D D Fuller

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Episodic hypoxia induces long-term facilitation of neural drive to tongue protrudor and retractor muscles
    D D Fuller
    Department of Physical Therapy, University of Florida, 100 S Newell Dr, PO Box 100154, Gainesville, FL 32610, USA
    J Appl Physiol 98:1761-7. 2005
  2. pmc Modest spontaneous recovery of ventilation following chronic high cervical hemisection in rats
    D D Fuller
    University of Florida, College of Health and Health Professions, Department of Physical Therapy, 100 Newell Drive, Gainesville, FL 32610, USA
    Exp Neurol 211:97-106. 2008
  3. ncbi request reprint Recovery of phrenic activity and ventilation after cervical spinal hemisection in rats
    David D Fuller
    Dept of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA
    J Appl Physiol 100:800-6. 2006
  4. ncbi request reprint Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptors
    David D Fuller
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA
    J Neurotrauma 22:203-13. 2005
  5. pmc Induced recovery of hypoxic phrenic responses in adult rats exposed to hyperoxia for the first month of life
    D D Fuller
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53076, USA
    J Physiol 536:917-26. 2001
  6. ncbi request reprint Adult carotid chemoafferent responses to hypoxia after 1, 2, and 4 wk of postnatal hyperoxia
    G E Bisgard
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, WI 53706, USA
    J Appl Physiol 95:946-52. 2003
  7. pmc Ventilation and phrenic output following high cervical spinal hemisection in male vs. female rats
    N J Doperalski
    University of Florida, College of Public Health and Health Professions, Department of Physical Therapy, PO Box 100154, 100 Newell Drive, Gainesville, FL 32610, USA
    Respir Physiol Neurobiol 162:160-7. 2008
  8. pmc Respiratory recovery following high cervical hemisection
    M S Sandhu
    Department of Physical Therapy, College of Public Health and Health Professions, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Respir Physiol Neurobiol 169:94-101. 2009
  9. ncbi request reprint Chronic intermittent hypoxia elicits serotonin-dependent plasticity in the central neural control of breathing
    L Ling
    Departments of Comparative Biosciences and Preventive Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 21:5381-8. 2001
  10. ncbi request reprint Synaptic pathways to phrenic motoneurons are enhanced by chronic intermittent hypoxia after cervical spinal cord injury
    David D Fuller
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 23:2993-3000. 2003

Research Grants

  1. Female Sex Hormones and Spinal Injury
    David Fuller; Fiscal Year: 2006
  2. Control of Breathing & Glycogen Storage Disease
    David Fuller; Fiscal Year: 2007

Detail Information

Publications45

  1. ncbi request reprint Episodic hypoxia induces long-term facilitation of neural drive to tongue protrudor and retractor muscles
    D D Fuller
    Department of Physical Therapy, University of Florida, 100 S Newell Dr, PO Box 100154, Gainesville, FL 32610, USA
    J Appl Physiol 98:1761-7. 2005
    ..These data demonstrate that episodic hypoxia induces LTF of inspiratory drive to both tongue protrudor and retractor muscles and underscore the potential contribution of tongue muscle coactivation to regulation of upper airway patency...
  2. pmc Modest spontaneous recovery of ventilation following chronic high cervical hemisection in rats
    D D Fuller
    University of Florida, College of Health and Health Professions, Department of Physical Therapy, 100 Newell Drive, Gainesville, FL 32610, USA
    Exp Neurol 211:97-106. 2008
    ..2-week post-injury. We conclude that recovery of ventilation deficits occurs over 2-12-week post-C2HS; however, intrinsic neuroplasticity remains insufficient to concurrently restore a normal level of ipsilateral phrenic output...
  3. ncbi request reprint Recovery of phrenic activity and ventilation after cervical spinal hemisection in rats
    David D Fuller
    Dept of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA
    J Appl Physiol 100:800-6. 2006
    ..Enhanced crossed phrenic activity post-C2HS may reflect plasticity associated with spinal axons not activated by our ventrolateral spinal stimulation...
