Yi Fu

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Plasmon-enhanced fluorescence from single fluorophores end-linked to gold nanorods
    Yi Fu
    University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    J Am Chem Soc 132:5540-1. 2010
  2. pmc Fluorescent avidin-bound silver particle: a strategy for single target molecule detection on a cell membrane
    Jian Zhang
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Anal Chem 81:883-9. 2009
  3. pmc Plasmonic enhancement of single-molecule fluorescence near a silver nanoparticle
    Yi Fu
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, 725 W Lombard Street, Baltimore, MD 21201, USA
    J Fluoresc 17:811-6. 2007
  4. pmc Target molecule imaging on tissue specimens by fluorescent metal nanoprobes
    Jian Zhang
    University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, Baltimore, Maryland 21201, USA
    J Biomed Opt 16:116004. 2011
  5. pmc Fluorescent metal nanoshell and CK19 detection on single cell image
    Jian Zhang
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, MD 21201, USA
    Biochem Biophys Res Commun 413:53-7. 2011
  6. pmc Direct observation to chemokine receptor 5 on T-lymphocyte cell surface using fluorescent metal nanoprobes
    Jian Zhang
    Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA
    Biochem Biophys Res Commun 400:111-6. 2010
  7. pmc Large enhancement of single molecule fluorescence by coupling to hollow silver nanoshells
    Yi Fu
    Department of Molecular Biology and Biochemistry, University of Maryland School of Medicine, 725 W Lombard Street, Baltimore, MD 21201, USA
    Chem Commun (Camb) 48:9726-8. 2012
  8. pmc Detection of CXCR4 receptors on cell surface using a fluorescent metal nanoshell
    Jian Zhang
    University of Maryland School of Medicine, Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    J Biomed Opt 16:016011. 2011
  9. pmc Metal-enhanced single-molecule fluorescence on silver particle monomer and dimer: coupling effect between metal particles
    Jian Zhang
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Nano Lett 7:2101-7. 2007
  10. pmc Fluorescence images of DNA-bound YOYO between coupled silver particles
    Jian Zhang
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Langmuir 23:11734-9. 2007

