid artery disease
    Cara L Carty
    University of Washington, Department of Epidemiology, Seattle, Wash, USA
    Arterioscler Thromb Vasc Biol 26:2738-44. 2006
    ..We evaluated whether the APR magnitude in men with severe carotid artery disease (CAAD) (>80% stenosis) differed from that of men without stenosis (<15% stenosis)...
  48. doi request reprint Immunosensor towards low-cost, rapid diagnosis of tuberculosis
    Jong Hoon Kim
    Department of Mechanical Engineering, University of Washington, Box 352600, Seattle, Washington 98195, USA
    Lab Chip 12:1437-40. 2012
    ..Immunofluorescence is then used to detect the captured cells on the microtip. The detection limit in sputum is 200 CFU mL(-1) with a success rate of 96%, which is comparable to PCR...
  49. pmc Additional Common Polymorphisms in the PON Gene Cluster Predict PON1 Activity but Not Vascular Disease
    Daniel S Kim
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Lipids 2012:476316. 2012
    ..This study identifies new genetic variants that predict additional PON1 AREase activity. Identification of SNPs associated with PON1 activity is required when evaluating the many phenotypes associated with genetic variation near PON1...
  50. pmc Surface plasmon resonance detection using antibody-linked magnetic nanoparticles for analyte capture, purification, concentration, and signal amplification
    Scott D Soelberg
    Department of Medicine Division of Medical Genetics and Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Anal Chem 81:2357-63. 2009
    ..Multiple detections of SEB in stool were performed using the same sensor surface by regenerating the sensor surfaces with a pH 2.2 buffer wash...
  51. ncbi request reprint Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease
    S Zaja-Milatovic
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Neurology 64:545-7. 2005
    ..In contrast, MSN dendrite spine degeneration was unevenly distributed with the greatest loss in caudal putamen. The authors propose that these structural changes in MSN may contribute to late-stage motor complications of PD...
  52. ncbi request reprint The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status
    Laura S Rozek
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    J Lipid Res 46:1888-95. 2005
    ..We found that PON1 activity was correlated with HDL traits in controls and with LDL- and VLDL-related traits in cases. We hypothesize differences in the joint regulation of PON1 and lipoproteins in cases and controls...
  53. ncbi request reprint Discussion and conclusions
    Michael C R Alavanja
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    J Biochem Mol Toxicol 19:192-3. 2005
  54. ncbi request reprint Paraoxonase (PON1): from toxicology to cardiovascular medicine
    Lucio G Costa
    Dept of Human Anatomy, Pharmacology and Forensic Science, University of Parma Medical School, Parma, Italy
    Acta Biomed 76:50-7. 2005
    ....
  55. pmc Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population
    Brenda Eskenazi
    Center for Children s Environmental Health Research, School of Public Health, University of California Berkeley, 94720 7380, USA
    Environ Health Perspect 112:1116-24. 2004
    ..However, despite these observed associations, the rate of preterm delivery in this population (6.4%) was lower than in a U.S. reference population...
  56. ncbi request reprint Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates
    Jessica G Young
    Center for Children s Environmental Health Research, School of Public Health, UC Berkeley, 2150 Shattuck Ave, Suite 600, Berkeley, CA 94720 7380, USA
    Neurotoxicology 26:199-209. 2005
    ..Whether neonatal reflex functioning is predictive of neuropsychological functioning as the child matures will continue to be evaluated in this birth cohort...

Research Grants10

  1. Structure & Function of the Human PON1 Polymorphism
    Clement Furlong; Fiscal Year: 2007
    ..Specific aim 5 involves development of a human pharmacokinetic/pharmacodynamic (PDPK/PD) model of organophosphate exposure using humanized transgenic PON1 knockout mice expressing varying levels of each human PON1-192 isoform. ..
  2. STRUCTURE/FUNCTION OF THE HUMAN PON1 POLYMORPHISM
    Clement Furlong; Fiscal Year: 2001
    ..Sequence cassettes from individuals expressing very high enzyme levels will be compared with those from individuals expressing very low enzyme levels for their ability to regulate the expression of the reporter gene. ..
  3. Structure and Function of the Human PON1 Polymorphism
    Clement E Furlong; Fiscal Year: 2010
    ..Engineering recombinant human PON1 will provide therapeutics for treating nerve agent and insecticide exposures. ..