Janet L Funk

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Curcuminoids limit neutrophil-mediated reperfusion injury in experimental stroke by targeting the endothelium
    Janet L Funk
    Department of Medicine, University of Arizona, Tucson, Arizona, USA
    Microcirculation 20:544-54. 2013
  2. pmc Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer
    Laura E Wright
    1656 E Mabel St, PO Box 24 5218, Tucson, AZ 85724, USA
    Curr Pharm Des 19:6218-25. 2013
  3. pmc Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.)
    Janet L Funk
    Department of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    J Agric Food Chem 58:842-9. 2010
  4. pmc Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis
    Janet L Funk
    Department of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    J Nat Prod 72:403-7. 2009
  5. ncbi request reprint Bone protective effect of simvastatin in experimental arthritis
    Janet L Funk
    Department of Medicine, University of Arizona, AHSC, Box 24 5218, Tucson, AZ 85724, USA
    J Rheumatol 35:1083-91. 2008
  6. ncbi request reprint Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis
    Janet L Funk
    University of Arizona, Tucson, USA
    Arthritis Rheum 54:3452-64. 2006
  7. pmc Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis
    Janet L Funk
    Arizona Center for Phytomedicine Research, Department of Medicine, Department of Cell Biology and Anatomy, University of Arizona, Tucson, 85724, USA
    J Nat Prod 69:351-5. 2006
  8. ncbi request reprint Blockade of parathyroid hormone-related protein prevents joint destruction and granuloma formation in streptococcal cell wall-induced arthritis
    J L Funk
    University of Arizona Health Science Center, University of Arizona, Tucson, Arizona 85724, USA
    Arthritis Rheum 48:1721-31. 2003
  9. ncbi request reprint Parathyroid hormone-related protein induction in focal stroke: a neuroprotective vascular peptide
    Janet L Funk
    Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1021-30. 2003
  10. pmc Expression of parathyroid hormone-related protein and the parathyroid hormone/parathyroid hormone-related protein receptor in rat thymic epithelial cells
    J L Funk
    University of Arizona, Tucson, USA
    J Anat 194:255-64. 1999

