Deborah H Fuller

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression follow
    Helen Horton
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Virol 76:7187-202. 2002
  2. ncbi request reprint DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued
    Deborah Heydenburg Fuller
    PowderJect Vaccines, Inc, Middleton, WI 53562, USA
    Virology 348:200-15. 2006
  3. ncbi request reprint Preclinical and clinical progress of particle-mediated DNA vaccines for infectious diseases
    Deborah H Fuller
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh, School of Medicine, 260 Kappa Drive, PA 15238, USA
    Methods 40:86-97. 2006
  4. ncbi request reprint Immunogenicity of hybrid DNA vaccines expressing hepatitis B core particles carrying human and simian immunodeficiency virus epitopes in mice and rhesus macaques
    Deborah Heydenburg Fuller
    PowderJect Vaccines Inc, Madison, WI 53562, USA
    Virology 364:245-55. 2007
  5. ncbi request reprint Differences between T cell epitopes recognized after immunization and after infection
    Thorsten U Vogel
    Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capital Court, Madison, WI 53715, USA
    J Immunol 169:4511-21. 2002
  6. pmc Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239
    Thorsten U Vogel
    Wisconsin Primate Research Center Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Virol 77:13348-60. 2003
  7. pmc DNA/Ad5 vaccination with SIV epitopes induced epitope-specific CD4⁺ T cells, but few subdominant epitope-specific CD8⁺ T cells
    Lara Vojnov
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Drive, Madison, WI 53711, USA
    Vaccine 29:7483-90. 2011
  8. pmc Plasmid vectors encoding cholera toxin or the heat-labile enterotoxin from Escherichia coli are strong adjuvants for DNA vaccines
    Joshua Arrington
    PowderJect Vaccines, Inc, Madison, Wisconsin 53711, USA
    J Virol 76:4536-46. 2002
  9. ncbi request reprint Clinical safety and efficacy of a powdered Hepatitis B nucleic acid vaccine delivered to the epidermis by a commercial prototype device
    Lee K Roberts
    PowderJect Vaccines Inc, Middleton, WI, USA
    Vaccine 23:4867-78. 2005
  10. ncbi request reprint Particle-mediated DNA vaccination of mice, monkeys and men: looking beyond the dogma
    Lendon G Payne
    Address PowderJect Vaccines Inc, Madison, WI 53711, USA
    Curr Opin Mol Ther 4:459-66. 2002

Collaborators

Detail Information

Publications10

  1. pmc Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression follow
    Helen Horton
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Virol 76:7187-202. 2002
    ..01). However, despite the induction of virus-specific cellular immune responses and reduced peak viral loads, most animals still suffered from gradual CD4 depletion and progressed to disease...
  2. ncbi request reprint DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued
    Deborah Heydenburg Fuller
    PowderJect Vaccines, Inc, Middleton, WI 53562, USA
    Virology 348:200-15. 2006
    ..Immunizing before infection or with multi-epitopes enhanced these effects. These results demonstrate that DNA immunization during antiretroviral therapy may be an effective strategy to treat HIV infection...
  3. ncbi request reprint Preclinical and clinical progress of particle-mediated DNA vaccines for infectious diseases
    Deborah H Fuller
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh, School of Medicine, 260 Kappa Drive, PA 15238, USA
    Methods 40:86-97. 2006
    ..Finally, efforts currently in progress for commercial development of particle-mediated DNA vaccines are discussed...
  4. ncbi request reprint Immunogenicity of hybrid DNA vaccines expressing hepatitis B core particles carrying human and simian immunodeficiency virus epitopes in mice and rhesus macaques
    Deborah Heydenburg Fuller
    PowderJect Vaccines Inc, Madison, WI 53562, USA
    Virology 364:245-55. 2007
    ..These data demonstrate that immunization with hybrid HBcAg-epitope DNA vaccines is an effective strategy to increase the magnitude and breadth of HIV-specific CTL responses...
  5. ncbi request reprint Differences between T cell epitopes recognized after immunization and after infection
    Thorsten U Vogel
    Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capital Court, Madison, WI 53715, USA
    J Immunol 169:4511-21. 2002
    ..The repertoire of the immune response detected in the peripheral blood after immunization substantially differed from the immune response detected in the peripheral blood after infection...
  6. pmc Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239
    Thorsten U Vogel
    Wisconsin Primate Research Center Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Virol 77:13348-60. 2003
    ....
  7. pmc DNA/Ad5 vaccination with SIV epitopes induced epitope-specific CD4⁺ T cells, but few subdominant epitope-specific CD8⁺ T cells
    Lara Vojnov
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Drive, Madison, WI 53711, USA
    Vaccine 29:7483-90. 2011
    ..Broadening the CD8(+) T cell response against subdominant MHC class I epitopes was, therefore, more difficult than we initially anticipated...
  8. pmc Plasmid vectors encoding cholera toxin or the heat-labile enterotoxin from Escherichia coli are strong adjuvants for DNA vaccines
    Joshua Arrington
    PowderJect Vaccines, Inc, Madison, Wisconsin 53711, USA
    J Virol 76:4536-46. 2002
    ....
  9. ncbi request reprint Clinical safety and efficacy of a powdered Hepatitis B nucleic acid vaccine delivered to the epidermis by a commercial prototype device
    Lee K Roberts
    PowderJect Vaccines Inc, Middleton, WI, USA
    Vaccine 23:4867-78. 2005
    ..5. Skin reactions at sites of vaccine administration were equivalent with both devices. This is the first clinical demonstration of the safe and effective PMED of a nucleic acid vaccine with the ND 5.5 device...
  10. ncbi request reprint Particle-mediated DNA vaccination of mice, monkeys and men: looking beyond the dogma
    Lendon G Payne
    Address PowderJect Vaccines Inc, Madison, WI 53711, USA
    Curr Opin Mol Ther 4:459-66. 2002
    ..This review highlights the current body of data showing that particle-mediated DNA immunization is highly effective in the induction Th1-type responses and is an efficient method for inducing immune responses in humans...