K Fujiwara

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation
    Yi Jen Chiu
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, West Henrietta, NY 14586, USA
    J Cell Biol 182:753-63. 2008
  2. ncbi request reprint Is PECAM-1 a mechanoresponsive molecule?
    K Fujiwara
    Center for Cardiovascular Research, Department of Medicine, University of Rochester, NY 14624, USA
    Cell Struct Funct 26:11-7. 2001
  3. ncbi request reprint Platelet endothelial cell adhesion molecule-1 and mechanotransduction in vascular endothelial cells
    K Fujiwara
    Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Intern Med 259:373-80. 2006
  4. ncbi request reprint Endothelial cell-cell adhesion and mechanosignal transduction
    Yi Jen Chiu
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Endothelium 11:59-73. 2004
  5. pmc ECM remodeling in hypertensive heart disease
    Bradford C Berk
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    J Clin Invest 117:568-75. 2007
  6. ncbi request reprint Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus
    Joseph M Miano
    Cardiovascular Research Institute, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 292:C70-81. 2007
  7. ncbi request reprint GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions
    Geerten P van Nieuw Amerongen
    Center for Cardiovascular Research and Department of Medicine, Aab Institute for Biomedical Sciences, University of Rochester, Rochester, NY 14642, USA
    Circ Res 94:1041-9. 2004
  8. pmc Down-regulation of ERK but not MEK phosphorylation in cultured endothelial cells by repeated changes in cyclic stretch
    Feng Shi
    Cardiovascular Research Institute, University of Rochester, 601 Elmwood Avenue, Box 679, Rochester, NY 14642, USA
    Cardiovasc Res 73:813-22. 2007
  9. ncbi request reprint Vascular endothelial cells that express dystroglycan are involved in angiogenesis
    Hiroshi Hosokawa
    Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Rochester NY 14642 8679, USA
    J Cell Sci 115:1487-96. 2002
  10. pmc Phosphorylation and localization of protein-zero related (PZR) in cultured endothelial cells
    Ken ichi Kusano
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14586, USA
    Endothelium 15:127-36. 2008

Collaborators

  • Tara A Bullard
  • B C Berk
  • M Masuda
  • Judith Haendeler
  • J M Miano
  • Masahiro Sokabe
  • JANE M SOTTILE
  • Yi Jen Chiu
  • Feng Shi
  • Ken ichi Kusano
  • Patrizia Nigro
  • Tamlyn N Thomas
  • Geerten P van Nieuw Amerongen
  • Masaki Osawa
  • Hiroshi Hosokawa
  • Jennifer Harman
  • Jian dong Li
  • Michael R O'Dell
  • Kimio Satoh
  • Jae Hyang Lim
  • Jun Ichi Abe
  • Kyung Sun Heo
  • Carolyn McClain
  • Hakjoo Lee
  • Chang Hoon Woo
  • Elena McBeath
  • Youngsun Cho
  • Victor W M van Hinsbergh
  • Ryan J Hoefen
  • Kanchana Natarajan
  • Guoyong Yin
  • A J Ridley
  • M Osawa
  • Haruaki Ninomiya
  • Tomoh Masaki
  • Yukisato Kitamura

