Research Topics
| D D FullerSummaryAffiliation: University of Wisconsin Country: USA Publications
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Detail Information
Publications
Fatiguing contractions of tongue protrudor and retractor muscles: influence of systemic hypoxiaD D Fuller
Respiratory Physiology Laboratory, Department of Physiology, University of Arizona, Tucson 85719, USA
J Appl Physiol 88:2123-30. 2000..05). We conclude that hypoxia attenuates tongue protrudor and retractor muscle endurance performance; potential mechanisms include neuromuscular transmission failure and/or diminished sarcolemmal excitability...- Synaptic pathways to phrenic motoneurons are enhanced by chronic intermittent hypoxia after cervical spinal cord injuryDavid D Fuller
Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
J Neurosci 23:2993-3000. 2003..05). We conclude that CIH induced spinal cord plasticity-enhanced phrenic motor output. This plasticity required preconditions established by chronic spinal injury... 
Life-long impairment of hypoxic phrenic responses in rats following 1 month of developmental hyperoxiaD D Fuller
Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53076, USA
J Physiol 538:947-55. 2002..4 (+/- 1.6) x 10(6) microm3; P <0.01). We conclude that exposure to hyperoxia for the first month of life causes life-long impairment of carotid chemoreceptor function and, consequently, blunted phrenic responses to hypoxia...- Induced recovery of hypoxic phrenic responses in adult rats exposed to hyperoxia for the first month of lifeD D Fuller
Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53076, USA
J Physiol 536:917-26. 2001.... - Chronic cervical spinal sensory denervation reveals ineffective spinal pathways to phrenic motoneurons in the ratDavid D Fuller
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
Neurosci Lett 323:25-8. 2002..v.) had no effect on the crossed phrenic potential amplitude (91+/-17% of control at 800 microA; P>0.05). Thus, CDR enhances crossed phrenic pathways but serotonin receptor activation is not necessary to maintain this effect... - Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxiaD D Fuller
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA
J Appl Physiol 90:2001-6; discussion 2000. 2001..Conversely, ketanserin pretreatment abolished phrenic LTF. We conclude that 5-HT receptor activation is necessary to initiate (during hypoxia) but not maintain (following hypoxia) phrenic LTF... - Expression of hypoglossal long-term facilitation differs between substrains of Sprague-Dawley ratD D Fuller
Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
Physiol Genomics 4:175-81. 2001..We conclude that the expression of hypoglossal LTF differs between SD rat substrains, indicating a difference in their genetic predisposition to neural plasticity... - Chronic intermittent hypoxia elicits serotonin-dependent plasticity in the central neural control of breathingL Ling
Departments of Comparative Biosciences and Preventive Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
J Neurosci 21:5381-8. 2001..The results suggest that CIH elicits unique forms of serotonin-dependent plasticity in the central neural control of breathing. Enhanced LTF after CIH may involve an upregulation of a non-5-HT(2) serotonin receptor subtype or subtypes... - Adult carotid chemoafferent responses to hypoxia after 1, 2, and 4 wk of postnatal hyperoxiaG E Bisgard
Department of Comparative Biosciences, University of Wisconsin Madison, Madison, WI 53706, USA
J Appl Physiol 95:946-52. 2003..These studies illustrate the importance of normoxia during the first 2 wk of life in development of carotid chemoreceptor afferent function... - Developmental plasticity of the hypoxic ventilatory response in rats induced by neonatal hypoxiaR W Bavis
Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
J Physiol 557:645-60. 2004..The basis of sex differences in this developmental plasticity is unknown... - Invited review: Intermittent hypoxia and respiratory plasticityG S Mitchell
Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
J Appl Physiol 90:2466-75. 2001.... - Long term facilitation of phrenic motor outputD D Fuller
Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
Respir Physiol 121:135-46. 2000.... - Respiratory plasticity: differential actions of continuous and episodic hypoxia and hypercapniaT L Baker
Center for Neuroscience, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
Respir Physiol 129:25-35. 2001..We hypothesize that the response of respiratory motoneurons to serotonergic and noradrenergic modulation may contribute to pattern sensitivity to hypoxia and hypercapnia... - Breathing patterns after mid-cervical spinal contusion in ratsF J Golder
Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706 1102, USA
Exp Neurol 231:97-103. 2011.... - Effect of pulmonary stretch receptor feedback and CO(2) on upper airway and respiratory pump muscle activity in the ratE F Bailey
