C D Funk

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Lipoxygenase genes and their targeted disruption
    Colin D Funk
    Department of Pharmacology, Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia 19104, USA
    Prostaglandins Other Lipid Mediat 68:303-12. 2002
  2. ncbi request reprint Prostaglandins and leukotrienes: advances in eicosanoid biology
    C D Funk
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 294:1871-5. 2001
  3. ncbi request reprint 12/15-lipoxygenase, oxidative modification of LDL and atherogenesis
    C D Funk
    BRBII III Rm 814, Department of Pharmacology, Center for Experimental Therapeutics, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Trends Cardiovasc Med 11:116-24. 2001
  4. ncbi request reprint Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice
    T Cyrus
    Center for Experimental Therapeutics, Department of Medicine, University of Pennsylvania, Philadelphia, USA
    Circulation 103:2277-82. 2001
  5. ncbi request reprint The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization
    Y Hui
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biol Chem 276:47489-95. 2001
  6. ncbi request reprint Cloning of a human "epidermal-type" 12-lipoxygenase-related gene and chromosomal localization to 17p13
    D Sun
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia PA USA
    Cytogenet Cell Genet 81:79-82. 1998
  7. ncbi request reprint Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein
    D Sun
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6100, USA
    J Biol Chem 271:24055-62. 1996
  8. ncbi request reprint Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors
    V Martin
    Center for Experimental Therapeutics, 814 BRB II III, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Biochem Pharmacol 62:1193-200. 2001
  9. pmc Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice
    T Cyrus
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 103:1597-604. 1999
  10. ncbi request reprint Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment
    D Sun
    Center for Experimental Therapeutics, Departments of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 273:33540-7. 1998

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Lipoxygenase genes and their targeted disruption
    Colin D Funk
    Department of Pharmacology, Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia 19104, USA
    Prostaglandins Other Lipid Mediat 68:303-12. 2002
    ..While the knockout mice appear outwardly normal, a number of important findings have been discovered using these mice and these will be covered in this review...
  2. ncbi request reprint Prostaglandins and leukotrienes: advances in eicosanoid biology
    C D Funk
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 294:1871-5. 2001
    ..Important insights into the mechanisms of inflammatory responses, pain, and fever have been gleaned from our current understanding of eicosanoid biology...
  3. ncbi request reprint 12/15-lipoxygenase, oxidative modification of LDL and atherogenesis
    C D Funk
    BRBII III Rm 814, Department of Pharmacology, Center for Experimental Therapeutics, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Trends Cardiovasc Med 11:116-24. 2001
    ..In contrast, previous experiments with macrophage expressing 15-lipoxygenase transgenic rabbits have suggested an anti-atherogenic role. Possible explanations are presented that may elucidate these differences...
  4. ncbi request reprint Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice
    T Cyrus
    Center for Experimental Therapeutics, Department of Medicine, University of Pennsylvania, Philadelphia, USA
    Circulation 103:2277-82. 2001
    ....
  5. ncbi request reprint The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization
    Y Hui
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biol Chem 276:47489-95. 2001
    ..The identification of mCysLT(2)R will be useful for establishing CysLT(2)R-deficient mice and determining novel leukotriene functions...
  6. ncbi request reprint Cloning of a human "epidermal-type" 12-lipoxygenase-related gene and chromosomal localization to 17p13
    D Sun
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia PA USA
    Cytogenet Cell Genet 81:79-82. 1998
    ..Based on several criteria, humans appear to lack a functional e-12LO gene but instead have acquired an expressed pseudogene. The pseudogene designated ALOX12P2 was localized to chromosome 17p13 by analysis of somatic hybrid DNA panels...
  7. ncbi request reprint Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein
    D Sun
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6100, USA
    J Biol Chem 271:24055-62. 1996
    ..Thus, 12/15-lipoxygenase-deficient mice will be useful for the study of interaction between lipoxygenase pathways and determination of the in vivo role of 12/15-lipoxygenase-catalyzed oxidation of LDL in atherogenesis...
  8. ncbi request reprint Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors
    V Martin
    Center for Experimental Therapeutics, 814 BRB II III, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Biochem Pharmacol 62:1193-200. 2001
    ..Functional elucidation of mCysLT(1)R properties as described here will enable further experiments to clarify the selective role of LTD(4) in murine models of inflammation and asthma...