  4. ncbi request reprint Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptors
    David D Fuller
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA
    J Neurotrauma 22:203-13. 2005
    ..05). Our data are consistent with the hypothesis that spontaneous increase in 5-HT2A receptor expression on or near phrenic motoneurons contributes to strengthened crossed-spinal synaptic pathways to phrenic motoneurons following C2HS...
  5. pmc Induced recovery of hypoxic phrenic responses in adult rats exposed to hyperoxia for the first month of life
    D D Fuller
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53076, USA
    J Physiol 536:917-26. 2001
    ....
  6. ncbi request reprint Adult carotid chemoafferent responses to hypoxia after 1, 2, and 4 wk of postnatal hyperoxia
    G E Bisgard
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, WI 53706, USA
    J Appl Physiol 95:946-52. 2003
    ..These studies illustrate the importance of normoxia during the first 2 wk of life in development of carotid chemoreceptor afferent function...
  7. pmc Ventilation and phrenic output following high cervical spinal hemisection in male vs. female rats
    N J Doperalski
    University of Florida, College of Public Health and Health Professions, Department of Physical Therapy, PO Box 100154, 100 Newell Drive, Gainesville, FL 32610, USA
    Respir Physiol Neurobiol 162:160-7. 2008
    ..These differences are consistent with the hypothesis that ovarian sex hormones influence respiratory recovery after cervical spinal cord injury...
  8. pmc Respiratory recovery following high cervical hemisection
    M S Sandhu
    Department of Physical Therapy, College of Public Health and Health Professions, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Respir Physiol Neurobiol 169:94-101. 2009
    ..1+/-0.19ms lag from zero on the abscissa. These data are consistent with prolonged conduction time to IL (vs. CL) PhrMNs and the possibility of polysynaptic inputs to IL PhrMNs after chronic C2HS...
  9. ncbi request reprint Chronic intermittent hypoxia elicits serotonin-dependent plasticity in the central neural control of breathing
    L Ling
    Departments of Comparative Biosciences and Preventive Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 21:5381-8. 2001
    ..The results suggest that CIH elicits unique forms of serotonin-dependent plasticity in the central neural control of breathing. Enhanced LTF after CIH may involve an upregulation of a non-5-HT(2) serotonin receptor subtype or subtypes...
  10. ncbi request reprint Synaptic pathways to phrenic motoneurons are enhanced by chronic intermittent hypoxia after cervical spinal cord injury
    David D Fuller
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 23:2993-3000. 2003
    ..05). We conclude that CIH induced spinal cord plasticity-enhanced phrenic motor output. This plasticity required preconditions established by chronic spinal injury...
  11. ncbi request reprint Respiratory motor recovery after unilateral spinal cord injury: eliminating crossed phrenic activity decreases tidal volume and increases contralateral respiratory motor output
    Francis J Golder
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Neurosci 23:2494-501. 2003
    ..Moreover, by preventing ipsilateral phrenic motor recovery in rats with unilateral SCI, segmental and supraspinal changes could be induced in contralateral respiratory motor output beyond that seen with SCI alone...
  12. pmc Prenatal nicotine exposure alters respiratory long-term facilitation in neonatal rats
    D D Fuller
    Department of Physical Therapy, University of Florida, College of Public Health and Health Professions, 100 Newell Dr, Gainesville, FL 32610, USA
    Respir Physiol Neurobiol 169:333-7. 2009
    ..01) with similar values at P9-11 but enhanced LTF in saline (30+/-8%BL) vs. PN pups (6+/-5%BL; p=0.01) at P15-17. We conclude that the post-natal developmental time course of hypoxia-induced LTF is influenced by PN...
  13. pmc Developmental plasticity of the hypoxic ventilatory response in rats induced by neonatal hypoxia
    R W Bavis
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 557:645-60. 2004
    ..The basis of sex differences in this developmental plasticity is unknown...
