D G Fujikawa

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Chronic epileptic encephalopathy in adult patients with bilaterally synchronous frequent and/or prolonged subclinical epileptiform discharges
    Denson G Fujikawa
    Neurology Department, VA Greater Los Angeles Healthcare System, North Hills, CA, USA
    Epilepsy Behav 25:442-8. 2012
  2. doi request reprint Mild as well as severe insults produce necrotic, not apoptotic, cells: evidence from 60-min seizures
    Denson G Fujikawa
    Experimental Neurology Laboratory, VA Greater Los Angeles Healthcare System, North Hills, CA 91343 2036, USA
    Neurosci Lett 469:333-7. 2010
  3. ncbi request reprint Caspase-dependent programmed cell death pathways are not activated in generalized seizure-induced neuronal death
    Denson G Fujikawa
    Experimental Neurology Laboratory, VA Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    Brain Res 1135:206-18. 2007
  4. ncbi request reprint Prolonged seizures and cellular injury: understanding the connection
    Denson G Fujikawa
    Experimental Neurology Laboratory, VA Greater Los Angeles Healthcare System, Sepulveda, CA, USA
    Epilepsy Behav 7:S3-11. 2005
  5. ncbi request reprint Caspase-3 is not activated in seizure-induced neuronal necrosis with internucleosomal DNA cleavage
    Denson G Fujikawa
    Experimental Neurology Laboratory 151B4, Department of Veterans Affairs, Greater Los Angeles Healthcare System, 16111 Plummer Street, Sepulveda, CA 91343, USA
    J Neurochem 83:229-40. 2002
  6. ncbi request reprint Effects of N-methyl-D-aspartate-receptor blockade on high-potassium-induced neuronal death and glutamate release
    D G Fujikawa
    Experimental Neurology Laboratory, VA Medical Center 151B4, Sepulveda, CA 91343, USA
    Neurosci Lett 226:25-8. 1997
  7. ncbi request reprint Seizure-induced neuronal necrosis: implications for programmed cell death mechanisms
    D G Fujikawa
    Neurology Department, Sepulveda Ambulatory Care Center, VA Greater Los Angeles Healthcare System, California 91343, USA
    Epilepsia 41:S9-13. 2000
  8. ncbi request reprint Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy
    D G Fujikawa
    Neurology Department, VA Greater Los Angeles Healthcare System, Sepulveda Ambulatory Care Center, California 91343, USA
    Epilepsia 41:981-91. 2000
  9. ncbi request reprint Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms
    D G Fujikawa
    Experimental Neurology Laboratory, VA Greater Los Angeles Healthcare System, Sepulveda Ambulatory Care Center and Nursing Home Care Unit, Sepulveda CA 91343, USA
    Neuroscience 98:41-53. 2000
  10. ncbi request reprint Lithium-pilocarpine-induced status epilepticus produces necrotic neurons with internucleosomal DNA fragmentation in adult rats
    D G Fujikawa
    Experimental Neurology Laboratory, VA Greater Los Angeles Healthcare System, Sepulveda Ambulatory Care Center and Nursing Home, Sepulveda, CA 91343, USA
    Eur J Neurosci 11:1605-14. 1999