  9. pmc Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice
    T Cyrus
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 103:1597-604. 1999
    ..The combined data indicate a role for 12/15-lipoxygenase in the pathogenesis of atherosclerosis and suggest that inhibition of this enzyme may decrease disease progression...
  10. ncbi request reprint Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment
    D Sun
    Center for Experimental Therapeutics, Departments of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 273:33540-7. 1998
    ..5 in epidermis, nasal epithelium, and surface of the tongue. These results broaden the mammalian lipoxygenase family to include a 12(R)-lipoxygenase whose biological function remains to be determined...
  11. ncbi request reprint Insight into prostaglandin, leukotriene, and other eicosanoid functions using mice with targeted gene disruptions
    S C Austin
    Center for Experimental Therapeutics, Stellar Chance Labs, University of Pennsylvania, Philadelphia 19104, USA
    Prostaglandins Other Lipid Mediat 58:231-52. 1999
    ..g., receptors for various prostaglandins). This minireview will outline the phenotype of these knockout mice and what has been learned about eicosanoid functions through use of this novel methodology...
  12. pmc Absence of 12/15 lipoxygenase reduces brain oxidative stress in apolipoprotein E-deficient mice
    Cinzia M Chinnici
    Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, John Morgan Building, Room 124, Philadelphia, PA 19104, USA
    Am J Pathol 167:1371-7. 2005
    ....
  13. ncbi request reprint Role of 'platelet-type' 12-lipoxygenase in skin carcinogenesis
    J Virmani
    Department of Pharmacology, Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104-6160, USA
    Cancer Lett 162:161-5. 2001
    ..Overall, these data suggest that the P-12LO pathway may contribute to tumor incidence and progression in two-stage, but not complete, carcinogenesis, depending on the genetic background...
  14. ncbi request reprint The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation
    X S Chen
    Department of Pharmacology, Center for Experimental Therapeutics University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:811-8. 2001
    ..Thus, the predicted beta-barrel domain of 5-lipoxygenase may function like the C2 domain within protein kinase C and cytosolic phospholipase A(2) with unique determinants that direct its localization to the nuclear envelope...
  15. pmc Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase
    E N Johnson
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 95:3100-5. 1998
    ..The enhanced ADP sensitivity of P-12LO-/- mice appears to reveal a mechanism by which a product of the P-12LO pathway suppresses platelet activation by ADP...
  16. ncbi request reprint The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice
    C D Funk
    Stellar Chance Laboratories, University of Pennsylvania, Philadelphia 19104 6100, USA
    Biochim Biophys Acta 1304:65-84. 1996
  17. ncbi request reprint Basal transepidermal water loss is increased in platelet-type 12-lipoxygenase deficient mice
    E N Johnson
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Invest Dermatol 112:861-5. 1999
    ..These results indicate that the platelet-type 12-lipoxygenase pathway in mice is partly responsible for normal permeability barrier function but the mechanism awaits further elucidation...
  18. pmc 12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress
    Domenico Pratico
    Center for Experimental Therapeutics, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 164:1655-62. 2004
    ..These data show that the 12/15-LOX metabolic pathway is increased and correlates with an oxidative imbalance in the AD brain, implying that this enzyme might contribute to the pathogenesis of this neurodegenerative disorder...
  19. ncbi request reprint 12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway
    Lei Zhao
    Institute of Translational Medicine and Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Prostaglandins Other Lipid Mediat 78:185-93. 2005
    ..These results suggest that early 12/15-LO-mediated lipid peroxidation triggers ensuing non-enzymatic peroxidation that is susceptible to Vitamin E antioxidant action in a common pathway of atherogenesis...
  20. ncbi request reprint Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia
    Lei Zhao
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:35350-6. 2002
    ..The data provide support for a novel mechanism linking the 12/15-lipoxygenase pathway to a known immunomodulatory Th1 cytokine in atherogenesis...
  21. ncbi request reprint Augmented responses to morphine and cocaine in mice with a 12-lipoxygenase gene disruption
    Carrie L Walters
    Department of Pharmacology, 125 John Morgan Building, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Psychopharmacology (Berl) 170:124-31. 2003
    ..A similar mechanism has been shown for the regulation of glutamate release in the ventral tegmental area (VTA) during acute withdrawal from morphine, although the functional significance of these effects in vivo are not known...