  14. doi request reprint Recovery of inspiratory intercostal muscle activity following high cervical hemisection
    B J Dougherty
    University of Florida, College of Medicine, McKnight Brain Institute, Department of Neuroscience, Gainesville, FL 32611, United States
    Respir Physiol Neurobiol 183:186-92. 2012
    ..55; P<0.001). We conclude that plasticity occurring within a "crossed-intercostal" circuitry enables a robust, spontaneous recovery of ipsilateral intercostal activity following C2HS in rats...
  15. pmc Graded unilateral cervical spinal cord injury and respiratory motor recovery
    D D Fuller
    Department of Physical Therapy, College of Public Health and Health Professions, McKnight Brain Institute, University of Florida, P O Box 100154, 100 S Newell Drive, Gainesville, FL 32610, USA
    Respir Physiol Neurobiol 165:245-53. 2009
    ..In addition, respiratory deficits can emerge in the adult rat after high cervical SCI even when relatively extensive VM sparing occurs...
  16. pmc Breathing patterns after mid-cervical spinal contusion in rats
    F J Golder
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706 1102, USA
    Exp Neurol 231:97-103. 2011
    ....
  17. ncbi request reprint Expression of hypoglossal long-term facilitation differs between substrains of Sprague-Dawley rat
    D D Fuller
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Physiol Genomics 4:175-81. 2001
    ..We conclude that the expression of hypoglossal LTF differs between SD rat substrains, indicating a difference in their genetic predisposition to neural plasticity...
  18. ncbi request reprint Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia
    D D Fuller
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA
    J Appl Physiol 90:2001-6; discussion 2000. 2001
    ..Conversely, ketanserin pretreatment abolished phrenic LTF. We conclude that 5-HT receptor activation is necessary to initiate (during hypoxia) but not maintain (following hypoxia) phrenic LTF...
  19. ncbi request reprint Invited review: Intermittent hypoxia and respiratory plasticity
    G S Mitchell
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Appl Physiol 90:2466-75. 2001
    ....
  20. ncbi request reprint Long term facilitation of phrenic motor output
    D D Fuller
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    Respir Physiol 121:135-46. 2000
    ....
  21. pmc Spinal circuitry and respiratory recovery following spinal cord injury
    Michael A Lane
    Department of Neuroscience, College of Medicine, and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, United States
    Respir Physiol Neurobiol 169:123-32. 2009
    ....
  22. pmc The phrenic motor nucleus in the adult mouse
    K Qiu
    University of Florida, College of Public Health and Health Professions, McKnight Brain Institute, Department of Physical Therapy, PO Box 100154, 100 Newell Dr, Gainesville, FL 32610, USA
    Exp Neurol 226:254-8. 2010
    ....
  23. pmc Neuronal progenitor transplantation and respiratory outcomes following upper cervical spinal cord injury in adult rats
    Todd E White
    Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, PO Box 100244, 100 S Newell Dr, Gainesville, FL 32610, USA
    Exp Neurol 225:231-6. 2010
    ....
  24. ncbi request reprint Respiratory plasticity: differential actions of continuous and episodic hypoxia and hypercapnia
    T L Baker
    Center for Neuroscience, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    Respir Physiol 129:25-35. 2001
    ..We hypothesize that the response of respiratory motoneurons to serotonergic and noradrenergic modulation may contribute to pattern sensitivity to hypoxia and hypercapnia...
  25. ncbi request reprint Ventilatory long-term facilitation in unanesthetized rats
    E B Olson
    The John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison, 53705 2368, USA
    J Appl Physiol 91:709-16. 2001
    ..Ventilatory LTF appeared similar in its magnitude (after accounting for CO(2) feedback), time course, and dependence on intermittent hypoxia to phrenic LTF previously observed in anesthetized, vagotomized, paralyzed rats...
  26. ncbi request reprint Long-term facilitation of ipsilateral but not contralateral phrenic output after cervical spinal cord hemisection
    N J Doperalski
    Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA
    Exp Neurol 200:74-81. 2006
    ..05), but not C2HS rats. We conclude that compensatory responses to unilateral cervical spinal cord injury prevent the expression of LTF in contralateral phrenic motoneurons...