Collaborators

Detail Information

Publications24

  1. pmc Curcuminoids limit neutrophil-mediated reperfusion injury in experimental stroke by targeting the endothelium
    Janet L Funk
    Department of Medicine, University of Arizona, Tucson, Arizona, USA
    Microcirculation 20:544-54. 2013
    ..We sought to test the hypothesis that turmeric-derived curcuminoids limit reperfusion brain injury in an experimental model of stroke via blockade of early microvascular inflammation during reperfusion...
  2. pmc Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer
    Laura E Wright
    1656 E Mabel St, PO Box 24 5218, Tucson, AZ 85724, USA
    Curr Pharm Des 19:6218-25. 2013
    ....
  3. pmc Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.)
    Janet L Funk
    Department of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    J Agric Food Chem 58:842-9. 2010
    ..These results do not support the isolated use of TEO for arthritis treatment but, instead, identify potential safety concerns in vertebrates exposed to TEO...
  4. pmc Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis
    Janet L Funk
    Department of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    J Nat Prod 72:403-7. 2009
    ..In conclusion, these data document a very significant joint-protective effect of these ginger samples and suggest that nongingerol components are bioactive and can enhance the antiarthritic effects of the more widely studied gingerols...
  5. ncbi request reprint Bone protective effect of simvastatin in experimental arthritis
    Janet L Funk
    Department of Medicine, University of Arizona, AHSC, Box 24 5218, Tucson, AZ 85724, USA
    J Rheumatol 35:1083-91. 2008
    ..We investigated whether simvastatin, a potent HMG-CoA reductase inhibitor, alters bone turnover in an animal model of RA, thus preventing periarticular bone loss...
  6. ncbi request reprint Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis
    Janet L Funk
    University of Arizona, Tucson, USA
    Arthritis Rheum 54:3452-64. 2006
    ..Therefore, we undertook studies to determine the antiarthritic efficacy and mechanism of action of a well-characterized turmeric extract using an animal model of rheumatoid arthritis (RA)...
  7. pmc Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis
    Janet L Funk
    Arizona Center for Phytomedicine Research, Department of Medicine, Department of Cell Biology and Anatomy, University of Arizona, Tucson, 85724, USA
    J Nat Prod 69:351-5. 2006
    ....
  8. ncbi request reprint Blockade of parathyroid hormone-related protein prevents joint destruction and granuloma formation in streptococcal cell wall-induced arthritis
    J L Funk
    University of Arizona Health Science Center, University of Arizona, Tucson, Arizona 85724, USA
    Arthritis Rheum 48:1721-31. 2003
    ....
  9. ncbi request reprint Parathyroid hormone-related protein induction in focal stroke: a neuroprotective vascular peptide
    Janet L Funk
    Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1021-30. 2003
    ..In summary, PTHrP expression increases at sites of ischemic brain injury in the cerebrovasculature. This local increase in PTHrP could be an adaptive response that enhances blood flow to the ischemic brain, thus limiting cell injury...
  10. pmc Expression of parathyroid hormone-related protein and the parathyroid hormone/parathyroid hormone-related protein receptor in rat thymic epithelial cells
    J L Funk
    University of Arizona, Tucson, USA
    J Anat 194:255-64. 1999
    ....
  11. ncbi request reprint A role for parathyroid hormone-related protein in the pathogenesis of inflammatory/autoimmune diseases
    J L Funk
    Department of Medicine, University of Arizona, Tucson, AZ, USA
    Int Immunopharmacol 1:1101-21. 2001
    ..TNF-alpha-blockade in the treatment of endotoxemia will be reviewed, and potential future areas of research, including assessment of the effects of PTHrP blockade in the treatment of RA, will be discussed...
  12. pmc Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis
    J L Funk
    Department of Medicine, Arizona Arthritis Center, The University of Arizona, Tucson, Arizona 85724, USA
    J Clin Invest 101:1362-71. 1998
    ....
  13. ncbi request reprint Parathyroid hormone-related protein (PTHrP) induction in reactive astrocytes following brain injury: a possible mediator of CNS inflammation
    J L Funk
    Department of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Brain Res 915:195-209. 2001
    ..These studies suggest that PTHrP, analogous to its regulatory functions in other non-CNS models of inflammation, may be an important mediator of the inflammatory response in brain...
  14. ncbi request reprint Expression of PTHrP and its cognate receptor in the rheumatoid synovial microcirculation
    J L Funk
    Department of Medicine, Arizona Health Sciences Center, University of Arizona, Tucson, AZ 85724, USA
    Biochem Biophys Res Commun 297:890-7. 2002
    ....
  15. pmc Curcuminoids block TGF-β signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis
    Laura E Wright
    Endocrinology Section, Department of Medicine, The University of Arizona, Tucson, Arizona 85724, USA
    J Nat Prod 76:316-21. 2013
    ..These data suggest that curcuminoids prevent TGF-β induction of PTHrP and reduce osteolytic bone destruction by blockade of Smad signaling in breast cancer cells...
  16. pmc Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) is dependent on extract composition
    Laura E Wright
    Department of Medicine, The University of Arizona, P O Box 245218, Tucson, Arizona 85724, USA
    J Agric Food Chem 58:9498-504. 2010
    ..These results suggest that turmeric may have bone-protective effects but that extract composition is a critical factor...
  17. doi request reprint Exaggerated neutrophil-mediated reperfusion injury after ischemic stroke in a rodent model of type 2 diabetes
    Leslie Ritter
    College of Nursing, University of Arizona, Tucson, Arizona, USA
    Microcirculation 18:552-61. 2011
    ..We tested the hypothesis that both chronic and acute inflammatory processes contribute to worse reperfusion injury and stroke outcome in an experimental model of T2DM...
  18. pmc Modeling perimenopause in Sprague-Dawley rats by chemical manipulation of the transition to ovarian failure
    Jennifer B Frye
    Department of Medicine, College of Medicine, The University of Arizona, Tucson, Arizona, USA
    Comp Med 62:193-202. 2012
    ....
  19. ncbi request reprint Parathyroid hormone-related protein is expressed by transformed and fetal human astrocytes and inhibits cell proliferation
    P P Shankar
    Department of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    Brain Res 868:230-40. 2000
    ....
  20. pmc 4-Vinylcyclohexene diepoxide (VCD) inhibits mammary epithelial differentiation and induces fibroadenoma formation in female Sprague Dawley rats
    Laura E Wright
    Department of Medicine, The University of Arizona, 1656 E Mabel St, PO Box 245218, Tucson, AZ 85724, United States
    Reprod Toxicol 32:26-32. 2011
    ..VCD administration to 1-month rats acutely decreased mammary alveolar bud number and expression of β-casein, suggesting that VCD's tumorigenic effect requires exposure during mammary epithelial differentiation...
  21. doi request reprint Skeletal muscle fat content is inversely associated with bone strength in young girls
    Joshua N Farr
    Department of Physiological Sciences, University of Arizona, Tucson, AZ 85721 0093, USA
    J Bone Miner Res 26:2217-25. 2011
    ..03-0.05, p > .05), except the distal tibia (β = 0.09, p = .03). In conclusion, skeletal muscle fat content of the calf and thigh is inversely associated with weight-bearing bone strength in young girls...
  22. pmc Parathyroid hormone-related protein is induced during lethal endotoxemia and contributes to endotoxin-induced mortality in rodents
    J L Funk
    Department of Medicine, University of California, San Francisco, USA
    Mol Med 2:204-10. 1996
    ..We have therefore hypothesized that, with higher, lethal doses of endotoxin, PTHrP could be induced in multiple tissues to such a degree that it could contribute to the lethality of septic shock...
  23. pmc Comparison of skeletal effects of ovariectomy versus chemically induced ovarian failure in mice
    Laura E Wright
    Department of Physiology, The University of Arizona, Tucson, Arizona, USA
    J Bone Miner Res 23:1296-303. 2008
    ....
  24. pmc Hibiscus sabdariffa L. in the treatment of hypertension and hyperlipidemia: a comprehensive review of animal and human studies
    Allison L Hopkins
    Department of Family and Community Medicine, University of Arizona, Tucson, AZ 85724, USA
    Fitoterapia 85:84-94. 2013
    ....