  22. ncbi request reprint 12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses
    Steven J Feinmark
    Department of Pharmacology, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    J Neurosci 23:11427-35. 2003
    ....
  23. pmc Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting
    X Sun
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 96:628-33. 1999
    ....
  24. ncbi request reprint Functional expression and cellular localization of a mouse epidermal lipoxygenase
    C D Funk
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 271:23338-44. 1996
    ..The epidermal lipoxygenase gene (Aloxe) resides on mouse chromosome 11 closely linked with the two 12-lipoxygenase genes (Alox12p and Alox12l)...
  25. ncbi request reprint Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells
    V Martin
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 274:8597-603. 1999
    ..Isolation of the m-BLTR gene will form the basis of future experiments to elucidate the selective role of LTB4, as opposed to cysteinyl-leukotrienes, in murine models of inflammation...
  26. pmc Cyclooxygenase-2-dependent prostacyclin formation and blood pressure homeostasis: targeted exchange of cyclooxygenase isoforms in mice
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, 153 Johnson Pavilion, Philadelphia, PA 19104, USA
    Circ Res 106:337-45. 2010
    ..Both traditional nonsteroidal antiinflammatory drugs (NSAIDs) that inhibit COX-1 and COX-2 and NSAIDs designed to be selective for inhibition of COX-2 cause sodium retention and elevate blood pressure...
  27. ncbi request reprint Leukotriene-deficient mice generated by targeted disruption of the 5-lipoxygenase gene
    C D Funk
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Adv Prostaglandin Thromboxane Leukot Res 23:145-50. 1995
  28. ncbi request reprint The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm
    Lei Zhao
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    Nat Med 10:966-73. 2004
    ..These data link the 5-LO pathway to hyperlipidemia-dependent inflammation of the arterial wall and to pathogenesis of aortic aneurysms through a potential chemokine intermediary route...
  29. pmc Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function
    Yan Cheng
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 116:1391-9. 2006
    ..These results suggest that inhibitors of mPGES-1 may retain their antiinflammatory efficacy by depressing PGE(2), while avoiding the adverse cardiovascular consequences associated with PGHS-2-mediated PGI(2) suppression...
  30. ncbi request reprint Genetic model of selective COX2 inhibition reveals novel heterodimer signaling
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, 421 Curie Boulevard, BRB II III, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:699-704. 2006
    ..The heterodimerization of PGHS1-PGHS2 may explain how the ductus arteriosus closes normally at birth in mice expressing PGHS2 Y385F, but not in PGHS2-null mice...
  31. ncbi request reprint Characterization of epidermal 12(S) and 12(R) lipoxygenases
    Maeve McDonnell
    Center for Experimental Therapeutics, Rm 820 BRB II III, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 507:147-53. 2002
  32. ncbi request reprint Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient mice
    Tillmann Cyrus
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia 19104, USA
    Circulation 106:1282-7. 2002
    ..We wished to determine the effect of low-dose aspirin on vascular inflammation, plaque composition, and atherogenesis in LDL receptor-deficient mice fed a high fat diet...
  33. ncbi request reprint A novel genetic model of selective COX-2 inhibition: comparison with COX-2 null mice
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Prostaglandins Other Lipid Mediat 82:77-84. 2007
    ..In this short review, we compare a novel genetic COX-2 selective inhibition mouse model with the originally described COX-2 null mice in these different physiological functions...
  34. pmc Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Clin Invest 115:986-95. 2005
    ..PGHS1(Neo/Neo) mice provide a model of low-dose aspirin therapy that elucidates how prevention or delay of preeclampsia might be achieved without compromising reproductive function...
  35. ncbi request reprint Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:1498-506. 2007
    ..These mice will provide a valuable reagent with which to elucidate the distinct roles of the COX enzymes in mammalian biology...
  36. ncbi request reprint Lipoxygenase pathways in atherogenesis
    Lei Zhao
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    Trends Cardiovasc Med 14:191-5. 2004
    ..Development of novel pharmacologic tools to dissect the individual enzymes and receptors in the LO pathways should improve understanding of the individual components in the inflammatory aspects of atherosclerosis disease progression...