  27. pmc Neural deficits contribute to respiratory insufficiency in Pompe disease
    Lara R DeRuisseau
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 106:9419-24. 2009
    ..We conclude that neural output to the diaphragm is deficient in Gaa(-/-) mice, and therapies targeting muscle alone may be ineffective in Pompe disease...
  28. pmc Influence of vagal afferents on supraspinal and spinal respiratory activity following cervical spinal cord injury in rats
    Kun Ze Lee
    Univ of Florida, Coll of Public Health and Health Professions, McKnight Brain Inst, Dept of Physical Therapy, PO Box 100154, 100 Newell Dr, Gainesville, FL 32610, USA
    J Appl Physiol 109:377-87. 2010
    ..These vagotomy data appear to explain the variability in the literature regarding the onset of the spontaneous crossed phrenic phenomenon in spontaneously breathing (vagal intact) vs. ventilated (vagotomized) preparations...
  29. pmc Gel-mediated delivery of AAV1 vectors corrects ventilatory function in Pompe mice with established disease
    Cathryn S Mah
    Powell Gene Therapy Center, University of Florida, Gainesville, Florida 32610, USA
    Mol Ther 18:502-10. 2010
    ..These results demonstrate that gel-mediated delivery of rAAV2/1 vectors can significantly augment ventilatory function at initial and late phases of disease in a model of muscular dystrophy...
  30. pmc Preinspiratory and inspiratory hypoglossal motor output during hypoxia-induced plasticity in the rat
    Kun Ze Lee
    Department of Physical Therapy, University of Florida, College of Public Health and Health Professions, McKnight Brain Institute, PO Box 100154, 100 Newell Dr, Gainesville, FL 32610, USA
    J Appl Physiol 108:1187-98. 2010
    ..In addition, both recruitment of silent MNs and rate coding of active I MNs contribute to increases in XII motor output following hypoxia...
  31. pmc Respiratory neuroplasticity and cervical spinal cord injury: translational perspectives
    Michael A Lane
    Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, Gainesville, FL 32610, USA
    Trends Neurosci 31:538-47. 2008
    ..Translational considerations are also emphasized, with specific attention directed at the clinical and interpretational strengths of different lesion models and outcome measures...
  32. pmc Hypoxia-induced short-term potentiation of respiratory-modulated facial motor output in the rat
    Kun Ze Lee
    University of Florida, College of Public Health and Health Professions, McKnight Brain Institute, Department of Physical Therapy, PO Box 100154, 100 Newell Dr, Gainesville, FL 32610, United States
    Respir Physiol Neurobiol 173:107-11. 2010
    ..e. post-hypoxia STP) but both Pre-I and tonic activity immediately returned to baseline values. We conclude that STP following hypoxia is preferentially expressed in I compared to Pre-I and tonic VII activity...
  33. ncbi request reprint Chronic cervical spinal sensory denervation reveals ineffective spinal pathways to phrenic motoneurons in the rat
    David D Fuller
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    Neurosci Lett 323:25-8. 2002
    ..v.) had no effect on the crossed phrenic potential amplitude (91+/-17% of control at 800 microA; P>0.05). Thus, CDR enhances crossed phrenic pathways but serotonin receptor activation is not necessary to maintain this effect...
  34. pmc Phrenic motoneuron discharge patterns during hypoxia-induced short-term potentiation in rats
    Kun Ze Lee
    Department of Physical Therapy, College of Public Health and Health Professions, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    J Neurophysiol 102:2184-93. 2009
    ..post-hypoxia STP primarily reflects persistent increases in the discharge of PhrMNs, which were active before hypoxia...
  35. pmc Recovery of airway protective behaviors after spinal cord injury
    Donald C Bolser
    Dept of Physiological Sciences, College of Veterinary Medicine, University of Florida, United States
    Respir Physiol Neurobiol 169:150-6. 2009
    ..These mechanisms may contribute to functional resiliency of the cough reflex that has been observed following chronic spinal cord injury in the cat...
  36. ncbi request reprint BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia
    Tracy L Baker-Herman
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Nat Neurosci 7:48-55. 2004
    ..These experiments also illustrate the potential use of RNAi to investigate functional consequences of gene expression in the mammalian nervous system in vivo...