Detail Information

Publications14

  1. pmc Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation
    Yi Jen Chiu
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, West Henrietta, NY 14586, USA
    J Cell Biol 182:753-63. 2008
    ..We suggest that PECAM-1 and Fyn are essential components of a PECAM-1-based mechanosensory complex in ECs...
  2. ncbi request reprint Is PECAM-1 a mechanoresponsive molecule?
    K Fujiwara
    Center for Cardiovascular Research, Department of Medicine, University of Rochester, NY 14624, USA
    Cell Struct Funct 26:11-7. 2001
    ..This PE-CAM-1 phosphorylation initiates a signaling cascade leading to ERK activation. Here we review what is known about PECAM-1 tyrosine phosphorylation and suggest a possible role of PECAM-1 in mechanosensing by endothelial cells...
  3. ncbi request reprint Platelet endothelial cell adhesion molecule-1 and mechanotransduction in vascular endothelial cells
    K Fujiwara
    Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Intern Med 259:373-80. 2006
    ..These results appear to indicate that PECAM-1 is a mechanotransduction molecule. To our knowledge, this is the first mammalian molecule that is shown to respond to mechanical force directly exerted to it...
  4. ncbi request reprint Endothelial cell-cell adhesion and mechanosignal transduction
    Yi Jen Chiu
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Endothelium 11:59-73. 2004
    ..We will also review the available evidence for PECAM-1 as a mechanotransducing molecule in endothelial cells...
  5. pmc ECM remodeling in hypertensive heart disease
    Bradford C Berk
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    J Clin Invest 117:568-75. 2007
    ..Recent research suggests that therapies targeting the expression, synthesis, or activation of the enzymes responsible for ECM homeostasis might represent novel opportunities to modify the natural progression of HHD...
  6. ncbi request reprint Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus
    Joseph M Miano
    Cardiovascular Research Institute, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 292:C70-81. 2007
    ..This review summarizes the recent genomic and genetic analyses of CArG-SRF that support its role as an ancient, master regulator of the actin cytoskeleton and contractile machinery...
  7. ncbi request reprint GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions
    Geerten P van Nieuw Amerongen
    Center for Cardiovascular Research and Department of Medicine, Aab Institute for Biomedical Sciences, University of Rochester, Rochester, NY 14642, USA
    Circ Res 94:1041-9. 2004
    ....
  8. pmc Down-regulation of ERK but not MEK phosphorylation in cultured endothelial cells by repeated changes in cyclic stretch
    Feng Shi
    Cardiovascular Research Institute, University of Rochester, 601 Elmwood Avenue, Box 679, Rochester, NY 14642, USA
    Cardiovasc Res 73:813-22. 2007
    ..Experiments were designed to study how endothelial cells maintained under certain levels of cyclic stretch responded to shifts in stretch frequencies and amplitudes...
  9. ncbi request reprint Vascular endothelial cells that express dystroglycan are involved in angiogenesis
    Hiroshi Hosokawa
    Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Rochester NY 14642 8679, USA
    J Cell Sci 115:1487-96. 2002
    ..Our results suggest that the expression of DG in endothelial cells is under a dynamic regulation and may play a role in angiogenesis...
  10. pmc Phosphorylation and localization of protein-zero related (PZR) in cultured endothelial cells
    Ken ichi Kusano
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14586, USA
    Endothelium 15:127-36. 2008
    ..These results suggest that PZR is a cell adhesion protein that may be involved in SHP-2-dependent signaling at interendothelial cell contacts...
  11. pmc Collagen I matrix turnover is regulated by fibronectin polymerization
    Feng Shi
    Aab Cardiovascular Research Institute, Univ of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 298:C1265-75. 2010
    ..These data highlight the complexity of ECM remodeling. This multifaceted regulatory process may be important to ensure tight regulation of ECM fibronectin and collagen I levels...
  12. pmc PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5
    Patrizia Nigro
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 116:1971-9. 2010
    ..Taken together our results show that PKCĪ¶ binds and phosphorylates ERK5, thereby decreasing eNOS protein stability and contributing to early events of atherosclerosis...
  13. pmc Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?
    Masaki Osawa
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    J Cell Biol 158:773-85. 2002
    ..Binding of the beads by itself or pulling on the cell surface using poly-l-coated beads did not induce phosphorylation of PECAM-1 and ERK. These results suggest that PECAM-1 is a mechanotransduction molecule...
  14. ncbi request reprint Mechanical stresses keep endothelial cells healthy: beneficial effects of a physiological level of cyclic stretch on endothelial barrier function
    Keigi Fujiwara
    Am J Physiol Lung Cell Mol Physiol 285:L782-4. 2003