  37. ncbi request reprint Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice
    Richard Yang Cao
    Department of Physiology, Queen s University, Kingston, Ont K7L 3N6, Canada
    Prostaglandins Other Lipid Mediat 84:34-42. 2007
    ..Abrogation of the 5-LO pathway in mice indicates a lack of role of leukotrienes in Ang II-induced AAA pathogenesis stressing the need for additional non-rodent AAA pre-clinical models to be tested...
  38. ncbi request reprint The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient mice
    Michael P W Moos
    The Institute for Vascular Medicine, Friedrich Schiller University of Jena, Germany
    Arterioscler Thromb Vasc Biol 25:2386-91. 2005
    ..Cells of adaptive immunity have been implicated in atherogenesis. Though substantial information is available on immune cells in atherosclerotic lesions of the lamina intima, cells in the lamina adventitia have received less attention...
  39. pmc Actin polymerization in macrophages in response to oxidized LDL and apoptotic cells: role of 12/15-lipoxygenase and phosphoinositide 3-kinase
    Yury I Miller
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Mol Biol Cell 14:4196-206. 2003
    ....
  40. pmc Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice
    Peter B Anning
    Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Am J Pathol 166:653-62. 2005
    ....
  41. ncbi request reprint Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice
    Yuqing Huo
    University of Virginia, Charlottesville, VA, USA
    Circulation 110:2024-31. 2004
    ..12/15-LO is expressed in a variety of cells, including vascular cells, adipocytes, macrophages, and cardiomyocytes. The purpose of this study was to determine which cellular source of 12/15-LO is important for atherosclerosis...
  42. pmc Anion exchanger 2 is essential for spermiogenesis in mice
    Juan F Medina
    Division of Hepatology and Gene Therapy, University Hospital School of Medicine, Fundacion para la Investigacion Medica Aplicada, University of Navarra, E 31008 Pamplona, Spain
    Proc Natl Acad Sci U S A 100:15847-52. 2003
    ..Our findings reveal an essential role of Ae2 in mouse spermiogenesis and stress the recently postulated involvement of bicarbonate in germ-cell differentiation through the bicarbonate-sensitive soluble-adenylyl-cyclase pathway...
  43. pmc Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury
    Wei Jiang
    Department of Physiology, 433 Botterell Hall, Stuart St, Queen s University, Kingston, ON K7L 3N6 Canada
    Am J Pathol 172:592-602. 2008
    ....
  44. ncbi request reprint Selective 5-lipoxygenase expression in Langerhans cells and impaired dendritic cell migration in 5-LO-deficient mice reveal leukotriene action in skin
    Sandra Doepping
    Institute for Vascular Medicine, Friedrich Schiller University of Jena, Jena, Germany
    J Invest Dermatol 127:1692-700. 2007
    ....
  45. ncbi request reprint Is there a role for the macrophage 5-lipoxygenase pathway in aortic aneurysm development in apolipoprotein E-deficient mice?
    Colin D Funk
    Department of Physiology, Queen s University, Kingston, ON K7L 3N6 Canada
    Ann N Y Acad Sci 1085:151-60. 2006
    ..We are currently exploring the potential mechanisms for 5-LO/LT involvement in aneurysm pathogenesis and if this pathway might come into play in other models such as induction by angiotensin II...
  46. ncbi request reprint Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice
    Margarete Mehrabian
    Department of Medicine, UCLA School of Medicine, Los Angeles, Calif 90095 1679, USA
    Circ Res 91:120-6. 2002
    ..These results indicate that 5-LO contributes importantly to the atherogenic process and they provide strong presumptive evidence that reduced 5-LO expression is partly responsible for the resistance to atherosclerosis in CON6 mice...
  47. ncbi request reprint Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma
    Scott B Shappell
    Department of Pathology, Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2561, USA
    Cancer Res 63:2256-67. 2003
    ....
  48. ncbi request reprint Lipoxygenase pathways as mediators of early inflammatory events in atherosclerosis
    Colin D Funk
    Arterioscler Thromb Vasc Biol 26:1204-6. 2006
  49. ncbi request reprint Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress
    Uwe J F Tietge
    Department of Medicine, Charite Campus Mitte, Humboldt University, Berlin, Germany
    J Lipid Res 46:1604-14. 2005
    ....