  37. pmc Cervical prephrenic interneurons in the normal and lesioned spinal cord of the adult rat
    Michael A Lane
    Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Comp Neurol 511:692-709. 2008
    ..Their connectivity and relative stability after cervical hemisection raise speculation for potentially diverse roles in modulating phrenic function normally and postinjury...
  38. pmc Neurogenesis of cough, other airway defensive behaviors and breathing: A holarchical system?
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
    Respir Physiol Neurobiol 152:255-65. 2006
    ..As such, co-expression of multiple rhythmic behaviors such as cough and swallow can occur without compromising airway defense...
  39. ncbi request reprint Physiological correction of Pompe disease by systemic delivery of adeno-associated virus serotype 1 vectors
    Cathryn Mah
    Powell Gene Therapy Center, University of Florida, Gainesville, Florida, USA
    Mol Ther 15:501-7. 2007
    ....
  40. pmc Life-long impairment of hypoxic phrenic responses in rats following 1 month of developmental hyperoxia
    D D Fuller
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53076, USA
    J Physiol 538:947-55. 2002
    ..4 (+/- 1.6) x 10(6) microm3; P <0.01). We conclude that exposure to hyperoxia for the first month of life causes life-long impairment of carotid chemoreceptor function and, consequently, blunted phrenic responses to hypoxia...
  41. ncbi request reprint Differences in time-dependent hypoxic phrenic responses among inbred rat strains
    Francis J Golder
    Department of Comparative Bioscience, University of Wisconsin, Madison, Wisconsin, USA
    J Appl Physiol 98:838-44. 2005
    ..Furthermore, genetic diversity observed in hypoxic ventilatory responses in unanesthetized rats may arise from multiple neural mechanisms...
  42. pmc Phrenicotomy alters phrenic long-term facilitation following intermittent hypoxia in anesthetized rats
    M S Sandhu
    Dept of Physical Therapy, College of Public Health and Health Professions, McKnight Brain Institute, Univ of Florida, PO Box 100154, 100 S Newell Dr, Gainesville, FL 32610, USA
    J Appl Physiol 109:279-87. 2010
    ..01 vs. pre-PhrX). We conclude that, after PhrX, axotomy of phrenic motoneurons and, possibly, removal of phrenic afferents result in increased phrenic motoneuron excitability and enhanced LTF following IH...
  43. ncbi request reprint Pulmonary C-fiber receptor activation abolishes uncoupled facial nerve activity from phrenic bursting during positive end-expired pressure in the rat
    Kun Ze Lee
    Dept of Life Science, National Taiwan Normal Univ, Taipei, Taiwan
    J Appl Physiol 104:119-29. 2008
    ..We conclude that activation of PCF receptors can inhibit FN bursting during PEEP-induced phrenic apnea by inhibiting EI and I facial motoneuron discharge...
  44. ncbi request reprint Uncoupling of upper airway motor activity from phrenic bursting by positive end-expired pressure in the rat
    Kun Ze Lee
    Dept of Life Science, National Taiwan Normal University, Taipei, Taiwan
    J Appl Physiol 102:878-89. 2007
    ..The relationship between PEEP and EI motoneuron discharge rate differs during preinspiratory and I periods; this may indicate that bursting during these phases of the respiratory cycle is controlled by distinct neuronal outputs...
  45. ncbi request reprint Neural drive to tongue protrudor and retractor muscles following pulmonary C-fiber activation
    Kun Ze Lee
    Department of Life Science, National Taiwan Normal University, Taipei, Taiwan, ROC
    J Appl Physiol 102:434-44. 2007
    ..Accordingly, reductions in upper airway stiffness associated with reduced XII burst amplitude may be offset by enhanced tonic activity in tongue protrudor muscles...

Research Grants2

  1. Female Sex Hormones and Spinal Injury
    David Fuller; Fiscal Year: 2006
    ..abstract_text> ..
  2. Control of Breathing & Glycogen Storage Disease
    David Fuller; Fiscal Year: 2007
    ....