Department of Physiology, College of Medicine, The University of Arizona, Tucson, AZ 85721 0093, USA
J Physiol 532:525-34. 2001..Hypoglossal motoneurons driving tongue protrudor and retractor muscles respond identically to these stimuli... - Ventilatory long-term facilitation in unanesthetized ratsE B Olson
The John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison, 53705 2368, USA
J Appl Physiol 91:709-16. 2001..Ventilatory LTF appeared similar in its magnitude (after accounting for CO(2) feedback), time course, and dependence on intermittent hypoxia to phrenic LTF previously observed in anesthetized, vagotomized, paralyzed rats... - Respiratory-related control of extrinsic tongue muscle activityR F Fregosi
Department of Physiology, University of Arizona, Tucson 85721 0093, USA
Respir Physiol 110:295-306. 1997..The possible mechanical consequences of tongue muscle co-activation are briefly considered... - Pulmonary C-fiber receptor activation abolishes uncoupled facial nerve activity from phrenic bursting during positive end-expired pressure in the ratKun Ze Lee
Dept of Life Science, National Taiwan Normal Univ, Taipei, Taiwan
J Appl Physiol 104:119-29. 2008..We conclude that activation of PCF receptors can inhibit FN bursting during PEEP-induced phrenic apnea by inhibiting EI and I facial motoneuron discharge... - Uncoupling of upper airway motor activity from phrenic bursting by positive end-expired pressure in the ratKun Ze Lee
Dept of Life Science, National Taiwan Normal University, Taipei, Taiwan
J Appl Physiol 102:878-89. 2007..The relationship between PEEP and EI motoneuron discharge rate differs during preinspiratory and I periods; this may indicate that bursting during these phases of the respiratory cycle is controlled by distinct neuronal outputs... - Neural drive to tongue protrudor and retractor muscles following pulmonary C-fiber activationKun Ze Lee
Department of Life Science, National Taiwan Normal University, Taipei, Taiwan, ROC
J Appl Physiol 102:434-44. 2007..Accordingly, reductions in upper airway stiffness associated with reduced XII burst amplitude may be offset by enhanced tonic activity in tongue protrudor muscles... - Respiratory motor recovery after unilateral spinal cord injury: eliminating crossed phrenic activity decreases tidal volume and increases contralateral respiratory motor outputFrancis J Golder
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
J Neurosci 23:2494-501. 2003..Moreover, by preventing ipsilateral phrenic motor recovery in rats with unilateral SCI, segmental and supraspinal changes could be induced in contralateral respiratory motor output beyond that seen with SCI alone... - Recovery of phrenic activity and ventilation after cervical spinal hemisection in ratsDavid D Fuller
Dept of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA
J Appl Physiol 100:800-6. 2006..Enhanced crossed phrenic activity post-C2HS may reflect plasticity associated with spinal axons not activated by our ventrolateral spinal stimulation... - Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptorsDavid D Fuller
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA
J Neurotrauma 22:203-13. 2005..05). Our data are consistent with the hypothesis that spontaneous increase in 5-HT2A receptor expression on or near phrenic motoneurons contributes to strengthened crossed-spinal synaptic pathways to phrenic motoneurons following C2HS... - Differences in time-dependent hypoxic phrenic responses among inbred rat strainsFrancis J Golder
Department of Comparative Bioscience, University of Wisconsin, Madison, Wisconsin, USA
J Appl Physiol 98:838-44. 2005..Furthermore, genetic diversity observed in hypoxic ventilatory responses in unanesthetized rats may arise from multiple neural mechanisms... - BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxiaTracy L Baker-Herman
Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
Nat Neurosci 7:48-55. 2004..These experiments also illustrate the potential use of RNAi to investigate functional consequences of gene expression in the mammalian nervous system in vivo... - Respiratory-related activation of human abdominal muscles during exerciseKirk A Abraham
Department of Physiology, The University of Arizona Health Sciences Center, Tucson, AZ 85721, USA
J Physiol 541:653-63. 2002..The contribution of abdominal muscles to ventilation during constant work rate exercise is variable, and expiratory activity does not 'drift' significantly with time... - Physiological correction of Pompe disease by systemic delivery of adeno-associated virus serotype 1 vectorsCathryn Mah
Powell Gene Therapy Center, University of Florida, Gainesville, Florida, USA
Mol Ther 15:501-7. 2007.... - Neurogenesis of cough, other airway defensive behaviors and breathing: A holarchical system?Donald C Bolser
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
Respir Physiol Neurobiol 152:255-65. 2006..As such, co-expression of multiple rhythmic behaviors such as cough and swallow can occur without compromising airway defense...