Collaborators

Detail Information

Publications16

  1. doi request reprint Chronic epileptic encephalopathy in adult patients with bilaterally synchronous frequent and/or prolonged subclinical epileptiform discharges
    Denson G Fujikawa
    Neurology Department, VA Greater Los Angeles Healthcare System, North Hills, CA, USA
    Epilepsy Behav 25:442-8. 2012
    ..They illustrate the importance of minimizing the occurrence of SWDs with appropriate antiepileptic drugs and long-term monitoring with neuropsychological tests because chronic cognitive deficits are potentially reversible...
  2. doi request reprint Mild as well as severe insults produce necrotic, not apoptotic, cells: evidence from 60-min seizures
    Denson G Fujikawa
    Experimental Neurology Laboratory, VA Greater Los Angeles Healthcare System, North Hills, CA 91343 2036, USA
    Neurosci Lett 469:333-7. 2010
    ..Following seizures, a mild as well as a severe insult produces caspase-3-negative necrotic neurons. These results do not support the hypothesis that mild insults produce apoptotic, and severe insults, necrotic, cells...
  3. ncbi request reprint Caspase-dependent programmed cell death pathways are not activated in generalized seizure-induced neuronal death
    Denson G Fujikawa
    Experimental Neurology Laboratory, VA Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    Brain Res 1135:206-18. 2007
    ..In contrast, there is increasing evidence that caspase-independent programmed mechanisms play a prominent role in seizure-induced neuronal death...
  4. ncbi request reprint Prolonged seizures and cellular injury: understanding the connection
    Denson G Fujikawa
    Experimental Neurology Laboratory, VA Greater Los Angeles Healthcare System, Sepulveda, CA, USA
    Epilepsy Behav 7:S3-11. 2005
    ..In the future, rational combinations of central nervous system-penetrable neuroprotective agents, based on our knowledge of excitotoxic mechanisms, may be useful in refractory human SE...
  5. ncbi request reprint Caspase-3 is not activated in seizure-induced neuronal necrosis with internucleosomal DNA cleavage
    Denson G Fujikawa
    Experimental Neurology Laboratory 151B4, Department of Veterans Affairs, Greater Los Angeles Healthcare System, 16111 Plummer Street, Sepulveda, CA 91343, USA
    J Neurochem 83:229-40. 2002
    ..Either caspase-activated DNase is activated by another enzyme, or a caspase-independent DNase is responsible for the DNA cleavage...
  6. ncbi request reprint Effects of N-methyl-D-aspartate-receptor blockade on high-potassium-induced neuronal death and glutamate release
    D G Fujikawa
    Experimental Neurology Laboratory, VA Medical Center 151B4, Sepulveda, CA 91343, USA
    Neurosci Lett 226:25-8. 1997
    ..Although neither concentration reduced tissue edema, 360 microM CGP 40116 was neuroprotective and prevented the high-K+-induced elevations of glutamate...
  7. ncbi request reprint Seizure-induced neuronal necrosis: implications for programmed cell death mechanisms
    D G Fujikawa
    Neurology Department, Sepulveda Ambulatory Care Center, VA Greater Los Angeles Healthcare System, California 91343, USA
    Epilepsia 41:S9-13. 2000
    ..Endogenous glutamate release is probably responsible for neuronal death in both seizure models, because neuronal death in both is N-methyl-D-aspartate receptor-mediated...
  8. ncbi request reprint Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy
    D G Fujikawa
    Neurology Department, VA Greater Los Angeles Healthcare System, Sepulveda Ambulatory Care Center, California 91343, USA
    Epilepsia 41:981-91. 2000
    ..To determine the regional distribution of neuronal damage caused strictly by status epilepticus (SE) without systemic complications, underlying brain pathology, or a history of preexisting epilepsy...
  9. ncbi request reprint Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms
    D G Fujikawa
    Experimental Neurology Laboratory, VA Greater Los Angeles Healthcare System, Sepulveda Ambulatory Care Center and Nursing Home Care Unit, Sepulveda CA 91343, USA
    Neuroscience 98:41-53. 2000
    ..Programmed cell death mechanisms activated by kainic acid-induced status epilepticus occur in neurons which become necrotic and could contribute to necrotic, as well as apoptotic, neuronal death...
  10. ncbi request reprint Lithium-pilocarpine-induced status epilepticus produces necrotic neurons with internucleosomal DNA fragmentation in adult rats
    D G Fujikawa
    Experimental Neurology Laboratory, VA Greater Los Angeles Healthcare System, Sepulveda Ambulatory Care Center and Nursing Home, Sepulveda, CA 91343, USA
    Eur J Neurosci 11:1605-14. 1999
    ..Internucleosomal DNA cleavage and other programmed cell death mechanisms can be activated by SE in neurons which become necrotic...
  11. doi request reprint Nuclear translocation of mitochondrial cytochrome c, lysosomal cathepsins B and D, and three other death-promoting proteins within the first 60 minutes of generalized seizures
    Shuangping Zhao
    Experimental Neurology Laboratory, VA Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
    J Neurosci Res 88:1727-37. 2010
    ..The appearance of these mitochondrial proteins and lysosomal enzymes before signs of irreversible neuronal death suggests that they could contribute to seizure-induced nuclear pyknosis and DNA fragmentation...
  12. pmc Hypoxic neuronal necrosis: protein synthesis-independent activation of a cell death program
    Jerome Niquet
    Epilepsy Research, Research 151, Veterans Affairs Greater Los Angeles Healthcare System and Department of Neurology David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:2825-30. 2003
    ..Hypoxic neuronal necrosis may be an active process in which the direct effect of hypoxia on mitochondria may lead to the final common pathway of caspase-3-mediated neuronal death...
  13. ncbi request reprint Effects of AMPA-receptor and voltage-sensitive sodium channel blockade on high potassium-induced glutamate release and neuronal death in vivo
    Aiguo Wu
    Experimental Neurology Laboratory, VA Greater Los Angeles Healthcare System, Sepulveda Ambulatory Care Center and Nursing Home Care Unit, Sepulveda, CA 91343, USA
    Brain Res 946:119-29. 2002
    ..Our results suggest that in vivo, sodium influx through voltage-sensitive sodium channels but not through ligand-gated AMPA receptor channels contributes to high potassium-induced neuronal necrosis...
  14. ncbi request reprint Nonconvulsive status epilepticus with frontal features: quantitating severity of subclinical epileptiform discharges provides a marker for treatment efficacy, recurrence and outcome
    E A Licht
    Department of Neurology, VA Greater Los Angeles Healthcare System, Sepulveda Ambulatory Care Center and Nursing Home Care Unit, 16111 Plummer Street, Sepulveda, CA 91343, USA
    Epilepsy Res 51:13-21. 2002
    ....
  15. ncbi request reprint Neuronal death in mesial temporal sclerosis: separating morphology from mechanism
    Denson G Fujikawa
    Epilepsia 44:1607; author reply 1607-8. 2003
  16. ncbi request reprint Apoptosis: ignoring morphology and focusing on biochemical mechanisms will not eliminate confusion
    Denson G Fujikawa
    Trends Pharmacol Sci 23:309-10; author reply 310. 2002