Makoto Fukuda

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Induction of leptin resistance by activation of cAMP-Epac signaling
    Makoto Fukuda
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 13:331-9. 2011
  2. pmc PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis
    Yong Xu
    Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 12:88-95. 2010
  3. pmc Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA Department of Neuroscience, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA Electronic address
    Cell Metab 20:471-82. 2014
  4. pmc Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons
    Jose Donato
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Endocrinology 151:5415-27. 2010
  5. pmc 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
    Yong Xu
    Division of Hypothalamic Research and Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 13:1457-9. 2010
  6. pmc SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
    Giorgio Ramadori
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 12:78-87. 2010
  7. pmc Monitoring FoxO1 localization in chemically identified neurons
    Makoto Fukuda
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Neurosci 28:13640-8. 2008
  8. pmc Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice
    Ingrid W Asterholm
    Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390 8549, USA
    Diabetologia 57:1209-18. 2014
  9. pmc Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance
    Lin Jia
    1 Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA 2
    Nat Commun 5:3878. 2014
  10. pmc Central nervous control of energy and glucose balance: focus on the central melanocortin system
    Yong Xu
    Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann N Y Acad Sci 1243:1-14. 2011

Collaborators

Detail Information

Publications10

  1. pmc Induction of leptin resistance by activation of cAMP-Epac signaling
    Makoto Fukuda
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 13:331-9. 2011
    ..Finally, central infusion of an Epac activator blunted the anorexigenic actions of leptin. Thus, activation of hypothalamic cAMP-Epac pathway is sufficient to induce multiple indices of leptin resistance...
  2. pmc PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis
    Yong Xu
    Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 12:88-95. 2010
    ..Collectively, our results indicate that PI3K activity in VMH neurons plays a physiologically relevant role in the regulation of energy expenditure...
  3. pmc Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA Department of Neuroscience, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA Electronic address
    Cell Metab 20:471-82. 2014
    ..Together our results identify critical molecular mechanisms linking ER stress in arcuate Pomc neurons to acute leptin and insulin resistance as well as liver metabolism in diet-induced obesity and diabetes...
  4. pmc Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons
    Jose Donato
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Endocrinology 151:5415-27. 2010
    ..Herein we identified the first-order neurons potentially involved in NO-mediated effects of leptin and demonstrate that leptin regulates nNOS activity predominantly through posttranslational mechanisms...
  5. pmc 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
    Yong Xu
    Division of Hypothalamic Research and Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 13:1457-9. 2010
    ..Our findings indicate that 5-HT(2C)Rs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose homeostasis in the liver...
  6. pmc SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
    Giorgio Ramadori
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 12:78-87. 2010
    ..In summary, our results provide direct genetic evidence that SIRT1 in POMC neurons is required for normal autonomic adaptations against diet-induced obesity...
  7. pmc Monitoring FoxO1 localization in chemically identified neurons
    Makoto Fukuda
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Neurosci 28:13640-8. 2008
    ..Thus, our FoxO1GFP mouse provides a tool for monitoring the status of PI3K-Akt signaling in a cell-specific manner under physiological and pathophysiological conditions...
  8. pmc Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice
    Ingrid W Asterholm
    Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390 8549, USA
    Diabetologia 57:1209-18. 2014
    ..Clinically, resistin has also been implicated in cardiovascular disease in a number of different patient populations. Our aim was to simultaneously address these phenomena...
  9. pmc Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance
    Lin Jia
    1 Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA 2
    Nat Commun 5:3878. 2014
    ....
  10. pmc Central nervous control of energy and glucose balance: focus on the central melanocortin system
    Yong Xu
    Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann N Y Acad Sci 1243:1-14. 2011
    ..These findings suggest that targeting the specific branches of melanocortin circuits may be potential avenues to combat the current obesity and diabetes epidemics...