Detail Information

Publications25

  1. pmc Plasmon-enhanced fluorescence from single fluorophores end-linked to gold nanorods
    Yi Fu
    University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    J Am Chem Soc 132:5540-1. 2010
    ..The bioconjugated nanoantenna structure implicates an approach that is more convenient and amenable to integration for photonic, optoelectronic, and biotechnological applications...
  2. pmc Fluorescent avidin-bound silver particle: a strategy for single target molecule detection on a cell membrane
    Jian Zhang
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Anal Chem 81:883-9. 2009
    ..On the basis of this curve, we expect to develop an approach that can be used to quantify the amount of target molecules on the cell surfaces using the cell intensity and lifetime images at the single cell level...
  3. pmc Plasmonic enhancement of single-molecule fluorescence near a silver nanoparticle
    Yi Fu
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, 725 W Lombard Street, Baltimore, MD 21201, USA
    J Fluoresc 17:811-6. 2007
    ..These results demonstrate that the use of fluorophore-metal interactions can increase the brightness and photostability of fluorophores for single molecule detection...
  4. pmc Target molecule imaging on tissue specimens by fluorescent metal nanoprobes
    Jian Zhang
    University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, Baltimore, Maryland 21201, USA
    J Biomed Opt 16:116004. 2011
    ..This observation demonstrates that the metal nanoprobes can be used for single target molecule detection on tissues during fluorescence imaging measurements...
  5. pmc Fluorescent metal nanoshell and CK19 detection on single cell image
    Jian Zhang
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, MD 21201, USA
    Biochem Biophys Res Commun 413:53-7. 2011
    ..These emission signals could also be precisely counted on single cell images. The count number may provide an approach for quantifying the target molecules in the cells...
  6. pmc Direct observation to chemokine receptor 5 on T-lymphocyte cell surface using fluorescent metal nanoprobes
    Jian Zhang
    Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA
    Biochem Biophys Res Commun 400:111-6. 2010
    ....
  7. pmc Large enhancement of single molecule fluorescence by coupling to hollow silver nanoshells
    Yi Fu
    Department of Molecular Biology and Biochemistry, University of Maryland School of Medicine, 725 W Lombard Street, Baltimore, MD 21201, USA
    Chem Commun (Camb) 48:9726-8. 2012
    ..The enhancement of the quantum efficiency is attributed to enhanced absorption and increased radiative decay rate...
  8. pmc Detection of CXCR4 receptors on cell surface using a fluorescent metal nanoshell
    Jian Zhang
    University of Maryland School of Medicine, Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    J Biomed Opt 16:016011. 2011
    ..In addition, the CXCR4 receptors are estimated to distribute on ̃approximately 70% area of the cell surface...
  9. pmc Metal-enhanced single-molecule fluorescence on silver particle monomer and dimer: coupling effect between metal particles
    Jian Zhang
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Nano Lett 7:2101-7. 2007
    ..Finite-difference time-domain (FDTD) calculations were employed to study the distribution of electric field near the metal monomer and dimer. The coupling effect of metal particle on the fluorescence enhancement was discussed...
  10. pmc Fluorescence images of DNA-bound YOYO between coupled silver particles
    Jian Zhang
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Langmuir 23:11734-9. 2007
    ..The shortened lifetime of YOYO molecules between the coupled metal particles indicated that the fluorescence was enhanced via a near-field interaction mechanism between the fluorophore and the metal nanoparticle...
  11. pmc Enhanced fluorescence images for labeled cells on silver island films
    Jian Zhang
    Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Langmuir 24:12452-7. 2008
    ..Thus, the metal supports can be used to improve the detection sensitivity for target molecules on cell surfaces when they are fluorescently labeled...
  12. pmc Reduced blinking and long-lasting fluorescence of single fluorophores coupling to silver nanoparticles
    Yi Fu
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Langmuir 24:3429-33. 2008
    ..The results show that plasmonic-controlled fluorescence can lead to a novel physical mechanism to enhance fluorescence intensity, reduce blinking, and increase photostability...
  13. pmc Largely enhanced single-molecule fluorescence in plasmonic nanogaps formed by hybrid silver nanostructures
    Yi Fu
    Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 W Lombard Street, Baltimore, Maryland 21201, USA
    Langmuir 29:2731-8. 2013
    ..These effects may be used for increased detectability of single molecules bound to surfaces which contain metallic structures for either biophysical studies or high sensitivity assays...
  14. pmc Metal plasmon-coupled fluorescence imaging and label free coenzyme detection in cells
    Jian Zhang
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, MD 21201, USA
    Biochem Biophys Res Commun 425:696-700. 2012
    ..Fluorescence cell imaging on the metallic particle substrates may provide a non-invasive strategy for collecting the information of coenzymes in cells...
  15. pmc Fluorescent metal nanoshell probe to detect single miRNA in lung cancer cell
    Jian Zhang
    Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Anal Chem 82:4464-71. 2010
    ..The results may reflect a genomic signal change and provide a reference to lung cancer early diagnosis as well as other diseases...
  16. pmc Enhanced fluorescence of Cy5-labeled oligonucleotides near silver island films: a distance effect study using single molecule spectroscopy
    Yi Fu
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, Baltimore, Maryland 21201 USA
    J Phys Chem B 110:22557-62. 2006
    ..These studies illustrate the exclusive information that is otherwise hidden in ensemble measurements...
  17. pmc Direct observation of chemokine receptors 5 on T-lymphocyte cell surfaces using fluorescent metal nanoprobes 2: Approximation of CCR5 populations
    Jian Zhang
    Department of Biochemistry and Molecular Biology, Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, United States
    Biochem Biophys Res Commun 407:63-7. 2011
    ....
  18. pmc Single-cell fluorescence imaging using metal plasmon-coupled probe 2: single-molecule counting on lifetime image
    Jian Zhang
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, MD 21201, USA
    Nano Lett 8:1179-86. 2008
    ..The metal-associated fluorophores thus are suggested using as novel molecular imaging agents to quantify the components and describe their distributions on the cell surfaces...
  19. pmc Metal-enhanced fluorescence of single green fluorescent protein (GFP)
    Yi Fu
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, 725 W Lombard Street, Baltimore, MD 21201, USA
    Biochem Biophys Res Commun 376:712-7. 2008
    ..Accordingly, we observed longer duration time and suppressed blinking. The single-molecule lifetime histograms indicate the relatively heterogeneous distributions of protein mutants inside the structure...
  20. pmc Plasmon-controlled fluorescence: a new paradigm in fluorescence spectroscopy
    Joseph R Lakowicz
    University of Maryland School of Medicine, Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, 725 W Lombard St, Baltimore, MD 21201, USA
    Analyst 133:1308-46. 2008
    ..Additionally, we summarize the recent work on metal-fluorophore interactions and suggest how these effects will result in new classes of experimental procedures, novel probes, bioassays and devices...
  21. pmc Single cell fluorescence imaging using metal plasmon-coupled probe
    Jian Zhang
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Bioconjug Chem 18:800-5. 2007
    ..PCPs were conjugated on HEK 293 A cells. Imaging results demonstrate that cells labeled by PCPs were 20-fold brighter than those by free labeled con A...
  22. pmc Highly efficient detection of single fluorophores in blood serum samples with high autofluorescence
    Yi Fu
    Department of Biochemistry and Molecular Biology, Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, USA
    Photochem Photobiol 85:646-51. 2009
    ..Increased SNR near metallic nanostructure could probably overcome the need for diffraction-limited volumes and enhance our ability to do in situ SMD...
  23. doi Enhanced single molecule fluorescence and reduced observation volumes on nanoporous gold (NPG) films
    Yi Fu
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, 725 W Lombard Street, Baltimore, MD, USA
    Chem Commun (Camb) 49:10874-6. 2013
    ..The enhanced localized plasmon field existing in the "nanovoid" regions can be visualized from the overlaid mapping image derived from surface reflectance and fluorescence emission. ..
  24. pmc Photophysical behaviors of single fluorophores localized on zinc oxide nanostructures
    Yi Fu
    Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland School of Medicine, 725 Lombard Street, Baltimore, MD 21201, USA E Mails J Z J R L
    Int J Mol Sci 13:12100-12. 2012
    ..The fluorescence fluctuation dynamics were found to be inhomogeneous from molecule to molecule and from time to time, showing significant static and dynamic disorders in the interfacial electron transfer reaction processes...
  25. ncbi Enhanced fluorescence of Cy5-labeled DNA tethered to silver island films: fluorescence images and time-resolved studies using single-molecule spectroscopy
    Yi Fu
    Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA
    Anal Chem 78:6238-45. 2006
    ..In addition, time-correlated single-photon counting results reveal the reduced lifetimes of single molecules tethered to silver island films...