Affiliation: University of Rochester
- Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylationYi Jen Chiu
Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, West Henrietta, NY 14586, USA
J Cell Biol 182:753-63. 2008..We suggest that PECAM-1 and Fyn are essential components of a PECAM-1-based mechanosensory complex in ECs...
- Is PECAM-1 a mechanoresponsive molecule?K Fujiwara
Center for Cardiovascular Research, Department of Medicine, University of Rochester, NY 14624, USA
Cell Struct Funct 26:11-7. 2001..This PE-CAM-1 phosphorylation initiates a signaling cascade leading to ERK activation. Here we review what is known about PECAM-1 tyrosine phosphorylation and suggest a possible role of PECAM-1 in mechanosensing by endothelial cells...
- Platelet endothelial cell adhesion molecule-1 and mechanotransduction in vascular endothelial cellsK Fujiwara
Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, NY 14642, USA
J Intern Med 259:373-80. 2006..These results appear to indicate that PECAM-1 is a mechanotransduction molecule. To our knowledge, this is the first mammalian molecule that is shown to respond to mechanical force directly exerted to it...
- Endothelial cell-cell adhesion and mechanosignal transductionYi Jen Chiu
Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
Endothelium 11:59-73. 2004..We will also review the available evidence for PECAM-1 as a mechanotransducing molecule in endothelial cells...
- ECM remodeling in hypertensive heart diseaseBradford C Berk
Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
J Clin Invest 117:568-75. 2007..Recent research suggests that therapies targeting the expression, synthesis, or activation of the enzymes responsible for ECM homeostasis might represent novel opportunities to modify the natural progression of HHD...
- Serum response factor: master regulator of the actin cytoskeleton and contractile apparatusJoseph M Miano
Cardiovascular Research Institute, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
Am J Physiol Cell Physiol 292:C70-81. 2007..This review summarizes the recent genomic and genetic analyses of CArG-SRF that support its role as an ancient, master regulator of the actin cytoskeleton and contractile machinery...
- GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesionsGeerten P van Nieuw Amerongen
Center for Cardiovascular Research and Department of Medicine, Aab Institute for Biomedical Sciences, University of Rochester, Rochester, NY 14642, USA
Circ Res 94:1041-9. 2004....
- Down-regulation of ERK but not MEK phosphorylation in cultured endothelial cells by repeated changes in cyclic stretchFeng Shi
Cardiovascular Research Institute, University of Rochester, 601 Elmwood Avenue, Box 679, Rochester, NY 14642, USA
Cardiovasc Res 73:813-22. 2007..Experiments were designed to study how endothelial cells maintained under certain levels of cyclic stretch responded to shifts in stretch frequencies and amplitudes...
- Vascular endothelial cells that express dystroglycan are involved in angiogenesisHiroshi Hosokawa
Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Rochester NY 14642 8679, USA
J Cell Sci 115:1487-96. 2002..Our results suggest that the expression of DG in endothelial cells is under a dynamic regulation and may play a role in angiogenesis...
- Phosphorylation and localization of protein-zero related (PZR) in cultured endothelial cellsKen ichi Kusano
Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14586, USA
Endothelium 15:127-36. 2008..These results suggest that PZR is a cell adhesion protein that may be involved in SHP-2-dependent signaling at interendothelial cell contacts...
- Collagen I matrix turnover is regulated by fibronectin polymerizationFeng Shi
Aab Cardiovascular Research Institute, Univ of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Am J Physiol Cell Physiol 298:C1265-75. 2010..These data highlight the complexity of ECM remodeling. This multifaceted regulatory process may be important to ensure tight regulation of ECM fibronectin and collagen I levels...
- PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5Patrizia Nigro
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
Blood 116:1971-9. 2010..Taken together our results show that PKCζ binds and phosphorylates ERK5, thereby decreasing eNOS protein stability and contributing to early events of atherosclerosis...
- Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?Masaki Osawa
Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
J Cell Biol 158:773-85. 2002..Binding of the beads by itself or pulling on the cell surface using poly-l-coated beads did not induce phosphorylation of PECAM-1 and ERK. These results suggest that PECAM-1 is a mechanotransduction molecule...
- Mechanical stresses keep endothelial cells healthy: beneficial effects of a physiological level of cyclic stretch on endothelial barrier functionKeigi Fujiwara
Am J Physiol Lung Cell Mol Physiol 285:L782-4. 2003